Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 11.94 uM | Concentration that reducedthe MT-4 cell viability by 50%. | ChEMBL. | 12672256 |
CC50 (functional) | = 11.94 uM | Concentration that reducedthe MT-4 cell viability by 50%. | ChEMBL. | 12672256 |
IC50 (functional) | = 0.31 uM | Concentration required to inhibit the viral (SIV mac251) cytopathic effect by 50% in MT-4 cells. | ChEMBL. | 12672256 |
IC50 (functional) | = 0.38 uM | Concentration required to inhibit the viral (HIV-1 NNRTI resistant strain) cytopathic effect by 50% in MT-4 cells. | ChEMBL. | 12672256 |
IC50 (functional) | = 0.63 uM | Concentration required to inhibit the viral (HIV-1 NL4.3 strain) cytopathic effect by 50% in MT-4 cells. | ChEMBL. | 12672256 |
IC50 (functional) | = 0.72 uM | Concentration required to inhibit the viral (HIV-1 IIIB strain) cytopathic effect by 50% in MT-4 cells. | ChEMBL. | 12672256 |
IC50 (functional) | = 0.72 uM | Concentration required to inhibit the viral (HIV-2 ROD) cytopathic effect by 50% in MT-4 cells. | ChEMBL. | 12672256 |
IC50 (functional) | = 5.37 uM | Tested for inhibitory concentration against MSV-Induced transformation of C3H/3T3 embryo murine fibroblast in vitro | ChEMBL. | 12672256 |
IC50 (functional) | = 5.37 uM | Tested for inhibitory concentration against MSV-Induced transformation of C3H/3T3 embryo murine fibroblast in vitro | ChEMBL. | 12672256 |
MIC (functional) | >= 12.6 uM | Tested for minimum inhibitory concentration against MSV-Induced transformation of C3H/3T3 embryo murine fibroblast in vitro | ChEMBL. | 12672256 |
MIC (functional) | >= 12.6 uM | Tested for minimum inhibitory concentration against MSV-Induced transformation of C3H/3T3 embryo murine fibroblast in vitro | ChEMBL. | 12672256 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 12672256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.