Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0547 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.1494 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1494 | 0.2644 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.4127 | 0.3787 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1494 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0547 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4127 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0547 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1494 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4127 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1494 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1494 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1494 | 0.1313 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0208 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0547 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0547 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.4127 | 0.3787 |
Onchocerca volvulus | 0.0023 | 0.1494 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0547 | 0.2642 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1494 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.1494 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1494 | 0.1313 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1494 | 0.2644 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0547 | 0.3665 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1494 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.4127 | 0.3787 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0208 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.1494 | 0.2644 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0547 | 0.3665 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0547 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0547 | 0.0347 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.1494 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.4127 | 0.3787 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0547 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.1494 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1494 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0547 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0208 | 0.139 |
Brugia malayi | hypothetical protein | 0.0035 | 0.4127 | 0.3787 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0208 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1494 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4127 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.1494 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1494 | 0.1001 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1494 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1494 | 0.1313 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0547 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0547 | 0.0347 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.1494 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1494 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0547 | 0.2642 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1494 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0547 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibiofilm activity against Escherichia coli O157:H7 assessed as induction of flhD gene expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | ChEMBL. | 24456071 | |
Activity (ADMET) | Antimicrobial activity against Escherichia coli O157:H7 assessed as growth inhibition up to 50 ug/ml by spectrophotometry | ChEMBL. | 24456071 | |
Activity (functional) | Antibiofilm activity against Escherichia coli O157:H7 assessed as induction of qseB gene expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | ChEMBL. | 24456071 | |
Activity (functional) | Antibiofilm activity against Escherichia coli O157:H7 assessed as induction of motB gene expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | ChEMBL. | 24456071 | |
Activity (functional) | Antibiofilm activity against Escherichia coli O157:H7 assessed as induction of fliA gene expression at 20 ug/ml after 5 hrs by qRT-PCR analysis | ChEMBL. | 24456071 | |
Inhibition (functional) | Antibiofilm activity against Escherichia coli O157:H7 after 24 hrs by spectrophotometry | ChEMBL. | 24456071 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.