Detailed information for compound 544761

Basic information

Technical information
  • TDR Targets ID: 544761
  • Name: 1-[(E)-cinnamyl]-4-(3-fluoro-6,11-dihydrobenz o[c][1]benzoxepin-11-yl)piperazine; fumaric a cid
  • MW: 646.659 | Formula: C35H35FN2O9
  • H donors: 4 H acceptors: 8 LogP: -0.4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc2c(c1)OCc1c(C2N2CCN(CC2)C/C=C/c2ccccc2)cccc1.OC(=O)C=CC(=O)O.OC(=O)C=CC(=O)O
  • InChi: 1S/C27H27FN2O.2C4H4O4/c28-23-12-13-25-26(19-23)31-20-22-10-4-5-11-24(22)27(25)30-17-15-29(16-18-30)14-6-9-21-7-2-1-3-8-21;2*5-3(6)1-2-4(7)8/h1-13,19,27H,14-18,20H2;2*1-2H,(H,5,6)(H,7,8)/b9-6+;2*2-1+
  • InChiKey: BGBBGKWUEFWPAV-PBCGGMKNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-but-2-enedioic acid; 1-(3-fluoro-6,11-dihydrobenzo[c][1]benzoxepin-11-yl)-4-[(E)-3-phenylprop-2-enyl]piperazine
  • AJ 3941
  • 143110-70-7
  • AJ-3941
  • Piperazine, 1-(3-fluoro-6,11-dihydrodibenz(b,e)oxepin-11-yl)-4-(3-phenyl-2-propenyl)-, (E)-(+-)-, (Z)-2-butenedioate (1:2)
  • (+-)-(E)-1-(3-Fluoro-6,11-dihydrodibenz(b,e)oxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate
  • 1-(3-Fluoro-6,11-dihydrodibenz(b,e)oxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.1172 1
Echinococcus granulosus lysine specific demethylase 5A 0.0092 0.0255 0.0254
Echinococcus multilocularis chromobox protein 1 0.029 0.1154 0.1153
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.0363 0.8438
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.0122 0.0121
Schistosoma mansoni hypothetical protein 0.013 0.0427 0.0396
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0387 0.1598 0.1597
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.0413 0.9837
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.0317 0.0316
Loa Loa (eye worm) TAR-binding protein 0.072 0.3114 0.41
Leishmania major cathepsin L-like protease 0.0127 0.0413 0.9837
Brugia malayi Protein cec-1. 0.0047 0.0051 0.0065
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0065
Brugia malayi Heterochromatin protein 1 0.029 0.1154 0.1518
Echinococcus multilocularis Chromobox protein 3 0.0047 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0387 0.1598 0.2103
Brugia malayi Cytochrome P450 family protein 0.0049 0.0061 0.0077
Echinococcus granulosus GPCR family 2 0.013 0.0427 0.0426
Trichomonas vaginalis set domain proteins, putative 0.194 0.8664 1
Schistosoma mansoni hypothetical protein 0.0281 0.1113 0.1085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0317 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0317 0.7151
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0193 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0076 0.0182 0.0181
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0019 0.0018
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.019 0.0189
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0122 0.0158
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0064 0.0082
Plasmodium falciparum phd finger protein, putative 0.0063 0.0122 0.4688
Schistosoma mansoni hypothetical protein 0.0128 0.0418 0.0388
Brugia malayi jmjC domain containing protein 0.0092 0.0255 0.0333
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0696 0.3002 0.3953
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.1172 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0065
Loa Loa (eye worm) latrophilin receptor protein 2 0.013 0.0427 0.056
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0301 0.1204 0.1204
Brugia malayi Bromodomain containing protein 0.0328 0.1328 0.1747
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.0957 0.0956
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0051 0.0542
Loa Loa (eye worm) PHD-finger family protein 0.0173 0.0622 0.0816
Schistosoma mansoni hypothetical protein 0.013 0.0427 0.0396
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0317 0.0308
Loa Loa (eye worm) cytochrome P450 family protein 0.0108 0.0328 0.043
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0193 0.9455
Loa Loa (eye worm) acetyltransferase 0.0318 0.1283 0.1687
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0206 0.0773 0.0772
Echinococcus multilocularis musashi 0.0083 0.0215 0.0214
Echinococcus granulosus intermediate filament protein 0.0083 0.0215 0.0214
Loa Loa (eye worm) hypothetical protein 0.0162 0.0575 0.0755
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.013 0.0427 0.0426
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0047 0.0051 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0575 0.0608
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0244 0.0948 1
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0215 0.0281
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0039 0.0049
Echinococcus granulosus lamin dm0 0.0083 0.0215 0.0214
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.019 0.0161
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.019 0.0161
Loa Loa (eye worm) hypothetical protein 0.0592 0.253 0.333
Loa Loa (eye worm) hypothetical protein 0.0108 0.0326 0.0427
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.013 0.0427 0.0426
Schistosoma mansoni chromobox protein 0.029 0.1154 0.1126
Schistosoma mansoni bromodomain containing protein 0.0537 0.228 0.2255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1172 0.1301
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.013 0.0427 0.0426
Loa Loa (eye worm) hypothetical protein 0.0348 0.1421 0.1869
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0317 0.0286
Schistosoma mansoni methyl-cpg binding protein mbd 0.0143 0.0485 0.0455
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0359 0.0357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Loa Loa (eye worm) inositol-1 0.0078 0.019 0.0248
Schistosoma mansoni tar DNA-binding protein 0.072 0.3114 0.3092
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0175 0.0631 0.0673
Trypanosoma cruzi ISWI complex protein 0.0128 0.0418 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.0983 0.1292
Loa Loa (eye worm) helicase 0.0047 0.0051 0.0065
Echinococcus multilocularis tar DNA binding protein 0.072 0.3114 0.3114
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.019 0.3019
Echinococcus multilocularis lamin dm0 0.0083 0.0215 0.0214
Brugia malayi intermediate filament protein 0.0083 0.0215 0.0281
Echinococcus granulosus chromobox protein 1 0.029 0.1154 0.1153
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.0317 0.0316
Loa Loa (eye worm) hypothetical protein 0.0086 0.0227 0.0296
Loa Loa (eye worm) hypothetical protein 0.0039 0.0012 0.0013
Loa Loa (eye worm) RNA binding protein 0.072 0.3114 0.41
Brugia malayi chromobox protein homolog 3 0.0162 0.0575 0.0755
Schistosoma mansoni hypothetical protein 0.013 0.0427 0.0396
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.0317 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0162 0.0575 0.0608
Echinococcus granulosus methyl CpG binding domain protein 2 0.0143 0.0485 0.0485
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1172 0.1301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0047 0.0051 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0413 0.9837
Schistosoma mansoni kinase 0.0054 0.008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0065
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0193 0.3099
Loa Loa (eye worm) hypothetical protein 0.0199 0.074 0.0973
Loa Loa (eye worm) hypothetical protein 0.0127 0.0415 0.0544
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0411 0.1704 0.2243
Brugia malayi Bromodomain containing protein 0.009 0.0245 0.032
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0074 0.0026
Brugia malayi Inositol-1 0.0078 0.019 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Onchocerca volvulus 0.0047 0.0051 0.000000054109
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0063 0.0124 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0317 0.0308
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0193 0.3099
Brugia malayi Associated with TFs and helicases family protein 0.0047 0.0051 0.0065
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0047 0.0051 0.0542
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0193 0.2038
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0047 0.0051 0.002
Plasmodium vivax SET domain protein, putative 0.0244 0.0948 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0193 0.2944
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0318 0.1283 0.1282
Loa Loa (eye worm) CHromoDomain protein family member 0.0063 0.0124 0.0161
Brugia malayi Pre-SET motif family protein 0.1704 0.7592 1
Trypanosoma brucei polo-like protein kinase 0.0106 0.0317 0.7151
Loa Loa (eye worm) bromodomain containing protein 0.0155 0.0542 0.0711
Echinococcus granulosus histone acetyltransferase KAT2B 0.0107 0.0325 0.0324
Loa Loa (eye worm) hypothetical protein 0.0086 0.0227 0.0296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1172 0.1301
Brugia malayi Valyl-tRNA synthetase 0.0047 0.0051 0.0065
Schistosoma mansoni jumonji domain containing protein 0.0164 0.058 0.055
Brugia malayi F/Y-rich N-terminus family protein 0.0046 0.0043 0.0054
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.368 0.368
Echinococcus granulosus tar DNA binding protein 0.072 0.3114 0.3114
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0047 0.0051 0.0051
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0153 0.1976
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0244 0.0948 0.0919
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0039 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0292 0.1164 0.1136
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.013 0.0427 0.0426
Loa Loa (eye worm) hypothetical protein 0.013 0.0427 0.056
Onchocerca volvulus 0.0199 0.074 0.08
Loa Loa (eye worm) jmjC domain-containing protein 0.0092 0.0255 0.0333
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0489 1
Onchocerca volvulus 0.194 0.8664 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0189 0.0694 0.0665
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0107 0.0325 0.3426
Schistosoma mansoni lamin 0.0083 0.0215 0.0184
Trypanosoma brucei ISWI complex protein 0.0128 0.0418 1
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0215 0.0281
Schistosoma mansoni hypothetical protein 0.013 0.0427 0.0396
Onchocerca volvulus 0.0083 0.0215 0.019
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0189 0.0694 0.0694
Echinococcus multilocularis microtubule associated protein 2 0.2233 1 1
Schistosoma mansoni zinc finger protein 0.0171 0.0615 0.0585
Brugia malayi jmjC domain containing protein 0.0206 0.0773 0.1015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0122 0.009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.072 0.3114 0.41
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0107 0.0325 0.3426
Echinococcus granulosus peregrin 0.009 0.0245 0.0244
Brugia malayi TAR-binding protein 0.072 0.3114 0.41
Brugia malayi Bromodomain containing protein 0.0635 0.2726 0.3589
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0413 0.9837
Schistosoma mansoni eyes absent homolog 0.0086 0.0227 0.0195
Loa Loa (eye worm) hypothetical protein 0.0083 0.0215 0.0281
Echinococcus multilocularis jumonji domain containing protein 0.0087 0.0234 0.0233
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0047 0.0051 0.002
Brugia malayi CHD4 protein 0.0063 0.0124 0.0161
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0318 0.1283 0.1255
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0193 0.2038
Trichomonas vaginalis chromobox protein, putative 0.0175 0.0631 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0359 0.0357
Schistosoma mansoni lipoxygenase 0.0054 0.0081 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1172 0.1301
Loa Loa (eye worm) hypothetical protein 0.0082 0.0208 0.0272
Plasmodium vivax heterochromatin protein 1, putative 0.0047 0.0051 0.0542
Schistosoma mansoni chromobox protein 0.029 0.1154 0.1126
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.0317 0.7151
Echinococcus granulosus chromobox protein 1 0.029 0.1154 0.1153
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0411 0.1704 0.2243
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0107 0.0325 0.3426
Brugia malayi follicle stimulating hormone receptor 0.0696 0.3002 0.3953
Brugia malayi latrophilin 2 splice variant baaae 0.0281 0.1113 0.1464
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.0317 0.0414
Echinococcus multilocularis tumor protein p63 0.1358 0.6017 0.6017
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0051 0.0542
Leishmania major cathepsin L-like protease 0.0127 0.0413 0.9837
Brugia malayi RNA recognition motif domain containing protein 0.072 0.3114 0.41
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0575 0.0608
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0153 0.1976
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1172 0.1301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0065
Brugia malayi PHD-finger family protein 0.0063 0.0122 0.0158
Echinococcus granulosus lamin 0.0083 0.0215 0.0214
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.019 0.3611
Trichomonas vaginalis chromobox protein, putative 0.0175 0.0631 0.0673
Giardia lamblia Kinase, PLK 0.0106 0.0317 0.1854
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0063 0.0124 0.0093
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.0317 0.2365
Echinococcus granulosus fetal alzheimer antigen falz 0.0189 0.0694 0.0694
Loa Loa (eye worm) heterochromatin protein 1 0.029 0.1154 0.1518
Schistosoma mansoni intermediate filament proteins 0.0083 0.0215 0.0184
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.013 0.0427 0.056
Brugia malayi PHD-finger family protein 0.0216 0.0818 0.1075
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0081 0.008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0507 0.2143 0.2143
Leishmania major cathepsin L-like protease 0.0127 0.0413 0.9837
Brugia malayi hypothetical protein 0.0246 0.0957 0.1258
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0122 0.0121
Trichomonas vaginalis chromobox protein, putative 0.029 0.1154 0.128
Loa Loa (eye worm) hypothetical protein 0.0364 0.1494 0.1965
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0143 0.0485 0.0485
Echinococcus granulosus chromobox protein 2 0.0047 0.0051 0.0051
Brugia malayi hypothetical protein 0.0086 0.0227 0.0296
Schistosoma mansoni zinc finger protein 0.0128 0.0418 0.0388
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0206 0.0773 0.0772
Brugia malayi acetyltransferase, GNAT family protein 0.0318 0.1283 0.1687
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0074 0.0026
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.019 0.0161
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0122 0.1284
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.007 0.0069
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.019 0.1235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1704 0.7592 1
Leishmania major hypothetical protein, conserved 0.0128 0.0418 1
Echinococcus multilocularis lamin 0.0083 0.0215 0.0214
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.019 0.0189
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.019 0.3611
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.1154 0.1154
Echinococcus granulosus zinc finger protein 0.0171 0.0615 0.0614
Brugia malayi Calcitonin receptor-like protein seb-1 0.0411 0.1704 0.2243
Echinococcus multilocularis Chromo domain 0.0047 0.0051 0.0051
Onchocerca volvulus 0.0083 0.0215 0.019
Echinococcus granulosus tumor protein p63 0.1358 0.6017 0.6017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0235 0.0907 0.0907
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0193 0.5
Brugia malayi RNA binding protein 0.072 0.3114 0.41
Echinococcus granulosus histone lysine methyltransferase setb 0.0387 0.1598 0.1597
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0063 0.0122 0.009
Loa Loa (eye worm) hypothetical protein 0.0246 0.0957 0.1258
Schistosoma mansoni chromobox protein 0.0047 0.0051 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0107 0.0325 0.0317
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0317 0.0308
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1172 0.1301
Loa Loa (eye worm) hypothetical protein 0.0063 0.0122 0.0158
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.019 0.3611
Echinococcus granulosus Chromo domain 0.0047 0.0051 0.0051
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0122 0.1284
Schistosoma mansoni inositol monophosphatase 0.0078 0.019 0.0159
Echinococcus multilocularis chromobox protein 2 0.0047 0.0051 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0061 0.0077
Loa Loa (eye worm) hypothetical protein 0.0411 0.1704 0.2243
Schistosoma mansoni cellular tumor antigen P53 0.0199 0.074 0.0711
Echinococcus multilocularis chromobox protein 1 0.029 0.1154 0.1153
Trichomonas vaginalis chromobox protein, putative 0.029 0.1154 0.128
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0301 0.1204 0.1204
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0122 0.1284
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.0983 0.1292
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.0957 0.0956
Loa Loa (eye worm) hypothetical protein 0.0281 0.1113 0.1464
Schistosoma mansoni tar DNA-binding protein 0.072 0.3114 0.3092
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0317 0.0308
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.0426 0.0559
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.007 0.0069
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0255 0.0224
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0317 0.0308
Schistosoma mansoni survival motor neuron protein 0.005 0.0064 0.0033
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0065
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0193 0.0193
Loa Loa (eye worm) CYP4Cod1 0.0049 0.0061 0.0077
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0387 0.1598 0.1571
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.1172 1
Echinococcus multilocularis GPCR, family 2 0.013 0.0427 0.0426
Brugia malayi Cytochrome P450 family protein 0.0108 0.0328 0.043
Brugia malayi MH2 domain containing protein 0.0252 0.0983 0.1292
Loa Loa (eye worm) hypothetical protein 0.0039 0.0012 0.0013
Schistosoma mansoni tar DNA-binding protein 0.072 0.3114 0.3092
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.1172 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0143 0.0485 0.0455
Schistosoma mansoni lamin 0.0083 0.0215 0.0184
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0489 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0022
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0193 0.2038
Echinococcus granulosus Chromobox protein 3 0.0047 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0079 0.0193 0.0252
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.019 0.3611
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0193 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Brugia malayi Cytochrome P450 family protein 0.0049 0.0061 0.0077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0255 0.0224
Brugia malayi Latrophilin receptor protein 2 0.013 0.0427 0.056
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0047 0.0051 0.0065
Echinococcus granulosus jumonji domain containing protein 0.0087 0.0234 0.0233
Schistosoma mansoni tar DNA-binding protein 0.072 0.3114 0.3092
Schistosoma mansoni hypothetical protein 0.0047 0.0051 0.002
Brugia malayi SET domain containing protein 0.0056 0.0092 0.0119
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0081 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0387 0.1598 0.1571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Brugia malayi Pre-SET motif family protein 0.0244 0.0948 0.1247
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0201 0.0758
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0317 0.7151
Trypanosoma cruzi ISWI complex protein 0.0128 0.0418 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0047 0.0051 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0061 0.0077
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0065
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0019 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1172 0.1301
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0489 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0193 0.0162
Brugia malayi hypothetical protein 0.0047 0.0051 0.0065
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.019 0.2002
Onchocerca volvulus Alhambra homolog 0.0063 0.0122 0.0082
Schistosoma mansoni microtubule-associated protein tau 0.2233 1 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0047 0.0051 0.0542
Schistosoma mansoni hypothetical protein 0.0173 0.0622 0.0592
Schistosoma mansoni tar DNA-binding protein 0.072 0.3114 0.3092
Brugia malayi Probable ClpP-like protease 0.0079 0.0193 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0413 0.9837
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0317 0.0308
Schistosoma mansoni inositol monophosphatase 0.0078 0.019 0.0159
Onchocerca volvulus 0.0292 0.1164 0.1292
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0289 0.6385
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0244 0.0948 0.0948
Onchocerca volvulus 0.0127 0.0415 0.0422
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0063 0.0124 0.0123
Echinococcus multilocularis peregrin 0.009 0.0245 0.0244
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0065
Echinococcus multilocularis zinc finger protein 0.0171 0.0615 0.0614
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0413 0.9837
Loa Loa (eye worm) hypothetical protein 0.0321 0.1297 0.1707
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.0317 0.0414
Onchocerca volvulus 0.005 0.0064 0.0015
Brugia malayi M-phase phosphoprotein, mpp8 0.0047 0.0051 0.0065
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0507 0.2143 0.2143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1172 0.1301
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0107 0.0325 0.0317
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0215 0.0281
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0201 0.1338
Schistosoma mansoni chromobox protein 0.0047 0.0051 0.002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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