Detailed information for compound 544794

Basic information

Technical information
  • TDR Targets ID: 544794
  • Name: 2-(2-pyridyl)pyridine; ruthenium(2+)
  • MW: 569.622 | Formula: C30H24N6Ru++
  • H donors: 0 H acceptors: 6 LogP: 4.44 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: c1ccc(nc1)c1ccccn1.c1ccc(nc1)c1ccccn1.c1ccc(nc1)c1ccccn1.[Ru+2]
  • InChi: 1S/3C10H8N2.Ru/c3*1-3-7-11-9(5-1)10-6-2-4-8-12-10;/h3*1-8H;/q;;;+2
  • InChiKey: HNVRWFFXWFXICS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-pyridin-2-ylpyridine; ruthenium(2+)
  • tris(2,2'-bipyridine)ruthenium II
  • tris(2,2'-bipyridyl)ruthenium(II)
  • 2-pyridin-2-ylpyridine; ruthenium(+2) cation
  • 2-(2-pyridyl)pyridine; ruthenium(+2) cation
  • 23677-82-9
  • 69028-29-1
  • 71031-51-1
  • Ru(II)-Tris(bipyridyl)
  • Ruthenium II tris(2,2'-bipyridine)
  • Ruthenium(2+), tris(2,2'-bipyridine-N,N')-, (OC-6-11)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0033 0.0072 0.1215
Brugia malayi Pre-SET motif family protein 0.0154 0.0644 0.1287
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0273 0.0273
Schistosoma mansoni microtubule-associated protein tau 0.2135 1 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0033 0.0072 0.1215
Loa Loa (eye worm) cysteine protease 0.0033 0.0071 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0131 0.0131
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0033 0.0072 0.1215
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0033 0.0072 0.1215
Plasmodium vivax SET domain containing protein 0.0024 0.0027 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0094 0.0165
Loa Loa (eye worm) hypothetical protein 0.0195 0.0834 0.1668
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0141 0.2744
Leishmania major DNA polymerase kappa, putative 0.0019 0.0002 0.0044
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0131 0.0131
Brugia malayi RNA recognition motif domain containing protein 0.0653 0.3001 0.5999
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0252 0.1103 0.2204
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0131 0.2028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1299 0.2277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0063
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0057 0.0183 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0201 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.0144
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0002 0.0038
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0094 0.1844
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0141 0.014
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0094 0.0165
Schistosoma mansoni lamin 0.003 0.0055 0.0055
Leishmania major DNA polymerase eta, putative 0.0031 0.0058 0.1133
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0071 0.1383
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0057 0.0183 0.2838
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0222 0.0964 0.0964
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.029 0.058
Toxoplasma gondii exonuclease III APE 0.0018 0 0.0002
Leishmania major cathepsin L-like protease 0.0127 0.0512 1
Schistosoma mansoni tar DNA-binding protein 0.0653 0.3001 0.3001
Trypanosoma brucei unspecified product 0.0019 0.0002 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Brugia malayi follicle stimulating hormone receptor 0.0716 0.3295 0.6587
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0058 0.0902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.0144
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0119 0.0238
Echinococcus granulosus intermediate filament protein 0.003 0.0055 0.0055
Brugia malayi jmjC domain containing protein 0.0047 0.0138 0.0276
Brugia malayi Bromodomain containing protein 0.024 0.105 0.2099
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0057 0.0185 0.0324
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.029 0.029
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0033 0.0072 0.1215
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0002 0.0004
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0183 0.1406
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0273 1
Brugia malayi Cytochrome P450 family protein 0.0033 0.0072 0.0144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0044
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0071 0.0142
Trichomonas vaginalis hypothetical protein 0.0057 0.0183 0.032
Giardia lamblia DINP protein human, muc B family 0.0019 0.0002 0.0017
Loa Loa (eye worm) acetyltransferase 0.016 0.067 0.134
Schistosoma mansoni hypothetical protein 0.0128 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0105
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0112
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0582 0.0582
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0273 0.0478
Echinococcus granulosus histone lysine methyltransferase setb 0.026 0.1142 0.1142
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0002 0.0044
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0364 0.7106
Brugia malayi Cathepsin L-like precursor 0.0033 0.0071 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0033 0.0072 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0834 0.1462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Brugia malayi hypothetical protein 0.002 0.0006 0.0012
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.067 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.0144
Loa Loa (eye worm) hypothetical protein 0.0057 0.0183 0.0365
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0141 0.0246
Plasmodium falciparum heterochromatin protein 1 0.0057 0.0183 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0158 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0192 0.3251
Echinococcus granulosus dna polymerase kappa 0.0019 0.0002 0.0002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0141 0.2744
Brugia malayi intermediate filament protein 0.003 0.0055 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Echinococcus multilocularis lamin dm0 0.003 0.0055 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0183 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0033 0.0072 0.1215
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0408 0.6907
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0141 0.0246
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0071 0.1383
Echinococcus multilocularis tar DNA binding protein 0.0653 0.3001 0.3001
Brugia malayi TAR-binding protein 0.0653 0.3001 0.5999
Toxoplasma gondii cytochrome p450 superfamily protein 0.0033 0.0072 0.1116
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0273 0.4613
Echinococcus multilocularis Chromobox protein 3 0.0057 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0369 0.0369
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0222 0.0964 0.0964
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0002 0.0004
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0071 0.3882
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0033 0.0072 0.1215
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0021 0.0413
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0139 0.0573 0.0572
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0006 0.0006
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0364 0.28
Loa Loa (eye worm) RNA binding protein 0.0653 0.3001 0.5999
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0094 0.1842
Schistosoma mansoni bromodomain containing protein 0.003 0.0056 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1299 0.2277
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0057 0.0183 1
Echinococcus granulosus peregrin 0.0048 0.0139 0.0139
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0033 0.0072 0.1215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0141 0.1082
Brugia malayi PHD-finger family protein 0.0158 0.0659 0.1317
Brugia malayi Cathepsin L-like precursor 0.0033 0.0071 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0211 0.0912 0.0912
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0275 0.0275
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0053 0.0053
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.1135 0.1135
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0033 0.0072 0.1215
Echinococcus granulosus chromobox protein 2 0.0057 0.0183 0.0183
Brugia malayi Thioredoxin reductase 0.0046 0.0131 0.0261
Leishmania major cathepsin L-like protease 0.0033 0.0071 0.1383
Echinococcus multilocularis GPCR, family 2 0.008 0.029 0.029
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0408 0.6907
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.0512 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0071 0.0124
Brugia malayi cathepsin L-like precursor 0.0022 0.0019 0.0038
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0071 0.0071
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0033 0.0072 0.1215
Schistosoma mansoni hypothetical protein 0.0057 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0106
Brugia malayi SET domain containing protein 0.0063 0.021 0.0419
Schistosoma mansoni chromobox protein 0.0348 0.1556 0.1556
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0364 0.0637
Onchocerca volvulus 0.0033 0.0071 0.0114
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0141 0.0281
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0138 0.0276
Echinococcus granulosus chromobox protein 1 0.0348 0.1556 0.1556
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0057 0.0185 0.2876
Loa Loa (eye worm) CYP4Cod1 0.0052 0.0158 0.0316
Echinococcus multilocularis dna polymerase eta 0.0043 0.0119 0.0119
Loa Loa (eye worm) intermediate filament protein 0.003 0.0055 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0105 0.0412 0.0412
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1299 0.2277
Echinococcus granulosus Chromobox protein 3 0.0057 0.0183 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0364 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0273 0.5325
Leishmania major cytochrome p450-like protein 0.0033 0.0072 0.1402
Echinococcus granulosus tumor protein p63 0.1016 0.4715 0.4715
Trichomonas vaginalis chromobox protein, putative 0.0057 0.0183 0.032
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0006 0.0006
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0006 0.0096
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0033 0.0072 0.1215
Entamoeba histolytica hypothetical protein 0.0057 0.0183 0.1406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.0144
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0154 0.0644 0.0644
Brugia malayi Inositol-1 0.0076 0.0273 0.0545
Loa Loa (eye worm) hypothetical protein 0.0149 0.0617 0.1233
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0033 0.0072 0.1402
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0653 0.3001 0.5999
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.046 0.8986
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0006 0.0006
Brugia malayi Doublecortin family protein 0.002 0.0006 0.0012
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0131 0.2209
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0033 0.0072 0.1215
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0512 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1299 0.2277
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0183 0.032
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0033 0.0072 0.1215
Schistosoma mansoni inositol monophosphatase 0.0076 0.0273 0.0272
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0273 0.5324
Brugia malayi PHD-finger family protein 0.0029 0.0053 0.0106
Loa Loa (eye worm) hypothetical protein 0.0437 0.198 0.3959
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0141 0.2744
Loa Loa (eye worm) hypothetical protein 0.0018 0 0.0001
Schistosoma mansoni eyes absent homolog 0.0087 0.0326 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0066 0.0115
Onchocerca volvulus Heterochromatin protein 1 homolog 0.021 0.0904 0.1576
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0107 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0063
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0273 0.2098
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0369 0.0369
Echinococcus multilocularis musashi 0.003 0.0055 0.0055
Loa Loa (eye worm) doublecortin family protein 0.002 0.0006 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.0727 0.1453
Loa Loa (eye worm) hypothetical protein 0.005 0.0152 0.0304
Schistosoma mansoni inositol monophosphatase 0.0076 0.0273 0.0272
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0057 0.0183 0.0183
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0154 0.0644 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0015 0.0015
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0192 0.2984
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0033 0.0072 0.1215
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0033 0.0072 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Schistosoma mansoni cellular tumor antigen P53 0.0149 0.0617 0.0617
Brugia malayi Calcitonin receptor-like protein seb-1 0.0252 0.1103 0.2204
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.1299 1
Brugia malayi glutathione reductase 0.0046 0.0131 0.0261
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.067 0.134
Loa Loa (eye worm) hypothetical protein 0.0057 0.0183 0.0365
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Loa Loa (eye worm) helicase 0.0057 0.0183 0.0365
Schistosoma mansoni hypothetical protein 0.0029 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0033 0.0072 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.0144
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0172 0.0172
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0137 0.0239
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0158 0.3089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0019 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0006 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0252 0.1103 0.2204
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0163 0.0326
Onchocerca volvulus 0.0033 0.0071 0.0114
Trichomonas vaginalis chromobox protein, putative 0.0057 0.0183 0.032
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0119 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Brugia malayi chromobox protein homolog 3 0.0195 0.0834 0.1668
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.029 0.029
Mycobacterium tuberculosis Probable reductase 0.0105 0.0408 0.6907
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.067 0.067
Onchocerca volvulus 0.0153 0.0635 0.1104
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0071 0.3882
Brugia malayi Valyl-tRNA synthetase 0.0057 0.0183 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.0144
Loa Loa (eye worm) CHromoDomain protein family member 0.0069 0.0239 0.0477
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0071 0.3882
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0006 0.0339
Loa Loa (eye worm) hypothetical protein 0.008 0.029 0.058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1077 0.5002 1
Trichomonas vaginalis chromobox protein, putative 0.021 0.0904 0.1585
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1299 1
Schistosoma mansoni tar DNA-binding protein 0.0653 0.3001 0.3001
Schistosoma mansoni hypothetical protein 0.008 0.029 0.029
Trichomonas vaginalis chromobox protein, putative 0.021 0.0904 0.1585
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0364 0.7106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0716 0.3295 0.6587
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0019 0.0002 0.0004
Brugia malayi cytochrome P450 0.0033 0.0072 0.0144
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0095 0.0361 0.0361
Schistosoma mansoni tar DNA-binding protein 0.0653 0.3001 0.3001
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0033 0.0072 0.1215
Giardia lamblia Kinase, PLK 0.0095 0.0364 0.2799
Leishmania major cathepsin L-like protease 0.0033 0.0071 0.1383
Schistosoma mansoni polycystin 1-related 0.002 0.0006 0.0006
Leishmania major cathepsin L-like protease 0.0033 0.0071 0.1383
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0149 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.0727 0.1453
Schistosoma mansoni hypothetical protein 0.0172 0.0727 0.0726
Loa Loa (eye worm) hypothetical protein 0.0256 0.1121 0.2241
Echinococcus multilocularis chromobox protein 2 0.0057 0.0183 0.0183
Toxoplasma gondii histone lysine methyltransferase SET1 0.0024 0.0027 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0061 0.0107
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0033 0.0072 0.1215
Brugia malayi CHD4 protein 0.0069 0.0239 0.0477
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0364 0.0727
Onchocerca volvulus 0.0033 0.0071 0.0114
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0033 0.0072 0.1215
Onchocerca volvulus 0.1226 0.5705 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0364 0.0727
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0158 0.0316
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0071 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0094 0.0165
Brugia malayi Cathepsin L-like precursor 0.0022 0.0019 0.0038
Loa Loa (eye worm) hypothetical protein 0.0153 0.0635 0.127
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0033 0.0072 0.1215
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0364 0.0627
Loa Loa (eye worm) hypothetical protein 0.0057 0.0183 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0094 0.0165
Trypanosoma cruzi ISWI complex protein 0.0095 0.0361 0.7051
Echinococcus multilocularis chromobox protein 1 0.0348 0.1556 0.1556
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0071 0.0546
Toxoplasma gondii cathepsin CPL 0.0033 0.0071 0.1102
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0512 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0364 0.0637
Echinococcus granulosus histone acetyltransferase KAT2B 0.0057 0.0185 0.0185
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0119 0.2326
Schistosoma mansoni bromodomain containing protein 0.0395 0.178 0.1779
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0033 0.0072 0.1215
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0071 0.0071
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0183 0.032
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0069 0.0239 0.0239
Leishmania major trypanothione reductase 0.0046 0.0131 0.2549
Onchocerca volvulus 0.0211 0.0912 0.159
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0107 0.0107
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0002 0.0038
Echinococcus multilocularis zinc finger protein 0.0125 0.0503 0.0503
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0033 0.0072 0.1215
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0533 0.1065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0048 0.0084
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0141 0.2746
Brugia malayi hypothetical protein 0.002 0.0006 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Brugia malayi hypothetical protein 0.0057 0.0183 0.0365
Schistosoma mansoni lipoxygenase 0.002 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0566 0.0991
Schistosoma mansoni rab6-interacting 0.002 0.0006 0.0006
Leishmania major cathepsin L-like protease 0.0127 0.0512 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0033 0.0072 0.1215
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0033 0.0072 0.1215
Schistosoma mansoni chromobox protein 0.0348 0.1556 0.1556
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0053 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0183 0.032
Schistosoma mansoni lipoxygenase 0.0055 0.0172 0.0172
Echinococcus multilocularis microtubule associated protein 2 0.2135 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0273 0.5324
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Leishmania major cytochrome p450-like protein 0.0052 0.0158 0.3089
Onchocerca volvulus 0.003 0.0055 0.0086
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0082 0.0082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0463 0.7542
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0057 0.0183 0.0183
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0183 0.1406
Brugia malayi hypothetical protein 0.0087 0.0326 0.0652
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0057 0.0183 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0183 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0086
Brugia malayi hypothetical protein 0.0259 0.1135 0.227
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0069 0.0239 0.0239
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0033 0.0072 0.1215
Trypanosoma brucei trypanothione reductase 0.0046 0.0131 0.2551
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0183 0.2838
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0192 0.3251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0083 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.0448 0.0896
Echinococcus granulosus cathepsin l1 0.0033 0.0071 0.0071
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0273 0.5324
Loa Loa (eye worm) hypothetical protein 0.0087 0.0326 0.0652
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0 0.0008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0273 0.0478
Brugia malayi Cytochrome P450 family protein 0.0052 0.0158 0.0316
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0183 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0408 0.6907
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0192 0.3751
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0071 0.0071
Echinococcus granulosus tar DNA binding protein 0.0653 0.3001 0.3001
Leishmania major DNA polymerase eta, putative 0.0043 0.0119 0.2324
Brugia malayi Bromodomain containing protein 0.0048 0.0139 0.0278
Schistosoma mansoni chromobox protein 0.0057 0.0183 0.0183
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0053 0.0053
Echinococcus granulosus chromobox protein 1 0.0348 0.1556 0.1556
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0033 0.0072 0.1215
Schistosoma mansoni survival motor neuron protein 0.0053 0.0163 0.0163
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0002
Loa Loa (eye worm) ctsf protein 0.0033 0.0071 0.0142
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0463 0.784
Schistosoma mansoni tar DNA-binding protein 0.0653 0.3001 0.3001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0183 0.032
Echinococcus granulosus lamin 0.003 0.0055 0.0055
Onchocerca volvulus 0.0022 0.0019 0.0023
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0033 0.0072 0.1402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0139 0.0573 0.0573
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1299 0.2277
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0183 0.1406
Plasmodium vivax heterochromatin protein 1, putative 0.0057 0.0183 0.2838
Loa Loa (eye worm) hypothetical protein 0.0057 0.0183 0.0365
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0192 0.0192
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0195 0.0834 0.1453
Onchocerca volvulus 0.0149 0.0617 0.1071
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0138 0.0138
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0235 0.3144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1299 0.2277
Schistosoma mansoni methyl-cpg binding protein mbd 0.0105 0.0412 0.0412
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0072 0.1402
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0364 0.0364
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0057 0.0183 0.0365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0033 0.0072 0.1215
Brugia malayi Protein cec-1. 0.0057 0.0183 0.0365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0141 0.0281
Echinococcus multilocularis tumor protein p63 0.1016 0.4715 0.4715
Plasmodium vivax SET domain protein, putative 0.0154 0.0644 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0002 0.0002
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0158 0.3089
Trypanosoma cruzi major cysteine proteinase, putative 0.0099 0.0384 0.7499
Echinococcus granulosus methyl CpG binding domain protein 2 0.0105 0.0412 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0137 0.0239
Brugia malayi Cathepsin L-like precursor 0.0033 0.0071 0.0142
Trichomonas vaginalis chromobox protein, putative 0.0057 0.0183 0.032
Echinococcus granulosus RUN 0.002 0.0006 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0463 0.784
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0591 1
Onchocerca volvulus 0.0053 0.0163 0.0275
Plasmodium falciparum thioredoxin reductase 0.0046 0.0131 0.7146
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0055 0.011
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0033 0.0072 0.1215
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.026 0.1142 0.1142
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0071 0.0071
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0033 0.0072 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0033 0.0072 0.1215
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0141 0.2744
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0002 0.0038
Loa Loa (eye worm) hypothetical protein 0.026 0.1142 0.2283
Echinococcus granulosus lamin dm0 0.003 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0273 0.4234
Schistosoma mansoni methyl-cpg binding protein mbd 0.0105 0.0412 0.0412
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0002 0.0018
Echinococcus granulosus fetal alzheimer antigen falz 0.0139 0.0573 0.0573
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0058 0.1133
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0141 0.0141
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0033 0.0072 0.1215
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.029 0.058
Brugia malayi Bromodomain containing protein 0.0467 0.2122 0.4242
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0019 0.0038
Trichomonas vaginalis chromobox protein, putative 0.0348 0.1556 0.2727
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.029 0.029
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0008 0.0158
Schistosoma mansoni hypothetical protein 0.008 0.029 0.029
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0033 0.0072 0.1215
Trypanosoma brucei ISWI complex protein 0.0095 0.0361 0.7052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0183 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0141 0.0246
Schistosoma mansoni cytochrome P450 0.0033 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0048 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.1135 0.1135
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Onchocerca volvulus 0.003 0.0055 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0183 0.2838
Loa Loa (eye worm) inositol-1 0.0076 0.0273 0.0545
Schistosoma mansoni DNA polymerase eta 0.0043 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0364 0.0364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1299 0.2277
Echinococcus granulosus GPCR family 2 0.008 0.029 0.029
Brugia malayi Pre-SET motif family protein 0.1077 0.5002 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0071 0.0124
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0057 0.0185 0.2876
Schistosoma mansoni loxhd1 0.002 0.0006 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0138 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.026 0.1142 0.1142
Trichomonas vaginalis bromodomain-containing protein, putative 0.0057 0.0185 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Giardia lamblia PHD finger protein 15 0.0029 0.0053 0.0406
Loa Loa (eye worm) hypothetical protein 0.0057 0.0183 0.0365
Brugia malayi Cathepsin L-like precursor 0.0022 0.0019 0.0038
Echinococcus multilocularis lamin 0.003 0.0055 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0053 0.082
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0 0.0003
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0141 0.0141
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0192 0.3251
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0591 1
Schistosoma mansoni rab6-interacting 0.002 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0183 0.032
Echinococcus granulosus Chromo domain 0.0057 0.0183 0.0183
Schistosoma mansoni zinc finger protein 0.0125 0.0503 0.0503
Brugia malayi Cathepsin L-like precursor 0.0033 0.0071 0.0142
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0463 0.784
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0019 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0044
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0053 0.082
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0057 0.0183 0.0183
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0192 0.3251
Loa Loa (eye worm) glutathione reductase 0.0046 0.0131 0.0261
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0141 0.1082
Echinococcus multilocularis cysteine protease 0.0033 0.0071 0.0071
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0183 0.032
Plasmodium falciparum phd finger protein, putative 0.0029 0.0053 0.2891
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0053 0.0053
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0019 0.0033
Brugia malayi jmjC domain containing protein 0.0096 0.0369 0.0737
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0192 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0072 0.1402
Loa Loa (eye worm) PHD-finger family protein 0.0128 0.0517 0.1033
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0192 0.0192
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1299 1
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0019 0.0147
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0052 0.0158 0.2677
Plasmodium vivax vivapain-2 0.0033 0.0071 0.1102
Brugia malayi RNA binding protein 0.0653 0.3001 0.5999
Echinococcus granulosus dna polymerase eta 0.0043 0.0119 0.0119
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0033 0.0072 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0033 0.0072 0.1215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.026 0.1142 0.1142
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0071 0.0114
Schistosoma mansoni intermediate filament proteins 0.003 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0053 0.082
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0364 0.0364
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0099 0.0762
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0364 0.0637
Echinococcus granulosus cathepsin l1 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0002 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0408 0.6479
Trichomonas vaginalis Heterochromatin protein, putative 0.0057 0.0183 0.032
Toxoplasma gondii thioredoxin reductase 0.0046 0.0131 0.2028
Onchocerca volvulus Alhambra homolog 0.0029 0.0053 0.0082
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0141 0.2746
Loa Loa (eye worm) hypothetical protein 0.0267 0.1177 0.2353
Echinococcus granulosus lysine specific demethylase 5A 0.0047 0.0138 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0063
Schistosoma mansoni kinase 0.0048 0.0143 0.0142
Entamoeba histolytica hypothetical protein 0.0057 0.0183 0.1406
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0364 0.0637
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0071 0.0142
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0071 0.0071
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0887 0.4103 0.4103
Loa Loa (eye worm) hypothetical protein 0.0259 0.1135 0.227
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0033 0.0072 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0094 0.0165
Onchocerca volvulus 0.0033 0.0071 0.0114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0183 0.032
Trichomonas vaginalis set domain proteins, putative 0.1226 0.5705 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0131 0.2549
Plasmodium vivax vivapain-2 0.0033 0.0071 0.1102
Brugia malayi PHD-finger family protein 0.0021 0.0015 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0071 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0063
Echinococcus multilocularis cysteine protease 0.0033 0.0071 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0047
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0006 0.0006
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0057 0.0183 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1299 0.2277
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0033 0.0072 0.1215
Trichomonas vaginalis chromobox protein, putative 0.0348 0.1556 0.2727
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0107 0.0107
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0364 0.0637
Entamoeba histolytica cysteine protease, putative 0.0033 0.0071 0.0546
Leishmania major cathepsin L-like protease 0.0033 0.0071 0.1383
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0119 0.2324
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0002 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0033 0.0072 0.1215
Trypanosoma brucei polo-like protein kinase 0.0095 0.0364 0.7107
Onchocerca volvulus 0.0057 0.0183 0.031
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0408 0.6907
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0002
Onchocerca volvulus 0.0033 0.0071 0.0114
Trypanosoma cruzi ISWI complex protein 0.0095 0.0361 0.7051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0183 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0071 0.0071
Leishmania major cathepsin L-like protease 0.0033 0.0071 0.1383
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0591 1
Echinococcus granulosus cytochrome P450 2K1 0.0033 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Brugia malayi Cytochrome P450 family protein 0.0052 0.0158 0.0316
Loa Loa (eye worm) heterochromatin protein 1 0.0348 0.1556 0.311
Brugia malayi Cytochrome P450 family protein 0.0113 0.0448 0.0896
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.1299 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0183 0.032
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0131 0.0261
Loa Loa (eye worm) bromodomain containing protein 0.0113 0.0447 0.0894
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0069 0.0239 0.0238
Schistosoma mansoni hypothetical protein 0.008 0.029 0.029
Brugia malayi Associated with TFs and helicases family protein 0.0057 0.0183 0.0365
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0042 0.0084
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0099 0.0763
Brugia malayi M-phase phosphoprotein, mpp8 0.0057 0.0183 0.0365
Schistosoma mansoni hypothetical protein 0.008 0.029 0.029
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0063
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0373 0.1675 0.1675
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0033 0.0072 0.1215
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0235 0.3977
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0094 0.1842
Loa Loa (eye worm) hypothetical protein 0.0057 0.0183 0.0365
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0408 0.6907
Brugia malayi Cathepsin L-like precursor 0.0033 0.0071 0.0142
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0071 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0154 0.0644 0.0644
Brugia malayi MH2 domain containing protein 0.0131 0.0533 0.1065
Schistosoma mansoni hypothetical protein 0.0053 0.0163 0.0163
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0057 0.0183 0.2838
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0373 0.1675 0.1675
Giardia lamblia GTOR 0.0048 0.0141 0.1081
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0002 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Entamoeba histolytica hypothetical protein 0.0057 0.0183 0.1406
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0834 0.1462
Trypanosoma brucei cytochrome P450, putative 0.0052 0.0158 0.3091
Echinococcus multilocularis peregrin 0.0048 0.0139 0.0139
Echinococcus multilocularis Chromo domain 0.0057 0.0183 0.0183
Brugia malayi Heterochromatin protein 1 0.0348 0.1556 0.311
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0512 1
Echinococcus multilocularis chromobox protein 1 0.0348 0.1556 0.1556
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0192 0.0192
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0533 0.1065
Plasmodium vivax glutathione reductase, putative 0.0046 0.0131 0.2028
Loa Loa (eye worm) hypothetical protein 0.0237 0.1035 0.2069
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0364 0.0637
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0512 1
Loa Loa (eye worm) cytochrome P450 0.0033 0.0072 0.0144
Brugia malayi Cathepsin L-like precursor 0.0033 0.0071 0.0142
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0364 0.7106
Schistosoma mansoni zinc finger protein 0.0095 0.0361 0.0361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.029 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Loa Loa (eye worm) hypothetical protein 0.0087 0.0326 0.0652
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0057 0.0183 0.2838
Onchocerca volvulus 0.0033 0.0071 0.0114
Loa Loa (eye worm) hypothetical protein 0.0252 0.1103 0.2204
Schistosoma mansoni chromobox protein 0.0057 0.0183 0.0183
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Onchocerca volvulus 0.0033 0.0071 0.0114
Leishmania major cytochrome p450-like protein 0.0033 0.0072 0.1402
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0057 0.0185 0.2876
Leishmania major hypothetical protein, conserved 0.0095 0.0361 0.7051
Echinococcus multilocularis 0.0033 0.0072 0.0072
Onchocerca volvulus 0.0057 0.0183 0.031
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0033 0.0072 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0183 0.032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0273 0.0478
Loa Loa (eye worm) fibroinase 0.0033 0.0071 0.0142
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0083 0.1282
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0099 0.5428
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0071 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0063
Brugia malayi Latrophilin receptor protein 2 0.008 0.029 0.058
Loa Loa (eye worm) TAR-binding protein 0.0653 0.3001 0.5999
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0047
Echinococcus multilocularis RUN 0.002 0.0006 0.0006
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0071 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0071 0.0124
Schistosoma mansoni lamin 0.003 0.0055 0.0055
Leishmania major cathepsin L-like protease 0.0127 0.0512 1
Schistosoma mansoni tar DNA-binding protein 0.0653 0.3001 0.3001
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0057 0.0183 0.0365
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0055 0.011
Plasmodium falciparum glutathione reductase 0.0046 0.0131 0.7146
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0071 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0566 0.0991
Echinococcus granulosus zinc finger protein 0.0125 0.0503 0.0503
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0033 0.0072 0.1215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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