Detailed information for compound 544852

Basic information

Technical information
  • TDR Targets ID: 544852
  • Name: 1,3-dibutyl-2-thioxo-imidazolidine-4,5-dione
  • MW: 242.338 | Formula: C11H18N2O2S
  • H donors: 0 H acceptors: 2 LogP: 2.57 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN1C(=S)N(C(=O)C1=O)CCCC
  • InChi: 1S/C11H18N2O2S/c1-3-5-7-12-9(14)10(15)13(11(12)16)8-6-4-2/h3-8H2,1-2H3
  • InChiKey: XUHLNLNNPFTDLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-dibutyl-2-thioxoimidazolidine-4,5-dione
  • 1,3-dibutyl-2-sulfanylidene-imidazolidine-4,5-dione
  • 1,3-dibutyl-2-thioxo-imidazolidine-4,5-quinone
  • 1,3-dibutyl-2-sulfanylideneimidazolidine-4,5-dione
  • merodantoin
  • 143413-73-4
  • 1,3-Dibutyl-2-thioxo-4,5-imidazolidinedione
  • 4,5-Imidazolidinedione, 1,3-dibutyl-2-thioxo-
  • N,N'-Dibutyl-2-thio-4,5-imidazolidion

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0902 0.3157 0.5268
Echinococcus granulosus histone acetyltransferase KAT2B 0.0063 0.0139 0.0136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.007 0.0165 0.0241
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.007 0.0165 0.0163
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0126 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0165 0.0241
Echinococcus multilocularis microtubule associated protein 2 0.2804 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0268 0.0392
Loa Loa (eye worm) hypothetical protein 0.0143 0.0427 0.071
Plasmodium vivax SET domain containing protein 0.0032 0.003 0.0184
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0074 0.1819
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.0356 0.0354
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.007 0.0165 0.3967
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0165 0.0241
Schistosoma mansoni SET domain protein 0.0027 0.0009 0.0007
Loa Loa (eye worm) acetyltransferase 0.0167 0.0513 0.0853
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0151 0.0149
Onchocerca volvulus 0.0107 0.0299 0.0424
Trichomonas vaginalis Heterochromatin protein, putative 0.007 0.0165 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0008 0.0012
Brugia malayi jmjC domain containing protein 0.0124 0.0359 0.0596
Echinococcus granulosus Chromobox protein 3 0.007 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.0051 0.0097 0.0158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0171 0.0169
Toxoplasma gondii PHD-finger domain-containing protein 0.0088 0.0231 0.2787
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0041 0.0881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0014
Brugia malayi CXXC zinc finger family protein 0.003 0.002 0.0029
Plasmodium vivax heterochromatin protein 1, putative 0.007 0.0165 0.1936
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0268 0.0392
Loa Loa (eye worm) RNA binding protein 0.0902 0.3157 0.5268
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0139 0.0412 0.041
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.0513 0.0511
Echinococcus multilocularis neuropeptide s receptor 0.0479 0.1637 0.1635
Trypanosoma cruzi ISWI complex protein 0.0124 0.0361 1
Brugia malayi jmjC domain containing protein 0.0028 0.0016 0.0022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.007 0.0165 0.0241
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0074 0.0657
Trichomonas vaginalis chromobox protein, putative 0.0258 0.0841 0.1231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0041 0.006
Trichomonas vaginalis conserved hypothetical protein 0.024 0.0776 0.1135
Echinococcus granulosus jumonji domain containing protein 0.0123 0.0355 0.0353
Brugia malayi Cytochrome P450 family protein 0.0027 0.0011 0.0014
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0016 0.0022
Schistosoma mansoni intermediate filament proteins 0.011 0.0309 0.0307
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0151 0.0249
Echinococcus granulosus zinc finger protein 0.0165 0.0505 0.0503
Schistosoma mansoni chromodomain helicase DNA binding protein 0.007 0.0165 0.0163
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0016 0.0013
Brugia malayi Heterochromatin protein 1 0.0428 0.1452 0.242
Onchocerca volvulus 0.011 0.0309 0.0439
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0429 0.0427
Brugia malayi SET domain containing protein 0.0027 0.0009 0.0012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.0309 0.0512
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.0299 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0051 0.0074
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0491 0.1679 0.1677
Brugia malayi M-phase phosphoprotein, mpp8 0.007 0.0165 0.0272
Loa Loa (eye worm) hypothetical protein 0.0066 0.0151 0.0249
Loa Loa (eye worm) CHromoDomain protein family member 0.0087 0.0227 0.0375
Onchocerca volvulus 0.007 0.0165 0.0228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0243 0.0787 0.0785
Onchocerca volvulus 0.011 0.0309 0.0439
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0074 0.0072
Brugia malayi intermediate filament protein 0.011 0.0309 0.0512
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0126 0.3345
Echinococcus granulosus lamin 0.011 0.0309 0.0307
Trichomonas vaginalis set domain proteins, putative 0.1923 0.683 1
Echinococcus granulosus lysine specific demethylase 5A 0.0124 0.0359 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0008 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0048
Brugia malayi PHD-finger family protein 0.0208 0.0661 0.11
Brugia malayi jmjC domain containing protein 0.0028 0.0016 0.0022
Entamoeba histolytica hypothetical protein 0.007 0.0165 0.3967
Echinococcus multilocularis peregrin 0.0111 0.0313 0.0311
Echinococcus granulosus lamin dm0 0.011 0.0309 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0048
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.0309 0.0512
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0104 0.0287 0.6971
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0089 0.013
Trichomonas vaginalis chromobox protein, putative 0.007 0.0165 0.0241
Echinococcus granulosus neuropeptide s receptor 0.0479 0.1637 0.1635
Schistosoma mansoni zinc finger protein 0.0124 0.0361 0.0358
Echinococcus granulosus methyl CpG binding domain protein 2 0.0139 0.0412 0.041
Trypanosoma brucei ISWI complex protein 0.0124 0.0361 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.007 0.0165 0.1936
Schistosoma mansoni chromobox protein 0.007 0.0165 0.0163
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0742 0.074
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0289 0.0953 0.0951
Loa Loa (eye worm) hypothetical protein 0.0231 0.0742 0.1236
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0112 0.0183
Brugia malayi hypothetical protein 0.0231 0.0742 0.1236
Plasmodium vivax hypothetical protein, conserved 0.007 0.0165 0.1936
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0082 0.0134
Schistosoma mansoni chromobox protein 0.0428 0.1452 0.145
Trichomonas vaginalis chromobox protein, putative 0.0428 0.1452 0.2125
Trypanosoma cruzi ISWI complex protein 0.0124 0.0361 1
Echinococcus multilocularis zinc finger protein 0.0165 0.0505 0.0503
Giardia lamblia PHD finger protein 15 0.0088 0.0231 0.8228
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0178 0.026
Brugia malayi AF-10 protein 0.0029 0.0017 0.0024
Schistosoma mansoni inositol monophosphatase 0.0116 0.033 0.0328
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0116 0.033 0.9249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0014
Brugia malayi Valyl-tRNA synthetase 0.007 0.0165 0.0272
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0016 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0011 0.0014
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0016 0.0013
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.007 0.0165 0.3967
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0185 0.0579 0.0576
Schistosoma mansoni zinc finger protein 0.0165 0.0505 0.0503
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.0666 0.1107
Trichomonas vaginalis bromodomain-containing protein, putative 0.0063 0.0139 0.0203
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.169 0.5991 1
Loa Loa (eye worm) hypothetical protein 0.024 0.0776 0.1291
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0087 0.0227 0.0225
Trypanosoma brucei polo-like protein kinase 0.0099 0.0268 0.7355
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.0356 0.9873
Loa Loa (eye worm) MH2 domain-containing protein 0.0364 0.1222 0.2037
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0268 0.0444
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0151 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0902 0.3157 0.3155
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0268 0.0392
Schistosoma mansoni hypothetical protein 0.0066 0.0151 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0041 0.006
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0116 0.033 0.408
Brugia malayi follicle stimulating hormone receptor 0.024 0.0775 0.129
Giardia lamblia Kinase, PLK 0.0099 0.0268 1
Echinococcus granulosus neuropeptide receptor A26 0.0479 0.1637 0.1635
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0011 0.0014
Echinococcus multilocularis tar DNA binding protein 0.0902 0.3157 0.3155
Brugia malayi Bromodomain containing protein 0.0615 0.2126 0.3546
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.033 0.9131
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0087 0.0227 0.0225
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0016 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0048
Brugia malayi jmjC domain containing protein 0.0028 0.0016 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0268 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0165 0.0241
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.033 0.9131
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0017 0.018
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0126 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0524 0.0767
Toxoplasma gondii MAPEG family protein 0.0218 0.0697 0.8834
Trichomonas vaginalis hypothetical protein 0.007 0.0165 0.0241
Loa Loa (eye worm) hypothetical protein 0.0188 0.0589 0.098
Echinococcus multilocularis chromobox protein 1 0.0428 0.1452 0.145
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0021 0.0031
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0087 0.0227 0.0225
Loa Loa (eye worm) heterochromatin protein 1 0.0428 0.1452 0.242
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0165 0.0241
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0356 0.0354
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0074 0.1819
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0125 0.0205
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0289 0.0953 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0014
Schistosoma mansoni lamin 0.011 0.0309 0.0307
Echinococcus granulosus peregrin 0.0111 0.0313 0.0311
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0074 0.1819
Brugia malayi Associated with TFs and helicases family protein 0.007 0.0165 0.0272
Loa Loa (eye worm) hypothetical protein 0.007 0.0165 0.0272
Echinococcus multilocularis jumonji domain containing protein 0.0123 0.0355 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0074 0.0109
Brugia malayi chromobox protein homolog 3 0.024 0.0776 0.1291
Loa Loa (eye worm) hypothetical protein 0.011 0.0309 0.0512
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0016 0.0013
Echinococcus multilocularis Chromo domain 0.007 0.0165 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0165 0.0241
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0023 0.0363
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0063 0.0139 0.0203
Brugia malayi MH2 domain containing protein 0.0364 0.1222 0.2037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0126 0.3345
Loa Loa (eye worm) hypothetical protein 0.0046 0.0079 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0041 0.006
Schistosoma mansoni hypothetical protein 0.0124 0.0361 0.0358
Echinococcus multilocularis neuropeptide receptor A26 0.0479 0.1637 0.1635
Toxoplasma gondii PHD-finger domain-containing protein 0.0088 0.0231 0.2787
Onchocerca volvulus 0.1923 0.683 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0077 0.0189 0.0277
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0151 0.0149
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0218 0.0697 0.0695
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0074 0.1819
Brugia malayi jmjC domain containing protein 0.0028 0.0016 0.0022
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0017 0.0017
Onchocerca volvulus 0.0188 0.0589 0.085
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.007 0.0165 0.0163
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0074 0.0072
Echinococcus granulosus dnaJ subfamily B 0.0422 0.1432 0.143
Trichomonas vaginalis chromobox protein, putative 0.0258 0.0841 0.1231
Echinococcus multilocularis chromobox protein 2 0.007 0.0165 0.0163
Schistosoma mansoni jumonji domain containing protein 0.023 0.0739 0.0737
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.0297 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.024 0.0776 0.1135
Echinococcus granulosus tar DNA binding protein 0.0902 0.3157 0.3155
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0292 0.0964 0.0962
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0041 0.0881
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0017 0.018
Echinococcus multilocularis PHD finger protein rhinoceros 0.0088 0.0231 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0048
Schistosoma mansoni inositol monophosphatase 0.0116 0.033 0.0328
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0742 0.074
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0104 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0165 0.0241
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0083 0.0081
Brugia malayi hypothetical protein 0.007 0.0165 0.0272
Schistosoma mansoni hypothetical protein 0.0143 0.0427 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0382 0.1286 0.1284
Plasmodium falciparum phd finger protein, putative 0.0088 0.0231 1
Loa Loa (eye worm) transcription factor SMAD2 0.0364 0.1222 0.2037
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0088 0.0231 0.0228
Onchocerca volvulus 0.0047 0.0082 0.0107
Loa Loa (eye worm) hypothetical protein 0.007 0.0165 0.0272
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0491 0.1679 0.1677
Schistosoma mansoni cpg binding protein 0.0047 0.0082 0.0079
Schistosoma mansoni kinase 0.005 0.0094 0.0091
Loa Loa (eye worm) intermediate filament protein 0.011 0.0309 0.0512
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0209 0.0666 0.1107
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.007 0.0165 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0041 0.006
Echinococcus multilocularis lamin 0.011 0.0309 0.0307
Brugia malayi PHD-finger family protein 0.0088 0.0231 0.0381
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0185 0.0579 0.0576
Loa Loa (eye worm) TAR-binding protein 0.0902 0.3157 0.5268
Loa Loa (eye worm) hypothetical protein 0.0108 0.0302 0.05
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0356 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0116 0.033 0.0483
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0074 0.0072
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.007 0.0165 0.0163
Giardia lamblia GTOR 0.0045 0.0074 0.085
Loa Loa (eye worm) hypothetical protein 0.0382 0.1286 0.2143
Echinococcus multilocularis inositol monophosphatase 1 0.0116 0.033 0.0328
Brugia malayi Bromodomain containing protein 0.0111 0.0313 0.0518
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.007 0.0165 0.0241
Brugia malayi Cytochrome P450 family protein 0.0057 0.0119 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0268 0.0392
Echinococcus multilocularis tumor protein p63 0.0732 0.2547 0.2545
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1598 0.5662 0.5661
Echinococcus granulosus phd:f box containing protein 0.0028 0.0016 0.0013
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0041 0.0881
Brugia malayi Protein cec-1. 0.007 0.0165 0.0272
Brugia malayi Bromodomain containing protein 0.0315 0.1046 0.1744
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0077 0.0189 0.0277
Echinococcus multilocularis cpg binding protein 0.0047 0.0082 0.0079
Brugia malayi PHD-finger family protein 0.0046 0.0079 0.0128
Echinococcus granulosus chromobox protein 1 0.0428 0.1452 0.145
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.0359 0.0596
Schistosoma mansoni hypothetical protein 0.0066 0.0151 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0018 0.0026
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0119 0.0195
Loa Loa (eye worm) hypothetical protein 0.0151 0.0457 0.076
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0056 0.1892
Echinococcus granulosus histone lysine methyltransferase setb 0.0382 0.1286 0.1284
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0077 0.0189 0.0277
Schistosoma mansoni methyl-cpg binding protein mbd 0.0139 0.0412 0.041
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0063 0.0139 0.1594
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.007 0.0165 0.6948
Brugia malayi SET domain containing protein 0.008 0.0199 0.0329
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0063 0.0139 0.1594
Brugia malayi Inositol-1 0.0116 0.033 0.0548
Trichomonas vaginalis chromobox protein, putative 0.0428 0.1452 0.2125
Echinococcus multilocularis lamin dm0 0.011 0.0309 0.0307
Echinococcus granulosus PHD finger protein rhinoceros 0.0088 0.0231 0.0228
Brugia malayi jmjC domain containing protein 0.0289 0.0953 0.1587
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.0356 0.4416
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.0356 0.0354
Loa Loa (eye worm) helicase 0.007 0.0165 0.0272
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0074 0.1819
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0016 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0268 0.0392
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.0427 0.071
Loa Loa (eye worm) inositol-1 0.0116 0.033 0.0548
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0063 0.0139 0.1594
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0083 0.0135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0075 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0077 0.0189 0.0277
Trichomonas vaginalis chromobox protein, putative 0.007 0.0165 0.0241
Loa Loa (eye worm) hypothetical protein 0.0053 0.0104 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0083 0.0081
Loa Loa (eye worm) jmjC domain-containing protein 0.0182 0.0569 0.0945
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0077 0.0189 0.0277
Echinococcus granulosus chromobox protein 2 0.007 0.0165 0.0163
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0104 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0243 0.0787 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0151 0.0149
Schistosoma mansoni microsomal glutathione s-transferase 0.0218 0.0697 0.0695
Trichomonas vaginalis inositol monophosphatase, putative 0.0116 0.033 0.0483
Echinococcus granulosus Chromo domain 0.007 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.007 0.0165 0.0272
Brugia malayi Pre-SET motif family protein 0.0243 0.0787 0.131
Loa Loa (eye worm) PHD-finger family protein 0.0168 0.0517 0.0859
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0313 0.1039 0.1037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0022
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.007 0.0165 0.1936
Schistosoma mansoni tar DNA-binding protein 0.0902 0.3157 0.3155
Schistosoma mansoni lamin 0.011 0.0309 0.0307
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.007 0.0165 0.1936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0048
Schistosoma mansoni chromobox protein 0.0428 0.1452 0.145
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0016 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0124 0.0359 0.0357
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0116 0.033 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0292 0.0964 0.0962
Echinococcus multilocularis Chromobox protein 3 0.007 0.0165 0.0163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0151 0.0149
Schistosoma mansoni hypothetical protein 0.0047 0.0082 0.008
Schistosoma mansoni bromodomain containing protein 0.004 0.0057 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0088 0.0231 0.2787
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0016 0.0022
Brugia malayi Pre-SET motif family protein 0.169 0.5991 1
Brugia malayi RNA recognition motif domain containing protein 0.0902 0.3157 0.5268
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0116 0.033 0.0483
Schistosoma mansoni hypothetical protein 0.0422 0.1432 0.143
Schistosoma mansoni tar DNA-binding protein 0.0902 0.3157 0.3155
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0268 0.7355
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0268 0.7355
Echinococcus granulosus chromobox protein 1 0.0428 0.1452 0.145
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0268 0.0379
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0083 0.0081
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0268 0.0266
Echinococcus multilocularis musashi 0.011 0.0309 0.0307
Plasmodium falciparum heterochromatin protein 1 0.007 0.0165 0.6948
Brugia malayi Type III restriction enzyme, res subunit family protein 0.007 0.0165 0.0272
Schistosoma mansoni hypothetical protein 0.007 0.0165 0.0163
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0089 0.013
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0218 0.0697 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0165 0.0241
Echinococcus granulosus cpg binding protein 0.0047 0.0082 0.0079
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0033 0.0225
Schistosoma mansoni hypothetical protein 0.0088 0.0231 0.0228
Loa Loa (eye worm) hypothetical protein 0.0335 0.1118 0.1863
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0083 0.0081
Echinococcus granulosus inositol monophosphatase 1 0.0116 0.033 0.0328
Echinococcus multilocularis GPCR, family 2 0.0066 0.0151 0.0149
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0074 0.0178 0.026
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.0513 0.0853
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0126 0.0207
Schistosoma mansoni cpg binding protein 0.0047 0.0082 0.0079
Schistosoma mansoni bromodomain containing protein 0.052 0.1783 0.1781
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0268 0.0392
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0352 0.118 0.1966
Onchocerca volvulus 0.0313 0.1039 0.1509
Echinococcus granulosus intermediate filament protein 0.011 0.0309 0.0307
Leishmania major hypothetical protein, conserved 0.0028 0.0016 0.0143
Schistosoma mansoni jumonji/arid domain-containing protein 0.0124 0.0359 0.0357
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0016 0.0143
Entamoeba histolytica hypothetical protein 0.007 0.0165 0.3967
Onchocerca volvulus Heterochromatin protein 1 homolog 0.024 0.0776 0.1123
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0165 0.0272
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0016 0.0143
Echinococcus granulosus microsomal glutathione S transferase 3 0.0218 0.0697 0.0695
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0083 0.0081
Loa Loa (eye worm) bromodomain containing protein 0.0147 0.0443 0.0736
Trichomonas vaginalis chromobox protein, putative 0.007 0.0165 0.0241
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0016 0.0013
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0356 0.0354
Brugia malayi F/Y-rich N-terminus family protein 0.0062 0.0137 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0524 0.0767
Onchocerca volvulus Alhambra homolog 0.0088 0.0231 0.0324
Leishmania major hypothetical protein, conserved 0.0124 0.0361 1
Loa Loa (eye worm) PHD-finger family protein 0.0088 0.0231 0.0381
Schistosoma mansoni hypothetical protein 0.0168 0.0517 0.0515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0074 0.012
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.0356 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0165 0.6948
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0268 0.7355
Schistosoma mansoni hypothetical protein 0.0066 0.0151 0.0149
Loa Loa (eye worm) hypothetical protein 0.0107 0.0299 0.0495
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0016 0.0013
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0016 0.0013
Entamoeba histolytica hypothetical protein 0.007 0.0165 0.3967
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0268 0.0266
Echinococcus granulosus GPCR family 2 0.0066 0.0151 0.0149
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0011 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.0666 0.1107
Schistosoma mansoni survival motor neuron protein 0.0047 0.0082 0.008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0902 0.3157 0.5268
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.033 0.9131
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0116 0.033 1
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0125 0.0205
Brugia malayi TAR-binding protein 0.0902 0.3157 0.5268
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0382 0.1286 0.1284
Schistosoma mansoni cpg binding protein 0.003 0.002 0.0017
Onchocerca volvulus 0.007 0.0165 0.0228
Loa Loa (eye worm) hypothetical protein 0.007 0.0165 0.0272
Schistosoma mansoni chromobox protein 0.007 0.0165 0.0163
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0077 0.0189 0.0277
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0092
Echinococcus granulosus fetal alzheimer antigen falz 0.0185 0.0579 0.0576
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0775 0.129
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.1432 0.143
Plasmodium vivax SET domain protein, putative 0.0243 0.0787 1
Brugia malayi CHD4 protein 0.0087 0.0227 0.0375
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0046 0.0078 0.0075
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0046 0.0078 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0165 0.0241
Schistosoma mansoni hypothetical protein 0.0029 0.0017 0.0015
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.007 0.0165 0.3967
Echinococcus multilocularis chromobox protein 1 0.0428 0.1452 0.145
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0243 0.0787 0.0785
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0126 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0268 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0902 0.3157 0.3155
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0356 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0017 0.0017
Echinococcus granulosus tumor protein p63 0.0732 0.2547 0.2545
Brugia malayi Cytochrome P450 family protein 0.0027 0.0011 0.0014
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.007 0.0165 0.0163
Schistosoma mansoni methyl-cpg binding protein mbd 0.0139 0.0412 0.041
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.0513 0.0511
Toxoplasma gondii histone lysine methyltransferase SET1 0.0088 0.023 0.2774
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0151 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0023 0.0101
Loa Loa (eye worm) hypothetical protein 0.007 0.0165 0.0272
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.033 0.9131
Plasmodium vivax hypothetical protein, conserved 0.007 0.0165 0.1936
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0126 0.3303
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0077 0.0189 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0083 0.0135
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0077 0.0189 0.0277
Loa Loa (eye worm) hypothetical protein 0.0575 0.1982 0.3306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0041 0.006
Loa Loa (eye worm) hypothetical protein 0.0051 0.0097 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0074 0.0109
Schistosoma mansoni hypothetical protein 0.0066 0.0151 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0083 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0233 0.0753 0.075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0073 0.0176 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0902 0.3157 0.3155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0074 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0382 0.1286 0.1284
Onchocerca volvulus 0.003 0.002 0.0015
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0074 0.0657
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0258 0.0841 0.1219
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0104 0.0287 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0356 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0268 0.7731
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.0666 0.1107
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0268 0.0444
Loa Loa (eye worm) hypothetical protein 0.0312 0.1036 0.1725
Schistosoma mansoni microtubule-associated protein tau 0.2804 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0231 0.0381
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0016 0.0013
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0016 0.0013
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0074 0.1819
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0074 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0033 0.0048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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