Detailed information for compound 544964

Basic information

Technical information
  • TDR Targets ID: 544964
  • Name: helical erythrocyte lysing peptide
  • MW: 3100.7 | Formula: C144H243N37O38
  • H donors: 38 H acceptors: 35 LogP: -4.44 Rotable bonds: 138
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)OC(=O)CC[C@@H](C(=O)N)NC(=O)[C@H](CCC(=O)N)N)CCCNC(=N)N)CCCCN)CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)N)CCC(=O)O)CCC(=O)OC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)N)CC(C)C)CC(C)C)CCC(=O)OC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](N)C)NC(=O)CNC(=O)[C@@H](NC(=O)CN)CC(C)C)CC(C)C)CC(C)C)Cc1ccccc1)CC(C)C)CC(C)C)CC(C)C)CCC(=O)O)Cc1ccccc1)CC(C)C
  • InChi: 1S/C144H243N37O38/c1-73(2)59-88(150)121(195)163-93(44-50-112(186)187)126(200)167-95(47-53-115(191)219-142(216)108(68-82(19)20)180-137(211)106(70-86-37-27-24-28-38-86)176-129(203)96(169-132(206)101(63-77(9)10)173-134(208)103(65-79(13)14)177-138(212)117(152)84(22)182)48-54-116(192)218-141(215)107(67-81(17)18)179-135(209)104(66-80(15)16)178-139(213)118(83(21)148)181-111(185)72-160-122(196)98(60-74(3)4)161-110(184)71-147)128(202)171-102(64-78(11)12)133(207)172-100(62-76(7)8)131(205)168-94(45-51-113(188)189)127(201)175-105(69-85-35-25-23-26-36-85)136(210)174-99(61-75(5)6)130(204)166-90(39-29-31-55-145)123(197)165-92(41-33-57-158-143(154)155)124(198)164-91(40-30-32-56-146)125(199)170-97(42-34-58-159-144(156)157)140(214)217-114(190)52-46-89(119(153)193)162-120(194)87(149)43-49-109(151)183/h23-28,35-38,73-84,87-108,117-118,182H,29-34,39-72,145-150,152H2,1-22H3,(H2,151,183)(H2,153,193)(H,160,196)(H,161,184)(H,162,194)(H,163,195)(H,164,198)(H,165,197)(H,166,204)(H,167,200)(H,168,205)(H,169,206)(H,170,199)(H,171,202)(H,172,207)(H,173,208)(H,174,210)(H,175,201)(H,176,203)(H,177,212)(H,178,213)(H,179,209)(H,180,211)(H,181,185)(H,186,187)(H,188,189)(H4,154,155,158)(H4,156,157,159)/t83-,84-,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,117+,118+/m1/s1
  • InChiKey: JQUPQFUEBRPCJS-JBKQOWAQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 143780-69-2
  • Amphipathic alpha-helical peptide help

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SET domain containing protein 0.0081 0.0248 0.0282
Brugia malayi PHD-finger family protein 0.003 0.0017 0.002
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.024 0.0239
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0427 0.1811 0.1818
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Schistosoma mansoni chromobox protein 0.0434 0.1841 0.185
Onchocerca volvulus 0.0057 0.0139 0.0138
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0192 0.0747 0.075
Schistosoma mansoni tar DNA-binding protein 0.0412 0.1743 0.1751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0007 0.0001
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0017 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0427 0.1811 0.1819
Echinococcus granulosus GPCR family 2 0.0048 0.0098 0.0097
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0116 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0051
Brugia malayi hypothetical protein 0.0071 0.0201 0.0229
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0092 0.0093
Brugia malayi MH1 domain containing protein 0.0027 0.0002 0.0002
Schistosoma mansoni intermediate filament proteins 0.0057 0.0139 0.0139
Echinococcus granulosus lamin dm0 0.0057 0.0139 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0201 0.0195
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0071 0.0201 0.0229
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0243 0.0979 0.0979
Onchocerca volvulus 0.0353 0.1476 0.1476
Brugia malayi Heterochromatin protein 1 0.0434 0.1841 0.2099
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0098 0.0097
Echinococcus granulosus zinc finger protein 0.0167 0.0632 0.0634
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0005 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0272 0.1108 0.1112
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.012 0.0137
Echinococcus multilocularis microtubule associated protein 2 0.2229 0.9952 1
Trypanosoma cruzi ISWI complex protein 0.013 0.0468 1
Echinococcus granulosus lamin 0.0057 0.0139 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0018 0.0012
Echinococcus multilocularis zinc finger protein 0.0167 0.0632 0.0634
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0201 0.0195
Schistosoma mansoni chromobox protein 0.0071 0.0201 0.0202
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0282 0.1155 1
Plasmodium vivax SET domain protein, putative 0.0282 0.1155 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0087 0.0274 0.0313
Echinococcus granulosus intermediate filament protein 0.0057 0.0139 0.0137
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.024 0.5
Brugia malayi CHD4 protein 0.0087 0.0274 0.0312
Brugia malayi jmjC domain containing protein 0.0053 0.012 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0092 0.1034
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.024 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0145 0.0535 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0038 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0201 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0201 0.0195
Loa Loa (eye worm) hypothetical protein 0.0602 0.2599 0.2963
Schistosoma mansoni zinc finger protein 0.013 0.0468 0.047
Schistosoma mansoni smad 0.0027 0.0002 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0139 0.0158
Plasmodium vivax hypothetical protein, conserved 0.003 0.0017 0.0118
Brugia malayi Associated with TFs and helicases family protein 0.0071 0.0201 0.0229
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0002 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0201 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0022 0.0017
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0201 0.0195
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0116 0.0114
Brugia malayi PHD-finger family protein 0.0212 0.0838 0.0955
Loa Loa (eye worm) hypothetical protein 0.0363 0.1519 0.1732
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0658 0.0653
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.033 0.033
Echinococcus granulosus peregrin 0.0051 0.0108 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0098 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0038 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0049 0.0043
Echinococcus granulosus tumor protein p63 0.0363 0.152 0.1526
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0508 0.2175 0.2184
Brugia malayi MH2 domain containing protein 0.0397 0.1673 0.1908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0038 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0201 0.1712
Trichomonas vaginalis chromobox protein, putative 0.0434 0.1841 0.1837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0038 0.0032
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0282 0.1155 0.1159
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0087 0.0274 0.0275
Echinococcus granulosus fetal alzheimer antigen falz 0.0192 0.0747 0.0748
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0017 0.0118
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0098 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0139 0.0158
Loa Loa (eye worm) MH2 domain-containing protein 0.0397 0.1673 0.1908
Trichomonas vaginalis chromobox protein, putative 0.0434 0.1841 0.1837
Loa Loa (eye worm) hypothetical protein 0.0071 0.0201 0.0229
Onchocerca volvulus 0.0057 0.0139 0.0138
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1968 0.8772 1
Loa Loa (eye worm) heterochromatin protein 1 0.0434 0.1841 0.2099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0053 0.012 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0007 0.0001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0262 0.1063 0.1063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0049 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0201 0.0195
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0092 0.0091
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0046 0.0044
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0071 0.007
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0071 0.0201 0.0202
Onchocerca volvulus 0.0071 0.0201 0.0201
Echinococcus granulosus chromobox protein 2 0.0071 0.0201 0.02
Schistosoma mansoni tar DNA-binding protein 0.0412 0.1743 0.1751
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0427 0.1811 0.1819
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0164 0.0187
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0098 0.0097
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0087 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0028 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0201 0.0195
Brugia malayi Pre-SET motif family protein 0.0282 0.1155 0.1317
Schistosoma mansoni jumonji/arid domain-containing protein 0.0053 0.012 0.012
Schistosoma mansoni methyl-cpg binding protein mbd 0.0145 0.0535 0.0538
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0092 0.1034
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.024 1
Brugia malayi Bromodomain containing protein 0.0051 0.0108 0.0123
Loa Loa (eye worm) hypothetical protein 0.0347 0.1446 0.1648
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.024 0.2048
Schistosoma mansoni Smad4 0.0027 0.0002 0.0002
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0238 0.0239
Schistosoma mansoni tar DNA-binding protein 0.0412 0.1743 0.1751
Echinococcus multilocularis peregrin 0.0051 0.0108 0.0107
Entamoeba histolytica hypothetical protein 0.0071 0.0201 1
Brugia malayi RNA binding protein 0.0412 0.1743 0.1986
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0201 0.0195
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0002 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0116 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0049 0.0043
Brugia malayi Smad1 0.0027 0.0002 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0098 0.0112
Schistosoma mansoni smad1 5 8 and 0.0027 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.024 0.5
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0071 0.0201 0.02
Schistosoma mansoni hypothetical protein 0.0048 0.0098 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0201 0.0195
Brugia malayi Valyl-tRNA synthetase 0.0071 0.0201 0.0229
Trichomonas vaginalis chromobox protein, putative 0.0262 0.1063 0.1058
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0139 0.0158
Schistosoma mansoni methyl-cpg binding protein mbd 0.0145 0.0535 0.0538
Loa Loa (eye worm) Smad1 0.0027 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0191 0.0742 0.0846
Onchocerca volvulus Alhambra homolog 0.003 0.0017 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0098 0.0097
Brugia malayi jmjC domain containing protein 0.01 0.033 0.0376
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0017 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0092 0.0087
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.057 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Echinococcus multilocularis lamin 0.0057 0.0139 0.0137
Trichomonas vaginalis chromobox protein, putative 0.0262 0.1063 0.1058
Schistosoma mansoni bromodomain containing protein 0.0538 0.2313 0.2323
Loa Loa (eye worm) PHD-finger family protein 0.0176 0.0673 0.0767
Entamoeba histolytica hypothetical protein 0.0071 0.0201 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0201 0.1712
Schistosoma mansoni bromodomain containing protein 0.0036 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0427 0.1811 0.2064
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.012 0.012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0306 0.1261 0.1265
Brugia malayi intermediate filament protein 0.0057 0.0139 0.0158
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.024 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0353 0.1476 0.1483
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0092 0.1034
Schistosoma mansoni hypothetical protein 0.0048 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.033 0.033
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0071 0.0201 0.1712
Echinococcus granulosus chromobox protein 1 0.0434 0.1841 0.1848
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0071 0.0201 0.8359
Echinococcus multilocularis lamin dm0 0.0057 0.0139 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0038 0.0032
Leishmania major hypothetical protein, conserved 0.013 0.0468 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0282 0.1155 0.1161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0049 0.0043
Brugia malayi Bromodomain containing protein 0.0638 0.2763 0.315
Echinococcus multilocularis chromobox protein 1 0.0434 0.1841 0.1848
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.0158
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0018 0.0021
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0071 0.0201 0.1712
Loa Loa (eye worm) hypothetical protein 0.0071 0.0201 0.0229
Brugia malayi Bromodomain containing protein 0.0326 0.1352 0.1541
Loa Loa (eye worm) transcription factor SMAD2 0.0397 0.1673 0.1908
Giardia lamblia GTOR 0.0047 0.0092 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0201 0.0195
Echinococcus granulosus lysine specific demethylase 5A 0.0053 0.012 0.0118
Loa Loa (eye worm) RNA binding protein 0.0412 0.1743 0.1987
Plasmodium falciparum phd finger protein, putative 0.003 0.0017 0.0576
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0352 0.0401
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0087 0.0274 0.0274
Echinococcus granulosus methyl CpG binding domain protein 2 0.0145 0.0535 0.0536
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0201 0.0195
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0092 0.0091
Schistosoma mansoni lamin 0.0057 0.0139 0.0139
Plasmodium falciparum heterochromatin protein 1 0.0071 0.0201 0.8359
Schistosoma mansoni zinc finger protein 0.0167 0.0632 0.0635
Loa Loa (eye worm) hypothetical protein 0.0071 0.0201 0.0229
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0092 0.0105
Echinococcus multilocularis Chromo domain 0.0071 0.0201 0.02
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0038 0.0296
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0071 0.0201 0.02
Brugia malayi chromobox protein homolog 3 0.0243 0.0979 0.1116
Schistosoma mansoni tar DNA-binding protein 0.0412 0.1743 0.1751
Trichomonas vaginalis Heterochromatin protein, putative 0.0071 0.0201 0.0195
Loa Loa (eye worm) hypothetical protein 0.0326 0.1355 0.1545
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0018 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0092 0.0105
Loa Loa (eye worm) bromodomain containing protein 0.015 0.0559 0.0637
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0092 0.1034
Loa Loa (eye worm) hypothetical protein 0.0243 0.0979 0.1116
Echinococcus multilocularis tumor protein p63 0.0363 0.152 0.1526
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0061 0.0056
Loa Loa (eye worm) hypothetical protein 0.0104 0.0352 0.0401
Trypanosoma brucei ISWI complex protein 0.013 0.0468 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0048 0.0098 0.0112
Echinococcus granulosus microtubule associated protein 2 0.2229 0.9952 1
Onchocerca volvulus 0.0053 0.012 0.012
Echinococcus granulosus Chromobox protein 3 0.0071 0.0201 0.02
Echinococcus multilocularis Chromobox protein 3 0.0071 0.0201 0.02
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0071 0.0201 0.0202
Echinococcus granulosus Chromo domain 0.0071 0.0201 0.02
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.013 0.0468 0.047
Schistosoma mansoni microtubule-associated protein tau 0.2229 0.9952 1
Schistosoma mansoni hypothetical protein 0.0071 0.0201 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0201 0.0195
Onchocerca volvulus 0.0071 0.0201 0.0201
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0192 0.0747 0.0748
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0201 0.0195
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0098 0.0097
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.024 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.012 0.0137
Trichomonas vaginalis hypothetical protein 0.0071 0.0201 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0412 0.1743 0.1751
Echinococcus multilocularis tar DNA binding protein 0.0412 0.1743 0.1749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0153 0.057 0.065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.057 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0979 0.0974
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.057 0.065
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0045 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0071 0.0201 0.0229
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.024 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0201 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0007 0.0001
Echinococcus granulosus tar DNA binding protein 0.0412 0.1743 0.1749
Trypanosoma cruzi ISWI complex protein 0.013 0.0468 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.024 0.5
Schistosoma mansoni hypothetical protein 0.0104 0.0352 0.0353
Toxoplasma gondii histone lysine methyltransferase SET1 0.0031 0.0018 0.0122
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0071 0.007
Entamoeba histolytica hypothetical protein 0.0071 0.0201 1
Brugia malayi Protein cec-1. 0.0071 0.0201 0.0229
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0116 0.4744
Loa Loa (eye worm) hypothetical protein 0.0071 0.0201 0.0229
Echinococcus granulosus histone lysine methyltransferase setb 0.0427 0.1811 0.1818
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0508 0.2175 0.2184
Loa Loa (eye worm) TAR-binding protein 0.0412 0.1743 0.1987
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0658 0.0653
Loa Loa (eye worm) hypothetical protein 0.0071 0.0201 0.0229
Brugia malayi M-phase phosphoprotein, mpp8 0.0071 0.0201 0.0229
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0002 0.0002
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0071 0.0201 0.1712
Brugia malayi MH2 domain containing protein 0.0027 0.0002 0.0002
Echinococcus granulosus chromobox protein 1 0.0434 0.1841 0.1848
Schistosoma mansoni lamin 0.0057 0.0139 0.0139
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0306 0.1261 0.1265
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0201 1
Schistosoma mansoni chromobox protein 0.0071 0.0201 0.0202
Brugia malayi Pre-SET motif family protein 0.1968 0.8772 1
Schistosoma mansoni hypothetical protein 0.0176 0.0673 0.0676
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0116 0.0114
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0201 0.0195
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0017 0.0015
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0201 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0002 0.0002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.024 0.2048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0092 0.0087
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0017 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0201 0.0195
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0092 0.1034
Loa Loa (eye worm) hypothetical protein 0.008 0.024 0.0273
Echinococcus multilocularis musashi 0.0057 0.0139 0.0137
Trichomonas vaginalis set domain proteins, putative 0.224 1 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0098 0.0097
Brugia malayi MH1 domain containing protein 0.0027 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0048 0.0098 0.0098
Echinococcus multilocularis chromobox protein 1 0.0434 0.1841 0.1848
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0201 0.0195
Brugia malayi TAR-binding protein 0.0412 0.1743 0.1986
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.024 1
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.024 0.024
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0071 0.0201 0.8359
Schistosoma mansoni chromobox protein 0.0434 0.1841 0.185
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0153
Schistosoma mansoni hypothetical protein 0.0048 0.0098 0.0098
Plasmodium vivax SET domain containing protein 0.0031 0.0018 0.0122
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0092 0.1034
Brugia malayi Probable ClpP-like protease 0.008 0.024 0.0273
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0005 0.0003
Loa Loa (eye worm) helicase 0.0071 0.0201 0.0229
Plasmodium vivax heterochromatin protein 1, putative 0.0071 0.0201 0.1712
Onchocerca volvulus 0.0191 0.0742 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0979 0.0974
Schistosoma mansoni hypothetical protein 0.003 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0049 0.0043
Loa Loa (eye worm) hypothetical protein 0.0052 0.0116 0.0132
Brugia malayi MH2 domain containing protein 0.0027 0.0002 0.0002
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0201 1
Brugia malayi RNA recognition motif domain containing protein 0.0412 0.1743 0.1986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0092 0.0087
Echinococcus multilocularis chromobox protein 2 0.0071 0.0201 0.02
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.024 0.2048
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0071 0.0201 0.0202
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0412 0.1743 0.1987

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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