Detailed information for compound 545013

Basic information

Technical information
  • TDR Targets ID: 545013
  • Name: 4-[2-(4-butoxyphenyl)ethoxy]-8-fluoro-quinoli ne
  • MW: 339.403 | Formula: C21H22FNO2
  • H donors: 0 H acceptors: 1 LogP: 5.44 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1ccc(cc1)CCOc1ccnc2c1cccc2F
  • InChi: 1S/C21H22FNO2/c1-2-3-14-24-17-9-7-16(8-10-17)12-15-25-20-11-13-23-21-18(20)5-4-6-19(21)22/h4-11,13H,2-3,12,14-15H2,1H3
  • InChiKey: FUTIZZJYOPWKBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-(4-butoxyphenyl)ethoxy]-8-fluoroquinoline
  • 124534-69-6
  • 4-(2-(4-Butoxyphenyl)ethoxy)-8-fluoroquinoline
  • Quinoline, 4-(2-(4-butoxyphenyl)ethoxy)-8-fluoro-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0053 0.0133 0.0137
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.008 0.0262 1
Loa Loa (eye worm) RNA binding protein 0.0327 0.1413 0.1795
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0094 0.009
Onchocerca volvulus 0.0325 0.1407 0.1559
Brugia malayi intermediate filament protein 0.0053 0.0133 0.0156
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0402 0.1767 0.1763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0051 0.0048
Trichomonas vaginalis chromobox protein, putative 0.008 0.0262 0.0282
Brugia malayi Protein kinase domain containing protein 0.1063 0.4859 0.6168
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0208 0.0859 0.085
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0246 0.9363
Echinococcus multilocularis lamin dm0 0.0053 0.0133 0.0128
Loa Loa (eye worm) hypothetical protein 0.0276 0.1175 0.1493
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.008 0.0262 0.0257
Schistosoma mansoni hypothetical protein 0.0048 0.0112 0.0102
Loa Loa (eye worm) bromodomain containing protein 0.0163 0.0648 0.0823
Plasmodium vivax SET domain containing protein 0.0031 0.0029 0.0198
Schistosoma mansoni chromobox protein 0.008 0.0262 0.0252
Loa Loa (eye worm) helicase 0.008 0.0262 0.0332
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0327 0.1413 0.1795
Echinococcus multilocularis musashi 0.0053 0.0133 0.0128
Loa Loa (eye worm) IKK protein kinase 0.1063 0.4859 0.6173
Brugia malayi Heterochromatin protein 1 0.0492 0.2186 0.2768
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0297 0.1273 0.1409
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0055 0.005
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0055 0.0058
Loa Loa (eye worm) hypothetical protein 0.0153 0.0601 0.0764
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0133 0.0169
Echinococcus multilocularis Chromo domain 0.008 0.0262 0.0257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0262 0.0282
Onchocerca volvulus 0.008 0.0262 0.0281
Echinococcus multilocularis chromobox protein 1 0.0492 0.2186 0.2183
Loa Loa (eye worm) hypothetical protein 0.0105 0.0375 0.0476
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0112 0.0107
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.008 0.0262 0.0282
Loa Loa (eye worm) hypothetical protein 0.008 0.0262 0.0332
Brugia malayi Pre-SET motif family protein 0.0245 0.1031 0.1299
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0094 0.0108
Echinococcus multilocularis Chromobox protein 3 0.008 0.0262 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0041 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0798 0.0881
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0262 0.0282
Entamoeba histolytica hypothetical protein 0.008 0.0262 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0094 0.012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0246 0.2314
Echinococcus granulosus methyl CpG binding domain protein 2 0.0157 0.0622 0.0617
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0344 0.034
Plasmodium vivax hypothetical protein, conserved 0.008 0.0262 0.2471
Echinococcus multilocularis peregrin 0.0052 0.0127 0.0123
Echinococcus granulosus tumor protein p63 0.0351 0.1528 0.1524
Trypanosoma cruzi ISWI complex protein 0.0141 0.0546 1
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0025 0.0032
Brugia malayi TAR-binding protein 0.0327 0.1413 0.1785
Echinococcus multilocularis GPCR, family 2 0.0048 0.0112 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0601 0.0753
Brugia malayi PHD-finger family protein 0.0027 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0142
Onchocerca volvulus 0.1943 0.8975 1
Echinococcus granulosus lamin dm0 0.0053 0.0133 0.0128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0245 0.1031 1
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1413 0.1405
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0094 0.0863
Trypanosoma cruzi ISWI complex protein 0.0141 0.0546 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0157 0.0622 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0094 0.0095
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0094 0.0863
Brugia malayi RNA recognition motif domain containing protein 0.0327 0.1413 0.1785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0394 0.1727 0.2194
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0262 0.0282
Brugia malayi Type III restriction enzyme, res subunit family protein 0.008 0.0262 0.0321
Echinococcus granulosus histone lysine methyltransferase setb 0.0402 0.1767 0.1763
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0018 0.0022
Echinococcus multilocularis zinc finger protein 0.0181 0.0731 0.0726
Plasmodium vivax SET domain protein, putative 0.0245 0.1031 1
Schistosoma mansoni zinc finger protein 0.0181 0.0731 0.0722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0051 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0041 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0051 0.0048
Echinococcus granulosus zinc finger protein 0.0181 0.0731 0.0726
Echinococcus granulosus GPCR family 2 0.0048 0.0112 0.0107
Schistosoma mansoni intermediate filament proteins 0.0053 0.0133 0.0123
Brugia malayi SET domain containing protein 0.009 0.0304 0.0374
Brugia malayi Bromodomain containing protein 0.0354 0.1539 0.1946
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0332 0.1437 0.1433
Loa Loa (eye worm) hypothetical protein 0.008 0.0262 0.0332
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.008 0.0262 0.2471
Trichomonas vaginalis set domain proteins, putative 0.1943 0.8975 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.008 0.0262 0.0257
Echinococcus granulosus Chromo domain 0.008 0.0262 0.0257
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1003 0.1274
Schistosoma mansoni zinc finger protein 0.0141 0.0546 0.0537
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.008 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0032
Schistosoma mansoni hypothetical protein 0.008 0.0262 0.0252
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.008 0.0262 0.2471
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0246 0.2314
Brugia malayi jmjC domain containing protein 0.0054 0.0137 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0325 0.1407 0.1399
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0262 0.0282
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0246 0.5
Echinococcus granulosus peregrin 0.0052 0.0127 0.0123
Echinococcus granulosus fetal alzheimer antigen falz 0.0208 0.0859 0.0855
Brugia malayi Pre-SET motif family protein 0.1707 0.7871 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0246 0.2314
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0551 0.2464 0.246
Loa Loa (eye worm) hypothetical protein 0.0653 0.294 0.3735
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0402 0.1767 0.1759
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0208 0.0859 0.0855
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0246 0.0241
Onchocerca volvulus 0.008 0.0262 0.0281
Loa Loa (eye worm) hypothetical protein 0.0051 0.0125 0.0159
Brugia malayi Associated with TFs and helicases family protein 0.008 0.0262 0.0321
Echinococcus granulosus chromobox protein 1 0.0492 0.2186 0.2183
Giardia lamblia GTOR 0.0045 0.0094 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.008 0.0262 0.0252
Plasmodium falciparum heterochromatin protein 1 0.008 0.0262 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0031 0.0029 0.0198
Leishmania major hypothetical protein, conserved 0.0141 0.0546 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0262 0.0282
Trypanosoma brucei ISWI complex protein 0.0141 0.0546 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0041 0.0036
Echinococcus granulosus intermediate filament protein 0.0053 0.0133 0.0128
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0112 0.0107
Schistosoma mansoni chromobox protein 0.0492 0.2186 0.2179
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0246 0.5
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0376 0.1645 0.2089
Brugia malayi Valyl-tRNA synthetase 0.008 0.0262 0.0321
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0098 0.0344 0.034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.008 0.0262 0.0282
Schistosoma mansoni hypothetical protein 0.0048 0.0112 0.0102
Trichomonas vaginalis chromobox protein, putative 0.0492 0.2186 0.2429
Entamoeba histolytica hypothetical protein 0.008 0.0262 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0094 0.009
Echinococcus multilocularis microtubule associated protein 2 0.2162 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0137 0.0128
Schistosoma mansoni hypothetical protein 0.0048 0.0112 0.0102
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0112 0.013
Onchocerca volvulus Alhambra homolog 0.003 0.0025 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Plasmodium falciparum phd finger protein, putative 0.003 0.0025 0.0634
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0246 0.5
Brugia malayi jmjC domain containing protein 0.0098 0.0344 0.0426
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.008 0.0262 1
Echinococcus multilocularis tumor protein p63 0.0351 0.1528 0.1524
Trichomonas vaginalis hypothetical protein 0.008 0.0262 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0094 0.0095
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0246 0.0236
Loa Loa (eye worm) hypothetical protein 0.0402 0.1767 0.2245
Echinococcus granulosus chromobox protein 2 0.008 0.0262 0.0257
Echinococcus granulosus jumonji domain containing protein 0.0042 0.008 0.0076
Brugia malayi Bromodomain containing protein 0.0052 0.0127 0.015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0216 0.0896 0.1139
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0245 0.1031 0.1026
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0025 0.0157
Loa Loa (eye worm) hypothetical protein 0.008 0.0262 0.0332
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0018 0.001
Echinococcus granulosus Chromobox protein 3 0.008 0.0262 0.0257
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0094 0.0863
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.008 0.0262 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.001 0.0001
Onchocerca volvulus 0.0053 0.0133 0.0137
Onchocerca volvulus 0.0051 0.0126 0.0129
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0094 0.0863
Schistosoma mansoni chromodomain helicase DNA binding protein 0.008 0.0262 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0051 0.0048
Schistosoma mansoni chromobox protein 0.0492 0.2186 0.2179
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0121 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0021 0.0013
Brugia malayi PHD-finger family protein 0.003 0.0025 0.002
Brugia malayi PHD-finger family protein 0.023 0.0961 0.121
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1413 0.1405
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.008 0.0262 0.0282
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0175 0.0222
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0551 0.2464 0.246
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0344 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0262 0.0282
Plasmodium vivax hypothetical protein, conserved 0.003 0.0025 0.0157
Echinococcus multilocularis chromobox protein 1 0.0492 0.2186 0.2183
Echinococcus multilocularis lamin 0.0053 0.0133 0.0128
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0601 0.0764
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1175 0.1301
Echinococcus granulosus lamin 0.0053 0.0133 0.0128
Schistosoma mansoni microtubule-associated protein tau 0.2162 1 1
Schistosoma mansoni hypothetical protein 0.019 0.0776 0.0767
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0013 0.0008
Loa Loa (eye worm) heterochromatin protein 1 0.0492 0.2186 0.2777
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0112 0.0107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0137 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0246 0.5
Brugia malayi MH2 domain containing protein 0.0239 0.1003 0.1263
Brugia malayi RNA binding protein 0.0327 0.1413 0.1785
Schistosoma mansoni methyl-cpg binding protein mbd 0.0157 0.0622 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0041 0.0036
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0094 0.0085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0262 0.0282
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0133 0.0156
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0098 0.0344 0.0335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0262 0.0282
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0098 0.0344 0.034
Schistosoma mansoni lamin 0.0053 0.0133 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.008 0.0262 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0276 0.1175 0.13
Trichomonas vaginalis chromobox protein, putative 0.0297 0.1273 0.141
Loa Loa (eye worm) PHD-finger family protein 0.019 0.0776 0.0986
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0025 0.0157
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.008 0.0262 0.0282
Echinococcus multilocularis tar DNA binding protein 0.0327 0.1413 0.1409
Brugia malayi Bromodomain containing protein 0.0692 0.3125 0.3962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0051 0.0048
Schistosoma mansoni bromodomain containing protein 0.0039 0.007 0.006
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0126 0.0116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0112 0.013
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1003 0.1274
Echinococcus granulosus tar DNA binding protein 0.0327 0.1413 0.1409
Loa Loa (eye worm) hypothetical protein 0.0052 0.0128 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0798 0.0881
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0375 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0041 0.0036
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0246 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0262 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0025 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0078 0.025 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.001 0.0001
Echinococcus granulosus lysine specific demethylase 5A 0.0054 0.0137 0.0133
Brugia malayi Protein cec-1. 0.008 0.0262 0.0321
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.008 0.0262 0.2471
Onchocerca volvulus 0.1063 0.4859 0.5409
Schistosoma mansoni hypothetical protein 0.0141 0.0546 0.0537
Loa Loa (eye worm) hypothetical protein 0.008 0.0262 0.0332
Brugia malayi hypothetical protein 0.008 0.0262 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1175 0.1301
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.008 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0133 0.0169
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0013 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0137 0.0174
Schistosoma mansoni bromodomain containing protein 0.0584 0.2618 0.2611
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1413 0.1405
Brugia malayi Probable ClpP-like protease 0.0077 0.0246 0.03
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.008 0.0262 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1707 0.7871 1
Trichomonas vaginalis chromobox protein, putative 0.0492 0.2186 0.2429
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0236 0.0988 0.0984
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0112 0.0142
Schistosoma mansoni hypothetical protein 0.003 0.0025 0.0016
Schistosoma mansoni chromobox protein 0.008 0.0262 0.0252
Brugia malayi chromobox protein homolog 3 0.0276 0.1175 0.1482
Brugia malayi CHD4 protein 0.0098 0.0344 0.0425
Loa Loa (eye worm) hypothetical protein 0.008 0.0262 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0041 0.0036
Echinococcus granulosus chromobox protein 1 0.0492 0.2186 0.2183
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0041 0.0307
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1413 0.1405
Trichomonas vaginalis chromobox protein, putative 0.0297 0.1273 0.141
Schistosoma mansoni lamin 0.0053 0.0133 0.0123
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0094 0.0863
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0157 0.0622 0.0617
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0017
Echinococcus multilocularis chromobox protein 2 0.008 0.0262 0.0257
Loa Loa (eye worm) CHromoDomain protein family member 0.0098 0.0344 0.0437
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0112 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0402 0.1767 0.1759
Loa Loa (eye worm) hypothetical protein 0.0077 0.0246 0.0312
Loa Loa (eye worm) hypothetical protein 0.0354 0.1542 0.196
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0246 0.0241
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0246 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.0089
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0094 0.0863
Brugia malayi M-phase phosphoprotein, mpp8 0.008 0.0262 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0094 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0064 0.0061
Plasmodium vivax hypothetical protein, conserved 0.008 0.0262 0.2471
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1413 0.1405
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.008 0.0262 0.0252
Loa Loa (eye worm) hypothetical protein 0.0051 0.0126 0.0159
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0332 0.1437 0.1433
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0121 0.4744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.001 0.0001
Entamoeba histolytica hypothetical protein 0.008 0.0262 1
Trichomonas vaginalis chromobox protein, putative 0.008 0.0262 0.0282
Plasmodium vivax heterochromatin protein 1, putative 0.008 0.0262 0.2471
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0121 0.0117
Loa Loa (eye worm) TAR-binding protein 0.0327 0.1413 0.1795
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0025 0.0021
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0025 0.0016
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0121 0.0117
Schistosoma mansoni hypothetical protein 0.0105 0.0375 0.0365
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0601 0.0753
Onchocerca volvulus 0.0216 0.0896 0.0989
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0245 0.1031 0.1022
Loa Loa (eye worm) hypothetical protein 0.0053 0.0133 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0262 0.0282
Schistosoma mansoni hypothetical protein 0.0048 0.0112 0.0102
Trichomonas vaginalis chromobox protein, putative 0.008 0.0262 0.0282
Loa Loa (eye worm) hypothetical protein 0.008 0.0262 0.0332
Trichomonas vaginalis Heterochromatin protein, putative 0.008 0.0262 0.0282
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0246 0.5
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0121 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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