Detailed information for compound 545047

Basic information

Technical information
  • TDR Targets ID: 545047
  • Name: copper 2-fluoroacetate
  • MW: 217.615 | Formula: C4H4CuF2O4
  • H donors: 0 H acceptors: 4 LogP: 1.63 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)CF.[O-]C(=O)CF.[Cu+2]
  • InChi: 1S/2C2H3FO2.Cu/c2*3-1-2(4)5;/h2*1H2,(H,4,5);/q;;+2/p-2
  • InChiKey: UMDZPTZRSLRIAV-UHFFFAOYSA-L  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • copper 2-fluoroethanoate
  • cupric 2-fluoroacetate
  • 20424-95-7
  • ACETIC ACID, FLUORO-, COPPER(II) SALT
  • Acetic acid, fluoro, copper(2+) salt
  • Copper (II) fluoroacetate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni methyl-cpg binding protein mbd 0.005 0.0161 0.0382
Echinococcus granulosus tumor protein p63 0.0677 0.4203 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.015 0.0805 0.5171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0231 0.0549
Trypanosoma brucei ISWI complex protein 0.0045 0.0128 0.027
Echinococcus multilocularis lamin 0.0054 0.0186 0.0183
Schistosoma mansoni zinc finger protein 0.0045 0.0128 0.0301
Loa Loa (eye worm) hypothetical protein 0.0208 0.1177 0.3706
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0091 0.0594
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0134 0.0703 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0091 0.0299
Echinococcus multilocularis protein dispatched 1 0.0047 0.0139 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0239 0.0807
Schistosoma mansoni hypothetical protein 0.0105 0.0514 0.1235
Echinococcus granulosus geminin 0.0164 0.0896 0.2124
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0047 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0386 0.1311
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0239 0.0807
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0048 0.0147 0.0409
Schistosoma mansoni fkbp-rapamycin associated protein 0.0048 0.0147 0.0348
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0253 0.1471 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0091 0.0342
Brugia malayi hypothetical protein 0.0514 0.3151 0.9918
Echinococcus granulosus cpg binding protein 0.0037 0.0075 0.0171
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0622 0.1472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0141 0.0332
Echinococcus granulosus zinc finger protein 0.0059 0.022 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0102 0.0337
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0085 0.0386 0.2407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0719 0.2452
Onchocerca volvulus 0.0069 0.0282 0.0954
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0091 0.0299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.1155 0.3636
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0462 0.111
Schistosoma mansoni hypothetical protein 0.0065 0.0255 0.0608
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0229 0.0721
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0243
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0004 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0048 0.0147 0.0737
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0091 0.0299
Echinococcus granulosus dnaJ subfamily B 0.042 0.2543 0.6046
Loa Loa (eye worm) phosphatidylinositol 3 0.0085 0.0386 0.1215
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.015 0.0805 0.7634
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0102 0.0098
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.012 0.0611 0.3766
Giardia lamblia GTOR 0.0253 0.1471 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0086 0.0396 0.0949
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0622 0.5892
Schistosoma mansoni hypothetical protein 0.0164 0.0896 0.2159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0147 0.0493
Loa Loa (eye worm) hypothetical protein 0.0054 0.0186 0.0587
Trypanosoma cruzi target of rapamycin kinase 3 0.0202 0.1139 0.7672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0386 0.1311
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0218 0.0675
Schistosoma mansoni survival motor neuron protein 0.0105 0.0514 0.1235
Echinococcus granulosus expressed conserved protein 0.009 0.0415 0.0981
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0091 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0814 0.2779
Echinococcus multilocularis survival motor neuron protein 1 0.0514 0.3151 0.3148
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0048 0.0147 0.0737
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0085 0.0386 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.1053 0.3597
Schistosoma mansoni tar DNA-binding protein 0.0518 0.3177 0.7678
Loa Loa (eye worm) hypothetical protein 0.0088 0.0404 0.1272
Schistosoma mansoni hypothetical protein 0.0039 0.0093 0.0215
Brugia malayi CXXC zinc finger family protein 0.0029 0.0028 0.0078
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0716 0.0713
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.0976 0.3063
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0177 0.098 0.0976
Loa Loa (eye worm) hypothetical protein 0.005 0.0161 0.0508
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1137 0.3886
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0253 0.1471 1
Echinococcus multilocularis dnaJ subfamily B 0.042 0.2543 0.254
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0404
Brugia malayi hypothetical protein 0.0035 0.0063 0.0187
Echinococcus multilocularis chromobox protein 1 0.0157 0.0848 0.0844
Toxoplasma gondii target of rapamycin (TOR), putative 0.0188 0.1053 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0141 0.0433
Echinococcus multilocularis methyl CpG binding domain protein 2 0.005 0.0161 0.0158
Schistosoma mansoni alpha glucosidase 0.0039 0.0091 0.0211
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0186 0.0576
Schistosoma mansoni hypothetical protein 0.0061 0.0229 0.0546
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0047 0.0147
Echinococcus granulosus lamin 0.0054 0.0186 0.0435
Schistosoma mansoni zinc finger protein 0.0059 0.022 0.0523
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0037 0.0077 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0141 0.0443
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0255 0.0599
Echinococcus granulosus inositol monophosphatase 1 0.015 0.0805 0.1908
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0047 0.0147
Entamoeba histolytica myo-inositol monophosphatase, putative 0.015 0.0805 0.5458
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0063 0.0059
Schistosoma mansoni cpg binding protein 0.0037 0.0075 0.0173
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0518 0.3177 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0253 0.1471 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0141 0.0332
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0253 0.1471 0.4626
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0202 0.1139 0.759
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0134 0.0703 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0047 0.0147
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0177 0.098 0.2324
Loa Loa (eye worm) hypothetical protein 0.0099 0.0477 0.1503
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0141 0.0332
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0102 0.0234
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0231 0.2162
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0025 0.0078
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0033 0.0051 0.0112
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.002
Echinococcus multilocularis expressed conserved protein 0.009 0.0415 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0141 0.0327
Schistosoma mansoni cpg binding protein 0.0037 0.0075 0.0173
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0257 0.2417
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0622 0.8321
Onchocerca volvulus 0.0054 0.0186 0.0627
Schistosoma mansoni lamin 0.0054 0.0186 0.0442
Brugia malayi RNA recognition motif domain containing protein 0.0518 0.3177 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0111 0.0553 0.1309
Schistosoma mansoni hypothetical protein 0.0037 0.0077 0.0178
Schistosoma mansoni intermediate filament proteins 0.0054 0.0186 0.0442
Loa Loa (eye worm) hypothetical protein 0.0052 0.0171 0.0539
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0048 0.0147 0.0979
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0192 0.0605
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0622 0.6886
Brugia malayi Heterochromatin protein 1 0.0157 0.0848 0.266
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0048 0.0147 0.0342
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0253 0.1471 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0277 0.0936
Brugia malayi Inositol-1 0.015 0.0805 0.2525
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0253 0.1471 1
Echinococcus multilocularis protein patched 0.0041 0.0102 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0147 0.0453
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.0976 0.3071
Loa Loa (eye worm) hypothetical protein 0.0095 0.0453 0.1425
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0091 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0047 0.0147
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0048 0.0147 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0216 0.1233 0.4213
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0094 0.0447 0.152
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0141 0.0327
Schistosoma mansoni lamin 0.0054 0.0186 0.0442
Echinococcus multilocularis zinc finger protein 0.0059 0.022 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0518 0.3177 0.7678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.1471 0.5032
Schistosoma mansoni hypothetical protein 0.0164 0.0896 0.2159
Echinococcus multilocularis tar DNA binding protein 0.0518 0.3177 0.3174
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0218 0.0518
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.2547 0.8018
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0091 0.0299
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0255 0.0803
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1137 0.3886
Trichomonas vaginalis myo inositol monophosphatase, putative 0.015 0.0805 0.2746
Leishmania major phosphatidylinositol 3-kinase, putative 0.0085 0.0386 0.2139
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0091 0.0299
Brugia malayi TAR-binding protein 0.0518 0.3177 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0047 0.0147
Brugia malayi Bromodomain containing protein 0.0112 0.0564 0.1765
Schistosoma mansoni bromodomain containing protein 0.0188 0.1047 0.2526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.1053 0.3597
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0453 0.306
Schistosoma mansoni hypothetical protein 0.042 0.2543 0.6144
Echinococcus multilocularis cpg binding protein 0.0037 0.0075 0.0072
Onchocerca volvulus 0.0478 0.2921 1
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0102 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.1053 0.3597
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0404
Onchocerca volvulus 0.0086 0.0396 0.1344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0255 0.0609
Loa Loa (eye worm) hypothetical protein 0.0204 0.1155 0.3636
Schistosoma mansoni alpha-glucosidase 0.0152 0.0817 0.1969
Echinococcus multilocularis Chromobox protein 3 0.0026 0.0004 0.000000016255
Onchocerca volvulus 0.0102 0.0496 0.1688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0147 0.0493
Loa Loa (eye worm) hypothetical protein 0.0032 0.0042 0.0132
Trypanosoma cruzi ISWI complex protein 0.0045 0.0128 0.0603
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0011
Entamoeba histolytica hypothetical protein 0.0048 0.0147 0.0979
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0253 0.1471 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0218 0.051
Trichomonas vaginalis chromobox protein, putative 0.0157 0.0848 0.2893
Echinococcus multilocularis serine protein kinase ATM 0.0048 0.0147 0.0144
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.2907 0.2904
Loa Loa (eye worm) hypothetical protein 0.0111 0.0553 0.1742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1137 0.3886
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.0976 0.0972
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0575
Brugia malayi CHD4 protein 0.0033 0.0051 0.0148
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0255 0.0599
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0033 0.0051 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.072 0.2456
Trichomonas vaginalis chromobox protein, putative 0.0094 0.0447 0.152
Schistosoma mansoni chromobox protein 0.0157 0.0848 0.2043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1137 0.3886
Echinococcus multilocularis lamin dm0 0.0054 0.0186 0.0183
Schistosoma mansoni alpha-glucosidase 0.0152 0.0817 0.1969
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0404 0.1373
Toxoplasma gondii FATC domain-containing protein 0.0048 0.0147 0.1369
Schistosoma mansoni hypothetical protein 0.0045 0.0128 0.0301
Loa Loa (eye worm) bromodomain containing protein 0.0052 0.0173 0.0544
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0255 0.0792
Trichomonas vaginalis myo inositol monophosphatase, putative 0.015 0.0805 0.2746
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0027 0.0079
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0053 0.0183 0.1705
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0253 0.1471 0.3495
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0622 0.6886
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0033 0.0051 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0518 0.3177 0.7678
Schistosoma mansoni cpg binding protein 0.0029 0.0028 0.006
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0453 0.0449
Echinococcus granulosus chromobox protein 1 0.0157 0.0848 0.201
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0085 0.0386 0.1205
Trichomonas vaginalis chromobox protein, putative 0.0157 0.0848 0.2893
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.015 0.0805 0.5336
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.4136 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0719 0.2452
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0202 0.1139 0.759
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0091 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.072 0.2456
Loa Loa (eye worm) helicase 0.0026 0.0004 0.0011
Loa Loa (eye worm) TAR-binding protein 0.0518 0.3177 1
Loa Loa (eye worm) RNA binding protein 0.0518 0.3177 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.018 0.0567
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0091 0.0299
Echinococcus multilocularis geminin 0.0164 0.0896 0.0892
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.015 0.0805 0.5336
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0091 0.0299
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.1155 0.3628
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0141 0.0137
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0068 0.0276 0.0273
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0255 0.0251
Brugia malayi PHD-finger family protein 0.0075 0.0321 0.1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0047 0.0147
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0622 0.1496
Echinococcus granulosus neuropeptide s receptor 0.0476 0.2907 0.6913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0386 0.1311
Loa Loa (eye worm) CHromoDomain protein family member 0.0033 0.0051 0.0159
Echinococcus granulosus tar DNA binding protein 0.0518 0.3177 0.7555
Loa Loa (eye worm) hypothetical protein 0.0514 0.3151 0.9918
Echinococcus granulosus methyl CpG binding domain protein 2 0.005 0.0161 0.0375
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0453 0.1069
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0404
Echinococcus multilocularis tumor protein p63 0.0677 0.4203 0.4201
Echinococcus multilocularis chromobox protein 1 0.0157 0.0848 0.0844
Echinococcus multilocularis inositol monophosphatase 1 0.015 0.0805 0.0801
Loa Loa (eye worm) heterochromatin protein 1 0.0157 0.0848 0.2668
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0622 0.1496
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0255 0.0792
Echinococcus granulosus GPCR family 2 0.0065 0.0255 0.0599
Echinococcus granulosus fetal alzheimer antigen falz 0.0068 0.0276 0.0649
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0716 0.1697
Schistosoma mansoni hypothetical protein 0.0039 0.0093 0.0215
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0011
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0218 0.0214
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0006 0.0007
Brugia malayi SET domain containing protein 0.0028 0.0022 0.0058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.1155 0.3628
Onchocerca volvulus 0.0105 0.0514 0.175
Schistosoma mansoni patched 1 0.0041 0.0102 0.0238
Loa Loa (eye worm) hypothetical protein 0.0113 0.0565 0.1778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0147 0.0493
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0063 0.0143
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0011
Schistosoma mansoni inositol monophosphatase 0.015 0.0805 0.1939
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.015 0.0805 0.5
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0085 0.0386 0.0925
Schistosoma mansoni hypothetical protein 0.014 0.0738 0.1778
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0106 0.0519 0.1227
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.015 0.0805 0.5171
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0085 0.0386 0.0383
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0068 0.0276 0.0659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.1053 0.3597
Echinococcus granulosus Chromobox protein 3 0.0026 0.0004 0.00000003869
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0037 0.0077 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0518 0.3177 0.7678
Schistosoma mansoni tar DNA-binding protein 0.0518 0.3177 0.7678
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0321
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0047 0.0147
Onchocerca volvulus 0.0054 0.0186 0.0627
Schistosoma mansoni hypothetical protein 0.0065 0.0255 0.0608
Schistosoma mansoni hypothetical protein 0.0065 0.0255 0.0608
Schistosoma mansoni inositol monophosphatase 0.015 0.0805 0.1939
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0453 0.1415
Loa Loa (eye worm) hypothetical protein 0.0069 0.0282 0.0888
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.4136 0.4134
Trichomonas vaginalis chromobox protein, putative 0.0094 0.0447 0.152
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0253 0.1471 0.3552
Schistosoma mansoni methyl-cpg binding protein mbd 0.005 0.0161 0.0382
Schistosoma mansoni hypothetical protein 0.0039 0.0093 0.0215
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0091 0.0275
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0231 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.017 0.0934 0.3189
Trypanosoma cruzi ISWI complex protein 0.0045 0.0128 0.0603
Plasmodium vivax SET domain protein, putative 0.0061 0.0231 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0077 0.0252
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0006 0.0003
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0218 0.092
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0111 0.0553 0.055
Brugia malayi CHE-14 protein 0.0041 0.0102 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0183 0.0613
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0088 0.0404 0.1373
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0085 0.0386 0.2139
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0027 0.0079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0147 0.0453
Echinococcus granulosus intermediate filament protein 0.0054 0.0186 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0553 0.133
Schistosoma mansoni chromobox protein 0.0157 0.0848 0.2043
Brugia malayi Pre-SET motif family protein 0.042 0.2547 0.8016
Echinococcus multilocularis GPCR, family 2 0.0065 0.0255 0.0251
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0255 0.0251
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0091 0.083
Plasmodium falciparum heterochromatin protein 1 0.0026 0.0004 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.0899 0.3068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.072 0.2456
Schistosoma mansoni hypothetical protein 0.0039 0.0093 0.0215
Trichomonas vaginalis inositol monophosphatase, putative 0.015 0.0805 0.2746
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0024 0.0068
Loa Loa (eye worm) inositol-1 0.015 0.0805 0.2533
Echinococcus granulosus chromobox protein 1 0.0157 0.0848 0.201
Loa Loa (eye worm) hypothetical protein 0.0065 0.0255 0.0803
Schistosoma mansoni hypothetical protein 0.0065 0.0255 0.0608
Brugia malayi chromobox protein homolog 3 0.0088 0.0404 0.1262
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0212 0.0496
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0477 0.1146
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0253 0.1471 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0657 0.2067
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.0976 0.0972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0814 0.2779
Echinococcus granulosus survival motor neuron protein 1 0.0514 0.3151 0.7493
Trichomonas vaginalis PIKK family atypical protein kinase 0.015 0.0805 0.2745
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0105 0.0517 0.3085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0042 0.0131
Echinococcus granulosus lamin dm0 0.0054 0.0186 0.0435
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0622 0.3847
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0011
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0085 0.0386 0.2139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.1471 0.5032
Loa Loa (eye worm) phosphatidylinositol 3 0.0253 0.1471 0.4632
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.072 0.2456
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.015 0.0805 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.1053 0.3597
Onchocerca volvulus 0.0099 0.0477 0.1624
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.2907 0.6913
Brugia malayi intermediate filament protein 0.0054 0.0186 0.0576
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0186 0.0587
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.2907 0.2904
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0404 0.1373
Brugia malayi Pre-SET motif family protein 0.0061 0.0231 0.0715
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0553 0.133
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0085 0.0386 0.2407
Onchocerca volvulus 0.0029 0.0028 0.0085
Echinococcus granulosus microtubule associated protein 2 0.0667 0.4136 0.984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.1053 0.3597
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0106 0.0519 0.0515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.014 0.0738 0.2324
Leishmania major hypothetical protein, conserved 0.0045 0.0128 0.027
Brugia malayi follicle stimulating hormone receptor 0.0253 0.1471 0.4623
Onchocerca volvulus 0.0026 0.0004 0.0000000557
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0091 0.0299
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0622 0.0619
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0026 0.0004 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0102 0.0321
Brugia malayi FAT domain containing protein 0.0037 0.0077 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1137 0.3886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0719 0.2452
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.1471 0.4629
Loa Loa (eye worm) hypothetical protein 0.012 0.061 0.1919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0386 0.1311
Brugia malayi RNA binding protein 0.0518 0.3177 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0085 0.0386 0.2139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.1053 0.3597
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0514 0.1609
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0048 0.0147 0.0144
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0028 0.0089
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0253 0.1471 0.1468
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0738 0.2316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0814 0.2779
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0253 0.1471 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.0976 0.2314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.1471 0.5032
Trichomonas vaginalis PIKK family atypical protein kinase 0.015 0.0805 0.2745
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0091 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0091 0.0342
Brugia malayi Bromodomain containing protein 0.0222 0.1269 0.3989
Trichomonas vaginalis set domain proteins, putative 0.0478 0.2921 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0147 0.0464
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0063 0.0141
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0622 0.6886
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0386 0.1311
Entamoeba histolytica protein kinase rad3, putative 0.0048 0.0147 0.0979
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0042 0.0131
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0091 0.0286
Echinococcus granulosus serine protein kinase ATM 0.0048 0.0147 0.0342
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0186 0.0587
Echinococcus multilocularis musashi 0.0054 0.0186 0.0183
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0025 0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.