Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | TP_TRANSPORTER: uptake of Taurocholic acid at a concentration of 0.65uM in MCT1-expressing MDA-MB231 cells | ChEMBL. | 10579682 | |
Activity (functional) | TP_TRANSPORTER: uptake of Taurocholic acid at a concentration of 41.9nM in OATP2B1-expressing HEK293 cells | ChEMBL. | 15640378 | |
IC50 (functional) | = -5.6 | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
IC50 (functional) | = -5.6 | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
IC50 (functional) | = -5.5 | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
IC50 (functional) | = -5.4 | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
Inhibition (binding) | = -19.1 % | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy | ChEMBL. | 18788725 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19734910 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.