Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0086 | 0.1638 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0086 | 0.1638 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.1638 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.5 |
Brugia malayi | uridine phosphorylase family protein | 0.0086 | 0.1638 | 0.1638 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0086 | 0.1638 | 0.1638 |
Leishmania major | trypanothione reductase | 0.0062 | 0.103 | 0.6287 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.033 | 0.7816 | 0.7816 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.0086 | 0.1638 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0086 | 0.1638 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.1638 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0086 | 0.1638 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Loa Loa (eye worm) | uridine phosphorylase | 0.0086 | 0.1638 | 0.0896 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0062 | 0.103 | 0.103 |
Chlamydia trachomatis | AMP nucleosidase | 0.0086 | 0.1638 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.1638 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0062 | 0.103 | 0.103 |
Schistosoma mansoni | uridine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0086 | 0.1638 | 0.1638 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.033 | 0.7816 | 0.7816 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.1638 |
Trypanosoma brucei | uridine phosphorylase | 0.0086 | 0.1638 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0062 | 0.103 | 0.103 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0086 | 0.1638 | 0.0896 |
Giardia lamblia | UPL-1 | 0.0086 | 0.1638 | 0.1638 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0086 | 0.1638 | 1 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.1638 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0086 | 0.1638 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.1638 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0416 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 1 |
Mycobacterium leprae | probable uridine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.7816 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0416 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0062 | 0.103 | 0.6287 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.0086 | 0.1638 | 0.1638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0086 | 0.1638 | 0.1638 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 1 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Plasmodium falciparum | thioredoxin reductase | 0.0062 | 0.103 | 0.6287 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0086 | 0.1638 | 1 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0086 | 0.1638 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0416 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0086 | 0.1638 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0086 | 0.1638 | 0.1638 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0086 | 0.1638 | 0.1638 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0086 | 0.1638 | 0.1638 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.033 | 0.7816 | 0.7816 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0086 | 0.1638 | 0.1638 |
Treponema pallidum | pfs protein (pfs) | 0.0086 | 0.1638 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0062 | 0.103 | 0.6287 |
Brugia malayi | glutathione reductase | 0.0062 | 0.103 | 0.103 |
Plasmodium falciparum | glutathione reductase | 0.0062 | 0.103 | 0.6287 |
Schistosoma mansoni | uridine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0062 | 0.103 | 0.103 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0086 | 0.1638 | 0.1638 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0416 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0416 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Brugia malayi | MTAP | 0.0086 | 0.1638 | 0.1638 |
Entamoeba histolytica | hypothetical protein | 0.0086 | 0.1638 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0062 | 0.103 | 0.6287 |
Plasmodium vivax | glutathione reductase, putative | 0.0062 | 0.103 | 0.6287 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0086 | 0.1638 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0062 | 0.103 | 0.6287 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0086 | 0.1638 | 0.1638 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.0086 | 0.1638 | 0.1638 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0086 | 0.1638 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0416 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0086 | 0.1638 | 0.1638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.