Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | endonuclease G, putative | 0.008 | 0.0454 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0588 | 0.0588 |
Echinococcus multilocularis | ectonucleotide | 0.0113 | 0.0695 | 0.0693 |
Onchocerca volvulus | 0.0098 | 0.0588 | 0.2887 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0588 | 0.0588 |
Brugia malayi | hypothetical protein | 0.0098 | 0.0588 | 0.0586 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0014 | 0.0012 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0638 | 0.4615 | 0.6103 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0021 | 0.0012 | 0.0101 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.008 | 0.0454 | 0.0452 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.056 | 0.4032 | 0.4032 |
Echinococcus multilocularis | Alkaline phosphatase, core domain | 0.0021 | 0.0012 | 0.001 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0021 | 0.0012 | 0.0101 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Brugia malayi | AEL166Cp | 0.0021 | 0.0012 | 0.001 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0088 | 0.0509 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0588 | 0.0588 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0067 | 0.0356 | 0.3394 |
Leishmania major | histone deacetylase, putative | 0.0088 | 0.0509 | 0.0507 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0014 | 0.0012 |
Brugia malayi | Histone deacetylase family protein | 0.0088 | 0.0509 | 0.0507 |
Echinococcus multilocularis | gpi ethanolamine phosphate transferase 1 | 0.0021 | 0.0012 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0012 | 0.0012 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0014 | 0.0012 |
Brugia malayi | Histone deacetylase 1 | 0.0159 | 0.1044 | 0.1043 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0695 | 0.0693 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.008 | 0.0454 | 0.0452 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0014 | 0.0014 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0055 | 0.0269 | 0.0267 |
Giardia lamblia | Hypothetical protein | 0.0191 | 0.1277 | 0.2766 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0014 | 0.0014 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0178 | 0.1689 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0012 | 0.001 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0159 | 0.1044 | 1 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0067 | 0.0356 | 0.3394 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.136 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0088 | 0.0509 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0269 | 0.0269 |
Trypanosoma brucei | histone deacetylase 4 | 0.0088 | 0.0509 | 0.0507 |
Schistosoma mansoni | hypothetical protein | 0.0288 | 0.2006 | 0.2004 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0002 | 0.0002 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Trypanosoma brucei | histone deacetylase, putative | 0.0088 | 0.0509 | 0.0507 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.008 | 0.0454 | 0.0452 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0098 | 0.0588 | 0.0586 |
Brugia malayi | hypothetical protein | 0.0191 | 0.1277 | 0.1275 |
Leishmania major | histone deacetylase, putative | 0.0088 | 0.0509 | 0.0507 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0014 | 0.0014 |
Trypanosoma brucei | endonuclease G, putative | 0.008 | 0.0454 | 0.0452 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0014 | 0.0012 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0014 | 0.0014 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0067 | 0.0356 | 0.0354 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0014 | 0.0012 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0134 | 0.0852 | 0.085 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0014 | 0.0012 |
Echinococcus granulosus | histone deacetylase 3 | 0.0159 | 0.1044 | 0.1043 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0098 | 0.0588 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0588 | 0.0588 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0012 | 0.001 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0852 | 0.0852 |
Echinococcus multilocularis | histone deacetylase | 0.0088 | 0.0509 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0159 | 0.1044 | 0.1044 |
Echinococcus granulosus | follistatin | 0.0067 | 0.0356 | 0.0354 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.136 | 1 | 1 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0067 | 0.0356 | 0.0354 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.002 | 0.0002 | 0.0004 |
Schistosoma mansoni | follistatin | 0.0067 | 0.0356 | 0.0354 |
Trypanosoma cruzi | endonuclease G, putative | 0.008 | 0.0454 | 0.0452 |
Echinococcus granulosus | Protein patched homolog 1 | 0.056 | 0.4032 | 0.4031 |
Plasmodium falciparum | histone deacetylase, putative | 0.0088 | 0.0509 | 0.4809 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.056 | 0.4032 | 0.4031 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0014 | 0.0012 |
Echinococcus multilocularis | Endonuclease G | 0.008 | 0.0454 | 0.0452 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0014 | 0.0012 |
Brugia malayi | hypothetical protein | 0.0098 | 0.0588 | 0.0586 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0178 | 0.0176 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0014 | 0.0012 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.056 | 0.4032 | 0.4031 |
Trypanosoma brucei | UNC119 | 0.0191 | 0.1277 | 0.1275 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0014 | 0.0012 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0012 | 0.001 |
Onchocerca volvulus | 0.0134 | 0.0852 | 0.4211 | |
Onchocerca volvulus | 0.0098 | 0.0588 | 0.2887 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0014 | 0.0012 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0014 | 0.0014 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0088 | 0.0509 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0356 | 0.0356 |
Brugia malayi | hypothetical protein | 0.0944 | 0.6895 | 0.6894 |
Onchocerca volvulus | 0.0134 | 0.0852 | 0.4211 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0014 | 0.0012 |
Onchocerca volvulus | 0.0098 | 0.0588 | 0.2887 | |
Brugia malayi | CHE-14 protein | 0.056 | 0.4032 | 0.4031 |
Echinococcus granulosus | histone deacetylase 7 | 0.0088 | 0.0509 | 0.0507 |
Loa Loa (eye worm) | agrin synaptic family protein | 0.0067 | 0.0356 | 0.0356 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0021 | 0.0012 | 0.001 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Schistosoma mansoni | organic anion transporter | 0.0098 | 0.0588 | 0.0586 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0055 | 0.0269 | 0.0267 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0055 | 0.0269 | 0.0269 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.136 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.136 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0014 | 0.0012 |
Schistosoma mansoni | retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase | 0.0944 | 0.6895 | 0.6894 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0014 | 0.0012 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0178 | 0.0176 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0014 | 0.0012 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.008 | 0.0454 | 0.4339 |
Trypanosoma brucei | endonuclease G, putative | 0.008 | 0.0454 | 0.0452 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0159 | 0.1044 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0014 | 0.0014 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0014 | 0.0012 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0178 | 0.1689 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0012 | 0.0012 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Echinococcus multilocularis | transferase | 0.0021 | 0.0012 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1044 | 0.1044 |
Onchocerca volvulus | 0.0098 | 0.0588 | 0.2887 | |
Schistosoma mansoni | patched 1 | 0.056 | 0.4032 | 0.4031 |
Trypanosoma cruzi | UNC119 | 0.0191 | 0.1277 | 0.1275 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0014 | 0.0014 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0159 | 0.1044 | 0.1043 |
Echinococcus granulosus | histone deacetylase 8 | 0.0055 | 0.0269 | 0.0267 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0014 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0012 | 0.001 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0638 | 0.4615 | 0.6103 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0014 | 0.0012 |
Trichomonas vaginalis | retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative | 0.0944 | 0.6895 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0638 | 0.4615 | 0.6103 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0088 | 0.0509 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0852 | 0.0852 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0021 | 0.0012 | 0.001 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.056 | 0.4032 | 0.4031 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0695 | 0.0693 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0944 | 0.6895 | 0.6895 |
Trypanosoma cruzi | UNC119 | 0.0191 | 0.1277 | 0.1275 |
Giardia lamblia | Histone deacetylase | 0.0159 | 0.1044 | 0.2263 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0098 | 0.0588 | 0.0588 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.136 | 1 | 1 |
Trypanosoma brucei | GPI ethanolamine phosphate transferase 3, putative | 0.0021 | 0.0012 | 0.001 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0014 | 0.0012 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0088 | 0.0509 | 0.0507 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0098 | 0.0588 | 0.0586 |
Loa Loa (eye worm) | type I phosphodiesterase/nucleotide pyrophosphatase | 0.0021 | 0.0012 | 0.0012 |
Onchocerca volvulus | Putative organic anion transporter | 0.0098 | 0.0588 | 0.2887 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0014 | 0.0012 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0098 | 0.0588 | 0.5622 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0356 | 0.0356 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Brugia malayi | Histone deacetylase family protein | 0.0088 | 0.0509 | 0.0507 |
Leishmania major | hypothetical protein, conserved | 0.0191 | 0.1277 | 0.1275 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0159 | 0.1044 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0014 | 0.0012 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0088 | 0.0509 | 0.0507 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.136 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Echinococcus granulosus | histone deacetylase | 0.0088 | 0.0509 | 0.0507 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0067 | 0.0356 | 0.0354 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0014 | 0.0009 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.002 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Onchocerca volvulus | 0.0098 | 0.0588 | 0.2887 | |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0695 | 0.0695 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0288 | 0.2006 | 0.2006 |
Entamoeba histolytica | histone deacetylase, putative | 0.0159 | 0.1044 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0588 | 0.0588 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Leishmania major | ethanolamine phosphotransferase, putative | 0.0021 | 0.0012 | 0.001 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0055 | 0.0269 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0356 | 0.0356 |
Schistosoma mansoni | agrin | 0.0067 | 0.0356 | 0.0354 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0178 | 0.0176 |
Echinococcus multilocularis | follistatin | 0.0067 | 0.0356 | 0.0354 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | kazal-type serine protease inhibitor domain-containing protein | 0.0067 | 0.0356 | 0.0356 |
Trypanosoma cruzi | MFS transporter, putative | 0.0098 | 0.0588 | 0.0586 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0012 | 0.001 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0014 | 0.0012 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0088 | 0.0509 | 0.4861 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0288 | 0.2006 | 0.2004 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0014 | 0.0012 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0014 | 0.0012 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0159 | 0.1044 | 0.1043 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0067 | 0.0356 | 0.3394 |
Echinococcus multilocularis | protein patched | 0.056 | 0.4032 | 0.4031 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0014 | 0.0012 |
Trypanosoma brucei | histone deacetylase 3 | 0.0088 | 0.0509 | 0.0507 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0014 | 0.0012 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0055 | 0.0269 | 0.2558 |
Echinococcus multilocularis | protein dispatched 1 | 0.056 | 0.4032 | 0.4031 |
Schistosoma mansoni | organic anion transporter | 0.0098 | 0.0588 | 0.0586 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0014 | 0.0009 |
Leishmania major | histone deacetylase, putative | 0.0159 | 0.1044 | 0.1043 |
Schistosoma mansoni | histone deacetylase | 0.0159 | 0.1044 | 0.1043 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0159 | 0.1044 | 0.1043 |
Echinococcus granulosus | histone deacetylase 6 | 0.0088 | 0.0509 | 0.0507 |
Echinococcus granulosus | ectonucleotide | 0.0113 | 0.0695 | 0.0693 |
Brugia malayi | histone deacetylase 11 | 0.0055 | 0.0269 | 0.0267 |
Loa Loa (eye worm) | histone deacetylase | 0.0088 | 0.0509 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0588 | 0.0588 |
Echinococcus granulosus | transferase | 0.0021 | 0.0012 | 0.001 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0178 | 0.1689 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0014 | 0.0012 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0638 | 0.4615 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0055 | 0.0269 | 0.0267 |
Plasmodium falciparum | histone deacetylase 2 | 0.0088 | 0.0509 | 0.4809 |
Giardia lamblia | ABC transporter, putative | 0.002 | 0.0002 | 0.0004 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.056 | 0.4032 | 0.4031 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0021 | 0.0012 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Plasmodium falciparum | histone deacetylase 1 | 0.0159 | 0.1044 | 1 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0098 | 0.0588 | 0.0586 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0021 | 0.0012 | 0.001 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0178 | 0.0176 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0021 | 0.0012 | 0.001 |
Echinococcus multilocularis | expressed protein | 0.0067 | 0.0356 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0588 | 0.0588 |
Echinococcus granulosus | histone deacetylase 1 | 0.0159 | 0.1044 | 0.1043 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0098 | 0.0588 | 0.0586 |
Onchocerca volvulus | 0.0021 | 0.0014 | 0.0009 | |
Onchocerca volvulus | 0.0067 | 0.0356 | 0.1722 | |
Brugia malayi | hypothetical protein | 0.0043 | 0.0178 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0014 | 0.0012 |
Echinococcus multilocularis | gpi ethanolamine phosphate transferase 3 | 0.0021 | 0.0012 | 0.001 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0055 | 0.0269 | 0.1285 |
Toxoplasma gondii | protease inhibitor PI2 | 0.0067 | 0.0356 | 0.3394 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0178 | 0.1689 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.0067 | 0.0356 | 0.3394 |
Onchocerca volvulus | Putative organic anion transporter | 0.0098 | 0.0588 | 0.2887 |
Schistosoma mansoni | histone deacetylase | 0.0159 | 0.1044 | 0.1043 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.008 | 0.0454 | 0.0452 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0088 | 0.0509 | 0.0507 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0014 | 0.0012 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.056 | 0.4032 | 0.4032 |
Trypanosoma brucei | histone deacetylase 2 | 0.0055 | 0.0269 | 0.0267 |
Echinococcus granulosus | histone deacetylase 6 | 0.0095 | 0.0561 | 0.0559 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0014 | 0.0012 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0095 | 0.0561 | 0.0559 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0014 | 0.0012 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0067 | 0.0356 | 0.0354 |
Schistosoma mansoni | endonuclease related | 0.008 | 0.0454 | 0.0452 |
Giardia lamblia | MRP-like ABC transporter | 0.002 | 0.0002 | 0.0004 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0159 | 0.1044 | 0.1043 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0096 | 0.0096 |
Mycobacterium leprae | hypothetical protein | 0.0021 | 0.0012 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0852 | 0.0852 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0012 | 0.0012 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0014 | 0.0012 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0021 | 0.0012 | 0.0027 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0055 | 0.0269 | 0.0267 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0098 | 0.0588 | 0.0586 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0088 | 0.0509 | 0.0507 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0012 | 0.001 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0014 | 0.0012 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0098 | 0.0588 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.136 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.136 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0014 | 0.0012 |
Trypanosoma cruzi | endonuclease G, putative | 0.008 | 0.0454 | 0.0452 |
Onchocerca volvulus | Putative organic anion transporter | 0.0098 | 0.0588 | 0.2887 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0088 | 0.0509 | 0.3095 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0088 | 0.0509 | 0.0507 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0159 | 0.1044 | 0.1043 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0055 | 0.0269 | 0.2558 |
Echinococcus multilocularis | agrin | 0.0067 | 0.0356 | 0.0354 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0014 | 0.0012 |
Echinococcus granulosus | gpi ethanolamine phosphate transferase 3 | 0.0021 | 0.0012 | 0.001 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0067 | 0.0356 | 0.0354 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0159 | 0.1044 | 0.1044 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0134 | 0.0852 | 0.085 |
Brugia malayi | SPARC precursor | 0.0067 | 0.0356 | 0.0354 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.056 | 0.4032 | 0.4031 |
Trichomonas vaginalis | conserved hypothetical protein | 0.056 | 0.4032 | 0.5107 |
Echinococcus granulosus | agrin | 0.0067 | 0.0356 | 0.0354 |
Echinococcus granulosus | Endonuclease G | 0.008 | 0.0454 | 0.0452 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0014 | 0.0012 |
Brugia malayi | prostaglandin transporter | 0.0098 | 0.0588 | 0.0586 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0095 | 0.0561 | 0.0559 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0014 | 0.0009 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0088 | 0.0509 | 0.0507 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0014 | 0.0012 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0159 | 0.1044 | 0.1043 |
Onchocerca volvulus | 0.0288 | 0.2006 | 1 | |
Plasmodium vivax | histone deacetylase, putative | 0.0088 | 0.0509 | 0.3095 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0014 | 0.0012 |
Trypanosoma brucei | endonuclease G, putative | 0.008 | 0.0454 | 0.0452 |
Trypanosoma brucei | histone deacetylase 1 | 0.0159 | 0.1044 | 0.1043 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.002 | 0.0002 | 0.0004 |
Leishmania major | histone deacetylase, putative | 0.0159 | 0.1044 | 0.1043 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0014 | 0.0012 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0014 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1277 | 0.1277 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0014 | 0.0012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K inact (binding) | = 0.009 s-1 | Inhibitory activity of the compound against thermolysin expressed as kinact | ChEMBL. | No reference |
K inact (binding) | = 0.009 s-1 | Inhibitory activity of the compound against thermolysin expressed as kinact | ChEMBL. | No reference |
Ki (binding) | = 0.0045 M | Inhibitory activity of the compound against thermolysin expressed as Ki | ChEMBL. | No reference |
Ki (binding) | = 0.0045 M | Inhibitory activity of the compound against thermolysin expressed as Ki | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.