Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.616 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.9167 | 0.5345 | 0.5 |
Onchocerca volvulus | 0.2387 | 0.0833 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.2387 | 0.0833 | 0.0833 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9167 | 0.5345 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1135 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.9167 | 0.5345 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9167 | 0.5345 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.616 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.616 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.616 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 1.616 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 1.616 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 1.616 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.9167 | 0.5345 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 1.616 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2387 | 0.0833 | 0.0833 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.9167 | 0.5345 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.616 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.