Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | nitroreductase | Curated by TDR Targets | No references |
Leishmania major | trypanothione reductase | Curated by TDR Targets | References |
Trypanosoma cruzi | nitroreductase | Curated by TDR Targets | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase | 491 aa | 551 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | histone deacetylase, putative | 0.0208259 | 0.0594664 | 0.17013 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0231283 | 0.067212 | 0.187723 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0930775 | 0.302524 | 0.383888 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0100098 | 0.0230807 | 0.0637568 |
Echinococcus granulosus | tubulin beta 1 chain | 0.105208 | 0.34333 | 0.34333 |
Trypanosoma brucei | beta tubulin | 0.105208 | 0.34333 | 1 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.00732058 | 0.014034 | 0.014034 |
Brugia malayi | proprotein convertase 2 | 0.0455026 | 0.14248 | 0.188247 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.00444421 | 0.00435776 | 0.0113302 |
Brugia malayi | hypothetical protein | 0.0443903 | 0.138738 | 0.183303 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus multilocularis | cathepsin b | 0.021476 | 0.0616536 | 0.0616536 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.00444421 | 0.00435776 | 0.00435776 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0208259 | 0.0594664 | 0.17013 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.00732058 | 0.014034 | 0.0373089 |
Onchocerca volvulus | 0.00767733 | 0.0152341 | 0.0503382 | |
Trypanosoma brucei | histone deacetylase 4 | 0.0208259 | 0.0594664 | 0.17013 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Loa Loa (eye worm) | serotonin transporter b | 0.0261804 | 0.0774793 | 0.201447 |
Brugia malayi | Dopamine receptor protein 1 | 0.0930775 | 0.302524 | 0.399699 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.00732058 | 0.014034 | 0.0312854 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0443903 | 0.138738 | 0.36072 |
Plasmodium vivax | glutathione reductase, putative | 0.00761339 | 0.015019 | 0.0341831 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0165279 | 0.0450077 | 0.122403 |
Brugia malayi | Cathepsin L-like precursor | 0.00732058 | 0.014034 | 0.018542 |
Onchocerca volvulus | 0.00732058 | 0.014034 | 0.0463711 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.00732058 | 0.014034 | 0.014034 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0102351 | 0.0238387 | 0.0238387 |
Echinococcus granulosus | g-protein coupled receptor | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.00994152 | 0.022851 | 0.0594127 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00767733 | 0.0152341 | 0.0396089 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021476 | 0.0616536 | 0.0782353 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0566644 | 0.180029 | 0.228448 |
Schistosoma mansoni | tyrosine kinase | 0.0159928 | 0.0432077 | 0.0548285 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0729523 | 0.234822 | 0.297978 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0101904 | 0.0236884 | 0.0236884 |
Brugia malayi | Papain family cysteine protease containing protein | 0.00415925 | 0.00339916 | 0.00449102 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0455026 | 0.14248 | 0.188247 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | hypothetical protein | 0.0259271 | 0.0766272 | 0.199231 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0930775 | 0.302524 | 0.302524 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.00352699 | 0.00127221 | 0.00161437 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Brugia malayi | Papain family cysteine protease containing protein | 0.00415925 | 0.00339916 | 0.00449102 |
Onchocerca volvulus | 0.00454365 | 0.00469231 | 0.0154912 | |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0208259 | 0.0594664 | 0.171993 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.00794944 | 0.0161495 | 0.0161495 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0930775 | 0.302524 | 0.786565 |
Brugia malayi | Histone deacetylase family protein | 0.0208259 | 0.0594664 | 0.0785679 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.105208 | 0.34333 | 0.892661 |
Schistosoma mansoni | opsin-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Leishmania major | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.192774 |
Plasmodium vivax | amine transporter, putative | 0.00444421 | 0.00435776 | 0.00281999 |
Schistosoma mansoni | amine GPCR | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.180847 | 0.597786 | 0.597786 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | cysteine protease | 0.00732058 | 0.014034 | 0.014034 |
Echinococcus multilocularis | histone deacetylase | 0.0208259 | 0.0594664 | 0.0594664 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.00732058 | 0.014034 | 0.0312854 |
Giardia lamblia | Beta tubulin | 0.105208 | 0.34333 | 1 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0930775 | 0.302524 | 0.383888 |
Loa Loa (eye worm) | insulin-degrading enzyme | 0.00352699 | 0.00127221 | 0.00330776 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0930775 | 0.302524 | 0.302524 |
Brugia malayi | Histone deacetylase 1 | 0.0231283 | 0.067212 | 0.0888015 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0216786 | 0.062335 | 0.062335 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0930775 | 0.302524 | 0.302524 |
Onchocerca volvulus | 0.00767733 | 0.0152341 | 0.0503382 | |
Loa Loa (eye worm) | hypothetical protein | 0.00444421 | 0.00435776 | 0.0113302 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0930775 | 0.302524 | 0.302524 |
Schistosoma mansoni | tubulin subunit beta | 0.105208 | 0.34333 | 0.435669 |
Echinococcus granulosus | Furin 1 | 0.0165279 | 0.0450077 | 0.0450077 |
Onchocerca volvulus | 0.0261804 | 0.0774793 | 0.256095 | |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0930775 | 0.302524 | 0.302524 |
Onchocerca volvulus | 0.0703174 | 0.225958 | 0.746905 | |
Leishmania major | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.192774 |
Loa Loa (eye worm) | hypothetical protein | 0.00969344 | 0.0220164 | 0.0572429 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.00444421 | 0.00435776 | 0.0112459 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | nardilysin (M16 family) | 0.00352699 | 0.00127221 | 0.00161437 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.187723 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Onchocerca volvulus | 0.0703174 | 0.225958 | 0.746905 | |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.111394 | 0.364141 | 0.946769 |
Plasmodium falciparum | amino acid transporter, putative | 0.00444421 | 0.00435776 | 0.00281999 |
Plasmodium falciparum | plasmepsin III | 0.00454365 | 0.00469231 | 0.00380416 |
Echinococcus multilocularis | serotonin receptor | 0.102173 | 0.333123 | 0.333123 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.00444421 | 0.00435776 | 0.00435776 |
Plasmodium vivax | histone deacetylase, putative | 0.00994152 | 0.022851 | 0.0572229 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus granulosus | sex peptide receptor | 0.0930775 | 0.302524 | 0.302524 |
Brugia malayi | hypothetical protein | 0.00444421 | 0.00435776 | 0.00575754 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0201104 | 0.0570597 | 0.0570597 |
Leishmania major | cathepsin L-like protease | 0.00732058 | 0.014034 | 0.0373089 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Trypanosoma brucei | histone deacetylase 3 | 0.0208259 | 0.0594664 | 0.17013 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0312137 | 0.0944114 | 0.119803 |
Echinococcus multilocularis | dnaJ subfamily B | 0.237407 | 0.788053 | 0.788053 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.00732058 | 0.014034 | 0.0364886 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.105208 | 0.34333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Toxoplasma gondii | rhoptry metalloprotease toxolysin TLN1 | 0.00352699 | 0.00127221 | 0.00224556 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.00415925 | 0.00339916 | 0.00621811 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.021476 | 0.0616536 | 0.0782353 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.105208 | 0.34333 | 1 |
Echinococcus granulosus | ephrin type A receptor 4 A | 0.0068572 | 0.0124752 | 0.0124752 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.00863583 | 0.0184586 | 0.0184586 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.00732058 | 0.014034 | 0.014034 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.00415925 | 0.00339916 | 0.00431337 |
Brugia malayi | Papain family cysteine protease containing protein | 0.00732058 | 0.014034 | 0.018542 |
Echinococcus granulosus | tubulin subunit beta | 0.105208 | 0.34333 | 0.34333 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.00444421 | 0.00435776 | 0.00435776 |
Trypanosoma brucei | histone deacetylase 1 | 0.0231283 | 0.067212 | 0.192774 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.111394 | 0.364141 | 0.481108 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0930775 | 0.302524 | 0.399699 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.132063 | 0.433672 | 0.550308 |
Echinococcus multilocularis | cathepsin b | 0.021476 | 0.0616536 | 0.0616536 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.00454365 | 0.00469231 | 0.0122217 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0201104 | 0.0570597 | 0.0570597 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.111394 | 0.364141 | 0.364141 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0930775 | 0.302524 | 0.302524 |
Brugia malayi | Cathepsin L-like precursor | 0.00732058 | 0.014034 | 0.018542 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.00732058 | 0.014034 | 0.0373089 |
Echinococcus multilocularis | tyrosine protein kinase csk | 0.00552727 | 0.00800125 | 0.00800125 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.00732058 | 0.014034 | 0.0178085 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.00444421 | 0.00435776 | 0.00435776 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Onchocerca volvulus | 0.00444421 | 0.00435776 | 0.0143854 | |
Onchocerca volvulus | 0.0061708 | 0.0101661 | 0.0335854 | |
Echinococcus multilocularis | tubulin subunit beta | 0.105208 | 0.34333 | 0.34333 |
Brugia malayi | G-protein coupled receptor | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0192184 | 0.0540589 | 0.15622 |
Trypanosoma brucei | beta tubulin | 0.105208 | 0.34333 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.105208 | 0.34333 | 0.892661 |
Loa Loa (eye worm) | ctsf protein | 0.00732058 | 0.014034 | 0.0364886 |
Loa Loa (eye worm) | hypothetical protein | 0.0443903 | 0.138738 | 0.36072 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0216786 | 0.062335 | 0.0791 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Brugia malayi | Blistered cuticle protein 3 | 0.00767733 | 0.0152341 | 0.0201276 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.105208 | 0.34333 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0192184 | 0.0540589 | 0.14903 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0930775 | 0.302524 | 0.302524 |
Schistosoma mansoni | neuropeptide receptor | 0.0930775 | 0.302524 | 0.383888 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Brugia malayi | RE15519p | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | hypothetical protein | 0.11748 | 0.384614 | 1 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.00454365 | 0.00469231 | 0.00619955 |
Schistosoma mansoni | tyrosine kinase | 0.0166792 | 0.0455168 | 0.0577585 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0145498 | 0.0383536 | 0.0506733 |
Loa Loa (eye worm) | hypothetical protein | 0.0729523 | 0.234822 | 0.610539 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.00444421 | 0.00435776 | 0.00435776 |
Plasmodium falciparum | plasmepsin VII | 0.00454365 | 0.00469231 | 0.00380416 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.00383521 | 0.00230907 | 0.00230907 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.105208 | 0.34333 | 0.34333 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.00444421 | 0.00435776 | 0.00435776 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Brugia malayi | LBP/BPI | 0.0259271 | 0.0766272 | 0.101241 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.00704164 | 0.0130957 | 0.0130957 |
Schistosoma mansoni | hypothetical protein | 0.0142889 | 0.0374758 | 0.0475549 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0231283 | 0.067212 | 0.187723 |
Loa Loa (eye worm) | hypothetical protein | 0.0259271 | 0.0766272 | 0.199231 |
Plasmodium vivax | aspartyl protease, putative | 0.00454365 | 0.00469231 | 0.00380416 |
Entamoeba histolytica | cysteine proteinase, putative | 0.00732058 | 0.014034 | 0.0312854 |
Loa Loa (eye worm) | hypothetical protein | 0.0261804 | 0.0774793 | 0.201447 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0930775 | 0.302524 | 0.302524 |
Plasmodium vivax | thioredoxin reductase, putative | 0.00761339 | 0.015019 | 0.0341831 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0305989 | 0.0923432 | 0.0923432 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00516513 | 0.00678298 | 0.0176358 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0259271 | 0.0766272 | 0.21542 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.00415925 | 0.00339916 | 0.00621811 |
Loa Loa (eye worm) | hypothetical protein | 0.00516513 | 0.00678298 | 0.0176358 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0101904 | 0.0236884 | 0.0236884 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0930775 | 0.302524 | 0.302524 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.00415925 | 0.00339916 | 0.00431337 |
Brugia malayi | insulin-degrading enzyme | 0.00352699 | 0.00127221 | 0.00168086 |
Plasmodium falciparum | plasmepsin IX | 0.00454365 | 0.00469231 | 0.00380416 |
Echinococcus granulosus | nuclear receptor co repressor related ncor | 0.0333333 | 0.101542 | 0.101542 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Brugia malayi | hypothetical protein | 0.0443903 | 0.138738 | 0.183303 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.00761339 | 0.015019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00454365 | 0.00469231 | 0.0122001 |
Brugia malayi | celfurPC protein | 0.0586634 | 0.186754 | 0.246742 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Trypanosoma cruzi | histone deacetylase, putative | 0.00994152 | 0.022851 | 0.0630851 |
Loa Loa (eye worm) | matrixin family protein | 0.00527779 | 0.00716198 | 0.0186212 |
Brugia malayi | Cathepsin L-like precursor | 0.00732058 | 0.014034 | 0.018542 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.0259271 | 0.0766272 | 0.199231 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0231283 | 0.067212 | 0.192774 |
Echinococcus granulosus | insulin receptor | 0.0101288 | 0.0234809 | 0.0234809 |
Schistosoma mansoni | hypothetical protein | 0.0930775 | 0.302524 | 0.383888 |
Loa Loa (eye worm) | histone deacetylase | 0.0208259 | 0.0594664 | 0.154613 |
Brugia malayi | G-protein coupled receptor | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus multilocularis | serotonin transporter | 0.0261804 | 0.0774793 | 0.0774793 |
Plasmodium vivax | tubulin beta chain, putative | 0.105208 | 0.34333 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.00415925 | 0.00339916 | 0.00339916 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0305989 | 0.0923432 | 0.240093 |
Loa Loa (eye worm) | TK protein kinase | 0.00863583 | 0.0184586 | 0.0479925 |
Loa Loa (eye worm) | TK/CSK protein kinase | 0.00552727 | 0.00800125 | 0.0208033 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0930775 | 0.302524 | 0.383888 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0930775 | 0.302524 | 0.383888 |
Leishmania major | cathepsin L-like protease | 0.00732058 | 0.014034 | 0.0373089 |
Brugia malayi | histone deacetylase 11 | 0.00994152 | 0.022851 | 0.030191 |
Echinococcus multilocularis | g protein coupled receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | histone deacetylase | 0.0208259 | 0.0594664 | 0.0594664 |
Echinococcus granulosus | allatostatin A receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | serotonin transporter | 0.0261804 | 0.0774793 | 0.0774793 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.00444421 | 0.00435776 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0261804 | 0.0774793 | 0.5 |
Echinococcus multilocularis | 0.0586634 | 0.186754 | 0.186754 | |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | hypothetical protein | 0.00454365 | 0.00469231 | 0.0122001 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0930775 | 0.302524 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0231283 | 0.067212 | 0.187723 |
Loa Loa (eye worm) | hypothetical protein | 0.0259271 | 0.0766272 | 0.199231 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.00767733 | 0.0152341 | 0.0396089 |
Plasmodium falciparum | plasmepsin V | 0.00454365 | 0.00469231 | 0.00380416 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.010361 | 0.0242621 | 0.0242621 |
Echinococcus multilocularis | serotonin receptor | 0.102173 | 0.333123 | 0.333123 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0128423 | 0.0326092 | 0.0430837 |
Loa Loa (eye worm) | SRC-1 | 0.0101904 | 0.0236884 | 0.06159 |
Echinococcus granulosus | furin | 0.0729523 | 0.234822 | 0.234822 |
Echinococcus multilocularis | sex peptide receptor | 0.0930775 | 0.302524 | 0.302524 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Echinococcus multilocularis | insulin receptor | 0.0101288 | 0.0234809 | 0.0234809 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0930775 | 0.302524 | 0.383888 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.105208 | 0.34333 | 0.892661 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.00994152 | 0.022851 | 0.065189 |
Echinococcus granulosus | cathepsin l1 | 0.00732058 | 0.014034 | 0.014034 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0192184 | 0.0540589 | 0.14903 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0455026 | 0.14248 | 0.14248 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00767733 | 0.0152341 | 0.0396089 |
Schistosoma mansoni | hypothetical protein | 0.0930775 | 0.302524 | 0.383888 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.00732058 | 0.014034 | 0.0373089 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0930775 | 0.302524 | 0.383888 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0192184 | 0.0540589 | 0.140554 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0305989 | 0.0923432 | 0.0923432 |
Schistosoma mansoni | tubulin subunit beta | 0.105208 | 0.34333 | 0.435669 |
Onchocerca volvulus | 0.00444421 | 0.00435776 | 0.0143854 | |
Echinococcus granulosus | cathepsin l1 | 0.00516513 | 0.00678298 | 0.00678298 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0439776 | 0.13735 | 0.394053 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.105208 | 0.34333 | 1 |
Brugia malayi | endoprotease bli-4 precursor | 0.0729523 | 0.234822 | 0.31025 |
Giardia lamblia | Histone deacetylase | 0.0231283 | 0.067212 | 0.137803 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0439776 | 0.13735 | 0.13735 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0192184 | 0.0540589 | 0.0540589 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0100098 | 0.0230807 | 0.0578987 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Trichomonas vaginalis | tubulin, putative | 0.105208 | 0.34333 | 1 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0166792 | 0.0455168 | 0.0455168 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.00444421 | 0.00435776 | 0.00435776 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.00863583 | 0.0184586 | 0.0184586 |
Echinococcus multilocularis | g protein coupled receptor | 0.0930775 | 0.302524 | 0.302524 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.00415925 | 0.00339916 | 0.00621811 |
Schistosoma mansoni | tubulin subunit beta | 0.105208 | 0.34333 | 0.435669 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Brugia malayi | Peroxidasin | 0.00767733 | 0.0152341 | 0.0201276 |
Brugia malayi | hypothetical protein | 0.0259271 | 0.0766272 | 0.101241 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Plasmodium vivax | plasmepsin IV, putative | 0.0192184 | 0.0540589 | 0.14903 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0208259 | 0.0594664 | 0.154613 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0231283 | 0.067212 | 0.174752 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | histone deacetylase 8 | 0.00994152 | 0.022851 | 0.022851 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.00863583 | 0.0184586 | 0.0184586 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0930775 | 0.302524 | 0.383888 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.00767733 | 0.0152341 | 0.0503382 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.0061708 | 0.0101661 | 0.026432 |
Brugia malayi | Dopamine receptor protein 2 | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | hypothetical protein | 0.102173 | 0.333123 | 0.866122 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus multilocularis | tyrosine protein kinase csk | 0.00552727 | 0.00800125 | 0.00800125 |
Brugia malayi | Serotonin receptor | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0101904 | 0.0236884 | 0.0236884 |
Schistosoma mansoni | opsin-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00415925 | 0.00339916 | 0.00621811 |
Trypanosoma cruzi | cysteine protease, putative | 0.00415925 | 0.00339916 | 0.00621811 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0231283 | 0.067212 | 0.0888015 |
Echinococcus multilocularis | beta tubulin | 0.105208 | 0.34333 | 0.34333 |
Echinococcus multilocularis | fmrfamide receptor | 0.0930775 | 0.302524 | 0.302524 |
Trypanosoma brucei | histone deacetylase, putative | 0.0208259 | 0.0594664 | 0.17013 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.00761339 | 0.015019 | 0.015019 |
Toxoplasma gondii | cathepsin CPL | 0.00732058 | 0.014034 | 0.0394707 |
Trypanosoma cruzi | beta tubulin, putative | 0.105208 | 0.34333 | 1 |
Trypanosoma brucei | beta tubulin | 0.105208 | 0.34333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289747 | 0.0868795 | 0.225887 |
Brugia malayi | SH2 domain containing protein | 0.00712146 | 0.0133642 | 0.017657 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0128423 | 0.0326092 | 0.0326092 |
Schistosoma mansoni | tyrosine kinase | 0.00383521 | 0.00230907 | 0.00293009 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0165279 | 0.0450077 | 0.122403 |
Brugia malayi | Histone deacetylase family protein | 0.0208259 | 0.0594664 | 0.0785679 |
Onchocerca volvulus | 0.0259271 | 0.0766272 | 0.253278 | |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.00454365 | 0.00469231 | 0.00619955 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0165279 | 0.0450077 | 0.11702 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0258375 | 0.0763257 | 0.0763257 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Leishmania major | histone deacetylase, putative | 0.0208259 | 0.0594664 | 0.17013 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Onchocerca volvulus | 0.00767733 | 0.0152341 | 0.0503382 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0192184 | 0.0540589 | 0.068598 |
Plasmodium falciparum | plasmepsin VI | 0.0192184 | 0.0540589 | 0.14903 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.00994152 | 0.022851 | 0.0594127 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0443903 | 0.138738 | 0.36072 |
Toxoplasma gondii | cathepsin B | 0.0100098 | 0.0230807 | 0.0658592 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0208259 | 0.0594664 | 0.164937 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.00444421 | 0.00435776 | 0.00435776 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.00454365 | 0.00469231 | 0.00619955 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.00448889 | 0.00450809 | 0.00572053 |
Brugia malayi | Cathepsin L-like precursor | 0.00516513 | 0.00678298 | 0.00896178 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.00516513 | 0.00678298 | 0.0161106 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.00484132 | 0.00569366 | 0.0188013 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.00761339 | 0.015019 | 0.015019 |
Onchocerca volvulus | Peroxidase homolog | 0.00767733 | 0.0152341 | 0.0503382 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021476 | 0.0616536 | 0.0782353 |
Brugia malayi | Animal haem peroxidase family protein | 0.00767733 | 0.0152341 | 0.0201276 |
Leishmania major | cathepsin L-like protease | 0.00732058 | 0.014034 | 0.0373089 |
Loa Loa (eye worm) | hypothetical protein | 0.021476 | 0.0616536 | 0.1603 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Onchocerca volvulus | 0.00444421 | 0.00435776 | 0.0143854 | |
Onchocerca volvulus | Cathepsin L homolog | 0.00732058 | 0.014034 | 0.0463711 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.00994152 | 0.022851 | 0.0755163 |
Brugia malayi | ephrin receptor 1 precursor | 0.00359448 | 0.00149923 | 0.00198081 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.00867608 | 0.018594 | 0.0235948 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.187723 |
Brugia malayi | follicle stimulating hormone receptor | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.00444421 | 0.00435776 | 0.0113302 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0305989 | 0.0923432 | 0.122005 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0101904 | 0.0236884 | 0.0236884 |
Onchocerca volvulus | 0.0703174 | 0.225958 | 0.746905 | |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0930775 | 0.302524 | 0.302524 |
Toxoplasma gondii | hypothetical protein | 0.00444421 | 0.00435776 | 0.0112459 |
Brugia malayi | Animal haem peroxidase family protein | 0.00767733 | 0.0152341 | 0.0201276 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0258375 | 0.0763257 | 0.0763257 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Echinococcus granulosus | cathepsin L | 0.00415925 | 0.00339916 | 0.00339916 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Plasmodium vivax | hypothetical protein, conserved | 0.00444421 | 0.00435776 | 0.00281999 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0101904 | 0.0236884 | 0.0236884 |
Loa Loa (eye worm) | BEN-1 protein | 0.105208 | 0.34333 | 0.892661 |
Giardia lamblia | Beta tubulin | 0.105208 | 0.34333 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0231283 | 0.067212 | 0.0888015 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Trypanosoma cruzi | histone deacetylase, putative | 0.0208259 | 0.0594664 | 0.17013 |
Loa Loa (eye worm) | hypothetical protein | 0.0192184 | 0.0540589 | 0.140554 |
Schistosoma mansoni | neuropeptide receptor | 0.0930775 | 0.302524 | 0.383888 |
Schistosoma mansoni | tubulin subunit beta | 0.105208 | 0.34333 | 0.435669 |
Brugia malayi | Protein kinase domain containing protein | 0.0101288 | 0.0234809 | 0.0310233 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.00516513 | 0.00678298 | 0.00896178 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0208259 | 0.0594664 | 0.0754599 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0165279 | 0.0450077 | 0.122403 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.00732058 | 0.014034 | 0.0373089 |
Echinococcus multilocularis | Furin 1 | 0.0165279 | 0.0450077 | 0.0450077 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.00732058 | 0.014034 | 0.0373089 |
Onchocerca volvulus | Matrilysin homolog | 0.00484132 | 0.00569366 | 0.0188013 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.00794944 | 0.0161495 | 0.0161495 |
Brugia malayi | GnHR receptor homolog | 0.22814 | 0.75688 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.00767733 | 0.0152341 | 0.0201276 |
Schistosoma mansoni | hypothetical protein | 0.237407 | 0.788053 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0566644 | 0.180029 | 0.228448 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.00444421 | 0.00435776 | 0.00575754 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0930775 | 0.302524 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | biogenic amine receptor | 0.0930775 | 0.302524 | 0.383888 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00516513 | 0.00678298 | 0.00995444 |
Echinococcus multilocularis | fmrfamide receptor | 0.0930775 | 0.302524 | 0.302524 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0192184 | 0.0540589 | 0.14903 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Trypanosoma brucei | trypanothione reductase | 0.00761339 | 0.015019 | 0.0401886 |
Leishmania major | cathepsin L-like protease | 0.00732058 | 0.014034 | 0.0373089 |
Onchocerca volvulus | 0.0703174 | 0.225958 | 0.746905 | |
Schistosoma mansoni | tyrosine kinase | 0.0101288 | 0.0234809 | 0.029796 |
Schistosoma mansoni | tyrosine kinase | 0.0101288 | 0.0234809 | 0.029796 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Toxoplasma gondii | thioredoxin reductase | 0.00761339 | 0.015019 | 0.0423439 |
Plasmodium vivax | aspartyl protease, putative | 0.00454365 | 0.00469231 | 0.00380416 |
Echinococcus multilocularis | histone deacetylase 8 | 0.00994152 | 0.022851 | 0.022851 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | hypothetical protein | 0.0443903 | 0.138738 | 0.36072 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0261804 | 0.0774793 | 0.0983174 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0729523 | 0.234822 | 0.610539 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.00994152 | 0.022851 | 0.0289967 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | biogenic amine receptor | 0.0930775 | 0.302524 | 0.383888 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Entamoeba histolytica | cysteine proteinase, putative | 0.00732058 | 0.014034 | 0.0312854 |
Loa Loa (eye worm) | hypothetical protein | 0.0443903 | 0.138738 | 0.36072 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0930775 | 0.302524 | 0.302524 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0443903 | 0.138738 | 0.183303 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0192184 | 0.0540589 | 0.0540589 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | amine GPCR | 0.0930775 | 0.302524 | 0.383888 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus granulosus | orexin receptor type 2 | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Brugia malayi | SRC-1 | 0.0101904 | 0.0236884 | 0.0312974 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Schistosoma mansoni | opsin-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.30041 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0101904 | 0.0236884 | 0.0236884 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.00352699 | 0.00127221 | 0.00161437 |
Toxoplasma gondii | beta tubulin | 0.105208 | 0.34333 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Brugia malayi | Cathepsin L-like precursor | 0.00732058 | 0.014034 | 0.018542 |
Leishmania major | cysteine peptidase A (CPA) | 0.00732058 | 0.014034 | 0.0373089 |
Loa Loa (eye worm) | hypothetical protein | 0.0231283 | 0.067212 | 0.174752 |
Toxoplasma gondii | sporozoite developmental protein | 0.00352699 | 0.00127221 | 0.00224556 |
Loa Loa (eye worm) | hypothetical protein | 0.00315057 | 0.00000593077 | 0.00001542 |
Giardia lamblia | Furin precursor putative serine protease | 0.0142889 | 0.0374758 | 0.0449495 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0439776 | 0.13735 | 0.394053 |
Loa Loa (eye worm) | hypothetical protein | 0.102173 | 0.333123 | 0.866122 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0261804 | 0.0774793 | 0.0983174 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.00704164 | 0.0130957 | 0.0130957 |
Loa Loa (eye worm) | SH2 domain-containing protein | 0.00643507 | 0.0110551 | 0.0287434 |
Brugia malayi | beta-tubulin, identical | 0.105208 | 0.34333 | 0.453613 |
Loa Loa (eye worm) | hypothetical protein | 0.00444421 | 0.00435776 | 0.0113302 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0930775 | 0.302524 | 0.302524 |
Plasmodium vivax | aspartyl protease, putative | 0.00454365 | 0.00469231 | 0.00380416 |
Loa Loa (eye worm) | tubulin beta chain | 0.105208 | 0.34333 | 0.892661 |
Echinococcus granulosus | tyrosine protein kinase csk | 0.00552727 | 0.00800125 | 0.00800125 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.00383521 | 0.00230907 | 0.00230907 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.00444421 | 0.00435776 | 0.00575754 |
Echinococcus granulosus | 3'partial|nardilysin | 0.00352699 | 0.00127221 | 0.00127221 |
Brugia malayi | Cathepsin L-like precursor | 0.00732058 | 0.014034 | 0.018542 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.105208 | 0.34333 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | hypothetical protein | 0.00444421 | 0.00435776 | 0.0113302 |
Loa Loa (eye worm) | hypothetical protein | 0.00444421 | 0.00435776 | 0.0113302 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.00444421 | 0.00435776 | 0.0112459 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0231283 | 0.067212 | 0.067212 |
Loa Loa (eye worm) | hypothetical protein | 0.00516513 | 0.00678298 | 0.0176358 |
Loa Loa (eye worm) | hypothetical protein | 0.0108844 | 0.0260227 | 0.0676592 |
Schistosoma mansoni | peroxidasin | 0.00767733 | 0.0152341 | 0.0193314 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0201104 | 0.0570597 | 0.0724058 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.187723 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.00444421 | 0.00435776 | 0.0112459 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Toxoplasma gondii | hypothetical protein | 0.00444421 | 0.00435776 | 0.0112459 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0231283 | 0.067212 | 0.187723 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0165279 | 0.0450077 | 0.122403 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.00415925 | 0.00339916 | 0.00621811 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Brugia malayi | larval opioid receptor | 0.0930775 | 0.302524 | 0.399699 |
Onchocerca volvulus | 0.00732058 | 0.014034 | 0.0463711 | |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0101904 | 0.0236884 | 0.0236884 |
Brugia malayi | glutathione reductase | 0.00761339 | 0.015019 | 0.0198434 |
Onchocerca volvulus | 0.00516513 | 0.00678298 | 0.0224021 | |
Echinococcus granulosus | serotonin receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | nardilysin | 0.00352699 | 0.00127221 | 0.00127221 |
Echinococcus multilocularis | g protein coupled receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Entamoeba histolytica | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.187723 |
Loa Loa (eye worm) | hypothetical protein | 0.00444421 | 0.00435776 | 0.0113302 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Brugia malayi | AKH receptor | 0.0930775 | 0.302524 | 0.399699 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0208259 | 0.0594664 | 0.0754599 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0231283 | 0.067212 | 0.192774 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | peroxidasin | 0.00767733 | 0.0152341 | 0.0152341 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0930775 | 0.302524 | 0.786565 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0930775 | 0.302524 | 0.302524 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.00454365 | 0.00469231 | 0.0122217 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0165279 | 0.0450077 | 0.0571125 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Toxoplasma gondii | beta-tubulin, putative | 0.105208 | 0.34333 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00415925 | 0.00339916 | 0.00621811 |
Echinococcus granulosus | tyrosine protein kinase csk | 0.00552727 | 0.00800125 | 0.00800125 |
Brugia malayi | Animal haem peroxidase family protein | 0.00767733 | 0.0152341 | 0.0201276 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0455026 | 0.14248 | 0.14248 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Brugia malayi | hypothetical protein | 0.00454365 | 0.00469231 | 0.00619955 |
Brugia malayi | putative neuropeptide receptor | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.109217 | 0.356819 | 0.356819 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0208259 | 0.0594664 | 0.0594664 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Trypanosoma cruzi | histone deacetylase, putative | 0.0208259 | 0.0594664 | 0.17013 |
Brugia malayi | Melatonin receptor type 1A | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.00732058 | 0.014034 | 0.0364886 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.102173 | 0.333123 | 0.422716 |
Loa Loa (eye worm) | hypothetical protein | 0.0443903 | 0.138738 | 0.36072 |
Trichomonas vaginalis | proprotein convertase subtilisin/kexin type, putative | 0.0142889 | 0.0374758 | 0.100246 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase csk | 0.00552727 | 0.00800125 | 0.00800125 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0101904 | 0.0236884 | 0.0236884 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0101904 | 0.0236884 | 0.0236884 |
Brugia malayi | Animal haem peroxidase family protein | 0.00767733 | 0.0152341 | 0.0201276 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.00383521 | 0.00230907 | 0.00293009 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | histone deacetylase 3 | 0.0231283 | 0.067212 | 0.067212 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0930775 | 0.302524 | 0.302524 |
Brugia malayi | map kinase activated protein kinase protein 2 | 0.0201104 | 0.0570597 | 0.075388 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0703174 | 0.225958 | 0.298539 |
Onchocerca volvulus | Cathepsin F homolog | 0.00732058 | 0.014034 | 0.0463711 |
Onchocerca volvulus | 0.0703174 | 0.225958 | 0.746905 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus multilocularis | c src tyrosine kinase | 0.00867608 | 0.018594 | 0.018594 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.132063 | 0.433672 | 0.433672 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Echinococcus multilocularis | beta tubulin | 0.105208 | 0.34333 | 0.34333 |
Brugia malayi | Cathepsin L-like precursor | 0.00516513 | 0.00678298 | 0.00896178 |
Leishmania major | cathepsin L-like protease | 0.00732058 | 0.014034 | 0.0373089 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0261804 | 0.0774793 | 0.102367 |
Echinococcus granulosus | dnaJ subfamily B | 0.237407 | 0.788053 | 0.788053 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Schistosoma mansoni | tyrosine kinase | 0.0166792 | 0.0455168 | 0.0577585 |
Echinococcus granulosus | cathepsin b | 0.021476 | 0.0616536 | 0.0616536 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0930775 | 0.302524 | 0.399699 |
Onchocerca volvulus | Cathepsin L homolog | 0.00732058 | 0.014034 | 0.0463711 |
Onchocerca volvulus | 0.00712146 | 0.0133642 | 0.0441568 | |
Loa Loa (eye worm) | aspartyl protease 6 | 0.00454365 | 0.00469231 | 0.0122001 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0274497 | 0.0817494 | 0.183197 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.00761339 | 0.015019 | 0.0401886 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.00444421 | 0.00435776 | 0.00435776 |
Plasmodium falciparum | tubulin beta chain | 0.105208 | 0.34333 | 1 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.00444421 | 0.00435776 | 0.00435776 |
Brugia malayi | neuropeptide F receptor | 0.0930775 | 0.302524 | 0.399699 |
Leishmania major | trypanothione reductase | 0.00761339 | 0.015019 | 0.0401886 |
Onchocerca volvulus | Peroxidase homolog | 0.00767733 | 0.0152341 | 0.0503382 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0930775 | 0.302524 | 0.399699 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0192184 | 0.0540589 | 0.14903 |
Loa Loa (eye worm) | beta-tubulin | 0.105208 | 0.34333 | 0.892661 |
Trichomonas vaginalis | leucine-rich repeat protein, BspA family | 0.0142889 | 0.0374758 | 0.100246 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0100098 | 0.0230807 | 0.0637568 |
Schistosoma mansoni | myosin xvIII | 0.0930775 | 0.302524 | 0.383888 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.00454365 | 0.00469231 | 0.00380416 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0231283 | 0.067212 | 0.194587 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0166792 | 0.0455168 | 0.0455168 |
Loa Loa (eye worm) | hypothetical protein | 0.0703174 | 0.225958 | 0.587493 |
Brugia malayi | Dopamine receptor | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0930775 | 0.302524 | 0.302524 |
Schistosoma mansoni | amine GPCR | 0.0930775 | 0.302524 | 0.383888 |
Onchocerca volvulus | 0.00732058 | 0.014034 | 0.0463711 | |
Plasmodium falciparum | plasmepsin II | 0.0192184 | 0.0540589 | 0.14903 |
Schistosoma mansoni | hypothetical protein | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0930775 | 0.302524 | 0.302524 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.00732058 | 0.014034 | 0.0178085 |
Plasmodium vivax | aspartyl proteinase, putative | 0.00454365 | 0.00469231 | 0.00380416 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.180847 | 0.597786 | 0.597786 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Brugia malayi | Serotonin receptor | 0.141839 | 0.466559 | 0.616424 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.00444421 | 0.00435776 | 0.00435776 |
Loa Loa (eye worm) | hypothetical protein | 0.00444421 | 0.00435776 | 0.0113302 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0930775 | 0.302524 | 0.383888 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Onchocerca volvulus | 0.0703174 | 0.225958 | 0.746905 | |
Loa Loa (eye worm) | cathepsin B | 0.0100098 | 0.0230807 | 0.0600101 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0101904 | 0.0236884 | 0.0236884 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0930775 | 0.302524 | 0.302524 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Schistosoma mansoni | neuropeptide receptor | 0.107945 | 0.352538 | 0.447352 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.102173 | 0.333123 | 0.333123 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0101904 | 0.0236884 | 0.0236884 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus multilocularis | nuclear receptor co repressor related (ncor) | 0.0333333 | 0.101542 | 0.101542 |
Plasmodium falciparum | glutathione reductase | 0.00761339 | 0.015019 | 0.0341831 |
Plasmodium falciparum | transporter, putative | 0.00444421 | 0.00435776 | 0.00281999 |
Plasmodium falciparum | thioredoxin reductase | 0.00761339 | 0.015019 | 0.0341831 |
Schistosoma mansoni | histone deacetylase | 0.0231283 | 0.067212 | 0.0852887 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.132063 | 0.433672 | 0.433672 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.00454365 | 0.00469231 | 0.0122001 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus granulosus | neuropeptide s receptor | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Plasmodium falciparum | histone deacetylase, putative | 0.0208259 | 0.0594664 | 0.164937 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0100098 | 0.0230807 | 0.0292883 |
Echinococcus multilocularis | allatostatin A receptor | 0.0930775 | 0.302524 | 0.302524 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Entamoeba histolytica | cysteine proteinase, putative | 0.00516513 | 0.00678298 | 0.00995444 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus multilocularis | neuropeptide receptor | 0.107945 | 0.352538 | 0.352538 |
Giardia lamblia | Beta tubulin | 0.105208 | 0.34333 | 1 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Onchocerca volvulus | Peroxidasin homolog | 0.00767733 | 0.0152341 | 0.0503382 |
Onchocerca volvulus | 0.0703174 | 0.225958 | 0.746905 | |
Plasmodium falciparum | plasmepsin X | 0.00454365 | 0.00469231 | 0.00380416 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.187723 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Loa Loa (eye worm) | hypothetical protein | 0.0261804 | 0.0774793 | 0.201447 |
Loa Loa (eye worm) | hypothetical protein | 0.0261804 | 0.0774793 | 0.201447 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.021476 | 0.0616536 | 0.0814576 |
Echinococcus granulosus | beta tubulin | 0.105208 | 0.34333 | 0.34333 |
Leishmania major | cathepsin L-like protease | 0.00732058 | 0.014034 | 0.0373089 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0930775 | 0.302524 | 0.302524 |
Schistosoma mansoni | tyrosine kinase | 0.0159928 | 0.0432077 | 0.0548285 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0165279 | 0.0450077 | 0.122403 |
Echinococcus multilocularis | 0.00931136 | 0.0207311 | 0.0207311 | |
Echinococcus granulosus | insulin degrading enzyme | 0.00352699 | 0.00127221 | 0.00127221 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Loa Loa (eye worm) | hypothetical protein | 0.0117371 | 0.0288913 | 0.0751176 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0166792 | 0.0455168 | 0.0455168 |
Echinococcus granulosus | histone deacetylase 6 | 0.0208259 | 0.0594664 | 0.0594664 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.00732058 | 0.014034 | 0.0373089 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0208259 | 0.0594664 | 0.0594664 |
Schistosoma mansoni | histamine h1 receptor | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | ephrin type A receptor 4 A | 0.0068572 | 0.0124752 | 0.0124752 |
Onchocerca volvulus | 0.00454365 | 0.00469231 | 0.0154912 | |
Brugia malayi | Pepsin A precursor | 0.00454365 | 0.00469231 | 0.00619955 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0208259 | 0.0594664 | 0.0594664 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | tubulin subunit beta | 0.105208 | 0.34333 | 0.435669 |
Brugia malayi | Cathepsin L-like precursor | 0.00732058 | 0.014034 | 0.018542 |
Brugia malayi | sulfakinin receptor protein | 0.0930775 | 0.302524 | 0.399699 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.00732058 | 0.014034 | 0.014034 |
Schistosoma mansoni | septate junction protein | 0.00373818 | 0.00198267 | 0.00251591 |
Schistosoma mansoni | tyrosine kinase | 0.0305989 | 0.0923432 | 0.117179 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.111394 | 0.364141 | 0.364141 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0216786 | 0.062335 | 0.062335 |
Schistosoma mansoni | adenoreceptor | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0930775 | 0.302524 | 0.786565 |
Plasmodium vivax | vivapain-2 | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.105208 | 0.34333 | 0.34333 |
Echinococcus granulosus | tyrosine kinase | 0.00863583 | 0.0184586 | 0.0184586 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0101904 | 0.0236884 | 0.0236884 |
Schistosoma mansoni | tubulin subunit beta | 0.105208 | 0.34333 | 0.435669 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.00863583 | 0.0184586 | 0.0184586 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Toxoplasma gondii | aspartyl protease | 0.00454365 | 0.00469231 | 0.0122217 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.105208 | 0.34333 | 0.34333 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Onchocerca volvulus | 0.0443903 | 0.138738 | 0.458591 | |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Onchocerca volvulus | 0.0703174 | 0.225958 | 0.746905 | |
Plasmodium vivax | plasmepsin V, putative | 0.00454365 | 0.00469231 | 0.00380416 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.00732058 | 0.014034 | 0.014034 |
Schistosoma mansoni | peroxidasin | 0.00767733 | 0.0152341 | 0.0193314 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Trypanosoma cruzi | histone deacetylase, putative | 0.00994152 | 0.022851 | 0.0630851 |
Echinococcus granulosus | neuropeptide receptor | 0.107945 | 0.352538 | 0.352538 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.00793631 | 0.0161054 | 0.0161054 |
Echinococcus granulosus | somatostatin receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0439776 | 0.13735 | 0.13735 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | c src tyrosine kinase | 0.00867608 | 0.018594 | 0.018594 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0101904 | 0.0236884 | 0.0236884 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0703174 | 0.225958 | 0.298539 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Loa Loa (eye worm) | hypothetical protein | 0.00444421 | 0.00435776 | 0.0113302 |
Schistosoma mansoni | biogenic amine receptor | 0.0930775 | 0.302524 | 0.383888 |
Onchocerca volvulus | Dual oxidase homolog | 0.00767733 | 0.0152341 | 0.0503382 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0101288 | 0.0234809 | 0.0610504 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00516513 | 0.00678298 | 0.00995444 |
Trypanosoma brucei | histone deacetylase 2 | 0.00994152 | 0.022851 | 0.0630851 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0101904 | 0.0236884 | 0.0236884 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0443903 | 0.138738 | 0.183303 |
Entamoeba histolytica | tubulin family protein | 0.105208 | 0.34333 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0231283 | 0.067212 | 0.067212 |
Schistosoma mansoni | amine GPCR | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus granulosus | beta tubulin | 0.105208 | 0.34333 | 0.34333 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.105208 | 0.34333 | 1 |
Schistosoma mansoni | nardilysin (M16 family) | 0.00352699 | 0.00127221 | 0.00161437 |
Brugia malayi | Matrixin family protein | 0.00527779 | 0.00716198 | 0.00946251 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.00516513 | 0.00678298 | 0.00860727 |
Trichomonas vaginalis | neuroendocrine convertase 2 precursor, putative | 0.0142889 | 0.0374758 | 0.100246 |
Echinococcus multilocularis | cysteine protease | 0.00732058 | 0.014034 | 0.014034 |
Leishmania major | cathepsin L-like protease | 0.00732058 | 0.014034 | 0.0373089 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0165279 | 0.0450077 | 0.122403 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Schistosoma mansoni | neuropeptide receptor | 0.0930775 | 0.302524 | 0.383888 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021476 | 0.0616536 | 0.0782353 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.30041 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.010361 | 0.0242621 | 0.0242621 |
Loa Loa (eye worm) | fibroinase | 0.00732058 | 0.014034 | 0.0364886 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Leishmania major | cathepsin L-like protease | 0.00732058 | 0.014034 | 0.0373089 |
Trypanosoma brucei | beta tubulin | 0.105208 | 0.34333 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0159928 | 0.0432077 | 0.0548285 |
Brugia malayi | Thioredoxin reductase | 0.00761339 | 0.015019 | 0.0198434 |
Echinococcus granulosus | g protein coupled receptor | 0.0930775 | 0.302524 | 0.302524 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.187723 |
Schistosoma mansoni | tyrosine kinase | 0.0101904 | 0.0236884 | 0.0300594 |
Echinococcus granulosus | histone deacetylase 6 | 0.0208259 | 0.0594664 | 0.0594664 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0192184 | 0.0540589 | 0.15622 |
Echinococcus granulosus | fmrfamide receptor | 0.0930775 | 0.302524 | 0.302524 |
Schistosoma mansoni | tyrosine kinase | 0.0101904 | 0.0236884 | 0.0300594 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00767733 | 0.0152341 | 0.0396089 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0930775 | 0.302524 | 0.383888 |
Echinococcus multilocularis | tyrosine protein kinase csk | 0.00552727 | 0.00800125 | 0.00800125 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Brugia malayi | ORL1-like opioid receptor | 0.0930775 | 0.302524 | 0.399699 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0930775 | 0.302524 | 0.786565 |
Loa Loa (eye worm) | cysteine protease | 0.00732058 | 0.014034 | 0.0364886 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0261804 | 0.0774793 | 0.201447 |
Onchocerca volvulus | 0.00732058 | 0.014034 | 0.0463711 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.105208 | 0.34333 | 0.453613 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231283 | 0.067212 | 0.187723 |
Echinococcus granulosus | hypothetical protein | 0.0930775 | 0.302524 | 0.302524 |
Entamoeba histolytica | tubulin family protein | 0.105208 | 0.34333 | 1 |
Echinococcus multilocularis | peroxidasin | 0.00767733 | 0.0152341 | 0.0152341 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.00994152 | 0.022851 | 0.065189 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.00793631 | 0.0161054 | 0.0161054 |
Plasmodium falciparum | histone deacetylase 2 | 0.0208259 | 0.0594664 | 0.164937 |
Plasmodium vivax | vivapain-2 | 0.00732058 | 0.014034 | 0.0312854 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.00415925 | 0.00339916 | 0.00431337 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0261804 | 0.0774793 | 0.201447 |
Echinococcus multilocularis | cathepsin L | 0.00415925 | 0.00339916 | 0.00339916 |
Echinococcus granulosus | tyrosine protein kinase csk | 0.00552727 | 0.00800125 | 0.00800125 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.00315057 | 0.00000593077 | 0.00000783581 |
Brugia malayi | hypothetical protein | 0.00454365 | 0.00469231 | 0.00619955 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0258375 | 0.0763257 | 0.198447 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Loa Loa (eye worm) | TK/EPH protein kinase | 0.00854898 | 0.0181664 | 0.0472328 |
Echinococcus multilocularis | somatostatin receptor | 0.0930775 | 0.302524 | 0.302524 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Entamoeba histolytica | protein kinase, putative | 0.00704164 | 0.0130957 | 0.0285249 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0231283 | 0.067212 | 0.174752 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0231283 | 0.067212 | 0.194587 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0101904 | 0.0236884 | 0.0236884 |
Onchocerca volvulus | 0.00732058 | 0.014034 | 0.0463711 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142889 | 0.0374758 | 0.100246 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0101904 | 0.0236884 | 0.0236884 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.109217 | 0.356819 | 0.356819 |
Echinococcus granulosus | cysteine protease | 0.00415925 | 0.00339916 | 0.00339916 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0930775 | 0.302524 | 0.302524 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0100098 | 0.0230807 | 0.0637568 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.105208 | 0.34333 | 0.34333 |
Brugia malayi | hypothetical protein | 0.0930775 | 0.302524 | 0.399699 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus granulosus | neuropeptide receptor | 0.0930775 | 0.302524 | 0.302524 |
Onchocerca volvulus | 0.0443903 | 0.138738 | 0.458591 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.00444421 | 0.00435776 | 0.00575754 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Entamoeba histolytica | cysteine protease, putative | 0.00732058 | 0.014034 | 0.0312854 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Onchocerca volvulus | 0.00732058 | 0.014034 | 0.0463711 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0930775 | 0.302524 | 0.302524 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0231283 | 0.067212 | 0.187723 |
Echinococcus granulosus | histone deacetylase 7 | 0.0208259 | 0.0594664 | 0.0594664 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.00732058 | 0.014034 | 0.0312854 |
Echinococcus granulosus | cathepsin b | 0.021476 | 0.0616536 | 0.0616536 |
Brugia malayi | protein-tyrosine kinase | 0.00863583 | 0.0184586 | 0.0243878 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0930775 | 0.302524 | 0.302524 |
Onchocerca volvulus | 0.00732058 | 0.014034 | 0.0463711 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.00732058 | 0.014034 | 0.014034 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.021476 | 0.0616536 | 0.176524 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0231283 | 0.067212 | 0.067212 |
Leishmania major | beta tubulin | 0.105208 | 0.34333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Echinococcus multilocularis | nardilysin | 0.00352699 | 0.00127221 | 0.00127221 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0703174 | 0.225958 | 0.587493 |
Loa Loa (eye worm) | matrixin family protein | 0.00484132 | 0.00569366 | 0.0148036 |
Loa Loa (eye worm) | hypothetical protein | 0.0443903 | 0.138738 | 0.36072 |
Schistosoma mansoni | amine GPCR | 0.0930775 | 0.302524 | 0.383888 |
Brugia malayi | cathepsin L-like precursor | 0.00516513 | 0.00678298 | 0.00896178 |
Echinococcus multilocularis | neuropeptide receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus multilocularis | insulin degrading enzyme | 0.00352699 | 0.00127221 | 0.00127221 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0443903 | 0.138738 | 0.183303 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Loa Loa (eye worm) | thioredoxin reductase | 0.00761339 | 0.015019 | 0.0390496 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.00863583 | 0.0184586 | 0.0184586 |
Brugia malayi | neuropeptide F receptor | 0.0930775 | 0.302524 | 0.399699 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.00444421 | 0.00435776 | 0.00575754 |
Brugia malayi | G protein-coupled receptor | 0.0930775 | 0.302524 | 0.399699 |
Loa Loa (eye worm) | BEN-1 protein | 0.105208 | 0.34333 | 0.892661 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00454365 | 0.00469231 | 0.00595431 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0703174 | 0.225958 | 0.298539 |
Loa Loa (eye worm) | hypothetical protein | 0.00732058 | 0.014034 | 0.0364886 |
Onchocerca volvulus | Peroxidasin homolog | 0.00767733 | 0.0152341 | 0.0503382 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0201104 | 0.0570597 | 0.148355 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0930775 | 0.302524 | 0.302524 |
Echinococcus granulosus | g protein coupled receptor | 0.0930775 | 0.302524 | 0.302524 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Echinococcus multilocularis | nardilysin | 0.00352699 | 0.00127221 | 0.00127221 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00767733 | 0.0152341 | 0.0396089 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.107945 | 0.352538 | 0.352538 |
Loa Loa (eye worm) | hypothetical protein | 0.00767733 | 0.0152341 | 0.0396089 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | TK protein kinase | 0.00704164 | 0.0130957 | 0.0340488 |
Onchocerca volvulus | 0.0930775 | 0.302524 | 1 | |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0930775 | 0.302524 | 0.383888 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.00444421 | 0.00435776 | 0.00552978 |
Brugia malayi | hypothetical protein | 0.00767733 | 0.0152341 | 0.0201276 |
Plasmodium vivax | histone deacetylase, putative | 0.0208259 | 0.0594664 | 0.164937 |
Schistosoma mansoni | histone deacetylase hda2 | 0.00994152 | 0.022851 | 0.0289967 |
Schistosoma mansoni | histone deacetylase | 0.0231283 | 0.067212 | 0.0852887 |
Schistosoma mansoni | tyrosine kinase | 0.0242433 | 0.0709628 | 0.0900482 |
Schistosoma mansoni | ephrin receptor | 0.0068572 | 0.0124752 | 0.0158304 |
Echinococcus granulosus | g protein coupled receptor | 0.0930775 | 0.302524 | 0.302524 |
Loa Loa (eye worm) | hypothetical protein | 0.0930775 | 0.302524 | 0.786565 |
Schistosoma mansoni | hypothetical protein | 0.0930775 | 0.302524 | 0.383888 |
Loa Loa (eye worm) | glutathione reductase | 0.00761339 | 0.015019 | 0.0390496 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0930775 | 0.302524 | 0.383888 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on liver histology at 300 mg/kg, ip | ChEMBL. | 18255195 | |
Activity (ADMET) | Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on kidney histology at 300 mg/kg, ip | ChEMBL. | 18255195 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as prevention of skeletal muscle inflammatory infiltrates at 60 mg/kg/day, po | ChEMBL. | 18255195 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as prevention of heart inflammatory infiltrates at 60 mg/kg/day, po | ChEMBL. | 18255195 | |
Activity (ADMET) | Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on heart histology at 450 mg/kg, po | ChEMBL. | 18255195 | |
Activity (ADMET) | Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on kidney histology at 450 mg/kg, po | ChEMBL. | 18255195 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as inhibition of heart amastigote nests at 60 mg/kg/day, po | ChEMBL. | 18255195 | |
Activity (functional) | Antimicrobial activity against Trypanosoma brucei infected in NMRI mouse assessed as decrease in parasitemia level at 100 mg/kg, ip QD for 3 days measured after 30 days by neubuaer hemocytometry | ChEMBL. | 20439607 | |
Activity (ADMET) | Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on liver histology at 450 mg/kg, po | ChEMBL. | 18255195 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as prevention of liver congestion at 60 mg/kg/day, po | ChEMBL. | 18255195 | |
Activity (ADMET) | Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on heart histology at 300 mg/kg, ip | ChEMBL. | 18255195 | |
Activity (ADMET) | Toxicity in NMRI mouse up to 200 mg/kg, ip QD daily for 3 days | ChEMBL. | 20439607 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as inhibition of skeletal muscle amastigote nests at 60 mg/kg/day, po | ChEMBL. | 18255195 | |
Activity (functional) | = 0 % | Unspecific cytotoxicity against murine J774 macrophages at 1 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 0 % | Unspecific cytotoxicity against murine J774 macrophages at 1 ug/ml | ChEMBL. | 16455249 |
Activity (ADMET) | = 0 % | Toxicity in CD1 mouse assessed as decrease in weight respect to day zero at 300 mg/kg, po after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 0 % | Cytotoxicity against mouse J774 cells assessed as reduction in cell viability at 1 ug/ml after 24 hrs by resazurin-based colorimetric assay | ChEMBL. | 21605926 |
Activity (ADMET) | = 0 % | Cytotoxicity against mouse J774 cells at 1 ug/mL after 24 hrs by MTT assay | ChEMBL. | 24513185 |
Activity (functional) | = 0.6 % | Unspecific cytotoxicity against murine J774 macrophages at 10 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 0.6 % | Unspecific cytotoxicity against murine J774 macrophages at 10 ug/ml | ChEMBL. | 16455249 |
Activity (ADMET) | = 0.6 % | Cytotoxicity against mouse J774 cells assessed as reduction in cell viability at 10 ug/ml after 24 hrs by resazurin-based colorimetric assay | ChEMBL. | 21605926 |
Activity (ADMET) | = 3 % | Toxicity in CD1 mouse assessed as decrease in weight respect to day zero at 300 mg/kg, ip after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 6 % | Toxicity in CD1 mouse assessed as decrease in weight respect to day zero at 450 mg/kg, po after 3 days | ChEMBL. | 19446929 |
Activity (functional) | = 25.9 % | Unspecific cytotoxicity against murine J774 macrophages at 100 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 25.9 % | Unspecific cytotoxicity against murine J774 macrophages at 100 ug/ml | ChEMBL. | 16455249 |
Activity (ADMET) | = 25.9 % | Cytotoxicity against mouse J774 cells assessed as reduction in cell viability at 100 ug/ml after 24 hrs by resazurin-based colorimetric assay | ChEMBL. | 21605926 |
Activity (ADMET) | = 39.3 % | Toxicity in CD1 mouse assessed as hematocrite level at 300 mg/kg, ip after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 40 % | Cytotoxicity against human Caco-2 cells at 25 uM by MTT assay | ChEMBL. | 19900812 |
Activity (ADMET) | = 42 % | Cytotoxicity against mouse L929 cells assessed as metabolic activity at 100 uM after 48 hrs by Alamar Blue assay relative to untreated control | ChEMBL. | 25576738 |
Activity (ADMET) | = 42.4 % | Toxicity in CD1 mouse assessed as hematocrite level at 450 mg/kg, po after 3 days | ChEMBL. | 19446929 |
Activity (functional) | = 50.89 % | Antitrypanosomal activity against Trypanosoma cruzi SN3 trypomastigotes infected in african green monkey Vero cells assessed as parasite viability at 3.4 uM after 24 hrs by MTT assay | ChEMBL. | 18762357 |
Activity (functional) | = 52.5 % | Antitrypanosomal activity against trypomastigote stage of Trypanosoma cruzi Dm28c at 10 umol/L after 24 hrs by MTT assay | ChEMBL. | 22832320 |
Activity (functional) | = 52.5 % | Antitrypanosomal activity against Trypanosoma cruzi Dm28c epimastigotes assessed as non-viable epimastigotes at 10 umol/L after 4 hrs by MTT assay relative to untreated control | ChEMBL. | No reference |
Activity (functional) | = 66.3 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen assessed as trypomastigote viability at 9.5 uM by MTT assay relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 66.3 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen assessed as trypomastigote viability at 9.5 uM by MTT assay relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 75.5 % | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 1 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 75.5 % | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 1 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 75.5 % | Antitrypanosomal activity against epimastigote forms of Trypanosoma cruzi CL-B5 transfected with Escherichia coli beta-galactosidase gene LacZ at 1 ug/ml after 72 hrs by chlorophenol red-Beta-D-galactopyranoside-based assay | ChEMBL. | 21605926 |
Activity (functional) | = 75.5 % | Trypanocidal activity against epimastigote stage of Trypanosoma cruzi CL Brener at 1 ug/mL after 72 hrs by beta-galactosidase reporter gene assay relative to control | ChEMBL. | 24513185 |
Activity (functional) | = 80 % | Effect on oxygen redox cycling in Trypanosoma cruzi Y epimastigotes assessed as rate of oxygen consumption at 180 uM in presence of cyanide relative to control | ChEMBL. | 17981471 |
Activity (functional) | = 80 % | Effect on oxygen redox cycling in Trypanosoma cruzi Y epimastigotes assessed as rate of oxygen consumption at 180 uM in presence of cyanide relative to control | ChEMBL. | 17981471 |
Activity (functional) | = 80 % | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as cell death at 10 uM after 2 days by MTT assay relative to control | ChEMBL. | 21506600 |
Activity (functional) | = 87 % | Antitrypanosomal activity against Trypanosoma cruzi Colombiana assessed as parasitic cytotoxicity at 25 uM after 5 days by MTT assay | ChEMBL. | 19616875 |
Activity (functional) | = 87 % | Antitrypanosomal activity against Trypanosoma cruzi Colombiana epimastigotes assessed as cell death at 10 uM after 2 days by MTT assay relative to control | ChEMBL. | 21506600 |
Activity (functional) | = 88.1 % | Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 1 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 88.1 % | Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 1 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 88.14 % | Antitrypanosomal activity against amastigote forms of Trypanosoma cruzi CL-B5 expressing Escherichia coli LacZ gene infected in NCTC929 fibroblasts at 1 ug/ml after 7 days by chlorophenol red-Beta-D-galactopyranoside-based assay | ChEMBL. | 21605926 |
Activity (functional) | = 90 % | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 10 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 90 % | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 10 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 90 % | Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes assessed as parasitic cytotoxicity at 25 uM after 5 days by MTT assay | ChEMBL. | 19616875 |
Activity (functional) | = 90 % | Antitrypanosomal activity against Trypanosoma cruzi CL Brener clone epimastigotes assessed as cell death at 10 uM after 2 days by MTT assay relative to control | ChEMBL. | 21506600 |
Activity (functional) | = 90 % | Antitrypanosomal activity against epimastigote forms of Trypanosoma cruzi CL-B5 transfected with Escherichia coli beta-galactosidase gene LacZ at 10 ug/ml after 72 hrs by chlorophenol red-Beta-D-galactopyranoside-based assay | ChEMBL. | 21605926 |
Activity (functional) | = 94.2 % | Antiparasitic activity against Trypanosoma cruzi Y trypomastigotes infected in rhesus monkey LLC-MK2 cells followed by re-infection of amastigotes in human U2OS cells assessed as reduction in parasite infection level after 96 hrs by draq5 staining based assay relative to control | ChEMBL. | 26774924 |
Activity (functional) | = 94.4 % | Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 10 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 94.4 % | Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 10 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 94.44 % | Antitrypanosomal activity against amastigote forms of Trypanosoma cruzi CL-B5 expressing Escherichia coli LacZ gene infected in NCTC929 fibroblasts at 10 ug/ml after 7 days by chlorophenol red-Beta-D-galactopyranoside-based assay | ChEMBL. | 21605926 |
Activity (functional) | = 98.7 % | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 100 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 98.7 % | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 100 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 98.7 % | Antitrypanosomal activity against epimastigote forms of Trypanosoma cruzi CL-B5 transfected with Escherichia coli LacZ gene at 100 ug/ml after 72 hrs by chlorophenol red-Beta-D-galactopyranoside-based assay | ChEMBL. | 21605926 |
Activity (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 100 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi infected NMRI mice at 50 mg/kg/day | ChEMBL. | 16455249 |
Activity (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 100 ug/ml | ChEMBL. | 16455249 |
Activity (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi infected NMRI mice at 50 mg/kg/day | ChEMBL. | 16455249 |
Activity (functional) | = 100 % | Antitrypanosomal activity against amastigote forms of Trypanosoma cruzi CL-B5 expressing Escherichia coli LacZ gene infected in NCTC929 fibroblasts at 100 ug/ml after 7 days by chlorophenol red-Beta-D-galactopyranoside-based assay | ChEMBL. | 21605926 |
Activity (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi Dm28c epimastigotes assessed as non-viable epimastigotes at 100 umol/L after 4 hrs by MTT assay relative to untreated control | ChEMBL. | No reference |
Activity (functional) | = 113 % | Effect on oxygen redox cycling in Trypanosoma cruzi Tulahuen assessed as oxygen consumption per mg of protein relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 113 % | Effect on oxygen redox cycling in Trypanosoma cruzi Tulahuen assessed as oxygen consumption per mg of protein relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 117 % | Effect on oxygen uptake in Trypanosoma cruzi Y epimastigotes assessed as rate of oxygen consumption at 180 uM relative to control | ChEMBL. | 17981471 |
Activity (functional) | = 117 % | Effect on oxygen uptake in Trypanosoma cruzi Y epimastigotes assessed as rate of oxygen consumption at 180 uM relative to control | ChEMBL. | 17981471 |
Activity (functional) | = 120.4 % | Effect on oxygen uptake per mg of protein in Trypanosoma cruzi Tulahuen epimastigotes relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 120.4 % | Effect on oxygen uptake per mg of protein in Trypanosoma cruzi Tulahuen epimastigotes relative to control | ChEMBL. | 18029184 |
Activity (ADMET) | = 5100 /uL | Toxicity in CD1 mouse assessed as leukocyte level at 300 mg/kg, ip after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 6700 /uL | Toxicity in CD1 mouse assessed as leukocyte level at 450 mg/kg, po after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 13.2 g/L | Toxicity in CD1 mouse assessed as haemoglobin level at 300 mg/kg, ip after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 13.5 g/L | Toxicity in CD1 mouse assessed as haemoglobin level at 450 mg/kg, po after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 32.5 IU/L | Toxicity in CD1 mouse assessed as glutamic-pyruvate transaminase level at 300 mg/kg, ip after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 49 IU/L | Toxicity in CD1 mouse assessed as glutamic-pyruvate transaminase level at 450 mg/kg, po after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 162 IU/L | Toxicity in CD1 mouse assessed as glutamic-oxalacetate transaminase level at 450 mg/kg, po after 3 days | ChEMBL. | 19446929 |
Activity (ADMET) | = 177 IU/L | Toxicity in CD1 mouse assessed as glutamic-oxalacetate transaminase level at 300 mg/kg, ip after 3 days | ChEMBL. | 19446929 |
Activity (functional) | = 0.6 ug ml-1 | Increase in squalene biosynthesis in Trypanosoma cruzi tulahuen 2 epimastigotes at ID50 concentration per 8 x 10'6 cells/ml after 120 mins by HPLC analysis (Rvb=0.6 to 2.1 ug/ml) | ChEMBL. | 19811923 |
CC50 (functional) | = 2.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Y metacyclic trypomastigotes isolated from infected LLC-MK2 cells assessed as parasite viability after 24 hrs by neubauer chamber analysis | ChEMBL. | 24561675 |
CC50 (functional) | = 2.7 uM | Antiparasitic activity against trypomastigotes of Trypanosoma cruzi Y assessed as reduction of parasite count after 24 hrs | ChEMBL. | 26231082 |
CC50 (functional) | > 50 uM | Tested for cytotoxicity towards human MRC-5 cells | ChEMBL. | 12443785 |
CC50 (functional) | > 50 uM | Tested for cytotoxicity towards human MRC-5 cells | ChEMBL. | 12443785 |
CC50 (ADMET) | = 97.2 uM | Cytotoxicity against human U2OS cells assessed as reduction in cell viability | ChEMBL. | 26774924 |
delta logD (ADMET) | = 0 | Delta logD (logD6.5 - logD7.4) | ChEMBL. | 10891117 |
Drug uptake (ADMET) | = 3 uM | Drug level in serum of patient with human african trypanosomiasis at 15 mg/kg, po administered every 8 hrs for 10 days | ChEMBL. | 20439607 |
EC50 (functional) | = 1708 nM | Trypanocidal activity against Trypanosoma brucei rhodesiense Z310 after 72 hrs by Alamar blue assay | ChEMBL. | 23281892 |
EC50 (functional) | = 0.26 uM | Antimicrobial activity against Trypanosoma brucei gambiense | ChEMBL. | 20439607 |
EC50 (functional) | = 0.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Sylvio-X10/7 infected in BESM cells measured after 88 hrs postinfection by HTS assay | ChEMBL. | 20547819 |
EC50 (functional) | = 1.2 uM | Antitrypanosomal activity against Trypanosoma cruzi CA-I/72 infected in BESM cells measured after 88 hrs postinfection by HTS assay | ChEMBL. | 20547819 |
EC50 (functional) | = 1.26 uM | Antiparasitic activity against Trypanosoma cruzi Y trypomastigotes infected in rhesus monkey LLC-MK2 cells followed by re-infection of amastigotes in human U2OS cells assessed as reduction in parasite infection level after 96 hrs by draq5 staining based assay | ChEMBL. | 26774924 |
EC50 (functional) | = 2.1 uM | Antitrypanosomal activity against Trypanosoma cruzi PSD-I infected in BESM cells measured after 88 hrs postinfection by HTS assay | ChEMBL. | 20547819 |
EC50 (functional) | = 2.4 uM | Antimicrobial activity against Trypanosoma brucei | ChEMBL. | 20439607 |
EC50 (functional) | = 7.3 uM | Trypanocidal activity against bloodstream form of N-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-5-nitrofuran-2-carboxamide-resistant Trypanosoma brucei after 72 hrs by Alamar blue assay | ChEMBL. | 23281892 |
EC50 (functional) | = 20.1 uM | Antimicrobial activity against Trypanosoma brucei NfxR1 | ChEMBL. | 20439607 |
EC50 (functional) | = 20.3 uM | Antimicrobial activity against Trypanosoma brucei NfxR2 | ChEMBL. | 20439607 |
EC50 (ADMET) | = 91.2 uM | Cytotoxicity against human HeLa cells after 65 hrs by Alamar blue assay | ChEMBL. | 23281892 |
ED50 (functional) | = 36.7 mg kg-1 | Antimicrobial activity against Trypanosoma brucei infected in NMRI mouse at 128 mg/kg, ip QD for 4 days | ChEMBL. | 20439607 |
ED50 (functional) | = 0.4 uM | Evaluated in vitro for antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 12443785 |
ED50 (functional) | = 0.4 uM | Evaluated in vitro for antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 12443785 |
ED99 (functional) | = 128 mg kg-1 | Antimicrobial activity against Trypanosoma brucei infected in NMRI mouse at 128 mg/kg, ip QD for 4 days | ChEMBL. | 20439607 |
F (ADMET) | = 79 % | Oral bioavailability in human | ChEMBL. | 10891117 |
GI (ADMET) | = 0 % | Growth inhibition of mouse J774 cells at 64 uM after 24 hrs by resazurin reduction assay | ChEMBL. | 23124218 |
GI (functional) | = 46 % | Growth inhibition of Trypanosoma cruzi Tulahuen 2 epimastigote at 5 uM after 5 days | ChEMBL. | 19446929 |
GI (functional) | = 49.9 % | Trypanocidal activity against Trypanosoma cruzi Y epimastigotes infected in mouse J774 cells assessed as growth inhibition of parasite at 5 uM measured on day 5 | ChEMBL. | 25008454 |
GI (functional) | = 91.57 % | Growth inhibition of epimastigote form of Trypanosoma cruzi CL-B5 at 64 uM after 72 hrs by lacZ reporter gene assay | ChEMBL. | 23124218 |
GI (functional) | = 93 % | Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigote form at 25 uM | ChEMBL. | 16722639 |
GI (functional) | = 93 % | Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigote form at 25 uM | ChEMBL. | 16722639 |
GI (functional) | = 96.54 % | Antimicrobial activity against amastigote stage of Trypanosoma cruzi CL Brener infected in mouse NCTC-929 cells assessed as growth inhibition at 0.5 uM after 7 days by beta-galactosidase reporter gene assay | ChEMBL. | 24461296 |
GI (functional) | = 100 % | Growth inhibition of Trypanosoma cruzi epimastigotes Tulahuen 2 at 25 uM | ChEMBL. | 18083035 |
GI (functional) | = 100 % | Percent inhibition of growth against Trypanosoma cruzi epimastigotes, Y strain at concentration 4 microg/ml (13-17 microM) | ChEMBL. | No reference |
GI (functional) | = 100 % | Growth inhibition of Trypanosoma cruzi epimastigotes Tulahuen 2 at 25 uM | ChEMBL. | 18083035 |
GI (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 at 25 uM after 5 days | ChEMBL. | 17709156 |
GI (functional) | = 100 % | Growth inhibition of Trypanosoma cruzi CL-Brener clone epimastigotes infected in mouse blood at 25 uM measured on day 5 postinfection by Brener method | ChEMBL. | 18762357 |
GI (functional) | = 100 % | Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi Tulahuen 2 at 25 uM relative to control | ChEMBL. | 18547811 |
GI (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of epimastigotes growth at 50 uM | ChEMBL. | 20116908 |
GI (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth at 25 uM relative to control | ChEMBL. | 20634064 |
GI (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as growth inhibition at 25 uM after 5 days relative to control | ChEMBL. | 21506600 |
GI (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth at 25 uM after 5 days by spectrophotometric analysis | ChEMBL. | 22000947 |
GI (functional) | = 100 % | Antichagasic activity against epimastigote form of Trypanosoma cruzi Tulahuen 2 assessed as parasite growth inhibition at 25 uM measured on day 5 relative to control | ChEMBL. | 23811257 |
GI (functional) | = 100 % | Antimicrobial activity against benznidazole-resistant epimastigotes of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition at 25 uM measured on day 5 by spectrophotometry | ChEMBL. | No reference |
GI50 (functional) | = 3.78 uM | Antitrypanosomal activity against epimastigote stage of Trypanosoma cruzi Y assessed as parasite growth inhibition after 5 days by spectrophotometric analysis | ChEMBL. | 23644203 |
IC50 (functional) | Antileishmanial activity against Leishmania donovani | ChEMBL. | 17629327 | |
IC50 (functional) | Antiplasmodial activity against Plasmodium falciparum W2 by flow cytometry | ChEMBL. | 20131843 | |
IC50 (binding) | Inhibition of Electrophorus electricus acetylcholinesterase pre-incubated for 20 mins before acetylthiocholine iodide substrate addition by spectrophotometry | ChEMBL. | 26479031 | |
IC50 (functional) | Antitrypanosomal activity against extracellular Trypanosoma cruzi Tulahuen clone C4 | ChEMBL. | 15497945 | |
IC50 (functional) | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes after 3 days | ChEMBL. | 12880308 | |
IC50 (ADMET) | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by spectrophotometric analysis | LITERATURE. | 27591008 | |
IC50 (functional) | 0 | Antileishmanial activity against Leishmania donovani | ChEMBL. | 17629327 |
IC50 (functional) | 0 | Cytotoxicity against human MCF7 cells | ChEMBL. | 17629327 |
IC50 (functional) | 0 | Cytotoxicity against human NCI-H460 | ChEMBL. | 17629327 |
IC50 (ADMET) | 0 | Cytotoxicity against human Vero cells by MTT assay | ChEMBL. | 17629327 |
IC50 (functional) | = 3 ug ml-1 | Antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 19007286 |
IC50 (functional) | = 3 ug ml-1 | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen infected in mouse 3T3 cells assessed as beta-galactosidase activity after 7 days by chagas bioassay | ChEMBL. | 20441198 |
IC50 (functional) | uM | Inhibitory concentration of the compound in vitro against blood stream trypanosoma brucei brucei AT1 knockout mutant with a non functional P2 transporter; ND is not determined | ChEMBL. | 16107157 |
IC50 (functional) | uM | Cytotoxicity of the compound was determined in macrophages; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | uM | In vitro anti protozoal activity of the compound against Plasmodium falciparum sensitive strain W2; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | uM | In vitro anti protozoal activity of the compound against Trypanosoma brucei strain S427 was determined; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | uM | In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana ;ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | uM | In vitro anti protozoal activity of the compound against Leishmania infantum strain MHOM-ET-67/L82 was determined; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | 0 uM | In vitro anti protozoal activity of the compound against Trypanosoma brucei strain S427 was determined; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | 0 uM | In vitro anti protozoal activity of the compound against Leishmania infantum strain MHOM-ET-67/L82 was determined; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | 0 uM | In vitro anti protozoal activity of the compound against Leishmania amazonensis strain MHOM/ET/L82/LV9 was determined; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | 0 uM | Cytotoxicity of the compound was determined in macrophages; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | 0 uM | In vitro anti protozoal activity of the compound against Plasmodium falciparum sensitive strain W2; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | 0 uM | In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana ;ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | 0 uM | Cytotoxicity of the compound was determined in MRC-5 cells; ND = Not determined | ChEMBL. | 15203133 |
IC50 (functional) | = 0.13 uM | Trypanocidal activity against bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing type I nitroreductase assessed as inhibition of proliferation after 3 days by resazurin assay in presence of tetracycline | ChEMBL. | 25240098 |
IC50 (functional) | = 0.13 uM | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing tet-inducible NTR in absence of tetracycline after 3 days | ChEMBL. | 22550999 |
IC50 (functional) | = 0.13 uM | Antitrypanosomal activity against tetracycline-induced blood-stream Trypanosoma brucei brucei overexpressing type 1 nitroreductase after 3 days by alamar blue assay | ChEMBL. | 22023653 |
IC50 (functional) | = 0.23 uM | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. | ChEMBL. | No reference |
IC50 (functional) | = 0.24 uM | Antitrypanosomal activity against Trypanosoma cruzi clone Cl-Brener infected in african green monkey Vero cells assessed as growth inhibition after 3 days by luciferase reporter gene assay | ChEMBL. | 20679506 |
IC50 (functional) | = 0.26 uM | Antitrypanosomal activity against Trypanosoma brucei bloodstream form overexpressing nitroreductase assessed as growth inhibition after 3 days by Alamar blue assay | ChEMBL. | 23031595 |
IC50 (functional) | = 0.39 uM | In vitro anti-protozoal parasite activity of the compound against T. cruzi TC-1 | ChEMBL. | 12781185 |
IC50 (functional) | = 0.39 uM | In vitro anti-protozoal parasite activity of the compound against T. cruzi TC-1 | ChEMBL. | 12781185 |
IC50 (functional) | = 0.39 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 by microdilution method | ChEMBL. | 15497942 |
IC50 (functional) | = 0.43 uM | Antiparasitic activity against blood stream form of Trypanosoma brucei brucei overexpressing type-1 nitroreductase after 3 days by Alamar blue assay in presence of tetracycline | ChEMBL. | 26344593 |
IC50 (functional) | = 0.43 uM | Antimicrobial activity against bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as reduction in cell viability after 3 days by alamar blue assay in presence of tetracycline | ChEMBL. | 26363868 |
IC50 (functional) | = 0.45 uM | In vitro anti protozoal activity against Trypanosoma cruzi strain Tulahuen CL2 was determined | ChEMBL. | 15203133 |
IC50 (functional) | = 0.45 uM | In vitro anti protozoal activity against Trypanosoma cruzi strain Tulahuen CL2 was determined | ChEMBL. | 15203133 |
IC50 (functional) | = 0.45 uM | Antitrypanosomal activity against Trypanosoma cruzi Sylvio X-10 amastigotes infected in African green monkey Vero cells assessed as eradication of amastigotes after 72 hrs by Giemsa staining-based assay | ChEMBL. | 24749923 |
IC50 (functional) | < 0.5 uM | Antimicrobial activity against amastigote stage of Trypanosoma cruzi CL Brener infected in mouse NCTC-929 cells assessed as growth inhibition after 7 days by beta-galactosidase reporter gene assay | ChEMBL. | 24461296 |
IC50 (functional) | = 0.52 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs | ChEMBL. | 18798609 |
IC50 (functional) | = 0.7 uM | Trypanocidal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 SV2 cells assessed as parasite growth inhibition after 168 hrs by beta-galactosidase assay | ChEMBL. | 25199582 |
IC50 (functional) | = 0.869 uM | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as inhibition of parasite growth after 3 days by resazurin assay in presence of tetracycline | ChEMBL. | 27092415 |
IC50 (functional) | = 1.4 uM | Antiparasitic activity against Trypanosoma cruzi 320I04 intracellular amastigotes infected in african green monkey Vero cells after 72 hrs | ChEMBL. | 19321339 |
IC50 (functional) | = 1.5 uM | In vitro inhibitory concentration of the compound against intracellular amastigotes of trypanosoma cruzi in rat skeletal myoblasts incubated for 37 degree C for 4 days | ChEMBL. | 16107157 |
IC50 (functional) | = 1.5 uM | Inhibitory concentration of the compound in vitro against blood stream Trypanosoma brucei rhodesiense incubated for 72 h at 37 degree C | ChEMBL. | 16107157 |
IC50 (functional) | = 1.7 uM | Antitrypanosomal activity against Trypanosoma brucei MITat 427 clone 221a trypomastigotes after 3 days by alamar blue assay | ChEMBL. | 22248858 |
IC50 (functional) | = 1.71 uM | Trypanocidal activity against bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing type I nitroreductase assessed as inhibition of proliferation after 3 days by resazurin assay in absence of tetracycline | ChEMBL. | 25240098 |
IC50 (functional) | = 1.71 uM | Antitrypanosomal activity against blood-stream Trypanosoma brucei brucei expressing type 1 nitroreductase after 3 days by alamar blue assay in absence of tetracycline | ChEMBL. | 22023653 |
IC50 (functional) | = 1.71 uM | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing tet-inducible NTR in presence of tetracycline after 3 days | ChEMBL. | 22550999 |
IC50 (functional) | = 1.8 uM | Antiparasitic activity against Trypanosoma brucei BSF after 3 days by Alamar blue assay | ChEMBL. | 20028822 |
IC50 (functional) | = 1.8 uM | Trypanocidal activity against Trypanosoma cruzi | ChEMBL. | 23518280 |
IC50 (functional) | = 1.83 uM | Antitrypanosomal activity against wild type Trypanosoma brucei bloodstream form assessed as growth inhibition after 3 days by Alamar blue assay | ChEMBL. | 23031595 |
IC50 (functional) | = 1.9 uM | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigote form after 11 days by Trypan blue exclusion method | ChEMBL. | 19539479 |
IC50 (functional) | = 1.9 uM | Antitypanosomal activity against benznidazole-resistant epimastigote stage of Trypanosoma cruzi Y assessed as parasite growth inhibition after 11 days by hemacytometric analysis | ChEMBL. | No reference |
IC50 (functional) | = 2 uM | Antimicrobial activity against Trypanosoma brucei rhodesiense | ChEMBL. | 20185316 |
IC50 (functional) | = 2.06 uM | Antitrypanosomal activity against Trypanosoma brucei BSF overexpressing NTR gene assessed as growth inhibition after 3 days by Alamar blue assay | ChEMBL. | 20679506 |
IC50 (functional) | = 2.1 uM | Antitrypanosomal activity against Trypanosoma cruzi clone CL-Brener epimastigotes after 14 days by alamar blue assay | ChEMBL. | 22248858 |
IC50 (functional) | = 2.3 uM | Antitrypanosomal activity against Trypanosoma cruzi 320I01 amastigotes infected in african green monkey Vero cells after 5 days by Giemsa staining | ChEMBL. | 20627590 |
IC50 (functional) | = 2.33 uM | Antitrypanosomal activity against Trypanosoma cruzi 320I01 epimastigotes after 72 hrs by haemocytometry | ChEMBL. | 20627590 |
IC50 (functional) | = 2.7 uM | Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi Y infected in LLC-MK2 cells assessed as parasite motility after 24 hrs | ChEMBL. | 23167554 |
IC50 (functional) | = 2.8 uM | Antimicrobial activity against Trypanosoma cruzi infected in rat L6E9 myoblasts assessed as inhibition of [3H]uracil incorporation by giemsa staining | ChEMBL. | 20625148 |
IC50 (functional) | = 2.9 uM | Trypanocidal activity against bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a after 72 hrs by AlamarBlue assay | ChEMBL. | 24119553 |
IC50 (functional) | = 3.29 uM | In vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigote, Ystrain | ChEMBL. | No reference |
IC50 (functional) | = 3.4 uM | Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs | ChEMBL. | 16516467 |
IC50 (functional) | = 3.4 uM | Antitrypanosomal activity against Trypanosoma cruzi CL-Brener clone epimastigotes infected in mouse blood measured on day 5 postinfection by Brener method | ChEMBL. | 18762357 |
IC50 (functional) | = 3.4 uM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes after 5 days | ChEMBL. | 19900812 |
IC50 (functional) | = 3.4 uM | Antitrypanosomal activity against Trypanosoma brucei brucei | ChEMBL. | 19715342 |
IC50 (functional) | = 3.4 uM | Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs | ChEMBL. | 16516467 |
IC50 (functional) | = 3.55 uM | In vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigote, SC-28 strain | ChEMBL. | No reference |
IC50 (functional) | = 3.59 uM | Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi Y assessed as parasite growth inhibition after 5 days by spectrophotometric analysis | ChEMBL. | 23816040 |
IC50 (functional) | = 3.61 uM | Growth inhibition of epimastigote form of Trypanosoma cruzi CL-B5 after 72 hrs by lacZ reporter gene assay | ChEMBL. | 23124218 |
IC50 (functional) | = 3.81 uM | In vitro antitrypanosomal activity against Trypanosoma cruzi epimastigote, CL strain | ChEMBL. | No reference |
IC50 (functional) | = 3.98 uM | Antitrypanosomal activity against wild type bloodstream form of Trypanosoma brucei brucei assessed as inhibition of parasite growth after 3 days by resazurin assay | ChEMBL. | 27092415 |
IC50 (functional) | = 4 uM | Antiparasitic activity against epimastigote stage of Trypanosoma cruzi infected in Vero cells assessed as parasite growth inhibition after 24 hrs by hemocytometery | ChEMBL. | 25173828 |
IC50 (functional) | = 4.1 uM | Inhibitory concentration of the compound against wild-type (427) trypanosoma brucei | ChEMBL. | 16107157 |
IC50 (functional) | = 4.3 uM | Inhibitory concentration of the compound against wild-type (427) with NAC trypanosoma brucei | ChEMBL. | 16107157 |
IC50 (functional) | = 4.4 uM | Anti-trypanosomal activity against Trypanosoma brucei gambiense Feo bloodstream forms assessed as inhibition of parasite growth rate after 72 hrs by resazurin assay | ChEMBL. | 25089808 |
IC50 (functional) | = 4.41 uM | Antimicrobial activity against bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as reduction in cell viability after 3 days by alamar blue assay in absence of tetracycline | ChEMBL. | 26363868 |
IC50 (functional) | = 4.41 uM | Antiparasitic activity against blood stream form of Trypanosoma brucei brucei overexpressing type-1 nitroreductase after 3 days by Alamar blue assay in absence of tetracycline | ChEMBL. | 26344593 |
IC50 (functional) | = 4.5 uM | Antitrypanosomal activity against Trypanosoma cruzi tulahuen C4 trypomastigotes infected in african green monkey Vero cells assessed as CPRG cleavage after 120 hrs by microplate reader | ChEMBL. | 20356752 |
IC50 (functional) | = 4.8 uM | Antiparasitic activity against Trypanosoma cruzi 320I04 epimastigotes infected in african green monkey Vero cells after 72 hrs | ChEMBL. | 19321339 |
IC50 (functional) | = 5.6 uM | In vitro inhibitory concentration of the compound against blood stream trypanosoma brucei brucei AT1 wild type incubated for 72 h at 37 degree C | ChEMBL. | 16107157 |
IC50 (functional) | = 5.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Dm28c epimastigotes assessed as inhibition of parasite proliferation after 5 days by hemocytometer analysis | ChEMBL. | 24561675 |
IC50 (functional) | = 6 uM | Antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 17629327 |
IC50 (functional) | = 6 uM | Antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 17629327 |
IC50 (functional) | = 6 uM | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes | ChEMBL. | 19606868 |
IC50 (functional) | = 6 uM | Antimicrobial activity against Trypanosoma brucei brucei | ChEMBL. | 20185316 |
IC50 (functional) | = 6.1 uM | Antichagasic activity against Trypanosoma cruzi Tulahuen 2 | ChEMBL. | 21550147 |
IC50 (functional) | = 6.359 uM | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as inhibition of parasite growth after 3 days by resazurin assay in absence of tetracycline | ChEMBL. | 27092415 |
IC50 (functional) | = 6.5 uM | Antitrypanosomatid activity against Trypanosoma cruzi Y epimastigote form | ChEMBL. | 16722639 |
IC50 (functional) | = 6.5 uM | Antitrypanosomatid activity against Trypanosoma cruzi Y epimastigotes assessed as reduction of growth after 5 days | ChEMBL. | 17287123 |
IC50 (functional) | = 6.5 uM | Antitrypanosomal activity against Trypanosoma cruzi Y | ChEMBL. | 17960923 |
IC50 (functional) | = 6.5 uM | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes after 48 hrs by MTT assay | ChEMBL. | 17981471 |
IC50 (functional) | = 6.5 uM | Antitrypanosomatid activity against Trypanosoma cruzi Y epimastigote form | ChEMBL. | 16722639 |
IC50 (functional) | = 6.5 uM | Antitrypanosomatid activity against Trypanosoma cruzi Y epimastigotes assessed as reduction of growth after 5 days | ChEMBL. | 17287123 |
IC50 (functional) | = 6.5 uM | Antitrypanosomal activity against Trypanosoma cruzi Y | ChEMBL. | 17960923 |
IC50 (functional) | = 6.5 uM | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes after 48 hrs by MTT assay | ChEMBL. | 17981471 |
IC50 (functional) | = 6.5 uM | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes | ChEMBL. | 18068272 |
IC50 (functional) | = 7 uM | Trypanocidal activity against Trypanosoma cruzi Y epimastigotes infected in mouse J774 cells assessed as growth inhibition of parasite measured on day 5 | ChEMBL. | 25008454 |
IC50 (functional) | = 7.7 uM | Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigote form | ChEMBL. | 16722639 |
IC50 (functional) | = 7.7 uM | Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as reduction of growth after 5 days | ChEMBL. | 17287123 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 | ChEMBL. | 17960923 |
IC50 (functional) | = 7.7 uM | Growth inhibition of Trypanosoma cruzi epimastigotes Tulahuen 2 | ChEMBL. | 18083035 |
IC50 (functional) | = 7.7 uM | Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigote form | ChEMBL. | 16722639 |
IC50 (functional) | = 7.7 uM | Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as reduction of growth after 5 days | ChEMBL. | 17287123 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 | ChEMBL. | 17960923 |
IC50 (functional) | = 7.7 uM | Growth inhibition of Trypanosoma cruzi epimastigotes Tulahuen 2 | ChEMBL. | 18083035 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 | ChEMBL. | 19110434 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi Tulahuen 2 | ChEMBL. | 18547811 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes after 5 days | ChEMBL. | 19168363 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes | ChEMBL. | 18068272 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as parasite growth inhibition after 5 days | ChEMBL. | 19837489 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of epimastigotes growth | ChEMBL. | 20116908 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes | ChEMBL. | 20634064 |
IC50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth after 5 days by spectrophotometric analysis | ChEMBL. | 22000947 |
IC50 (functional) | = 7.7 uM | Trypanosomicidal activity against axenic epimastigote stage of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition | ChEMBL. | 23202852 |
IC50 (functional) | = 7.7 uM | Trypanocidal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes after 5 days | ChEMBL. | 26750255 |
IC50 (functional) | = 7.7 uM | Antichagasic activity against epimastigote form of Trypanosoma cruzi Tulahuen 2 assessed as parasite growth inhibition measured on day 5 | ChEMBL. | 23811257 |
IC50 (functional) | = 8.5 uM | Antitrypanosomatid activity against Trypanosoma cruzi CL Brener epimastigote form | ChEMBL. | 16722639 |
IC50 (functional) | = 8.5 uM | Antitrypanosomatid activity against Trypanosoma cruzi CL Brener epimastigotes assessed as reduction of growth after 5 days | ChEMBL. | 17287123 |
IC50 (functional) | = 8.5 uM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener | ChEMBL. | 17960923 |
IC50 (functional) | = 8.5 uM | Antitrypanosomatid activity against Trypanosoma cruzi CL Brener epimastigote form | ChEMBL. | 16722639 |
IC50 (functional) | = 8.5 uM | Antitrypanosomatid activity against Trypanosoma cruzi CL Brener epimastigotes assessed as reduction of growth after 5 days | ChEMBL. | 17287123 |
IC50 (functional) | = 8.5 uM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener | ChEMBL. | 17960923 |
IC50 (functional) | = 8.5 uM | Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi CL Brener | ChEMBL. | 18547811 |
IC50 (functional) | = 8.5 uM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes | ChEMBL. | 18068272 |
IC50 (functional) | = 8.5 uM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes assessed as parasite viability after 5 days by MTT assay | ChEMBL. | 19837489 |
IC50 (functional) | = 8.5 uM | Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigote form after 24 hrs by Trypan blue exclusion method | ChEMBL. | 19539479 |
IC50 (functional) | = 8.5 uM | Antitypanosomal activity against benznidazole-resistant trypomastigote stage of Trypanosoma cruzi Y assessed as parasite growth inhibition after 24 hr by hemacytometric analysis | ChEMBL. | No reference |
IC50 (functional) | = 8.6 uM | Concentration required to inhibit proliferation of the epimastigote form of T. cruzi | ChEMBL. | 9554887 |
IC50 (functional) | = 8.6 uM | Concentration required to inhibit proliferation of the epimastigote form of T. cruzi | ChEMBL. | 9554887 |
IC50 (functional) | = 9.5 uM | Growth inhibition of Trypanosoma cruzi Tulahuen epimastigotes assessed as drug level causing decrease in growth constant | ChEMBL. | 18029184 |
IC50 (functional) | = 9.5 uM | Growth inhibition of Trypanosoma cruzi Tulahuen epimastigotes assessed as drug level causing decrease in growth constant | ChEMBL. | 18029184 |
IC50 (functional) | = 10 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in vero cells assessed as intracellular growth inhibition of trypomastigote by beta-galactosidase reporter gene assay | ChEMBL. | 18715036 |
IC50 (functional) | = 10.67 uM | Antitrypanosomal activity against epimastigote stage of Trypanosoma cruzi Tulahuen CL98 after 48 hrs by hemocytometry | ChEMBL. | 27345756 |
IC50 (functional) | = 11 uM | Antitrypanosomal activity against intracellular Trypanosoma cruzi Tulahuen clone C4 assessed as cleavage of chlorophenol red-beta-D-galactosidase | ChEMBL. | 15497945 |
IC50 (functional) | = 11 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen clone C4 trypomastigotes in HFF after 7 days by beta-galactosidase reporter gene assay | ChEMBL. | 12880308 |
IC50 (functional) | = 11 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 infected in african green monkey Vero cells assessed as growth inhibition of trypomastigotes by beta-galactosidase reporter gene assay | ChEMBL. | 17067146 |
IC50 (functional) | = 11.4 uM | Inhibitory concentration of the compound against wild-type (427) trypanosoma brucei | ChEMBL. | 16107157 |
IC50 (ADMET) | = 12 uM | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay | ChEMBL. | 19168363 |
IC50 (functional) | = 12.84 uM | Anti-trypanosomal activity against Trypanosoma cruzi Y epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay | ChEMBL. | 25899337 |
IC50 (functional) | = 13.5 uM | Antitrypanosomal activity against Trypanosoma cruzi at 16.9 uM | ChEMBL. | 19161344 |
IC50 (functional) | = 13.5 uM | Antiparasitic activity against Trypanosoma cruzi Tulahuen C4 infected african green monkey Vero cells expressing beta-galctosidase after 5 days | ChEMBL. | 20030365 |
IC50 (functional) | = 21.05 uM | Trypanocidal activity against epimastigote stage of Trypanosoma cruzi infected in african green monkey Vero cells assessed as cell viability after 24 hrs by MTT assay | ChEMBL. | 25127463 |
IC50 (ADMET) | = 64.8 uM | Cytotoxicity against human THP1 cells after 6 days by Alamar blue assay | ChEMBL. | 20028822 |
IC50 (functional) | = 68 uM | Inhibitory concentration of the compound in vitro against intracellular amastigotes of Leishmania donovani in rat skeletal myoblasts incubated for 96 h at 27 degree C | ChEMBL. | 16107157 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human THP1 cells by AlamarBlue assay | ChEMBL. | 24119553 |
IC50 (functional) | > 200 uM | Cytotoxicity against J774.1 cell line after 48 hrs | ChEMBL. | 16516467 |
IC50 (functional) | > 200 uM | Cytotoxicity against J774.1 cell line after 48 hrs | ChEMBL. | 16516467 |
IC50 | = 263.44 uM | Cytotoxicity against mouse RAW264 | LITERATURE. | 27908757 |
IC50 (ADMET) | = 280.48 uM | Cytotoxicity against mouse J774 cells after 48 hrs by MTT assay | ChEMBL. | 23816040 |
IC50 (ADMET) | = 316 uM | Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by MTT assay | ChEMBL. | 25008454 |
IC50 (ADMET) | = 316 uM | Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by MTT assay | ChEMBL. | 23811257 |
IC90 (functional) | = 25 ug | Antitrypanosomal activity against Trypanosoma cruzi Z2 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 25 ug | Antitrypanosomal activity against Trypanosoma cruzi C8 CL1 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 25 ug | Antitrypanosomal activity against Trypanosoma cruzi Y after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 25 ug | Antitrypanosomal activity against Trypanosoma cruzi TeCL2 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 25 ug | Antitrypanosomal activity against Trypanosoma cruzi R107 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 25 ug | Antitrypanosomal activity against Trypanosoma cruzi A99CL7 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 25 ug | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 50 ug | Antitrypanosomal activity against Trypanosoma cruzi MIL4CL10 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 50 ug | Antitrypanosomal activity against Trypanosoma cruzi Z1 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 50 ug | Antitrypanosomal activity against Trypanosoma cruzi Z2CL4 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 50 ug | Antitrypanosomal activity against Trypanosoma cruzi 13379 CL8 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 50 ug | Antitrypanosomal activity against Trypanosoma cruzi 9280CL1 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 50 ug | Antitrypanosomal activity against Trypanosoma cruzi M6241CL6 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | > 100 ug | Antitrypanosomal activity against Trypanosoma cruzi 13379 CL3 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 100 ug | Antitrypanosomal activity against Trypanosoma cruzi 13379 CL5 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | > 100 ug | Antitrypanosomal activity against Trypanosoma cruzi 13379 CL6 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 100 ug | Antitrypanosomal activity against Trypanosoma cruzi A98CL5 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 100 ug | Antitrypanosomal activity against Trypanosoma cruzi CL after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 100 ug | Antitrypanosomal activity against Trypanosoma cruzi 27R27CL1 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 100 ug | Antitrypanosomal activity against Trypanosoma cruzi 31R16CL1 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | = 25 ug ml-1 | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen | ChEMBL. | No reference |
IC90 (functional) | = 0.82 uM | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. | ChEMBL. | No reference |
IC90 (functional) | = 9.06 uM | Antitrypanosomal activity against Trypanosoma cruzi 320I01 amastigotes infected in african green monkey Vero cells after 5 days by Giemsa staining | ChEMBL. | 20627590 |
IC90 (functional) | = 11 uM | Antiparasitic activity against Trypanosoma cruzi 320I04 intracellular amastigotes infected in african green monkey Vero cells after 72 hrs | ChEMBL. | 19321339 |
IC90 (functional) | = 17 uM | Antiparasitic activity against Trypanosoma cruzi 320I04 epimastigotes infected in african green monkey Vero cells after 72 hrs | ChEMBL. | 19321339 |
IC90 (functional) | = 23.41 uM | Antitrypanosomal activity against Trypanosoma cruzi 320I01 epimastigotes after 72 hrs by haemocytometry | ChEMBL. | 20627590 |
ID50 (functional) | = 3.4 mM | Antitrypanosomal activity against Trypanosoma cruzi Colombiana after 5 days by MTT assay | ChEMBL. | 19616875 |
ID50 (functional) | = 4.9 mM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes after 5 days by MTT assay | ChEMBL. | 19616875 |
ID50 (functional) | = 9.7 mM | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes after 5 days by MTT assay | ChEMBL. | 19616875 |
ID50 (ADMET) | = 316000 nM | Cytotoxicity against mouse J774 cells | ChEMBL. | 21506600 |
ID50 (functional) | = 3.4 uM | In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Brener strain | ChEMBL. | 15203172 |
ID50 (functional) | = 3.4 uM | In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Brener strain | ChEMBL. | 15203172 |
ID50 (functional) | = 3.4 uM | Antitrypanosomal activity against Trypanosoma cruzi Colombiana epimastigotes assessed as cell death after 2 days by MTT assay | ChEMBL. | 21506600 |
ID50 (functional) | = 4.9 uM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener assessed as parasite viability after 5 days by MTT assay | ChEMBL. | 18706821 |
ID50 (functional) | = 4.9 uM | Antitrypanosomal activity against Trypanosoma cruzi CL Brener clone epimastigotes assessed as cell death after 2 days by MTT assay | ChEMBL. | 21506600 |
ID50 (functional) | = 7.7 uM | In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Tulahuen strain | ChEMBL. | 15203172 |
ID50 (functional) | = 7.7 uM | In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Tulahuen strain | ChEMBL. | 15203172 |
ID50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 after 5 days | ChEMBL. | 17709156 |
ID50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of epimastigotes growth after 5 days by MTT assay relative to control | ChEMBL. | 18706821 |
ID50 (functional) | = 7.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth after 5 days | ChEMBL. | 19616875 |
ID50 (functional) | = 7.7 uM | Antitrypanosomal activity against epimastigote stage of Trypanosoma cruzi Tulahuen 2 after 5 days relative to untreated control | ChEMBL. | No reference |
ID50 (functional) | = 9.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Y assessed as parasite viability after 5 days by MTT assay | ChEMBL. | 18706821 |
ID50 (functional) | = 9.7 uM | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as cell death after 2 days by MTT assay | ChEMBL. | 21506600 |
ID50 (ADMET) | > 300 uM | Cytotoxicity against human THP1 cells after 48 hrs | ChEMBL. | 17709156 |
ID50 (ADMET) | = 316 uM | Cytotoxicity against mouse J774 cells after 48 hrs by MTT assay | ChEMBL. | 19811923 |
ID50 (ADMET) | = 316 uM | Cytotoxicity against mouse J774 cells after 48 hrs by MTT assay | ChEMBL. | 20163894 |
ID50 (ADMET) | = 346 uM | Cytotoxicity against mouse J774 cells | ChEMBL. | 19616875 |
ID50 (functional) | = 7700 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as growth inhibition after 5 days | ChEMBL. | 21506600 |
Inhibition (functional) | Antimicrobial activity against Trypanosoma brucei NfxR1 infected in NMRI mouse assessed as effect on parasitemia level at 100 mg/kg, ip QD for 3 days measured in 6 days by neubuaer hemocytometry | ChEMBL. | 20439607 | |
Inhibition (binding) | Inhibition of Trypanosoma brucei rhodesiense rhodesain after 12 hrs by fluorescence spectroscopy-based on-bead assay | ChEMBL. | 19715342 | |
Inhibition (binding) | Inhibition of human liver cathepsin B at 100 uM | ChEMBL. | 19715342 | |
Inhibition (binding) | Inhibition of Trypanosoma brucei rhodesiense recombinant rhodesain at 100 uM | ChEMBL. | 19715342 | |
Inhibition (binding) | Compound was evaluated for the inhibition of human FECH at 10uM | MMV_PBOX. | No reference | |
Inhibition (functional) | % | Inhibitory activity of the compound against proliferationof HTLV-1 transformed cell lines (HUT-102) at 10 microM; ND = Not determined | ChEMBL. | 15203133 |
Inhibition (functional) | 0 % | Inhibitory activity of the compound against proliferationof HTLV-1 transformed cell lines (HUT-102) at 10 microM; ND = Not determined | ChEMBL. | 15203133 |
Inhibition (functional) | = 13.24 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 98 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 13.24 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 98 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 17.39 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 24 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 17.39 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 24 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 19.64 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 72 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 19.64 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 72 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 20 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 48 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 20 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 48 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 99 % | Antitrypanosomal activity against Trypanosoma cruzi infected in albino CF1 mouse assessed as reduction in number of parasites in blood at 104 mg/kg/day, intramuscular treatment started on day 10 of infection up to day 14 | ChEMBL. | 69024 |
Inhibition (functional) | = 100 % | The compound was tested in vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigotes at a dose of 25 microM | ChEMBL. | 10354402 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 98 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 98 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 24 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 24 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 48 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 48 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 72 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 72 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | The compound was tested in vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigotes at a dose of 25 microM | ChEMBL. | 10354402 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 98 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 98 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 24 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 24 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 48 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 48 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 72 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 72 hr | ChEMBL. | 15713399 |
Inhibition (functional) | = 100 % | Trypanocidal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes at 25 uM after 5 days | ChEMBL. | 26750255 |
Inhibition (functional) | = 100 % | Antiparasitic activity against epimastigote stage of Trypanosoma cruzi assessed as growth inhibition at 50 uM | ChEMBL. | No reference |
Ki (binding) | Inhibition of Trypanosoma brucei rhodesiense recombinant rhodesain | ChEMBL. | 19715342 | |
Ki (binding) | Inhibition of Trypanosoma brucei rhodesiense recombinant rhodesain by standard fluorescence assay | ChEMBL. | 20131843 | |
Ki (binding) | Inhibition of Trypanosoma brucei rhodesiense rhodesain | ChEMBL. | 16516467 | |
Ki (binding) | Inhibition of human liver cathepsin B | ChEMBL. | 19715342 | |
Ki (binding) | 0 | Inhibition of Trypanosoma brucei rhodesiense rhodesain | ChEMBL. | 16516467 |
LC50 (functional) | Antimicrobial activity against Leishmania mexicana MHOM/BZ/61/M379 after 24 hrs by haemocytometry | ChEMBL. | 25899334 | |
LC50 (functional) | = 8.5 ug ml-1 | Trypanocidal activity against epimastigote forms of Trypanosoma cruzi Queretaro after 24 hrs | ChEMBL. | 25238291 |
LC50 (functional) | = 310 uM | Antimicrobial activity against bloodstream trypomastigote stage of Trypanosoma cruzi INC-5 after 24 hrs by Brener method | ChEMBL. | 25899334 |
LD50 (ADMET) | > 800 mg kg-1 | Acute toxicity in ip dosed CFW mouse administered daily for 5 days | ChEMBL. | 406399 |
log1/IC50 (functional) | = 4.89 | Anti-trypanosomal activity against Trypanosoma cruzi Y epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay | ChEMBL. | 25899337 |
log1/IC50 (functional) | = 5.14 | Anti-trypanosomal activity against Trypanosoma cruzi Bug 2149 cl10 epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay | ChEMBL. | 25899337 |
log1/IC50 (functional) | = 5.22 | Anti-trypanosomal activity against Trypanosoma cruzi Silvio X10 cl1 epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay | ChEMBL. | 25899337 |
logD (ADMET) | = 0.08 | Partition coefficient (logD6.5) | ChEMBL. | 10891117 |
MIC (functional) | = 15.2 ug ml-1 | Antimicrobial activity against Trypanosoma brucei NfxR1 | ChEMBL. | 20439607 |
MIC (functional) | = 7.7 uM | Antimicrobial activity against benznidazole-resistant epimastigotes of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition measured on day 5 by spectrophotometry | ChEMBL. | No reference |
MIC (functional) | = 200 uM | Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs | ChEMBL. | 16516467 |
MIC (functional) | = 200 uM | Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs | ChEMBL. | 16516467 |
MST (functional) | = 60 day | Antiprotozoal activity against Trypanosoma cruzi BH infected in CFW mouse assessed as increase in host mean survival time at 100 mg/kg, ip administered daily for 5 days starting 4 hrs post-parasite infection (Rvb = 14 +/- 1 days) | ChEMBL. | 406399 |
Myoblasts with parasites (functional) | = 6.75 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 5.0 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 6.75 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 5.0 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 7 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 2.5 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 7 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 2.5 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 12.5 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 1.0 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 12.5 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 1.0 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 13.5 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 2.5 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 13.5 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 5.0 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 13.5 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 2.5 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 13.5 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 5.0 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 14 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 1.0 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 14 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 1.0 (microg/mL) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 16.25 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr (absence of compound) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 16.25 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr (absence of compound) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 20 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr (absence of compound) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 20 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr (absence of compound) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 34.5 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 24 h (absence of compound) | ChEMBL. | 9554887 |
Myoblasts with parasites (functional) | = 34.5 % | Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 24 h (absence of compound) | ChEMBL. | 9554887 |
P2 uptake (binding) | In vitro inhibitory concentration against P2 aminopurine transporter of trypanosoma brucei brucei 427 adenosine (0.5 uM) uptake in presence of 1 mM inosine; ND=not determined | ChEMBL. | 16107157 | |
pKa | ND 0 | Ionization constant (pKa) | ChEMBL. | 10891117 |
R (functional) | = 9.25 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 5.0 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 9.25 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 5.0 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 20.25 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 2.5 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 20.25 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 2.5 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 27 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 5.0 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 27 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 5.0 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 34.75 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 2.5 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 34.75 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 2.5 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 64.5 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 1.0 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 64.5 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 1.0 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 70.5 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 1.0 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 70.5 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 1.0 (microg/mL) | ChEMBL. | 9554887 |
R (functional) | = 80.25 % | Growth inhibition of the intracellular T. cruzi was measured by counting no. of parasites per 100 myoblasts (T. cruzi ) after 24 h (absence of compound) | ChEMBL. | 9554887 |
R (functional) | = 80.25 % | Growth inhibition of the intracellular T. cruzi was measured by counting no. of parasites per 100 myoblasts (T. cruzi ) after 24 h (absence of compound) | ChEMBL. | 9554887 |
R (functional) | = 155 % | Growth inhibition of the intracellular T. cruzi was measured by counting no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr (absence of compound) | ChEMBL. | 9554887 |
R (functional) | = 155 % | Growth inhibition of the intracellular T. cruzi was measured by counting no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr (absence of compound) | ChEMBL. | 9554887 |
R (functional) | = 321 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr (absence of compound) | ChEMBL. | 9554887 |
R (functional) | = 321 % | Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr (absence of compound) | ChEMBL. | 9554887 |
Ratio EC50 (functional) | = 8 | Selectivity ratio of EC50 for Trypanosoma brucei NfxR1 to EC50 for Trypanosoma brucei | ChEMBL. | 20439607 |
Ratio EC50 (functional) | = 8 | Selectivity ratio of EC50 for Trypanosoma brucei NfxR2 to EC50 for Trypanosoma brucei | ChEMBL. | 20439607 |
Ratio IC50 (functional) | = 1.5 | Ratio of nifurtimox IC50 to compound IC50 for axenic epimastigote stage of Trypanosoma cruzi Tulahuen 2 | ChEMBL. | 23202852 |
Ratio IC50 (functional) | = 2 | Selectivity index, ratio of IC50 for Trypanosoma cruzi Silvio X10 cl1 to IC50 for Trypanosoma cruzi Y | ChEMBL. | 25899337 |
Ratio IC50 (functional) | = 2 | Selectivity index, ratio of IC50 for Trypanosoma cruzi Bug 2149 cl10 to IC50 for Trypanosoma cruzi Y | ChEMBL. | 25899337 |
Ratio IC50 (functional) | = 7 | Ratio of IC50 for wild type Trypanosoma brucei bloodstream form to IC50 for Trypanosoma brucei bloodstream form overexpressing nitroreductase | ChEMBL. | 23031595 |
Ratio IC50 (functional) | = 7.3 | Ratio of IC50 for bloodstream form of Trypanosoma brucei brucei overexpressing type I nitroreductase in absence of tetracycline to IC50 for bloodstream form of Trypanosoma brucei brucei overexpressing type I nitroreductase in presence of tetracycline | ChEMBL. | 27092415 |
Ratio IC50 (functional) | = 10.3 | Ratio of IC50 for blood stream form of Trypanosoma brucei brucei overexpressing type-1 nitroreductase in absence of tetracycline to IC50 for blood stream form of Trypanosoma brucei brucei overexpressing type-1 nitroreductase in presence of tetracycline | ChEMBL. | 26344593 |
Ratio IC50 (functional) | = 10.3 | Ratio of IC50 for bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase in absence of tetracycline to IC50 for bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase in presence of tetracycline | ChEMBL. | 26363868 |
Ratio IC50 (functional) | = 11.4 | Ratio of nifurtimox IC50 to compound IC50 for amastigote stage of Trypanosoma cruzi Tulahuen C4 | ChEMBL. | 23202852 |
Ratio IC50 (functional) | = 13 | Selectivity ratio of IC50 for Trypanosoma brucei brucei Lister 427 clone 221a overexpressing tet-inducible NTR in presence of tetracycline to IC50 for Trypanosoma brucei brucei overexpressing tet-inducible NTR in absence of tetracyclin | ChEMBL. | 22550999 |
Ratio IC50 (functional) | = 13 | Ratio of IC50 for blood-stream Trypanosoma brucei brucei expressing type 1 nitroreductase in the absence of tetracycline to IC50 for tetracycline-induced blood-stream Trypanosoma brucei brucei overexpressing type 1 nitroreductase | ChEMBL. | 22023653 |
Ratio IC50 (functional) | = 13.2 | Ratio of IC50 for bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing type I nitroreductase in absence of tetracycline to IC50 for bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing type I nitroreductase in presence of tetracycline | ChEMBL. | 25240098 |
Ratio IC50 (functional) | > 58 | Selectivity index, IC50 for J774.1/IC50 for Trypanosoma brucei brucei | ChEMBL. | 16516467 |
TIME (functional) | = 7.3 hr | Antimicrobial activity against wild type Trypanosoma brucei assessed as growth doubling time | ChEMBL. | 20439607 |
TIME (functional) | = 12.8 hr | Antimicrobial activity against nifurtimox-resistant Trypanosoma brucei assessed as growth doubling time | ChEMBL. | 20439607 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 16107157 | ||
Trypanosoma cruzi | ChEMBL23 | 12781185 | |
Homo sapiens | ChEMBL23 | 19168363 | |
Trypanosoma brucei | ChEMBL23 | 16107157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania donovani | 22664 | |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 16037-91-5. chemical inhibition with various inhibitors leads to reduced enzyme activity in vitro; | References: | 15766869 | |
response to drug (GO:0042493) | decreased sensitivity toward (PATO:0001550) | epimastigote (BTO:0000409) | inferred from gain-of-function mutant phenotype (ECO:0000042) | Trypanosoma cruzi | 34081 | |
Annotator: | millerja@u.washington.edu | Comment: | References: | 18367671 | ||
response to drug (GO:0042493) | decreased sensitivity toward (PATO:0001550) | epimastigote (BTO:0000409) | inferred from gain-of-function mutant phenotype (ECO:0000042) | Trypanosoma cruzi | 32922 | |
Annotator: | millerja@u.washington.edu | Comment: | References: | 18367671 |
265 literature references were collected for this gene.