Detailed information for compound 547595

Basic information

Technical information
  • TDR Targets ID: 547595
  • Name: (2S,3R)-1,2,3,4-tetrabromobutane
  • MW: 373.706 | Formula: C4H6Br4
  • H donors: 0 H acceptors: 0 LogP: 3.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrC[C@H]([C@H](CBr)Br)Br
  • InChi: 1S/C4H6Br4/c5-1-3(7)4(8)2-6/h3-4H,1-2H2/t3-,4+
  • InChiKey: HGRZLIGHKHRTRE-ZXZARUISSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0178 0.2214 0.4459
Trichomonas vaginalis esterase, putative 0.0111 0.1234 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0517 0.0927
Brugia malayi hypothetical protein 0.0177 0.2208 0.3053
Brugia malayi intermediate filament protein 0.0032 0.0078 0.0108
Mycobacterium tuberculosis Carboxylesterase LipT 0.0061 0.0497 0.0497
Brugia malayi beta-lactamase 0.0111 0.1234 0.1706
Echinococcus multilocularis geminin 0.0178 0.2214 0.4459
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1234 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0359 0.4877 0.6744
Schistosoma mansoni neuroligin 3 (S09 family) 0.0061 0.0497 0.0886
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1076 0.1488
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.1234 0.1234
Onchocerca volvulus 0.0061 0.0497 0.0688
Loa Loa (eye worm) hypothetical protein 0.0359 0.4877 0.6744
Onchocerca volvulus 0.0032 0.0078 0.0108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0154 0.1871 0.2587
Echinococcus granulosus neuroligin 0.0061 0.0497 0.0886
Echinococcus multilocularis tumor protein p63 0.0345 0.4672 0.9574
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0517 0.4192
Schistosoma mansoni BC026374 protein (S09 family) 0.0061 0.0497 0.0886
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0078 0.0108
Plasmodium vivax hypothetical protein, conserved 0.0111 0.1234 1
Schistosoma mansoni lamin 0.0032 0.0078 0.0013
Loa Loa (eye worm) hypothetical protein 0.0111 0.1234 0.1706
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1234 1
Brugia malayi Carboxylesterase family protein 0.0061 0.0497 0.0688
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1871 0.3744
Schistosoma mansoni intermediate filament proteins 0.0032 0.0078 0.0013
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.1234 0.1234
Loa Loa (eye worm) hypothetical protein 0.0068 0.0611 0.0845
Schistosoma mansoni hypothetical protein 0.0068 0.0611 0.1123
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0061 0.0497 0.0886
Mycobacterium ulcerans carboxylesterase, LipT 0.0061 0.0497 0.4032
Mycobacterium tuberculosis Conserved protein 0.0111 0.1234 0.1234
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0061 0.0497 0.0886
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0061 0.0497 0.0886
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0135 0.0186
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.1234 0.1234
Brugia malayi Carboxylesterase family protein 0.0359 0.4877 0.6744
Loa Loa (eye worm) hypothetical protein 0.0061 0.0497 0.0688
Echinococcus granulosus acetylcholinesterase 0.0359 0.4877 1
Brugia malayi hypothetical protein 0.0061 0.0497 0.0688
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.1234 0.2418
Onchocerca volvulus 0.005 0.0348 0.0482
Loa Loa (eye worm) hypothetical protein 0.0061 0.0497 0.0688
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0517 0.4192
Schistosoma mansoni hypothetical protein 0.0178 0.2214 0.4459
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.1234 1
Echinococcus granulosus lamin dm0 0.0032 0.0078 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0517 0.4192
Loa Loa (eye worm) beta-lactamase 0.0111 0.1234 0.1706
Mycobacterium ulcerans lipase LipD 0.0111 0.1234 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1234 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.1234 0.2418
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0061 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0061 0.0497 0.0688
Loa Loa (eye worm) hypothetical protein 0.01 0.1076 0.1488
Loa Loa (eye worm) hypothetical protein 0.0177 0.2208 0.3053
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0517 0.0517
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0061 0.0497 0.0497
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.1234 0.1234
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1234 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0135 0.0131
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.1234 0.1706
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.1234 0.1706
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0078 0.0108
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.1234 0.1234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0517 0.4192
Loa Loa (eye worm) hypothetical protein 0.0061 0.0497 0.0688
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0078 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.1871 0.3744
Echinococcus multilocularis acetylcholinesterase 0.0359 0.4877 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.033 0.0456
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0348 0.0575
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1234 1
Mycobacterium ulcerans beta-lactamase 0.0111 0.1234 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1871 0.3744
Brugia malayi beta-lactamase family protein 0.0111 0.1234 0.1706
Mycobacterium tuberculosis Conserved protein 0.0111 0.1234 0.1234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1871 0.3744
Echinococcus multilocularis musashi 0.0032 0.0078 0.0013
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.3152 0.6409
Brugia malayi Carboxylesterase family protein 0.0061 0.0497 0.0688
Brugia malayi hypothetical protein 0.0519 0.7232 1
Mycobacterium leprae conserved hypothetical protein 0.0111 0.1234 1
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.1234 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0135 0.5
Loa Loa (eye worm) carboxylesterase 0.0359 0.4877 0.6744
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0 0.5
Onchocerca volvulus 0.0049 0.033 0.0456
Leishmania major hypothetical protein, conserved 0.0036 0.0135 0.1092
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0517 0.0927
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0061 0.0497 0.0886
Loa Loa (eye worm) hypothetical protein 0.0061 0.0497 0.0688
Brugia malayi hypothetical protein 0.0241 0.3152 0.4358
Schistosoma mansoni lamin 0.0032 0.0078 0.0013
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0517 0.348
Loa Loa (eye worm) hypothetical protein 0.0032 0.0072 0.0099
Loa Loa (eye worm) hypothetical protein 0.0519 0.7232 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1234 0.1706
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1076 0.1488
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0517 0.0927
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.3152 0.6409
Echinococcus granulosus intermediate filament protein 0.0032 0.0078 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1234 0.2418
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0061 0.0497 0.0886
Echinococcus multilocularis acetylcholinesterase 0.0359 0.4877 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0517 0.0927
Schistosoma mansoni survival motor neuron protein 0.0049 0.033 0.0537
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1234 1
Echinococcus granulosus geminin 0.0178 0.2214 0.4459
Onchocerca volvulus 0.0177 0.2208 0.3053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.1234 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0072 0.0099
Loa Loa (eye worm) hypothetical protein 0.005 0.0348 0.0482
Mycobacterium ulcerans hypothetical protein 0.0111 0.1234 1
Schistosoma mansoni acetylcholinesterase 0.0061 0.0497 0.0886
Echinococcus granulosus para nitrobenzyl esterase 0.0061 0.0497 0.0886
Loa Loa (eye worm) hypothetical protein 0.0241 0.3152 0.4358
Onchocerca volvulus 0.0061 0.0497 0.0688
Loa Loa (eye worm) hypothetical protein 0.0359 0.4877 0.6744
Echinococcus granulosus carboxylesterase 5A 0.0359 0.4877 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0154 0.1871 0.2587
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1076 0.1488
Loa Loa (eye worm) hypothetical protein 0.0111 0.1234 0.1706
Onchocerca volvulus 0.0032 0.0078 0.0108
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.1234 0.1234
Loa Loa (eye worm) carboxylesterase 0.0061 0.0497 0.0688
Echinococcus granulosus BC026374 protein S09 family 0.0061 0.0497 0.0886
Brugia malayi Carboxylesterase family protein 0.0061 0.0497 0.0688
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0611 0.0845
Onchocerca volvulus 0.0519 0.7232 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0061 0.0497 0.0886
Loa Loa (eye worm) hypothetical protein 0.0111 0.1234 0.1706
Echinococcus multilocularis BC026374 protein (S09 family) 0.0061 0.0497 0.0886
Schistosoma mansoni lozenge 0.0065 0.0563 0.1023
Echinococcus multilocularis lamin dm0 0.0032 0.0078 0.0013
Loa Loa (eye worm) hypothetical protein 0.0519 0.7232 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.1871 0.3744
Loa Loa (eye worm) runx1 0.0065 0.0563 0.0779
Brugia malayi Augmenter of liver regeneration 0.0036 0.0135 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0069 0.0096
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0135 0.0131
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.1871 0.3744
Loa Loa (eye worm) hypothetical protein 0.0111 0.1234 0.1706
Schistosoma mansoni gliotactin 0.0061 0.0497 0.0886
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0072 0.0099
Toxoplasma gondii ABC1 family protein 0.0111 0.1234 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0359 0.4877 1
Brugia malayi beta-lactamase family protein 0.0111 0.1234 0.1706
Loa Loa (eye worm) hypothetical protein 0.0111 0.1234 0.1706
Onchocerca volvulus 0.0111 0.1234 0.1706
Echinococcus multilocularis neuroligin 0.0061 0.0497 0.0886
Brugia malayi Carboxylesterase family protein 0.0061 0.0497 0.0688
Brugia malayi Carboxylesterase family protein 0.0359 0.4877 0.6744
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0072 0.0099
Onchocerca volvulus 0.0061 0.0497 0.0688
Echinococcus granulosus lamin 0.0032 0.0078 0.0013
Echinococcus multilocularis carboxylesterase 5A 0.0359 0.4877 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.1234 0.1234
Echinococcus granulosus acetylcholinesterase 0.0359 0.4877 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.1871 0.3744
Echinococcus multilocularis Protein lozenge 0.0065 0.0563 0.1023
Mycobacterium tuberculosis Conserved protein 0.0111 0.1234 0.1234
Onchocerca volvulus 0.0061 0.0497 0.0688
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1234 1
Onchocerca volvulus 0.0111 0.1234 0.1706
Loa Loa (eye worm) hypothetical protein 0.0061 0.0497 0.0688
Echinococcus multilocularis lamin 0.0032 0.0078 0.0013
Mycobacterium leprae Probable lipase LipE 0.0111 0.1234 1
Onchocerca volvulus 0.0061 0.0497 0.0688
Loa Loa (eye worm) hypothetical protein 0.0061 0.0497 0.0688
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1234 0.2418
Onchocerca volvulus 0.0111 0.1234 0.1706
Leishmania major hypothetical protein, conserved 0.0111 0.1234 1
Echinococcus granulosus tumor protein p63 0.0345 0.4672 0.9574
Loa Loa (eye worm) hypothetical protein 0.0032 0.0078 0.0108
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0 0.5
Schistosoma mansoni hypothetical protein 0.0049 0.033 0.0537
Loa Loa (eye worm) carboxylesterase 0.0061 0.0497 0.0688

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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