Detailed information for compound 547951

Basic information

Technical information
  • TDR Targets ID: 547951
  • Name: 10-O-(3-(4-azidobenzamido)propionyl)ryanodine
  • MW: 710.751 | Formula: C35H44N5O11
  • H donors: 7 H acceptors: 8 LogP: 1.96 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 3
  • SMILES: [NH-]=[N+]=Nc1ccc(cc1)C(=O)NCCC(=O)OC1C(C)CCC2(C31OC1(C4(C3(O)C(C2(C1)C)(O)C(C4(O)C(C)C)OC(=O)c1[nH]ccc1)C)O)O
  • InChi: 1S/C35H43N5O11/c1-18(2)32(46)27(50-26(43)22-7-6-15-37-22)33(47)28(4)17-31(45)29(32,5)35(33,48)34(51-31)24(19(3)12-14-30(28,34)44)49-23(41)13-16-38-25(42)20-8-10-21(11-9-20)39-40-36/h6-11,15,18-19,24,27,37,44-48H,12-14,16-17H2,1-5H3,(H,38,42)
  • InChiKey: GLMBUFFXAIWBPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 154505-02-9
  • 10-Abpr

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax heterochromatin protein 1, putative 0.0095 0.0166 0.1487
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0114 0.0233 0.0227
Leishmania major cysteine peptidase A (CPA) 0.005 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0183 0.047 0.0468
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.018 0.0175
Brugia malayi M-phase phosphoprotein, mpp8 0.0095 0.0166 0.0182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Onchocerca volvulus 0.011 0.0218 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Brugia malayi follicle stimulating hormone receptor 0.0937 0.3096 0.3527
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0051 0.0013 0.0007
Brugia malayi hypothetical protein 0.0085 0.013 0.0142
Onchocerca volvulus 0.011 0.0218 0.0211
Loa Loa (eye worm) PHD-finger family protein 0.0092 0.0156 0.0171
Loa Loa (eye worm) hypothetical protein 0.0056 0.0028 0.0025
Entamoeba histolytica hypothetical protein 0.0095 0.0166 0.1893
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0095 0.0166 0.1893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trichomonas vaginalis chromobox protein, putative 0.0351 0.1056 0.1051
Echinococcus multilocularis chromobox protein 2 0.0095 0.0166 0.016
Trichomonas vaginalis chromobox protein, putative 0.0582 0.1861 0.1856
Schistosoma mansoni tar DNA-binding protein 0.1038 0.3447 0.347
Schistosoma mansoni inositol monophosphatase 0.0118 0.0243 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0255 0.0723 0.0723
Brugia malayi TAR-binding protein 0.1038 0.3447 0.3928
Schistosoma mansoni methyl-cpg binding protein mbd 0.0193 0.0507 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0847 0.0842
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0118 0.0243 0.0238
Echinococcus granulosus microtubule associated protein 2 0.2898 0.9922 1
Loa Loa (eye worm) hypothetical protein 0.0435 0.1348 0.1531
Echinococcus multilocularis musashi 0.011 0.0218 0.0213
Toxoplasma gondii cathepsin CPL 0.005 0.0007 0.006
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0012 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0114 0.1273
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 0.5
Schistosoma mansoni eyes absent homolog 0.0085 0.013 0.0125
Loa Loa (eye worm) acetyltransferase 0.0325 0.0965 0.1094
Trichomonas vaginalis hypothetical protein 0.0095 0.0166 0.016
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0114 0.6727
Schistosoma mansoni tar DNA-binding protein 0.1038 0.3447 0.347
Loa Loa (eye worm) hypothetical protein 0.0108 0.0211 0.0233
Brugia malayi Bromodomain containing protein 0.0127 0.0275 0.0306
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0183 0.047 0.0468
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0118 0.0243 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0578 0.1845 0.2099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Plasmodium vivax SET domain protein, putative 0.0368 0.1115 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0046 0.004
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0303 0.0888 0.0889
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 0.3517
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0166 0.1487
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.005 0.0007 0.0001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.018 0.3587
Loa Loa (eye worm) cysteine protease 0.005 0.0007 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0231 0.0638 0.0633
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0095 0.0166 0.016
Echinococcus multilocularis lamin 0.011 0.0218 0.0213
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.0842 0.0843
Trypanosoma cruzi cysteine peptidase, putative 0.0189 0.0492 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0114 0.0233 0.0227
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0046 0.004
Onchocerca volvulus 0.0256 0.0725 0.0718
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0193 0.0507 0.0504
Brugia malayi Bromodomain containing protein 0.0441 0.137 0.1557
Brugia malayi Cathepsin L-like precursor 0.005 0.0007 0.0001
Trypanosoma cruzi major cysteine proteinase, putative 0.0148 0.0351 0.7101
Loa Loa (eye worm) hypothetical protein 0.0491 0.1542 0.1753
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0095 0.0166 0.016
Brugia malayi acetyltransferase, GNAT family protein 0.0325 0.0965 0.1094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0007 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.1038 0.3447 0.3928
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0578 0.1845 0.2099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0095 0.0166 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Loa Loa (eye worm) helicase 0.0095 0.0166 0.0182
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0241
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0021 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.018 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0368 0.1115 0.1118
Schistosoma mansoni lamin 0.011 0.0218 0.0213
Brugia malayi Calcitonin receptor-like protein seb-1 0.0578 0.1845 0.2099
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.012 0.1074
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 0.7106
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0847 1
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.097 0.0965
Schistosoma mansoni hypothetical protein 0.0183 0.047 0.0468
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0118 0.0243 0.2816
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Loa Loa (eye worm) hypothetical protein 0.0095 0.0166 0.0182
Loa Loa (eye worm) hypothetical protein 0.0095 0.0166 0.0182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0134 0.0299 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0095 0.0166 0.016
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0118 0.0243 0.4884
Loa Loa (eye worm) hypothetical protein 0.0183 0.047 0.053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0183 0.047 0.053
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0095 0.0166 0.016
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0847 1
Schistosoma mansoni hypothetical protein 0.0092 0.0156 0.015
Echinococcus granulosus tumor protein p63 0.2081 0.708 0.7133
Schistosoma mansoni hypothetical protein 0.0183 0.047 0.0468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Brugia malayi Cathepsin L-like precursor 0.005 0.0007 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0407 0.1252 0.1255
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0095 0.0166 0.1487
Loa Loa (eye worm) hypothetical protein 0.0053 0.0019 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0007 0.0001
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0114 0.0233 0.2085
Schistosoma mansoni chromobox protein 0.0095 0.0166 0.016
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0156 0.1398
Echinococcus multilocularis inositol monophosphatase 1 0.0118 0.0243 0.0239
Loa Loa (eye worm) RNA binding protein 0.1038 0.3447 0.3928
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.2565 0.8766 1
Schistosoma mansoni chromobox protein 0.0582 0.1861 0.187
Trypanosoma cruzi ISWI complex protein 0.0173 0.0438 0.8884
Brugia malayi Inositol-1 0.0118 0.0243 0.0271
Schistosoma mansoni tar DNA-binding protein 0.1038 0.3447 0.347
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0354 0.1068 0.107
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0173 0.0435 0.8825
Trypanosoma brucei polo-like protein kinase 0.0099 0.018 0.3587
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0095 0.0166 0.016
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0255 0.0723 0.0723
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 0.5
Plasmodium vivax vivapain-2 0.005 0.0007 0.006
Onchocerca volvulus 0.0463 0.1447 0.1441
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1038 0.3447 0.3928
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0166 0.1487
Loa Loa (eye worm) hypothetical protein 0.0158 0.0386 0.0433
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0095 0.0166 0.016
Trichomonas vaginalis chromobox protein, putative 0.0582 0.1861 0.1856
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0007 0.0001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0114 0.0233 0.0228
Loa Loa (eye worm) hypothetical protein 0.0469 0.1467 0.1667
Loa Loa (eye worm) hypothetical protein 0.0082 0.012 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.018 0.3587
Brugia malayi jmjC domain containing protein 0.0303 0.0888 0.1007
Onchocerca volvulus 0.0095 0.0166 0.0159
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0183 0.047 0.0468
Loa Loa (eye worm) hypothetical protein 0.0085 0.013 0.0142
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.012 0.0114
Echinococcus granulosus fetal alzheimer antigen falz 0.0255 0.0723 0.0723
Brugia malayi Cytochrome P450 family protein 0.0108 0.0211 0.0234
Schistosoma mansoni chromobox protein 0.0095 0.0166 0.016
Brugia malayi Bromodomain containing protein 0.0857 0.2818 0.321
Loa Loa (eye worm) inositol-1 0.0118 0.0243 0.0271
Loa Loa (eye worm) fibroinase 0.005 0.0007 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0684 0.2215 0.2227
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0118 0.0243 0.4884
Trichomonas vaginalis inositol monophosphatase, putative 0.0118 0.0243 0.0238
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.012 0.1074
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0095 0.0166 0.1487
Loa Loa (eye worm) hypothetical protein 0.0095 0.0166 0.0182
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.043 0.0484
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.018 0.2067
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0092 0.0156 0.015
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0095 0.0166 0.016
Brugia malayi Valyl-tRNA synthetase 0.0095 0.0166 0.0182
Trypanosoma brucei ISWI complex protein 0.0173 0.0438 0.8884
Schistosoma mansoni jumonji/arid domain-containing protein 0.0134 0.0299 0.0295
Brugia malayi Heterochromatin protein 1 0.0582 0.1861 0.2117
Schistosoma mansoni intermediate filament proteins 0.011 0.0218 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Echinococcus granulosus chromobox protein 1 0.0582 0.1861 0.187
Echinococcus multilocularis lamin dm0 0.011 0.0218 0.0213
Loa Loa (eye worm) hypothetical protein 0.0085 0.013 0.0142
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.012 0.0114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0095 0.0166 0.016
Loa Loa (eye worm) jmjC domain-containing protein 0.0191 0.0499 0.0562
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0021 0.0015
Schistosoma mansoni hypothetical protein 0.0234 0.0648 0.0647
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0095 0.0166 0.1893
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Loa Loa (eye worm) bromodomain containing protein 0.0207 0.0556 0.0628
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0561 0.1788 0.1796
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.0218 0.0241
Brugia malayi PHD-finger family protein 0.0092 0.0156 0.0171
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.012 0.1074
Plasmodium falciparum heterochromatin protein 1 0.0095 0.0166 1
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Brugia malayi PHD-finger family protein 0.029 0.0842 0.0954
Echinococcus granulosus lamin dm0 0.011 0.0218 0.0213
Trichomonas vaginalis Heterochromatin protein, putative 0.0095 0.0166 0.016
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0351 0.1056 0.105
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.0847 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0092 0.0156 0.015
Schistosoma mansoni hypothetical protein 0.0395 0.1209 0.1212
Loa Loa (eye worm) CHromoDomain protein family member 0.0117 0.0241 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Leishmania major cathepsin L-like protease 0.005 0.0007 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.018 0.0175
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0046 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Echinococcus multilocularis zinc finger protein 0.0229 0.0632 0.063
Echinococcus granulosus GPCR family 2 0.0183 0.047 0.0468
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0118 0.0243 0.7348
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.012 0.3199
Echinococcus granulosus intermediate filament protein 0.011 0.0218 0.0213
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.004 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0117 0.0241 0.0236
Echinococcus multilocularis PHD finger protein rhinoceros 0.0092 0.0156 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.018 0.0175
Schistosoma mansoni zinc finger protein 0.0229 0.0632 0.063
Loa Loa (eye worm) hypothetical protein 0.0578 0.1845 0.2099
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.012 0.0114
Loa Loa (eye worm) hypothetical protein 0.0561 0.1788 0.2034
Echinococcus multilocularis lysine specific demethylase 5A 0.0112 0.0224 0.0219
Echinococcus multilocularis Chromo domain 0.0095 0.0166 0.016
Loa Loa (eye worm) hypothetical protein 0.0801 0.2624 0.2988
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.012 0.3517
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.043 0.0427
Giardia lamblia PHD finger protein 15 0.0092 0.0156 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.097 0.0965
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.161 0.544 0.548
Brugia malayi jmjC domain containing protein 0.0134 0.0299 0.0334
Brugia malayi CHD4 protein 0.0117 0.0241 0.0268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Schistosoma mansoni lipoxygenase 0.0053 0.002 0.0013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0407 0.1252 0.1255
Brugia malayi Latrophilin receptor protein 2 0.0183 0.047 0.053
Leishmania major cathepsin L-like protease 0.005 0.0007 0.0009
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0156 0.1398
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.018 0.0175
Schistosoma mansoni cellular tumor antigen P53 0.0305 0.0895 0.0895
Trypanosoma cruzi ISWI complex protein 0.0173 0.0438 0.8884
Brugia malayi hypothetical protein 0.0095 0.0166 0.0182
Echinococcus granulosus histone lysine methyltransferase setb 0.0561 0.1788 0.1796
Echinococcus multilocularis GPCR, family 2 0.0183 0.047 0.0468
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0117 0.0241 0.0236
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0095 0.0166 0.016
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0019 0.0013
Echinococcus granulosus tar DNA binding protein 0.1038 0.3447 0.347
Brugia malayi Cathepsin L-like precursor 0.005 0.0007 0.0001
Echinococcus multilocularis tumor protein p63 0.2081 0.708 0.7133
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0463 0.1447 0.1452
Brugia malayi Associated with TFs and helicases family protein 0.0095 0.0166 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0847 0.0842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0095 0.0166 0.0182
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.001
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.043 0.0427
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0117 0.0241 0.0236
Leishmania major cathepsin L-like protease 0.0189 0.0492 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0847 0.0842
Loa Loa (eye worm) TAR-binding protein 0.1038 0.3447 0.3928
Loa Loa (eye worm) jmjC domain-containing protein 0.0134 0.0299 0.0334
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0046 0.1238
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0105 0.02 0.5823
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0046 0.1238
Schistosoma mansoni hypothetical protein 0.0183 0.047 0.0468
Onchocerca volvulus 0.0149 0.0353 0.0347
Schistosoma mansoni hypothetical protein 0.0095 0.0166 0.016
Brugia malayi latrophilin 2 splice variant baaae 0.0395 0.1209 0.1373
Onchocerca volvulus 0.0099 0.0179 0.0172
Brugia malayi Protein cec-1. 0.0095 0.0166 0.0182
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.043 0.0484
Schistosoma mansoni bromodomain containing protein 0.0056 0.0028 0.0022
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0326 0.097 0.0964
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0183 0.047 0.0468
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.004 0.0038
Schistosoma mansoni alpha-glucosidase 0.0147 0.0347 0.0344
Schistosoma mansoni inositol monophosphatase 0.0118 0.0243 0.0239
Loa Loa (eye worm) ctsf protein 0.005 0.0007 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.018 0.0175
Echinococcus multilocularis Chromobox protein 3 0.0095 0.0166 0.016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0303 0.0888 0.0889
Loa Loa (eye worm) hypothetical protein 0.0256 0.0725 0.082
Leishmania major cathepsin L-like protease 0.005 0.0007 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0183 0.047 0.053
Echinococcus granulosus chromobox protein 1 0.0582 0.1861 0.187
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.0218 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0847 0.0842
Echinococcus granulosus chromobox protein 2 0.0095 0.0166 0.016
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0046 0.0808
Echinococcus multilocularis chromobox protein 1 0.0582 0.1861 0.187
Trypanosoma cruzi cysteine peptidase, putative 0.0189 0.0492 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.018 0.0175
Brugia malayi SET domain containing protein 0.0109 0.0213 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0847 0.0842
Trichomonas vaginalis chromobox protein, putative 0.0095 0.0166 0.016
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0046 0.004
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0114 0.0233 0.2085
Schistosoma mansoni microtubule-associated protein tau 0.2898 0.9922 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Plasmodium vivax vivapain-2 0.005 0.0007 0.006
Loa Loa (eye worm) heterochromatin protein 1 0.0582 0.1861 0.2117
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0046 0.1238
Brugia malayi Pre-SET motif family protein 0.0368 0.1115 0.1266
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.0847 1
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.018 0.0199
Onchocerca volvulus 0.0305 0.0895 0.0889
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.018 0.0174
Echinococcus granulosus Chromobox protein 3 0.0095 0.0166 0.016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0561 0.1788 0.1796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0095 0.0166 0.016
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.002 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Brugia malayi hypothetical protein 0.0731 0.238 0.271
Brugia malayi Probable ClpP-like protease 0.0082 0.012 0.013
Trichomonas vaginalis chromobox protein, putative 0.0095 0.0166 0.016
Trypanosoma cruzi cruzipain precursor, putative 0.0189 0.0492 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0193 0.0507 0.0504
Loa Loa (eye worm) hypothetical protein 0.0092 0.0156 0.0171
Echinococcus granulosus survival motor neuron protein 1 0.0731 0.238 0.2394
Entamoeba histolytica hypothetical protein 0.0095 0.0166 0.1893
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0325 0.0965 0.0966
Loa Loa (eye worm) hypothetical protein 0.0395 0.1209 0.1373
Loa Loa (eye worm) hypothetical protein 0.0095 0.0166 0.0182
Loa Loa (eye worm) hypothetical protein 0.0305 0.0895 0.1014
Loa Loa (eye worm) hypothetical protein 0.0095 0.0166 0.0182
Leishmania major cathepsin L-like protease 0.0189 0.0492 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0095 0.0166 0.1487
Plasmodium falciparum phd finger protein, putative 0.0092 0.0156 0.9377
Onchocerca volvulus Alhambra homolog 0.0092 0.0156 0.0149
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0325 0.0965 0.0966
Schistosoma mansoni lamin 0.011 0.0218 0.0213
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.069 0.078
Leishmania major cathepsin L-like protease 0.005 0.0007 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0108 0.0211 0.0234
Schistosoma mansoni chromobox protein 0.0582 0.1861 0.187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0684 0.2215 0.2227
Onchocerca volvulus 0.0095 0.0166 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.0353 0.0396
Echinococcus multilocularis microtubule associated protein 2 0.2898 0.9922 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0368 0.1115 0.1118
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0329 1
Brugia malayi F/Y-rich N-terminus family protein 0.0065 0.0062 0.0063
Schistosoma mansoni survival motor neuron protein 0.0149 0.0353 0.035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0847 0.0842
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0007 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0012 0.0007
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0329 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0329 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0095 0.0166 0.1893
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.043 0.0427
Echinococcus multilocularis peregrin 0.0127 0.0275 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0561 0.1788 0.1796
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0118 0.0243 0.2182
Echinococcus granulosus lamin 0.011 0.0218 0.0213
Loa Loa (eye worm) hypothetical protein 0.0326 0.097 0.11
Brugia malayi Pre-SET motif family protein 0.2565 0.8766 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0118 0.0243 0.0238
Leishmania major cathepsin L-like protease 0.0189 0.0492 1
Echinococcus granulosus peregrin 0.0127 0.0275 0.027
Schistosoma mansoni kinase 0.0051 0.001 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0095 0.0166 0.016
Echinococcus multilocularis tar DNA binding protein 0.1038 0.3447 0.347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0095 0.0166 0.016
Loa Loa (eye worm) hypothetical protein 0.0731 0.238 0.271
Schistosoma mansoni tar DNA-binding protein 0.1038 0.3447 0.347
Leishmania major hypothetical protein, conserved 0.0173 0.0438 0.8884
Echinococcus granulosus inositol monophosphatase 1 0.0118 0.0243 0.0239
Brugia malayi chromobox protein homolog 3 0.0326 0.097 0.11
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0051 0.0013 0.0007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0937 0.3096 0.3527
Loa Loa (eye worm) intermediate filament protein 0.011 0.0218 0.0241
Schistosoma mansoni zinc finger protein 0.0173 0.0438 0.0435
Brugia malayi Cathepsin L-like precursor 0.005 0.0007 0.0001
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0007 0.0001
Schistosoma mansoni hypothetical protein 0.0173 0.0438 0.0435
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0183 0.047 0.0468
Trichomonas vaginalis chromobox protein, putative 0.0095 0.0166 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0095 0.0166 0.016
Brugia malayi Cathepsin L-like precursor 0.005 0.0007 0.0001
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0095 0.0166 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0847 0.0842
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0847 0.0842
Loa Loa (eye worm) PHD-finger family protein 0.0234 0.0648 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Plasmodium vivax hypothetical protein, conserved 0.0092 0.0156 0.1398
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0105 0.02 0.5823
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0114 0.0233 0.2085
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0118 0.0243 0.4884
Schistosoma mansoni tar DNA-binding protein 0.1038 0.3447 0.347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Brugia malayi PHD-finger family protein 0.0052 0.0015 0.001
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0095 0.0166 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Schistosoma mansoni bromodomain containing protein 0.0724 0.2356 0.2369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0007 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0193 0.0507 0.0504
Brugia malayi MH2 domain containing protein 0.0246 0.069 0.078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0095 0.0166 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.018 0.0175
Brugia malayi RNA binding protein 0.1038 0.3447 0.3928
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0046 0.004
Leishmania major cathepsin L-like protease 0.005 0.0007 0.0009
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.018 0.0199
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0095 0.0166 0.016
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.018 0.0175
Trichomonas vaginalis set domain proteins, putative 0.292 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0118 0.0243 0.4884
Echinococcus granulosus zinc finger protein 0.0229 0.0632 0.063
Loa Loa (eye worm) hypothetical protein 0.0095 0.0166 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.018 0.0175
Trypanosoma cruzi cysteine peptidase, putative 0.0189 0.0492 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0095 0.0166 0.0182
Echinococcus granulosus Chromo domain 0.0095 0.0166 0.016
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.069 0.078
Echinococcus granulosus jumonji domain containing protein 0.0129 0.0282 0.0278
Echinococcus multilocularis chromobox protein 1 0.0582 0.1861 0.187
Schistosoma mansoni alpha-glucosidase 0.0147 0.0347 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0231 0.0638 0.0633
Echinococcus multilocularis survival motor neuron protein 1 0.0731 0.238 0.2394
Giardia lamblia Kinase, PLK 0.0099 0.018 0.0909
Echinococcus multilocularis jumonji domain containing protein 0.0129 0.0282 0.0278
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0019 0.0013
Echinococcus granulosus lysine specific demethylase 5A 0.0134 0.0299 0.0295
Brugia malayi intermediate filament protein 0.011 0.0218 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0166 0.016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0095 0.0166 0.016
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.002 0.0013
Trichomonas vaginalis chromobox protein, putative 0.0351 0.1056 0.1051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0095 0.0166 0.016
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0046 0.0823
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0368 0.1115 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0189 0.0492 1
Schistosoma mansoni hypothetical protein 0.0149 0.0353 0.035
Entamoeba histolytica hypothetical protein 0.0095 0.0166 0.1893
Brugia malayi Cathepsin L-like precursor 0.005 0.0007 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.018 0.3587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0007 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0241 0.0671 0.067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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