Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0534 | 0.0534 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0534 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0534 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0058 | 0.8375 | 0.8375 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.9059 | 0.9059 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.8375 | 0.8284 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.9059 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.8375 | 0.8375 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0534 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0534 | 0.0534 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0534 | 0.0534 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.9059 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0534 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.8375 | 0.8375 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.8375 | 0.8375 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.8375 | 0.8375 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.8375 | 0.8375 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0534 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.9059 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0534 | 0.0534 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.9059 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0534 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0534 | 0.0534 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.8375 | 0.8375 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0534 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.9059 | 0.9059 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.9059 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.8375 | 0.8375 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.8375 | 0.8375 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.9059 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.9059 | 0.9059 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0534 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.9059 | 0.9059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.