Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.16 | 0.457 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.16 | 0.457 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.1404 | 0.3983 | 0.3983 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1404 | 0.3983 | 0.3983 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1404 | 0.3983 | 0.3983 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.16 | 0.457 | 1 |
Schistosoma mansoni | patched 1 | 0.1404 | 0.3983 | 0.3983 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.16 | 0.457 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3411 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1404 | 0.3983 | 0.3983 |
Brugia malayi | CHE-14 protein | 0.1404 | 0.3983 | 0.3983 |
Loa Loa (eye worm) | hypothetical protein | 0.1404 | 0.3983 | 0.3983 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3411 | 1 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1404 | 0.3983 | 0.3983 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1404 | 0.3983 | 0.3983 |
Echinococcus multilocularis | protein patched | 0.1404 | 0.3983 | 0.3983 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3411 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1404 | 0.3983 | 0.3983 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3411 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3411 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1404 | 0.3983 | 0.3983 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3411 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3411 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3411 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 mM | In vitro inhibitory activity against binding of Selectin E to human recombinant AGP (alpha-1 acid glycoprotein) at a concentration of 10 mM; NA- Not active | ChEMBL. | 11206447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.