Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 288 uM | Concentration required to reduce by 50% the viability of noninfected treated CEM-CL13 cells | ChEMBL. | 9154976 |
CC50 (functional) | > 288 uM | Concentration required to reduce by 50% the viability of noninfected treated CEM-CL13 cells | ChEMBL. | 9154976 |
EC50 (functional) | = 143 uM | Inhibition of HIV-1 LA1 cytopathic effects on CEM-CL13 cells in vitro. | ChEMBL. | 9154976 |
EC50 (binding) | = 143 uM | Reverse transcriptase activity was measured in the culture supernatant, concentration that reduces by 50% the HIV produced in the supernatant. | ChEMBL. | 9154976 |
EC50 (binding) | = 143 uM | Reverse transcriptase activity was measured in the culture supernatant, concentration that reduces by 50% the HIV produced in the supernatant. | ChEMBL. | 9154976 |
Ratio (functional) | = 2 | Ratio of CC50 in CEM-CL13 cells to EC50 in HIV-1 LA1 infected CEM-CL13 cells. | ChEMBL. | 9154976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.