Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0706 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0706 | 1 | 0.5 |
Onchocerca volvulus | 0.0706 | 1 | 0.5 | |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0417 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0706 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0706 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0694 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.9706 | 0.9604 |
Loa Loa (eye worm) | hypothetical protein | 0.0706 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0417 | 0.2852 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0694 | 0.9706 | 0.9706 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0706 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0694 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0417 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0706 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0417 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0694 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0417 | 0.2852 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.