Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 0.5196 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.3664 | 0.4215 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 0.5196 | 0.5196 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0121 | 0.6925 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.195 | 0.2243 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.195 | 0.195 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0121 | 0.6925 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.248 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2218 | 0.2551 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0121 | 0.6925 | 0.6925 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0121 | 0.6925 | 0.6925 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.248 | 0.3393 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.1781 | 0.6939 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1191 | 0.137 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1191 | 0.137 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.195 | 0.195 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0197 | 0.0197 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0197 | 0.0197 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0121 | 0.6925 | 0.6925 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.5196 | 0.5196 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2218 | 0.2551 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0197 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.3664 | 0.3664 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.8694 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.8694 | 0.8694 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8694 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8694 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.8694 | 0.8694 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0121 | 0.6925 | 0.6925 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.5196 | 0.5977 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.2054 | 0.3714 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1191 | 0.1191 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.248 | 0.4567 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.3664 | 0.4215 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 0.8521 | 0.8521 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.3664 | 0.4215 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.2054 | 0.3714 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.195 | 0.195 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.1781 | 0.1781 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0197 | 0.0227 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.195 | 0.195 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.1547 | 0.2701 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.1547 | 0.5914 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.5196 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.248 | 0.3393 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.5196 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 0.5196 | 0.5196 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.1547 | 0.2701 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0121 | 0.6925 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.248 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2218 | 0.2551 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.5196 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.0546 | 0.0546 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.1781 | 0.3169 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3664 | 0.3664 |
Schistosoma mansoni | kinase | 0.0048 | 0.2136 | 0.2136 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0121 | 0.6925 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.5196 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.3664 | 0.4215 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.195 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.248 | 0.2853 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.248 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.5196 | 1 |
Brugia malayi | RNA binding protein | 0.0071 | 0.3664 | 0.4215 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0121 | 0.6925 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 0.8521 | 0.8521 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 0.5196 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.5196 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3664 | 0.3664 |
Brugia malayi | hypothetical protein | 0.0034 | 0.1237 | 0.1423 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.5196 | 0.7431 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.195 | 0.2243 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0197 | 0.0227 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3664 | 0.3664 |
Brugia malayi | hypothetical protein | 0.0053 | 0.248 | 0.2853 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.3664 | 0.3664 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.0546 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3664 | 0.3664 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.5196 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.5196 | 0.5977 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.3664 | 0.4215 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.8694 | 0.8694 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.248 | 0.4567 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.1781 | 0.3169 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.248 | 0.4567 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3664 | 0.3664 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0197 | 0.0197 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.5196 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.1781 | 0.2355 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.5196 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.1781 | 0.2355 |
Giardia lamblia | Kinase, PLK | 0.0094 | 0.5196 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 0.8521 | 0.9802 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0197 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.195 | 0.195 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0141 | 0.8254 | 0.8254 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 0.5196 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0145 | 0.8521 | 0.9802 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0121 | 0.6925 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2218 | 0.2551 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.195 | 0.195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 20000 nM | BindingDB_Patents: Kinase Assay. Approximately 5-20 µg of purified GST-RET proteins were incubated with 1 mM ATP in 20 µL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4), at 30° C. for 30 minutes. The kinase reactions were terminated by boiling the samples in SDS-PAGE sample buffer. Samples were resolved on 10% acrylamide gels by SDS-PAGE followed by Western blotting. Phosphorylation was detected using a pan-phosphotyrosine pY99 antibody (available from Santa Cruz Biotechnology) or RET phospho-specific antibody (pY905, available from Cell Signaling, Beverly, Mass., USA). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.