Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydroorotate dehydrogenase (quinone) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | dihydroorotate dehydrogenase (quinone) | 395 aa | 361 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0485 | 0.0485 |
Echinococcus multilocularis | thymidylate synthase | 0.0111 | 0.4223 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0111 | 0.4223 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2132 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.7131 | 0.6985 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.2132 | 0.5049 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0053 | 0.0485 | 0.0485 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.2132 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2132 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.02 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0111 | 0.4223 | 0.4223 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0111 | 0.4223 | 0.4223 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2132 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.2132 | 0.5049 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.02 | 1 | 1 |
Onchocerca volvulus | 0.0111 | 0.4223 | 0.5 | |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2132 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.2132 | 0.5049 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0111 | 0.4223 | 0.4223 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.2132 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.02 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0111 | 0.4223 | 0.4223 |
Leishmania major | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0111 | 0.4223 | 0.4223 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2132 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.2132 | 0.5049 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2132 | 0.1732 |
Echinococcus granulosus | thymidylate synthase | 0.0111 | 0.4223 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0078 | 0.2132 | 0.2132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 250 nM | Ability to inhibit proliferation in human lymphocytes by mixed lymphocyte reaction (MLR) | ChEMBL. | No reference |
Ki (binding) | = 13 nM | Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver. | ChEMBL. | No reference |
Ki (binding) | = 13 nM | Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.