Detailed information for compound 549114

Basic information

Technical information
  • TDR Targets ID: 549114
  • Name: (1S,4S,5Z)-5-ethylidenebicyclo[2.2.1]hept-2-e ne
  • MW: 120.192 | Formula: C9H12
  • H donors: 0 H acceptors: 0 LogP: 2.21 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C\1/C[C@@H]2C[C@H]1C=C2
  • InChi: 1S/C9H12/c1-2-8-5-7-3-4-9(8)6-7/h2-4,7,9H,5-6H2,1H3/b8-2-/t7-,9-/m1/s1
  • InChiKey: OJOWICOBYCXEKR-GAFWVPIUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0025 0.0135 0.0537
Echinococcus multilocularis lysosomal alpha glucosidase 0.0107 0.119 0.119
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0071 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0071 0.0172
Loa Loa (eye worm) hypothetical protein 0.0082 0.0864 0.2085
Toxoplasma gondii aldehyde dehydrogenase 0.0041 0.0339 0.1348
Loa Loa (eye worm) hypothetical protein 0.0314 0.3838 0.9262
Onchocerca volvulus 0.0064 0.0638 0.3449
Echinococcus granulosus intermediate filament protein 0.0018 0.005 0.0088
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0143 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0172
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0026 0.0149 0.036
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.000000010724 0.000000019052
Schistosoma mansoni flap endonuclease-1 0.0023 0.0112 0.0199
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1309 0.3159
Loa Loa (eye worm) latrophilin receptor protein 2 0.0026 0.0149 0.036
Echinococcus multilocularis neutral alpha glucosidase AB 0.0024 0.0123 0.0123
Onchocerca volvulus 0.0018 0.005 0.0268
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0135 0.0537
Chlamydia trachomatis dihydrofolate reductase 0.0209 0.2498 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0288 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0071 0.0172
Schistosoma mansoni bromodomain containing protein 0.0062 0.0613 0.1089
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0133 0.0529
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0211 0.2514 1
Schistosoma mansoni intermediate filament proteins 0.0018 0.005 0.0088
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0071 0.0127
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0209 0.2498 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.002 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0172
Schistosoma mansoni inositol monophosphatase 0.0025 0.0135 0.024
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0123 0.0663
Brugia malayi Calcitonin receptor-like protein seb-1 0.0082 0.0864 0.2085
Schistosoma mansoni hypothetical protein 0.0026 0.0149 0.0265
Echinococcus granulosus inositol monophosphatase 1 0.0025 0.0135 0.024
Echinococcus granulosus zinc finger protein 0.0019 0.0064 0.0114
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0133 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0352 0.0625
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0071 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0071 0.0172
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0041 0.0339 0.0339
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.000000010724 0.000000019052
Schistosoma mansoni lamin 0.0018 0.005 0.0088
Echinococcus granulosus survival motor neuron protein 1 0.0314 0.3838 0.6818
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0071 0.0127
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0071 0.0172
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0071 0.0071
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0045 0.0393 0.0699
Echinococcus multilocularis microtubule associated protein 2 0.0454 0.5629 0.5629
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0071 0.0172
Echinococcus granulosus neutral alpha glucosidase AB 0.0024 0.0123 0.0218
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0071 0.0127
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0041 0.0339 0.099
Schistosoma mansoni lamin 0.0018 0.005 0.0088
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1309 0.3159
Brugia malayi hypothetical protein 0.0016 0.0021 0.0052
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0071 0.0172
Brugia malayi Latrophilin receptor protein 2 0.0026 0.0149 0.036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0964 0.1712
Loa Loa (eye worm) hypothetical protein 0.0042 0.0354 0.0854
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0107 0.119 0.2872
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0071 0.0127
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0209 0.2498 1
Schistosoma mansoni hypothetical protein 0.002 0.0077 0.0137
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0025 0.0135 0.5956
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0071 0.0127
Echinococcus multilocularis musashi 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0071 0.0127
Trypanosoma cruzi ISWI complex protein 0.0015 0.001 0.0041
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0071 0.0071
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0071 0.0386
Loa Loa (eye worm) voltage-dependent calcium channel 0.0118 0.1325 0.3198
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0338 0.4143 0.7361
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0018
Brugia malayi olfactory channel protein osm-9 0.0014 0.000000010724 0.000000025883
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0453 0.1803
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0045 0.0393 0.2127
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0123 0.0663
Echinococcus multilocularis thymidylate synthase 0.0104 0.1153 0.1153
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.000000010724 0.000000010724
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0681 0.1209
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0211 0.2514 1
Brugia malayi Pre-SET motif family protein 0.0139 0.1603 0.387
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0104 0.1153 0.4388
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0071 0.0172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0109
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0071 0.0172
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0042 0.0352 0.0849
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0032 0.0058
Trichomonas vaginalis inositol monophosphatase, putative 0.0025 0.0135 0.073
Echinococcus multilocularis voltage dependent calcium channel 0.0338 0.4143 0.4143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0964 0.1712
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0143 0.0283
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.0014 0.000000010724 0.000000025883
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0964 0.2326
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0071 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0964 0.1712
Schistosoma mansoni alpha glucosidase 0.0024 0.0123 0.0218
Onchocerca volvulus 0.0018 0.005 0.0268
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0211 0.2514 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0071 0.0172
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0338 0.4143 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0078 0.0811 0.0811
Schistosoma mansoni survival motor neuron protein 0.0064 0.0638 0.1134
Brugia malayi thymidylate synthase 0.0104 0.1153 0.2784
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0071 0.0127
Brugia malayi steroid hormone receptor 0.002 0.0071 0.0172
Schistosoma mansoni thyroid hormone receptor 0.002 0.0071 0.0127
Onchocerca volvulus 0.002 0.0074 0.0402
Brugia malayi MH2 domain containing protein 0.0116 0.1309 0.3159
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0025 0.0135 0.073
Loa Loa (eye worm) hypothetical protein 0.0014 0.000000010724 0.000000025883
Loa Loa (eye worm) intermediate filament protein 0.0018 0.005 0.012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0133 0.0321
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0964 0.2326
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0172
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0209 0.2498 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0338 0.4143 0.4143
Echinococcus granulosus dihydrofolate reductase 0.0209 0.2498 0.4438
Schistosoma mansoni coup transcription factor 0.002 0.0071 0.0127
Brugia malayi Bromodomain containing protein 0.0074 0.076 0.1834
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0339 0.0863
Brugia malayi Melibiase family protein 0.0045 0.0393 0.0949
Brugia malayi Dihydrofolate reductase 0.0209 0.2498 0.603
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0071 0.0127
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0143 0.0571
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0338 0.4143 0.4143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0071 0.0071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0041 0.0339 0.0602
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0071 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0123 0.0663
Trypanosoma cruzi ISWI complex protein 0.0015 0.001 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0172
Brugia malayi nuclear receptor NHR-88 0.002 0.0071 0.0172
Schistosoma mansoni thyroid hormone receptor 0.002 0.0071 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0071 0.0172
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.000000010724 0.000000019052
Echinococcus multilocularis GPCR, family 2 0.0026 0.0149 0.0149
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0339 0.0863
Toxoplasma gondii transporter, cation channel family protein 0.0118 0.1325 0.5269
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0071 0.0172
Schistosoma mansoni lipoxygenase 0.0054 0.0513 0.0911
Brugia malayi PHD-finger family protein 0.0024 0.0131 0.0316
Brugia malayi nuclear hormone receptor 0.002 0.0071 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0071 0.0172
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0338 0.4143 0.7361
Brugia malayi RNA recognition motif domain containing protein 0.0042 0.0352 0.0849
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0123 0.0663
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0071 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0964 0.1712
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0104 0.1153 0.4388
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0211 0.2514 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0071 0.0127
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0078 0.0811 0.1441
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0071 0.0071
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0135 0.0537
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0071 0.0071
Toxoplasma gondii melibiase subfamily protein 0.0067 0.0681 0.2707
Onchocerca volvulus 0.0104 0.1153 0.6235
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0067 0.0681 0.0681
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0143 0.0775
Schistosoma mansoni nuclear hormone receptor 0.002 0.0071 0.0127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0026 0.0149 0.0149
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0681 0.1209
Brugia malayi Glycosyl hydrolases family 31 protein 0.0107 0.119 0.2872
Trichomonas vaginalis sucrase-isomaltase, putative 0.0024 0.0123 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0071 0.0172
Trichomonas vaginalis set domain proteins, putative 0.0159 0.185 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0071 0.0127
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.002 0.0074 0.0296
Schistosoma mansoni alpha-glucosidase 0.0092 0.0999 0.1775
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0288 0.0288
Brugia malayi intermediate filament protein 0.0018 0.005 0.012
Loa Loa (eye worm) hypothetical protein 0.0338 0.4143 1
Leishmania major hypothetical protein, conserved 0.0025 0.0133 0.0529
Brugia malayi Inositol-1 0.0025 0.0135 0.0326
Loa Loa (eye worm) hypothetical protein 0.0014 0.000000010724 0.000000025883
Toxoplasma gondii hypothetical protein 0.0103 0.1143 0.4547
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0065 0.0115
Echinococcus multilocularis survival motor neuron protein 1 0.0314 0.3838 0.3838
Trypanosoma brucei ISWI complex protein 0.0015 0.001 0.0041
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0211 0.2514 1
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0143 0.0346
Loa Loa (eye worm) hypothetical protein 0.0103 0.1143 0.2759
Schistosoma mansoni lipoxygenase 0.0078 0.0811 0.1441
Onchocerca volvulus 0.0062 0.0612 0.3307
Schistosoma mansoni microtubule-associated protein tau 0.0454 0.5629 1
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.000000010724 0.000000010724
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0025 0.0135 0.073
Brugia malayi hypothetical protein 0.0314 0.3838 0.9262
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0071 0.0172
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0024 0.0123 0.0663
Loa Loa (eye worm) RNA binding protein 0.0042 0.0352 0.0849
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.0339 0.0602
Trypanosoma brucei glucosidase, putative 0.0024 0.0123 0.0488
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0123 0.0663
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0067 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0038 0.03 0.0724
Plasmodium falciparum flap endonuclease 1 0.0025 0.0143 0.0044
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0024 0.0123 0.0663
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0143 0.0571
Echinococcus multilocularis voltage dependent calcium channel 0.0338 0.4143 0.4143
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0143 0.0571
Schistosoma mansoni hypothetical protein 0.0225 0.2698 0.4794
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0082 0.0864 0.2085
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0032 0.0058
Echinococcus granulosus FTZ F1 alpha 0.002 0.0071 0.0127
Echinococcus granulosus voltage dependent calcium channel 0.0338 0.4143 0.7361
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0338 0.4143 0.7361
Echinococcus granulosus tar DNA binding protein 0.0042 0.0352 0.0625
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0032 0.0058
Echinococcus granulosus thymidylate synthase 0.0104 0.1153 0.2049
Echinococcus granulosus lysosomal alpha glucosidase 0.0107 0.119 0.2114
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0071 0.0071
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.004 0.0097
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0568 0.1009
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0681 0.1209
Echinococcus granulosus flap endonuclease 1 0.0025 0.0143 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0352 0.0625
Echinococcus granulosus microtubule associated protein 2 0.0454 0.5629 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0949
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0681 0.1209
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0133 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0071 0.0172
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0143 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0071 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0288 0.0512
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0077 0.0187
Schistosoma mansoni transient receptor potential channel 0.0014 0.000000010724 0.000000019052
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0211 0.2514 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0067 0.0681 0.1209
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0269 0.0269
Brugia malayi Pre-SET motif family protein 0.002 0.0074 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0074 0.0132
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0025 0.0135 0.5
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0143 0.0143
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0338 0.4143 0.4143
Brugia malayi hypothetical protein 0.0025 0.0133 0.0321
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.036
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0453 0.1467
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0101 0.018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0071 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0964 0.1712
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.012
Brugia malayi Intermediate filament tail domain containing protein 0.0018 0.005 0.012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0071 0.0172
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0139 0.1603 0.387
Loa Loa (eye worm) hypothetical protein 0.0056 0.0533 0.1287
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0026 0.0149 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0352 0.0625
Schistosoma mansoni inositol monophosphatase 0.0025 0.0135 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0123 0.0488
Leishmania major alpha glucosidase II subunit, putative 0.0024 0.0123 0.0488
Brugia malayi ecdysteroid receptor 0.002 0.0071 0.0172
Schistosoma mansoni zinc finger protein 0.0019 0.0064 0.0114
Schistosoma mansoni voltage-gated cation channel 0.0338 0.4143 0.7361
Loa Loa (eye worm) calcium channel 0.0338 0.4143 1
Leishmania major hypothetical protein, conserved 0.0015 0.001 0.0041
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0133 0.0529
Mycobacterium ulcerans thymidylate synthase 0.0104 0.1153 0.4309
Trichomonas vaginalis maltase-glucoamylase, putative 0.0024 0.0123 0.0663
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0071 0.0172
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0288 0.0512
Echinococcus granulosus GPCR family 2 0.0026 0.0149 0.0265
Echinococcus multilocularis lysosomal alpha glucosidase 0.0107 0.119 0.119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0071 0.0127
Echinococcus granulosus lamin dm0 0.0018 0.005 0.0088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0568 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0453 0.2451
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.000000010724 0.000000010724
Schistosoma mansoni hypothetical protein 0.0225 0.2698 0.4794
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0045 0.0393 0.0699
Schistosoma mansoni hypothetical protein 0.0026 0.0149 0.0265
Loa Loa (eye worm) hypothetical protein 0.0103 0.1143 0.2759
Brugia malayi TAR-binding protein 0.0042 0.0352 0.0849
Loa Loa (eye worm) dihydrofolate reductase 0.0209 0.2498 0.603
Loa Loa (eye worm) hypothetical protein 0.0118 0.1325 0.3198
Echinococcus multilocularis geminin 0.0225 0.2698 0.2698
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0071 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0071 0.0172
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0338 0.4143 0.7361
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0064 0.0638 0.154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0964 0.0964
Schistosoma mansoni aldehyde dehydrogenase 0.0041 0.0339 0.0602
Brugia malayi Flap endonuclease-1 0.0025 0.0143 0.0346
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0071 0.0127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0041 0.0339 0.0863
Schistosoma mansoni hypothetical protein 0.0026 0.0149 0.0265
Brugia malayi hypothetical protein 0.005 0.0453 0.1094
Brugia malayi latrophilin 2 splice variant baaae 0.0056 0.0533 0.1287
Schistosoma mansoni hypothetical protein 0.0056 0.0533 0.0947
Echinococcus granulosus lamin 0.0018 0.005 0.0088
Loa Loa (eye worm) TAR-binding protein 0.0042 0.0352 0.0849
Onchocerca volvulus 0.0159 0.185 1
Schistosoma mansoni hypothetical protein 0.0026 0.0149 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0071 0.0172
Loa Loa (eye worm) inositol-1 0.0025 0.0135 0.0326
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0024 0.0123 0.0296
Brugia malayi Glycosyl hydrolases family 31 protein 0.0024 0.0123 0.0296
Loa Loa (eye worm) hypothetical protein 0.0069 0.0706 0.1705
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0123 0.0488
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0032 0.0032
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0024 0.0123 0.0488
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0082 0.0864 0.2085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0071 0.0127
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0135 0.0537
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0041 0.0339 0.1348
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0172
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0071 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0172
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0071 0.0172
Schistosoma mansoni zinc finger protein 0.0015 0.001 0.0018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0018 0.005 0.012
Brugia malayi dihydrofolate reductase family protein 0.0209 0.2498 0.603
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0964 0.0964
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0118 0.1325 0.5269
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0352 0.0625
Brugia malayi RNA binding protein 0.0042 0.0352 0.0849
Schistosoma mansoni hypothetical protein 0.0064 0.0638 0.1134
Echinococcus granulosus geminin 0.0225 0.2698 0.4794
Echinococcus multilocularis lamin 0.0018 0.005 0.005
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0118 0.1325 0.5269
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0338 0.4143 0.4143
Brugia malayi Bromodomain containing protein 0.0038 0.0299 0.0722
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0143 0.0571
Schistosoma mansoni dihydrofolate reductase 0.0209 0.2498 0.4438
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0352 0.0625
Loa Loa (eye worm) thymidylate synthase 0.0104 0.1153 0.2784
Schistosoma mansoni transient receptor potential channel 0.0014 0.000000010724 0.000000019052
Echinococcus multilocularis zinc finger protein 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.033 0.0796
Echinococcus multilocularis lamin dm0 0.0018 0.005 0.005
Echinococcus granulosus voltage dependent calcium channel 0.0118 0.1325 0.2354
Onchocerca volvulus 0.002 0.0071 0.0386
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0104 0.1153 0.2049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0026 0.0149 0.0149
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0133 0.0529
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0026 0.0149 0.0265
Schistosoma mansoni alpha-glucosidase 0.0092 0.0999 0.1775
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0338 0.4143 0.7361
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0135 0.0537
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0101 0.018
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0269 0.0479
Echinococcus multilocularis inositol monophosphatase 1 0.0025 0.0135 0.0135
Echinococcus multilocularis dihydrofolate reductase 0.0209 0.2498 0.2498
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0071 0.0127
Echinococcus multilocularis tar DNA binding protein 0.0042 0.0352 0.0352
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0074 0.0132

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.