Detailed information for compound 549240

Basic information

Technical information
  • TDR Targets ID: 549240
  • Name: 9-(2-hydroxy-3,5-dinitro-phenyl)-3,3,6,6-tetr amethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-di one
  • MW: 456.445 | Formula: C23H24N2O8
  • H donors: 1 H acceptors: 7 LogP: 3.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC(C)(C)CC2=C1C(C1=C(O2)CC(CC1=O)(C)C)c1cc(cc(c1O)[N+](=O)[O-])[N+](=O)[O-]
  • InChi: 1S/C23H24N2O8/c1-22(2)7-14(26)19-16(9-22)33-17-10-23(3,4)8-15(27)20(17)18(19)12-5-11(24(29)30)6-13(21(12)28)25(31)32/h5-6,18,28H,7-10H2,1-4H3
  • InChiKey: YGAKKLXEGNXBRO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-(2-hydroxy-3,5-dinitrophenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
  • 9-(2-hydroxy-3,5-dinitro-phenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-quinone
  • MLS000713354
  • SMR000272835
  • AG-205/36485029
  • BAS 00434332
  • Oprea1_839775
  • A1155/0054026

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Melatonin receptor type 1A 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.0854 1 1
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0108 0.0108
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Onchocerca volvulus 0.0854 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.335 0.3278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Onchocerca volvulus 0.0854 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.335 0.3278
Trypanosoma cruzi C-8 sterol isomerase, putative 0.072 0.8373 0.8373
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0283 0.0283
Entamoeba histolytica cysteine proteinase, putative 0.0448 0.5074 0.4999
Loa Loa (eye worm) hypothetical protein 0.0038 0.0114 0.0114
Brugia malayi GnHR receptor homolog 0.0204 0.2121 0.2121
Echinococcus granulosus poly adp ribose polymerase 2 0.0063 0.042 0.0411
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Leishmania major cathepsin L-like protease 0.0854 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Giardia lamblia Cathepsin L-like protease 0.017 0.1715 0.2667
Onchocerca volvulus 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0577 0.6641 0.6604
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0084 0.0676 0.4201
Loa Loa (eye worm) cathepsin B 0.0325 0.3586 0.3586
Plasmodium vivax serine-repeat antigen (SERA), putative 0.017 0.1715 0.1715
Brugia malayi RE15519p 0.0029 0.0009 0.0009
Echinococcus granulosus microtubule associated protein 2 0.0721 0.8383 0.8381
Loa Loa (eye worm) hypothetical protein 0.0082 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Plasmodium vivax serine-repeat antigen (SERA) 0.017 0.1715 0.1715
Loa Loa (eye worm) hypothetical protein 0.0369 0.4118 0.4118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Entamoeba histolytica cysteine protease, putative 0.017 0.1715 0.159
Brugia malayi Papain family cysteine protease containing protein 0.017 0.1715 0.1715
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.017 0.1715 0.1624
Loa Loa (eye worm) hypothetical protein 0.01 0.0868 0.0868
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0325 0.3586 0.3516
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Echinococcus granulosus cathepsin l1 0.0577 0.6641 0.6638
Echinococcus granulosus cathepsin l1 0.0854 1 1
Echinococcus multilocularis GPCR, family 2 0.0038 0.0114 0.0105
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0325 0.3586 0.358
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.067 0.7765 0.7763
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0114 0.0105
Plasmodium vivax vivapain-1 0.0448 0.5074 0.5074
Loa Loa (eye worm) hypothetical protein 0.0088 0.0716 0.0716
Onchocerca volvulus 0.0854 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1034 0.0936
Echinococcus granulosus cathepsin L cysteine proteinase 0.0854 1 1
Schistosoma mansoni hypothetical protein 0.0041 0.0148 0.014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0108
Onchocerca volvulus 0.0577 0.6641 0.6638
Echinococcus granulosus cathepsin b 0.067 0.7765 0.7763
Echinococcus multilocularis cathepsin L 0.017 0.1715 0.1707
Giardia lamblia Cysteine protease 0.017 0.1715 0.2667
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.1459 1
Echinococcus granulosus cathepsin L 0.017 0.1715 0.1707
Schistosoma mansoni cathepsin C 0.017 0.1715 0.1707
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.335 0.3278
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.017 0.1715 0.1715
Giardia lamblia Dipeptidyl-peptidase I precursor 0.017 0.1715 0.2667
Plasmodium vivax unspecified product 0.0448 0.5074 0.5074
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0541 0.1762
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.017 0.1715 0.1707
Brugia malayi cathepsin Z-like cysteine proteinase 0.017 0.1715 0.1715
Loa Loa (eye worm) fibroinase 0.0854 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0577 0.6641 0.6641
Schistosoma mansoni cathepsin s 0.0277 0.3011 0.3005
Giardia lamblia Cathepsin B precursor 0.017 0.1715 0.2667
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.1715 0.1707
Giardia lamblia Cysteine protease 0.017 0.1715 0.2667
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0148 0.014
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0277 0.3011 0.3011
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Plasmodium vivax serine-repeat antigen (SERA) 0.017 0.1715 0.1715
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0448 0.5074 0.502
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0009 0.0009
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1034 0.1034
Plasmodium vivax vivapain-3 0.0448 0.5074 0.5074
Onchocerca volvulus 0.0038 0.0108 0.0099
Trypanosoma brucei C-8 sterol isomerase, putative 0.072 0.8373 0.8373
Loa Loa (eye worm) hypothetical protein 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0272 0.2944 0.2944
Plasmodium falciparum cysteine proteinase falcipain 3 0.0854 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0541 0.0532
Plasmodium falciparum serine repeat antigen 8 0.017 0.1715 0.1715
Echinococcus granulosus GPCR family 2 0.0038 0.0114 0.0105
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.1459 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.2131 0.2124
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0272 0.2944 0.2938
Onchocerca volvulus 0.0038 0.0108 0.0099
Brugia malayi cathepsin F-like cysteine proteinase 0.017 0.1715 0.1715
Schistosoma mansoni cathepsin F (C01 family) 0.0577 0.6641 0.6638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Entamoeba histolytica cysteine protease, putative 0.017 0.1715 0.159
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trypanosoma cruzi cysteine protease, putative 0.0448 0.5074 0.5074
Loa Loa (eye worm) hypothetical protein 0.0272 0.2944 0.2944
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0868 0.086
Onchocerca volvulus 0.0854 1 1
Brugia malayi putative neuropeptide receptor 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Toxoplasma gondii cathepsin B 0.0325 0.3586 0.3586
Brugia malayi fibroinase precursor 0.017 0.1715 0.1715
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0854 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1034 0.0936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Leishmania major cysteine peptidase A (CPA) 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.072 0.8373 0.8373
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.017 0.1715 0.1624
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0063 0.042 0.0411
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0336 0.0231
Giardia lamblia Cathepsin B precursor 0.017 0.1715 0.2667
Leishmania major cathepsin L-like protease 0.0854 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.017 0.1715 0.1707
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.2563 1
Loa Loa (eye worm) hypothetical protein 0.0577 0.6641 0.6641
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0115 0.1049 0.1041
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.017 0.1715 0.1715
Brugia malayi Papain family cysteine protease containing protein 0.017 0.1715 0.1715
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0541 0.3202
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.017 0.1715 0.1624
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0009 0.0009
Onchocerca volvulus Cathepsin F homolog 0.0854 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1034 0.1034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.017 0.1715 0.1624
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi cathepsin L precursor 0.017 0.1715 0.1715
Leishmania major cathepsin L-like protease 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Giardia lamblia Cysteine protease 0.017 0.1715 0.2667
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0063 0.042 0.042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.1715 0.1707
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0009 0.0009
Schistosoma mansoni microtubule-associated protein tau 0.0721 0.8383 0.8381
Leishmania major cathepsin L-like protease 0.0854 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0448 0.5074 0.5074
Loa Loa (eye worm) hypothetical protein 0.0277 0.3011 0.3011
Giardia lamblia Cathepsin L precursor 0.017 0.1715 0.2667
Plasmodium falciparum serine repeat antigen 6 0.017 0.1715 0.1715
Toxoplasma gondii preprocathepsin c precursor, putative 0.017 0.1715 0.1715
Loa Loa (eye worm) serotonin transporter b 0.0142 0.1367 0.1367
Echinococcus multilocularis cysteine protease 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.017 0.1715 0.1624
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0541 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.017 0.1715 0.1624
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.017 0.1715 0.1624
Brugia malayi G-protein coupled receptor 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.012 0.1111 0.1111
Plasmodium vivax unspecified product 0.0277 0.3011 0.3011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trypanosoma cruzi cruzipain precursor, putative 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0148 0.014
Loa Loa (eye worm) norepinephrine transporter 0.0142 0.1367 0.1367
Entamoeba histolytica cysteine proteinase, putative 0.0448 0.5074 0.4999
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0541 0.0541
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0854 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0448 0.5074 0.5074
Echinococcus multilocularis cathepsin b 0.067 0.7765 0.7763
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0055 0.0316 0.0308
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0448 0.5074 0.5074
Loa Loa (eye worm) hypothetical protein 0.017 0.1715 0.1715
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0009 0.0009
Onchocerca volvulus Cathepsin L homolog 0.0854 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0854 1 1
Plasmodium falciparum serine repeat antigen 5 0.017 0.1715 0.1715
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0142 0.1367 0.1367
Loa Loa (eye worm) beta-lactamase 0.0038 0.0108 0.0108
Plasmodium vivax serine-repeat antigen (SERA), putative 0.017 0.1715 0.1715
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi Cathepsin L-like cysteine proteinase 0.0577 0.6641 0.6641
Entamoeba histolytica cysteine proteinase, putative 0.0448 0.5074 0.4999
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.335 0.3278
Schistosoma mansoni hypothetical protein 0.0038 0.0114 0.0105
Giardia lamblia Cathepsin B precursor 0.017 0.1715 0.2667
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1034 0.1026
Echinococcus multilocularis cysteine protease 0.0854 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0009 0.0009
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0272 0.2944 0.2944
Giardia lamblia Cathepsin B precursor 0.0325 0.3586 1
Brugia malayi Papain family cysteine protease containing protein 0.0854 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.017 0.1715 0.2667
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.017 0.1715 0.1707
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0577 0.6641 0.659
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0009 0.0009
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0868 0.086
Trypanosoma cruzi major cysteine proteinase, putative 0.017 0.1715 0.1715
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.017 0.1715 0.1715
Schistosoma mansoni cathepsin F (C01 family) 0.0854 1 1
Brugia malayi WGR domain containing protein 0.0115 0.1049 0.1049
Loa Loa (eye worm) solute carrier family 6 member 4 0.0142 0.1367 0.1367
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0082 0.0649 0.0641
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1034 0.0936
Schistosoma mansoni hypothetical protein 0.0038 0.0114 0.0105
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0009 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0283 0.0275
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Leishmania major cathepsin L-like protease 0.0854 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0277 0.3011 0.3011
Echinococcus granulosus poly (ADP ribose) polymerase 0.0036 0.0086 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1034 0.1026
Leishmania major cathepsin L-like protease 0.0854 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1034 0.0899
Trypanosoma cruzi cysteine peptidase, putative 0.0854 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0142 0.1367 0.1367
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0854 1 1
Brugia malayi Dopamine receptor protein 2 0.0029 0.0009 0.0009
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0084 0.0676 0.0574
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Echinococcus granulosus serotonin transporter 0.0142 0.1367 0.1359
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0541 0.3202
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0541 0.0532
Giardia lamblia Cathepsin B precursor 0.017 0.1715 0.2667
Schistosoma mansoni cathepsin B (C01 family) 0.017 0.1715 0.1707
Brugia malayi neuropeptide F receptor 0.0029 0.0009 0.0009
Loa Loa (eye worm) cysteine protease 0.0854 1 1
Brugia malayi Cathepsin L-like precursor 0.0577 0.6641 0.6641
Loa Loa (eye worm) hypothetical protein 0.0277 0.3011 0.3011
Onchocerca volvulus 0.0854 1 1
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0063 0.042 0.0411
Onchocerca volvulus 0.017 0.1715 0.1707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0115 0.1049 0.0914
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Onchocerca volvulus 0.01 0.0868 0.086
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0541 0.0541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0114 0.0105
Brugia malayi cathepsin F-like cysteine proteinase 0.0277 0.3011 0.3011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.1715 0.1707
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0108 0.0108
Brugia malayi Papain family cysteine protease containing protein 0.017 0.1715 0.1715
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.335 1
Loa Loa (eye worm) transcription factor SMAD2 0.0261 0.2809 0.2809
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0009 0.0009
Echinococcus granulosus cathepsin b 0.067 0.7765 0.7763
Loa Loa (eye worm) hypothetical protein 0.0577 0.6641 0.6641
Echinococcus multilocularis geminin 0.0205 0.2131 0.2124
Loa Loa (eye worm) hypothetical protein 0.067 0.7765 0.7765
Leishmania major cathepsin L-like protease 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.017 0.1715 0.1624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0283 0.0275
Toxoplasma gondii cathepsin CPC2 0.017 0.1715 0.1715
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0009 0.0009
Echinococcus multilocularis cathepsin L cysteine protease 0.0854 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0577 0.6641 0.6641
Loa Loa (eye worm) hypothetical protein 0.0368 0.411 0.411
Loa Loa (eye worm) ctsf protein 0.0854 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0649 0.0649
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.017 0.1715 0.2667
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0283 0.0275
Entamoeba histolytica cysteine protease, putative 0.0854 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.335 0.3278
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0084 0.0676 0.4201
Plasmodium falciparum serine repeat antigen 2 0.017 0.1715 0.1715
Entamoeba histolytica cysteine protease, putative 0.017 0.1715 0.159
Brugia malayi Cathepsin L-like precursor 0.0277 0.3011 0.3011
Entamoeba histolytica cysteine protease, putative 0.017 0.1715 0.159
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0448 0.5074 0.5069
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.017 0.1715 0.1715
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0854 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.067 0.7765 0.7763
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.017 0.1715 0.1624
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0148 0.014
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0114 0.0114
Echinococcus multilocularis cathepsin L 0.0448 0.5074 0.5069
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1715 0.1624
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.067 0.7765 0.7763
Giardia lamblia Hypothetical protein 0.017 0.1715 0.2667
Schistosoma mansoni cathepsin F (C01 family) 0.0854 1 1
Brugia malayi Cathepsin L-like precursor 0.0577 0.6641 0.6641
Toxoplasma gondii cathepsin CPL 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.017 0.1715 0.1715
Onchocerca volvulus 0.0142 0.1367 0.1359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Plasmodium falciparum serine repeat antigen 4 0.017 0.1715 0.1715
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.017 0.1715 0.1624
Echinococcus granulosus expressed protein 0.0451 0.5111 0.5107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0577 0.6641 0.6604
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0142 0.1367 0.1359
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.017 0.1715 0.1707
Entamoeba histolytica cysteine proteinase, putative 0.0854 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.335 0.3278
Giardia lamblia Cathepsin B precursor 0.0325 0.3586 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0448 0.5074 0.5074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0114 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0108 0.0099
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0325 0.3586 0.3586
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1034 0.0936
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.017 0.1715 0.1715
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.335 0.325
Brugia malayi beta-lactamase family protein 0.0038 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.017 0.1715 0.1624
Brugia malayi G-protein coupled receptor 0.0029 0.0009 0.0009
Entamoeba histolytica cysteine proteinase 1, putative 0.0448 0.5074 0.4999
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.1715 0.1707
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Plasmodium falciparum serine repeat antigen 9 0.017 0.1715 0.1715
Leishmania major cathepsin L-like protease 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Plasmodium falciparum cysteine proteinase falcipain 1 0.0448 0.5074 0.5074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi Serotonin receptor 0.0029 0.0009 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.335 0.3278
Trypanosoma cruzi cysteine peptidase, putative 0.0854 1 1
Mycobacterium ulcerans hypothetical protein 0.0084 0.0676 0.4201
Leishmania major hypothetical protein, conserved 0.0038 0.0108 0.0108
Brugia malayi WGR domain containing protein 0.0063 0.042 0.042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0114 0.0114
Brugia malayi MH2 domain containing protein 0.0261 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.017 0.1715 0.1715
Entamoeba histolytica cysteine proteinase 2 0.0448 0.5074 0.4999
Onchocerca volvulus 0.0038 0.0108 0.0099
Echinococcus multilocularis cathepsin b 0.067 0.7765 0.7763
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1034 0.0936
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.017 0.1715 0.1715
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0108 0.0099
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0009 0.0009
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0009 0.0009
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0868 0.0868
Trypanosoma cruzi cysteine peptidase, putative 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.017 0.1715 0.1715
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1034 0.1034
Entamoeba histolytica cysteine protease, putative 0.017 0.1715 0.159
Entamoeba histolytica cysteine proteinase, putative 0.0448 0.5074 0.4999
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0325 0.3586 0.3586
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0084 0.0676 0.2312
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Giardia lamblia Cathepsin L-like protease 0.017 0.1715 0.2667
Loa Loa (eye worm) hypothetical protein 0.0142 0.1367 0.1367
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.012 0.1104 0.1104
Plasmodium vivax vivapain-2 0.0854 1 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0142 0.1367 0.1359
Giardia lamblia Encystation-specific protease 0.017 0.1715 0.2667
Brugia malayi Serotonin receptor 0.0029 0.0009 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0541 0.3202
Trypanosoma brucei poly(adp-ribose) polymerase 0.0063 0.042 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Brugia malayi sulfakinin receptor protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1034 0.1026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Mycobacterium tuberculosis Probable aminotransferase 0.0084 0.0676 0.2312
Brugia malayi Cathepsin L-like precursor 0.0854 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0108 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.017 0.1715 0.1715
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Giardia lamblia Cathepsin B precursor 0.0325 0.3586 1
Brugia malayi ORL1-like opioid receptor 0.0029 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.017 0.1715 0.1624
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0108 0.0108
Trypanosoma brucei polo-like protein kinase 0.0114 0.1034 0.1034
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0114 0.0105
Schistosoma mansoni hypothetical protein 0.0038 0.0114 0.0105
Loa Loa (eye worm) hypothetical protein 0.0369 0.4118 0.4118
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1034 0.1026
Brugia malayi cathepsin L-like cysteine proteinase 0.017 0.1715 0.1715
Echinococcus granulosus cathepsin L 0.0448 0.5074 0.5069
Brugia malayi Cathepsin L-like precursor 0.0854 1 1
Plasmodium vivax vivapain-2 0.0854 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.017 0.1715 0.159
Echinococcus granulosus tm gpcr rhodopsin 0.0708 0.8228 0.8227
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0063 0.042 0.042
Brugia malayi AKH receptor 0.0029 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0283 0.0275
Loa Loa (eye worm) hypothetical protein 0.017 0.1715 0.1715
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0854 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0277 0.3011 0.3011
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0045 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0142 0.1367 0.1367
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.067 0.7765 0.7765
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0448 0.5074 0.502
Schistosoma mansoni hypothetical protein 0.0205 0.2131 0.2124
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0009 0.0009
Brugia malayi G protein-coupled receptor 0.0029 0.0009 0.0009
Onchocerca volvulus Cathepsin L homolog 0.0854 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1111 0.1111
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.1459 0.5503
Loa Loa (eye worm) papain family cysteine protease containing protein 0.017 0.1715 0.1715
Schistosoma mansoni hypothetical protein 0.0038 0.0114 0.0105
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.335 0.9077
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.335 0.325
Echinococcus granulosus cathepsin l cysteine peptidase 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0277 0.3011 0.3011
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0868 0.086
Echinococcus granulosus geminin 0.0205 0.2131 0.2124
Plasmodium vivax unspecified product 0.017 0.1715 0.1715
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.017 0.1715 0.1624
Echinococcus multilocularis expressed protein 0.0451 0.5111 0.5107
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.017 0.1715 0.1624
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1715 0.1624
Brugia malayi Dopamine receptor protein 1 0.0029 0.0009 0.0009
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0115 0.1049 0.1041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.017 0.1715 0.1715
Plasmodium falciparum serine repeat antigen 1 0.017 0.1715 0.1715
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.1715 0.1707
Leishmania major C-8 sterol isomerase-like protein 0.072 0.8373 0.8373
Giardia lamblia Cathepsin L precursor 0.017 0.1715 0.2667
Loa Loa (eye worm) papain family cysteine protease containing protein 0.017 0.1715 0.1715
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.1111 0.1111
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1034 0.1034
Giardia lamblia Hypothetical protein 0.017 0.1715 0.2667
Plasmodium falciparum serine repeat antigen 7 0.017 0.1715 0.1715
Echinococcus granulosus cathepsin L cysteine protease 0.0448 0.5074 0.5069
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Brugia malayi hypothetical protein 0.0041 0.0148 0.0148
Trypanosoma cruzi cysteine proteinase, putative 0.0448 0.5074 0.5074
Onchocerca volvulus Cathepsin L homolog 0.017 0.1715 0.1707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.017 0.1715 0.1624
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.0854 1 1
Giardia lamblia Cathepsin L precursor 0.017 0.1715 0.2667
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.067 0.7765 0.7763
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0063 0.042 0.042
Brugia malayi cathepsin L-like precursor 0.0577 0.6641 0.6641
Entamoeba histolytica cysteine protease, putative 0.017 0.1715 0.159
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1034 0.0936
Toxoplasma gondii ABC1 family protein 0.0038 0.0108 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Giardia lamblia Cathepsin L precursor 0.017 0.1715 0.2667
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0009 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.335 0.3278
Trypanosoma cruzi cysteine peptidase, putative 0.0277 0.3011 0.3011
Echinococcus granulosus cysteine protease 0.0448 0.5074 0.5069
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0009 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0541 0.0532
Giardia lamblia Dipeptidyl-peptidase I precursor 0.017 0.1715 0.2667
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.017 0.1715 0.1715
Brugia malayi cathepsin Z-like cysteine proteinase 0.017 0.1715 0.1715
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1034 0.0936
Brugia malayi Cathepsin L-like precursor 0.0854 1 1
Brugia malayi larval opioid receptor 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.017 0.1715 0.1715
Brugia malayi Papain family cysteine protease containing protein 0.0448 0.5074 0.5074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.017 0.1715 0.1624
Giardia lamblia Cathepsin L precursor 0.017 0.1715 0.2667
Trypanosoma cruzi major cysteine proteinase, putative 0.017 0.1715 0.1715
Loa Loa (eye worm) MH2 domain-containing protein 0.0261 0.2809 0.2809
Brugia malayi cathepsin B-like cysteine proteinase 0.067 0.7765 0.7765
Echinococcus granulosus WGR domain containing protein 0.0036 0.0086 0.0078
Brugia malayi beta-lactamase family protein 0.0038 0.0108 0.0108
Toxoplasma gondii cathepsin CPC1 0.017 0.1715 0.1715
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Schistosoma mansoni kinase 0.0058 0.0355 0.0346
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0448 0.5074 0.5069
Loa Loa (eye worm) hypothetical protein 0.017 0.1715 0.1715
Brugia malayi beta-lactamase 0.0038 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.017 0.1715 0.1715
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0854 1 1
Giardia lamblia Cathepsin L precursor 0.017 0.1715 0.2667
Echinococcus granulosus poly ADP ribose polymerase 1 0.0115 0.1049 0.1041
Brugia malayi ERG2 and Sigma1 receptor like protein 0.072 0.8373 0.8373
Onchocerca volvulus 0.0854 1 1
Giardia lamblia Cysteine protease 0.017 0.1715 0.2667
Giardia lamblia Cathepsin B precursor 0.017 0.1715 0.2667
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.017 0.1715 0.1715
Entamoeba histolytica papain family cysteine protease domain containing protein 0.017 0.1715 0.159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0854 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0448 0.5074 0.5074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0448 0.5074 0.5074
Plasmodium falciparum serine repeat antigen 3 0.017 0.1715 0.1715
Echinococcus multilocularis microtubule associated protein 2 0.0721 0.8383 0.8381
Echinococcus multilocularis serotonin transporter 0.0142 0.1367 0.1359
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0854 1 1
Brugia malayi Dopamine receptor 0.0029 0.0009 0.0009
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.017 0.1715 0.1707
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.017 0.1715 0.1715
Trypanosoma brucei cysteine peptidase C (CPC) 0.0325 0.3586 0.3586
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0336 0.0231
Entamoeba histolytica cysteine protease, putative 0.0448 0.5074 0.4999
Brugia malayi neuropeptide F receptor 0.0029 0.0009 0.0009
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1034 0.1034
Entamoeba histolytica hypothetical protein 0.017 0.1715 0.159
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0708 0.8228 0.8227
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0448 0.5074 0.5069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.017 0.1715 0.1624
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0283 0.0275
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1111 0.1111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0283 0.0275
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0009 0.0009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0108 0.0099
Brugia malayi hypothetical protein 0.0029 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0854 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0283 0.0275

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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