Detailed information for compound 549566

Basic information

Technical information
  • TDR Targets ID: 549566
  • Name: (2R,4R,5R)-2-(hydroxymethyl)-5-(4-methylsulfa nylpyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofur an-3,4-diol
  • MW: 297.33 | Formula: C12H15N3O4S
  • H donors: 3 H acceptors: 5 LogP: -0.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H](C1O)O)n1ccc2c1ncnc2SC
  • InChi: 1S/C12H15N3O4S/c1-20-11-6-2-3-15(10(6)13-5-14-11)12-9(18)8(17)7(4-16)19-12/h2-3,5,7-9,12,16-18H,4H2,1H3/t7-,8?,9-,12-/m1/s1
  • InChiKey: ULAFTYMEZPGDOI-XHPIMKSCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,4R,5R)-2-(hydroxymethyl)-5-[4-(methylthio)-7-pyrrolo[2,3-d]pyrimidinyl]tetrahydrofuran-3,4-diol
  • (2R,4R,5R)-2-(hydroxymethyl)-5-(4-methylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
  • (2R,4R,5R)-2-methylol-5-[4-(methylthio)pyrrolo[2,3-d]pyrimidin-7-yl]tetrahydrofuran-3,4-diol
  • NSC 105,826
  • (2R,4R,5R)-2-(hydroxymethyl)-5-(4-methylsulfanylpyrrolo[3,2-e]pyrimidin-7-yl)oxolane-3,4-diol
  • (2R,4R,5R)-2-(hydroxymethyl)-5-(4-methylsulfanylpyrrolo[3,2-e]pyrimidin-7-yl)tetrahydrofuran-3,4-diol
  • (2R,4R,5R)-2-(hydroxymethyl)-5-[4-(methylthio)-7-pyrrolo[3,2-e]pyrimidinyl]tetrahydrofuran-3,4-diol
  • (2R,4R,5R)-2-methylol-5-[4-(methylthio)pyrrolo[3,2-e]pyrimidin-7-yl]tetrahydrofuran-3,4-diol
  • 4-Methylthio-7-beta-D-ribofuranosylpyrrolo(2,3-d)pyrimidine
  • NSC 105826

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni inositol monophosphatase 0.0043 0.0348 0.1152
Echinococcus granulosus ubiquinone biosynthesis monooxygenase COQ6 0.0015 0.0048 0.0053
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.079 0.0778
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0085 0.079 0.1437
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.048 1
Onchocerca volvulus 0.0085 0.079 0.5581
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0032 0.0232 0.0641
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0285 0.2918 1
Echinococcus granulosus orexin receptor type 2 0.0085 0.079 0.1192
Loa Loa (eye worm) hypothetical protein 0.0031 0.0217 0.0378
Entamoeba histolytica type A flavoprotein, putative 0.0109 0.1046 0.1724
Loa Loa (eye worm) FAD binding domain-containing protein 0.0285 0.2918 0.5375
Onchocerca volvulus 0.0085 0.079 0.5581
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0032 0.0232 0.0752
Plasmodium vivax flavodoxin domain containing protein 0.0253 0.2574 0.88
Echinococcus multilocularis sex peptide receptor 0.0085 0.079 0.0778
Schistosoma mansoni hypothetical protein 0.0167 0.1668 0.5697
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0136 0.205
Echinococcus multilocularis ubiquinone biosynthesis monooxygenase COQ6 0.0015 0.0048 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.2038 0.6578
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0085 0.079 0.0778
Schistosoma mansoni hypothetical protein 0.009 0.0844 0.2862
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0067 0.01
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0136 0.352
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.079 0.1192
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.079 0.1192
Schistosoma mansoni biogenic amine (5HT) receptor 0.0085 0.079 0.2673
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.079 0.1192
Giardia lamblia Hypothetical protein 0.0253 0.2574 1
Brugia malayi FAD binding domain containing protein 0.0176 0.1759 0.323
Treponema pallidum flavodoxin 0.0109 0.1046 1
Echinococcus multilocularis neuropeptide receptor 0.0085 0.079 0.0778
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.079 0.0778
Echinococcus multilocularis lamin 0.0032 0.0223 0.0211
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0085 0.079 0.1437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0457 0.153
Echinococcus granulosus peptide allatostatin:somatostatin 0.0085 0.079 0.1192
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0085 0.079 0.1437
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0573 0.0561
Brugia malayi sulfakinin receptor protein 0.0085 0.079 0.1437
Mycobacterium tuberculosis Possible oxygenase 0.0032 0.0232 0.4257
Mycobacterium ulcerans oxygenase 0.0032 0.0232 0.0641
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Echinococcus multilocularis neuropeptide s receptor 0.0624 0.6527 0.6523
Onchocerca volvulus 0.0085 0.079 0.5581
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0109 0.1046 0.2719
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus methionine synthase reductase 0.0176 0.1759 0.268
Echinococcus granulosus somatostatin receptor 0.0085 0.079 0.1192
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0109 0.1046 0.348
Schistosoma mansoni alpha-1 adrenergic receptor 0.0085 0.079 0.2673
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0013 0.0092
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0085 0.079 0.1192
Leishmania major p450 reductase, putative 0.0285 0.2918 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni hypothetical protein 0.0015 0.0048 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Echinococcus multilocularis allatostatin A receptor 0.0085 0.079 0.0778
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0573 0.1928
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0285 0.2918 1
Echinococcus granulosus lamin dm0 0.0032 0.0223 0.0323
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.048 0.1506
Echinococcus granulosus tachykinin peptides receptor 99D 0.0085 0.079 0.1192
Echinococcus multilocularis serotonin receptor 0.0085 0.079 0.0778
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.079 0.1192
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.079 0.1192
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.009 0.0844 0.0833
Onchocerca volvulus 0.0032 0.0223 0.1578
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.009 0.0844 0.1276
Onchocerca volvulus 0.0085 0.079 0.5581
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0032 0.0232 0.137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Schistosoma mansoni hypothetical protein 0.009 0.0844 0.2862
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0111
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.009 0.0844 0.0833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0457 0.0445
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0032 0.0232 0.0641
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0063 0.0357
Loa Loa (eye worm) hypothetical protein 0.0144 0.1415 0.2594
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0085 0.079 0.2673
Echinococcus granulosus G protein coupled receptor 139 0.0085 0.079 0.1192
Entamoeba histolytica protein kinase, putative 0.052 0.5418 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0285 0.2918 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0085 0.079 0.2673
Schistosoma mansoni diflavin oxidoreductase 0.0141 0.1391 0.4743
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.079 0.0778
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Plasmodium vivax hypothetical protein, conserved 0.0109 0.1046 0.348
Loa Loa (eye worm) FAD binding domain-containing protein 0.0176 0.1759 0.323
Leishmania major NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Echinococcus multilocularis fmrfamide receptor 0.0085 0.079 0.0778
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0136 0.0309
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.052 0.5418 0.8297
Onchocerca volvulus 0.0085 0.079 0.5581
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.079 0.1437
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0285 0.2918 0.446
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.009 0.0844 0.2862
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.079 0.0778
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0085 0.079 0.2673
Schistosoma mansoni lamin 0.0032 0.0223 0.0724
Onchocerca volvulus 0.0085 0.079 0.5581
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0348 0.1045
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0348 0.1045
Brugia malayi Ribonuclease 2-5A family protein 0.052 0.5418 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni inositol monophosphatase 0.0043 0.0348 0.1152
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0285 0.2918 1
Onchocerca volvulus 0.0085 0.079 0.5581
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.0232 0.4257
Entamoeba histolytica type A flavoprotein, putative 0.0109 0.1046 0.1724
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.079 0.1192
Brugia malayi neuropeptide F receptor 0.0085 0.079 0.1437
Schistosoma mansoni hypothetical protein 0.0167 0.1668 0.5697
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0573 0.1928
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0032 0.0232 0.4257
Schistosoma mansoni amine GPCR 0.0085 0.079 0.2673
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0348 0.2233
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) IRE protein kinase 0.052 0.5418 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.009 0.0844 0.1538
Schistosoma mansoni biogenic amine receptor 0.0085 0.079 0.2673
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0085 0.079 0.0778
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0136 0.0309
Schistosoma mansoni growth hormone secretagogue receptor 0.0085 0.079 0.2673
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.079 0.2673
Giardia lamblia Nitric oxide synthase, inducible 0.0253 0.2574 1
Brugia malayi Dopamine receptor protein 1 0.0085 0.079 0.1437
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.079 0.1192
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.009 0.0844 0.1276
Brugia malayi Tachykinin-like peptides receptor 99D 0.0085 0.079 0.1437
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.079 0.2673
Onchocerca volvulus 0.0085 0.079 0.5581
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.079 0.0778
Onchocerca volvulus 0.0085 0.079 0.5581
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0136 0.352
Loa Loa (eye worm) TYRA-2 protein 0.0085 0.079 0.1437
Leishmania major NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.048 0.0717
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0573 0.1928
Echinococcus multilocularis G protein coupled receptor 139 0.0085 0.079 0.0778
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni apoptosis regulator bax 0.009 0.0844 0.2862
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0085 0.079 0.2673
Brugia malayi MH2 domain containing protein 0.014 0.1376 0.2522
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0109 0.1046 0.348
Brugia malayi flavodoxin family protein 0.0285 0.2918 0.5375
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0223 0.0389
Schistosoma mansoni opsin-like receptor 0.0085 0.079 0.2673
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.079 0.1192
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus 7tm_1 domain containing protein 0.0085 0.079 0.1192
Brugia malayi flavodoxin family protein 0.0109 0.1046 0.1912
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0285 0.2918 1
Entamoeba histolytica type A flavoprotein, putative 0.0109 0.1046 0.1724
Plasmodium falciparum nitric oxide synthase, putative 0.0285 0.2918 1
Leishmania major reductase, putative 0.0032 0.0232 0.0641
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0013 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0136 0.0228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.079 0.2673
Echinococcus granulosus g protein coupled receptor 0.0085 0.079 0.1192
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.048 0.1506
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.079 0.1192
Brugia malayi putative neuropeptide receptor NPR1 0.0085 0.079 0.1437
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0073 0.0089
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni NADPH flavin oxidoreductase 0.0144 0.1414 0.4823
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Onchocerca volvulus 0.0032 0.0232 0.1636
Loa Loa (eye worm) hypothetical protein 0.0208 0.2099 0.386
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0348 0.1045
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0285 0.2918 1
Onchocerca volvulus Huntingtin homolog 0.0144 0.1415 1
Schistosoma mansoni amine GPCR 0.0085 0.079 0.2673
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni hypothetical protein 0.0085 0.079 0.2673
Trypanosoma cruzi reductase, putative 0.0032 0.0232 0.0641
Trypanosoma brucei NADH-dependent fumarate reductase 0.0032 0.0232 0.0641
Onchocerca volvulus 0.0085 0.079 0.5581
Echinococcus granulosus g-protein coupled receptor 0.0085 0.079 0.1192
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0136 0.0228
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0032 0.0232 0.0641
Mycobacterium ulcerans hypothetical protein 0.0023 0.0136 0.0309
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0073 0.0089
Echinococcus multilocularis g protein coupled receptor 0.0085 0.079 0.0778
Toxoplasma gondii flavodoxin domain-containing protein 0.0141 0.1391 1
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0032 0.0232 0.0641
Trypanosoma cruzi p450 reductase, putative 0.0032 0.0232 0.0641
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0136 0.0309
Trypanosoma brucei oxidoreductase-protein, putative 0.0032 0.0232 0.0641
Schistosoma mansoni amine GPCR 0.0085 0.079 0.2673
Echinococcus granulosus biogenic amine 5HT receptor 0.0085 0.079 0.1192
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0144 0.1415 0.2594
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0085 0.079 0.1437
Echinococcus granulosus cytochrome b5 reductase 4 0.0032 0.0232 0.0336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Brugia malayi G protein-coupled receptor F59B2.13 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0111
Schistosoma mansoni myosin xvIII 0.0085 0.079 0.2673
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0085 0.079 0.0778
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus multilocularis cytochrome b5 reductase 4 0.0032 0.0232 0.0219
Leishmania major NADH-dependent fumarate reductase-like protein 0.0032 0.0232 0.0641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Schistosoma mansoni intermediate filament proteins 0.0032 0.0223 0.0724
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0136 0.0309
Brugia malayi neuropeptide F receptor 0.0085 0.079 0.1437
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0253 0.2574 0.8659
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0073 0.0089
Schistosoma mansoni neuropeptide receptor 0.0085 0.079 0.2673
Echinococcus granulosus geminin 0.0167 0.1668 0.2541
Echinococcus granulosus lamin 0.0032 0.0223 0.0323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.079 0.0778
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0573 0.1928
Echinococcus multilocularis g protein coupled receptor 0.0085 0.079 0.0778
Brugia malayi RE15519p 0.0085 0.079 0.1437
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0457 0.0822
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0573 0.1928
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0049 0.0036
Brugia malayi G protein-coupled receptor 0.0085 0.079 0.1437
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0299 1
Echinococcus granulosus g protein coupled receptor 0.0085 0.079 0.1192
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0348 0.0335
Brugia malayi hypothetical protein 0.0144 0.1415 0.2594
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.2705 0.9171
Leishmania major hypothetical protein, conserved 0.0109 0.1046 0.348
Echinococcus granulosus biogenic amine 5HT receptor 0.0085 0.079 0.1192
Echinococcus granulosus g protein coupled receptor 0.0085 0.079 0.1192
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.048 0.1506
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0109 0.1046 0.2719
Echinococcus granulosus tar DNA binding protein 0.0064 0.0573 0.086
Trypanosoma cruzi oxidoreductase-protein, putative 0.0032 0.0232 0.0641
Trichomonas vaginalis sulfite reductase, putative 0.0285 0.2918 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0109 0.1046 0.2719
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.079 0.0778
Brugia malayi G-protein coupled receptor 0.0085 0.079 0.1437
Loa Loa (eye worm) flavodoxin family protein 0.0109 0.1046 0.1912
Loa Loa (eye worm) RNA binding protein 0.0064 0.0573 0.1036
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0032 0.0232 0.4257
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Onchocerca volvulus 0.0085 0.079 0.5581
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0085 0.079 0.1437
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0032 0.0232 0.0404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Onchocerca volvulus 0.0023 0.0136 0.0962
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0085 0.079 0.2673
Trypanosoma cruzi p450 reductase, putative 0.0285 0.2918 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.079 0.0778
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0109 0.1046 0.348
Schistosoma mansoni lamin 0.0032 0.0223 0.0724
Loa Loa (eye worm) hypothetical protein 0.009 0.0844 0.1538
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.079 0.1192
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0348 0.04
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0228
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Echinococcus multilocularis somatostatin receptor 0.0085 0.079 0.0778
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0073 0.015
Echinococcus granulosus allatostatin A receptor 0.0085 0.079 0.1192
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0136 0.0309
Mycobacterium ulcerans oxidoreductase 0.0032 0.0232 0.0641
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0085 0.079 0.0778
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0457 0.0445
Loa Loa (eye worm) diaphorase 0.0032 0.0232 0.0404
Brugia malayi FAD binding domain containing protein 0.0285 0.2918 0.5375
Echinococcus multilocularis geminin 0.0167 0.1668 0.1657
Echinococcus multilocularis protein MICAL 3 0.0015 0.0048 0.0035
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0223 0.0389
Echinococcus multilocularis serotonin receptor 0.0085 0.079 0.0778
Schistosoma mansoni histamine h1 receptor 0.0085 0.079 0.2673
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0457 0.0682
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Brugia malayi diaphorase 0.0032 0.0232 0.0404
Brugia malayi GnHR receptor homolog 0.0085 0.079 0.1437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Leishmania major nitrate reductase, putative 0.0032 0.0232 0.0641
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0299 0.5825
Leishmania major cytochrome P450 reductase, putative 0.0253 0.2574 0.88
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0348 0.0514
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0136 0.0309
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0032 0.0232 0.0641
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.079 0.0778
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0063 0.0357
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0457 0.0682
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0085 0.079 0.0778
Onchocerca volvulus 0.0085 0.079 0.5581
Leishmania major NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0348 0.1045
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0085 0.079 0.0778
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0265 0.2705 0.9171
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Onchocerca volvulus 0.0085 0.079 0.5581
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.1376 0.2522
Schistosoma mansoni opsin-like receptor 0.0085 0.079 0.2673
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0111
Loa Loa (eye worm) hypothetical protein 0.0285 0.2918 0.5375
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0228
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.079 0.0778
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0136 0.0228
Brugia malayi TAR-binding protein 0.0064 0.0573 0.1036
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0032 0.0232 0.0641
Leishmania major cytochrome-b5 reductase, putative 0.0032 0.0232 0.0641
Echinococcus granulosus neuropeptide receptor A26 0.0624 0.6527 1
Echinococcus multilocularis fmrfamide receptor 0.0085 0.079 0.0778
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0111
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0285 0.2918 0.446
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0348 0.1045
Echinococcus multilocularis g-protein coupled receptor 0.0085 0.079 0.0778
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0085 0.079 0.0778
Echinococcus granulosus neuropeptide s receptor 0.0624 0.6527 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Trypanosoma cruzi nitrate reductase, putative 0.0032 0.0232 0.0641
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0085 0.079 0.1437
Schistosoma mansoni neuropeptide receptor 0.0085 0.079 0.2673
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0032 0.0232 0.0336
Loa Loa (eye worm) apoptosis regulator protein 0.009 0.0844 0.1538
Leishmania major oxidoreductase-like protein 0.0032 0.0232 0.0641
Schistosoma mansoni hypothetical protein 0.0085 0.079 0.2673
Schistosoma mansoni adenoreceptor 0.0085 0.079 0.2673
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0032 0.0232 0.0641
Schistosoma mansoni neuropeptide f receptor 76f 0.0085 0.079 0.2673
Brugia malayi intermediate filament protein 0.0032 0.0223 0.0389
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0085 0.079 0.1192
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0032 0.0232 0.0219
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0085 0.079 0.5581
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0228
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.044 0.079
Brugia malayi Melatonin receptor type 1A 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.079 0.1192
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni amine GPCR 0.0085 0.079 0.2673
Echinococcus multilocularis lamin dm0 0.0032 0.0223 0.0211
Brugia malayi Inositol-1 0.0043 0.0348 0.0619
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Echinococcus granulosus alpha 1A adrenergic receptor 0.0085 0.079 0.1192
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0032 0.0232 0.0641
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0573 0.1036
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Onchocerca volvulus Huntingtin homolog 0.0144 0.1415 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.079 0.2673
Onchocerca volvulus Neuropeptide F receptor homolog 0.0085 0.079 0.5581
Brugia malayi Serotonin receptor 0.0085 0.079 0.1437
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.079 0.2673
Loa Loa (eye worm) inositol-1 0.0043 0.0348 0.0619
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0063 0.0357
Echinococcus multilocularis neuropeptide receptor 0.0085 0.079 0.0778
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.048 0.0467
Schistosoma mansoni neuropeptide receptor 0.0085 0.079 0.2673
Echinococcus multilocularis musashi 0.0032 0.0223 0.0211
Echinococcus granulosus intermediate filament protein 0.0032 0.0223 0.0323
Schistosoma mansoni neuropeptide receptor 0.0085 0.079 0.2673
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0109 0.1046 0.348
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni biogenic amine receptor 0.0085 0.079 0.2673
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0223 0.0389
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0136 0.0309
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.079 0.1192
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.079 0.1437
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0085 0.079 0.0778
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0285 0.2918 0.2909
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.2723 0.9327
Echinococcus multilocularis dro:myosuppressin receptor 0.0085 0.079 0.0778
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0457 0.153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Brugia malayi Dopamine receptor protein 2 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus protein MICAL 3 0.0015 0.0048 0.0053
Brugia malayi ORL1-like opioid receptor 0.0085 0.079 0.1437
Echinococcus multilocularis neuropeptide FF receptor 2 0.0085 0.079 0.0778
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.1376 0.2522
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0285 0.2918 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0013 0.0092
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.079 0.0778
Brugia malayi AKH receptor 0.0085 0.079 0.1437
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0085 0.079 0.2673
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.079 0.0778
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0085 0.079 0.1192
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.052 0.5418 0.5412
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0085 0.079 0.1192
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0085 0.079 0.2673
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0032 0.0232 0.0404
Echinococcus multilocularis g protein coupled receptor 0.0085 0.079 0.0778
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0085 0.079 0.0778
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0208 0.2099 0.386
Leishmania major cytochrome-b5 reductase, putative 0.0032 0.0232 0.0641
Schistosoma mansoni hypothetical protein 0.0085 0.079 0.2673
Toxoplasma gondii flavodoxin domain-containing protein 0.0141 0.1391 1
Echinococcus multilocularis orexin receptor type 2 0.0085 0.079 0.0778
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0049 0.0056
Echinococcus granulosus dro:myosuppressin receptor 0.0085 0.079 0.1192
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0285 0.2918 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0573 0.1036
Trypanosoma brucei NADH-dependent fumarate reductase 0.0032 0.0232 0.0641
Echinococcus multilocularis methionine synthase reductase 0.0176 0.1759 0.1748
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0136 0.205
Onchocerca volvulus 0.0032 0.0223 0.1578
Onchocerca volvulus 0.0085 0.079 0.5581
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0348 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0111
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0056
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.079 0.2673
Mycobacterium ulcerans electron transfer protein FdxB 0.0032 0.0232 0.0641
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0573 0.1036
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.079 0.1192
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0232 0.0641
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0085 0.079 0.2673
Entamoeba histolytica type A flavoprotein, putative 0.0109 0.1046 0.1724
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.048 0.0864
Entamoeba histolytica protein kinase, putative 0.052 0.5418 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0032 0.0223 0.0389
Plasmodium falciparum ferredoxin--NADP reductase 0.0032 0.0232 0.0641
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0067
Brugia malayi follicle stimulating hormone receptor 0.0085 0.079 0.1437
Onchocerca volvulus 0.0012 0.0013 0.0092
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Chlamydia trachomatis sulfite reductase 0.0176 0.1759 1
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Onchocerca volvulus 0.0085 0.079 0.5581
Schistosoma mansoni amine GPCR 0.0085 0.079 0.2673
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.079 0.1192
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus fmrfamide receptor 0.0085 0.079 0.1192
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus neuropeptide receptor 0.0085 0.079 0.1192
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0136 0.0309
Onchocerca volvulus 0.0085 0.079 0.5581
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.079 0.0778
Schistosoma mansoni cytochrome P450 reductase 0.0285 0.2918 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0085 0.079 0.1192
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.079 0.1437
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0063 0.0357
Brugia malayi G-protein coupled receptor 0.0085 0.079 0.1437
Echinococcus granulosus serotonin receptor 0.0085 0.079 0.1192
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0109 0.1046 0.348
Echinococcus granulosus 7TM GPCR rhodopsin 0.0085 0.079 0.1192
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0085 0.079 0.1437
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0032 0.0232 0.137
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.079 0.1192
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus cytochrome b5 reductase 4 0.0032 0.0232 0.0336
Echinococcus multilocularis neuropeptide receptor A26 0.0624 0.6527 0.6523
Onchocerca volvulus 0.0085 0.079 0.5581
Brugia malayi Serotonin receptor 0.0085 0.079 0.1437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.079 0.0778
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Echinococcus granulosus sex peptide receptor 0.0085 0.079 0.1192
Schistosoma mansoni biogenic amine (5HT) receptor 0.0085 0.079 0.2673
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0285 0.2918 1
Brugia malayi hypothetical protein 0.0085 0.079 0.1437
Schistosoma mansoni cytochrome B5 0.0032 0.0232 0.0752
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0032 0.0232 0.1075
Entamoeba histolytica type A flavoprotein, putative 0.0109 0.1046 0.1724
Echinococcus granulosus neuropeptide receptor 0.0085 0.079 0.1192
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.079 0.0778
Schistosoma mansoni monoxygenase 0.0015 0.0048 0.0119
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.048 0.1607
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0136 0.0309
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0285 0.2918 0.2909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0457 0.153
Echinococcus multilocularis G-protein coupled receptor, putative 0.0085 0.079 0.0778
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.079 0.1192
Leishmania major NADH-cytochrome b5 reductase, putative 0.0032 0.0232 0.0641
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.079 0.1437
Trypanosoma brucei nitrate reductase, putative 0.0032 0.0232 0.0641
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.079 0.0778
Loa Loa (eye worm) hypothetical protein 0.0085 0.079 0.1437
Brugia malayi putative neuropeptide receptor 0.0085 0.079 0.1437
Brugia malayi larval opioid receptor 0.0085 0.079 0.1437
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.079 0.2673
Mycobacterium tuberculosis Probable monooxygenase 0.0032 0.0232 0.4257
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0109 0.1046 0.2719
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.079 0.0778
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0073 0.0593
Echinococcus granulosus hypothetical protein 0.0085 0.079 0.1192
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0457 0.0822
Schistosoma mansoni hypothetical protein 0.0085 0.079 0.2673
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0136 0.0309
Brugia malayi Dopamine receptor 0.0085 0.079 0.1437
Mycobacterium ulcerans monooxygenase 0.0032 0.0232 0.0641
Schistosoma mansoni biogenic amine receptor 0.0085 0.079 0.2673
Schistosoma mansoni opsin-like receptor 0.0085 0.079 0.2673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.079 0.2673
Brugia malayi RNA binding protein 0.0064 0.0573 0.1036
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0285 0.2918 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0067 0.01
Schistosoma mansoni hypothetical protein 0.009 0.0844 0.2862
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0176 0.1759 0.6009
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0109 0.1046 0.348

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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