Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | selectin E | Starlite/ChEMBL | References |
Homo sapiens | vascular cell adhesion molecule 1 | Starlite/ChEMBL | References |
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Homo sapiens | intercellular adhesion molecule 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | c4b binding protein beta chain | selectin E | 610 aa | 551 aa | 22.1 % |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Thioredoxin reductase | 0.00761339 | 0.679989 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0105325 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.00263827 | 0.13459 | 0.5 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.00263827 | 0.13459 | 0.196645 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.00263827 | 0.13459 | 0.197929 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.00263827 | 0.13459 | 0.196645 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Loa Loa (eye worm) | thioredoxin reductase | 0.00761339 | 0.679989 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.00761339 | 0.679989 | 1 |
Treponema pallidum | NADH oxidase | 0.00263827 | 0.13459 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.00761339 | 0.679989 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.00263827 | 0.13459 | 0.196645 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0014899 | 0.00869946 | 0.011213 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0105325 | 1 | 1 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.00218968 | 0.0854141 | 0.124211 |
Loa Loa (eye worm) | hypothetical protein | 0.00155363 | 0.0156859 | 0.0215037 |
Trypanosoma brucei | thymidine kinase | 0.0105325 | 1 | 1 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Echinococcus granulosus | roundabout 2 | 0.00177684 | 0.0401558 | 0.0590536 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.00263827 | 0.13459 | 0.197929 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.00761339 | 0.679989 | 0.630221 |
Loa Loa (eye worm) | hypothetical protein | 0.00177684 | 0.0401558 | 0.0575471 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.00263827 | 0.13459 | 0.196645 |
Echinococcus multilocularis | roundabout 2 | 0.00177684 | 0.0401558 | 0.0590536 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.00263827 | 0.13459 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.00263827 | 0.13459 | 0.5 |
Brugia malayi | glutathione reductase | 0.00761339 | 0.679989 | 1 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.00761339 | 0.679989 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00263827 | 0.13459 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.00263827 | 0.13459 | 0.5 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Plasmodium falciparum | glutathione reductase | 0.00263827 | 0.13459 | 0.196645 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0014899 | 0.00869946 | 0.0127935 |
Loa Loa (eye worm) | hypothetical protein | 0.00177684 | 0.0401558 | 0.0575471 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.00263827 | 0.13459 | 0.196645 |
Plasmodium falciparum | thioredoxin reductase | 0.00761339 | 0.679989 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0014899 | 0.00869946 | 0.0127935 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.00142046 | 0.00108693 | 0.00159846 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.00193798 | 0.0578213 | 0.0835678 |
Echinococcus granulosus | C type lectin domian containing protein | 0.00142046 | 0.00108693 | 0.00159846 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.00263827 | 0.13459 | 0.197929 |
Echinococcus granulosus | c4b binding protein beta chain | 0.00142046 | 0.00108693 | 0.00159846 |
Loa Loa (eye worm) | glutathione reductase | 0.00761339 | 0.679989 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.00193798 | 0.0578213 | 0.0835678 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014899 | 0.00869946 | 0.011213 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.00263827 | 0.13459 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0105325 | 1 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0105325 | 1 | 0.5 |
Giardia lamblia | Thymidine kinase | 0.0105325 | 1 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0105325 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0105325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014899 | 0.00869946 | 0.011213 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.00263827 | 0.13459 | 0.196645 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.00761339 | 0.679989 | 1 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.00142046 | 0.00108693 | 0.00159846 |
Plasmodium falciparum | thioredoxin reductase | 0.00263827 | 0.13459 | 0.196645 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.00761339 | 0.679989 | 1 |
Leishmania major | thymidine kinase, putative | 0.0105325 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.00761339 | 0.679989 | 0.630221 |
Brugia malayi | GCC2 and GCC3 family protein | 0.00218968 | 0.0854141 | 0.124211 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00263827 | 0.13459 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.00263827 | 0.13459 | 0.196645 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Plasmodium falciparum | glutathione reductase | 0.00761339 | 0.679989 | 1 |
Leishmania major | trypanothione reductase | 0.00761339 | 0.679989 | 0.630221 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.00142046 | 0.00108693 | 0.00159846 |
Onchocerca volvulus | 0.00142046 | 0.00108693 | 0.5 | |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.00761339 | 0.679989 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 | > 10 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 0.54 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 0.546 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IC50 (binding) | = 2.5 uM | In vitro potency against TNF alpha induced expresion of VCAM-1 on human vascular endothelial cells using CAM ELISA assay | ChEMBL. | 11300880 |
IC50 (binding) | = 2.5 uM | In vitro potency against TNF alpha induced expresion of VCAM-1 on human vascular endothelial cells using CAM ELISA assay | ChEMBL. | 11300880 |
IC50 (binding) | = 3 uM | In vitro potency against TNF alpha induced expression of Selectin E on human vascular endothelial cells using CAM ELISA assay | ChEMBL. | 11300880 |
IC50 (binding) | = 3 uM | In vitro potency against TNF alpha induced expression of Selectin E on human vascular endothelial cells using CAM ELISA assay | ChEMBL. | 11300880 |
IC50 (binding) | = 6.3 uM | In vitro potency against TNF alpha induced expresion of intercellular adhesion molecule-1 on human vascular endothelial cells using CAM ELISA assay | ChEMBL. | 11300880 |
IC50 (binding) | = 6.3 uM | In vitro potency against TNF alpha induced expresion of intercellular adhesion molecule-1 on human vascular endothelial cells using CAM ELISA assay | ChEMBL. | 11300880 |
IC50 (ADMET) | = 95 uM | In vitro cellular toxicity against human umbelical vein endothelial cells (HUVEC) in MTS assay | ChEMBL. | 11300880 |
Inhibition (functional) | = -5.69 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.05 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.44 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (binding) | = 60 % | Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as inhibition of channel-mediated cell death in presence of Mg2+ incubated for 24 to 48 hrs by propidium iodide uptake assay | ChEMBL. | No reference |
Inhibition (functional) | = 65 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 4.83 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -20 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 65 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.18 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.65916 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.