Detailed information for compound 550221

Basic information

Technical information
  • TDR Targets ID: 550221
  • Name: 2,4,5-triiodo-1H-imidazole
  • MW: 445.767 | Formula: C3HI3N2
  • H donors: 1 H acceptors: 1 LogP: 2.12 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1[nH]c(c(n1)I)I
  • InChi: 1S/C3HI3N2/c4-1-2(5)8-3(6)7-1/h(H,7,8)
  • InChiKey: HIDCNJIBRZBEPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,4,5-triiodoimidazole
  • 1746-25-4
  • NSC 222411
  • ZINC04262624
  • 1H-Imidazole, 2,4,5-triiodo-
  • Imidazole, 2,4,5-triiodo-
  • NSC222411
  • 1H-Imidazole, 2,4,5-triiodo- (9CI)
  • BRN 0115451

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.013 0.0308
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0021 0.005
Loa Loa (eye worm) hypothetical protein 0.0031 0.017 0.0399
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1491 0.3532
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0021 0.0035
Entamoeba histolytica hypothetical protein 0.0456 0.3946 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0086 0.1148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.005 0.0082
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0005 0.0011
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0271 0.0641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Onchocerca volvulus 0.0017 0.005 0.0118
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0005 0.0033
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0042 0.0268 0.0441
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0014 0.0021 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0444 0.0729
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0005 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0126 0.102 0.1675
Echinococcus multilocularis beta LACTamase domain containing family member 0.0178 0.148 0.243
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0021 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0457 0.075
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0033
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0285 0.1901
Brugia malayi Cathepsin L-like precursor 0.0017 0.005 0.0118
Onchocerca volvulus 0.0178 0.148 0.3472
Mycobacterium ulcerans esterase/lipase LipP 0.0178 0.148 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0068
Schistosoma mansoni hypothetical protein 0.0126 0.102 0.1675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0042 0.0268 0.0441
Echinococcus granulosus beta LACTamase domain containing family member 0.0178 0.148 0.243
Schistosoma mansoni smad1 5 8 and 0.0016 0.0042 0.0069
Mycobacterium tuberculosis Probable reductase 0.0274 0.233 0.2327
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0545 0.0894
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.005 0.0127
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.005 0.0118
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0029 0.0161
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.017 0.04
Toxoplasma gondii cathepsin CPL 0.0017 0.005 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0107 0.0254
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0029 0.0067
Onchocerca volvulus 0.0017 0.005 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0457 0.075
Trichomonas vaginalis D-aminoacylase, putative 0.0178 0.148 0.3506
Echinococcus granulosus geminin 0.0698 0.609 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0021 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1491 0.3532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0158 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2325 0.5509
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0178 0.148 0.1476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0489
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0456 0.3946 0.6479
Plasmodium falciparum importin beta, putative 0.0029 0.0153 0.1584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0489
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0029 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0107 0.0254
Echinococcus granulosus expressed protein 0.0014 0.0021 0.0035
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0021 0.005
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0021 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0042 0.0268 0.1787
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0423 0.1071
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0086 0.058
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0005 0.0008
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0086 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0068
Leishmania major cathepsin L-like protease 0.0065 0.0474 0.3183
Entamoeba histolytica cysteine proteinase, putative 0.0011 0 0.0001
Onchocerca volvulus 0.0157 0.1294 0.3034
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0005 0.0008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0399 0.3442 0.8074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0068
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0042 0.0268 0.1787
Schistosoma mansoni ran 0.0021 0.0086 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1491 0.3532
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0042 0.0069
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0244 0.0401
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0178 0.148 0.1476
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0029 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1491 0.3532
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0268 0.1787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0207 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Toxoplasma gondii thioredoxin reductase 0.012 0.0965 0.6519
Mycobacterium ulcerans lipase LipD 0.0178 0.148 1
Brugia malayi MH2 domain containing protein 0.0016 0.0042 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0011
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.0021 0.005
Loa Loa (eye worm) RNA binding protein 0.0063 0.0457 0.1071
Echinococcus multilocularis expressed protein 0.0014 0.0021 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1995 0.4679
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0144 0.034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0423 0.2831
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0021 0.0035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0423 0.4379
Echinococcus granulosus chromobox protein 1 0.0069 0.0515 0.0846
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.2608 0.6117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Brugia malayi MH1 domain containing protein 0.0016 0.0042 0.0098
Schistosoma mansoni synaptojanin 0.0012 0.0005 0.0008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0268 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0245 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.013 0.0308
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0021 0.0035
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0178 0.148 0.3472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0186 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0489
Schistosoma mansoni smad 0.0016 0.0042 0.0069
Echinococcus multilocularis snurportin 1 0.0305 0.2608 0.4282
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0268 0.1787
Loa Loa (eye worm) hypothetical protein 0.0039 0.0244 0.0573
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0424 0.0696
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0033
Schistosoma mansoni cript-related 0.0012 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0011
Onchocerca volvulus 0.0178 0.148 0.3472
Leishmania major GTP-binding protein, putative 0.0021 0.0086 0.0549
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0423 1
Onchocerca volvulus 0.0011 0.000000022815 0.000000053514
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0207 0.1367
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0042 0.0268 0.2782
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.0021 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0301 0.0713
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0425 0.2845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0186 0.0441
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.0021 0.005
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0489
Onchocerca volvulus 0.0017 0.005 0.0118
Entamoeba histolytica hypothetical protein 0.0456 0.3946 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0021 0.005
Brugia malayi hypothetical protein 0.0456 0.3946 0.9256
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0457 0.075
Onchocerca volvulus 0.0017 0.005 0.0118
Plasmodium falciparum glutathione reductase 0.012 0.0965 1
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0005 0.0011
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0711 0.1684
Schistosoma mansoni hypothetical protein 0.0456 0.3946 0.6479
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0021 0.0035
Trichomonas vaginalis ran, putative 0.0021 0.0086 0.0203
Mycobacterium tuberculosis Probable oxidoreductase 0.0305 0.2602 0.2598
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0423 0.1271
Schistosoma mansoni synaptojanin 0.0012 0.0005 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0711 0.1684
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1491 0.3532
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0033
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0042 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Onchocerca volvulus 0.0012 0.0005 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0178 0.148 0.1476
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0301 0.0713
Trichomonas vaginalis D-aminoacylase, putative 0.0178 0.148 0.3506
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1491 0.3532
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2325 0.5509
Schistosoma mansoni importin beta-1 0.0029 0.0153 0.0251
Loa Loa (eye worm) hypothetical protein 0.0178 0.148 0.3472
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0423 0.0991
Brugia malayi Cathepsin L-like precursor 0.0011 0 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0457 0.1071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0268 0.1787
Loa Loa (eye worm) beta-lactamase 0.0178 0.148 0.3472
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0423 1
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0005 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0086 0.089
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0082 0.0521
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0244 0.0401
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0244 0.0573
Onchocerca volvulus 0.0031 0.017 0.0399
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0033
Onchocerca volvulus 0.0012 0.0005 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0126 0.102 0.2393
Brugia malayi MH1 domain containing protein 0.0016 0.0042 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0423 0.1279
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.005 0.0082
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0005 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.013 0.0308
Brugia malayi beta-lactamase family protein 0.0178 0.148 0.3472
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1577 0.3735
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0244 0.0579
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0042 0.0098
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0285 0.1901
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0042 0.0268 0.063
Brugia malayi Smad1 0.0016 0.0042 0.0098
Loa Loa (eye worm) hypothetical protein 0.0178 0.148 0.3472
Entamoeba histolytica Ran family GTPase 0.0021 0.0086 0.0218
Loa Loa (eye worm) hypothetical protein 0.0061 0.0444 0.1041
Schistosoma mansoni Smad4 0.0016 0.0042 0.0069
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0005 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0711 0.1684
Toxoplasma gondii ABC1 family protein 0.0178 0.148 1
Onchocerca volvulus 0.0017 0.005 0.0118
Onchocerca volvulus Phospholipase A2 homolog 0.0492 0.4263 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0285 0.1901
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0005 0.0008
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0005 0.0008
Loa Loa (eye worm) glutathione reductase 0.012 0.0965 0.2263
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.2325 0.5454
Trichomonas vaginalis glutathione reductase, putative 0.0042 0.0268 0.0636
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0711 0.1667
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Echinococcus granulosus tar DNA binding protein 0.0063 0.0457 0.075
Entamoeba histolytica hypothetical protein 0.0456 0.3946 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.005 0.0118
Loa Loa (eye worm) hypothetical protein 0.0178 0.148 0.3472
Echinococcus granulosus thioredoxin glutathione reductase 0.0121 0.0974 0.1599
Schistosoma mansoni nocturnin 0.0012 0.0005 0.0008
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Plasmodium vivax importin-beta 2, putative 0.0029 0.0153 0.1033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.005 0.0307
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0285 0.0723
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0086 0.0549
Loa Loa (eye worm) hypothetical protein 0.0178 0.148 0.3472
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0457 0.075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.274 0.4499
Echinococcus granulosus Chromobox protein 3 0.0011 0.000000022815 0.000000037461
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0033
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0244 0.0401
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0 0.0001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0178 0.148 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.2325 0.5454
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0351 0.2349
Leishmania major cathepsin L-like protease 0.0017 0.005 0.0307
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0457 0.075
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0444 0.0729
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0021 0.0035
Trypanosoma brucei polo-like protein kinase 0.0091 0.0711 0.4785
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0021 0.0035
Onchocerca volvulus 0.0178 0.148 0.3472
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0244 0.0401
Echinococcus multilocularis chromobox protein 1 0.0069 0.0515 0.0846
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.005
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0161
Plasmodium vivax hypothetical protein, conserved 0.0178 0.148 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0108 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0457 0.075
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0515 0.1221
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0423 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0108 0.0255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.274 0.4499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0285 0.0676
Brugia malayi Pre-SET motif family protein 0.0061 0.0444 0.1041
Onchocerca volvulus 0.0073 0.0545 0.1278
Schistosoma mansoni hypothetical protein 0.0305 0.2608 0.4282
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0118
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0005 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0178 0.148 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0021 0.0035
Onchocerca volvulus 0.0017 0.005 0.0118
Mycobacterium tuberculosis Conserved protein 0.0178 0.148 0.1476
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0021 0.0035
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0153 0.0251
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1491 0.3532
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0105 0.0248
Schistosoma mansoni hypothetical protein 0.0126 0.102 0.1675
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0268 0.1787
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0178 0.148 0.243
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0157 0.1294 0.3034
Brugia malayi Cathepsin L-like precursor 0.0017 0.005 0.0118
Brugia malayi Cathepsin L-like precursor 0.0017 0.005 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.274 0.4499
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0244 0.3393
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0005 0.0008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0423 0.0694
Loa Loa (eye worm) thioredoxin reductase 0.012 0.0965 0.2263
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0423 0.1001
Plasmodium falciparum thioredoxin reductase 0.0042 0.0268 0.2782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0042 0.0268 0.0441
Treponema pallidum NADH oxidase 0.0042 0.0268 0.6312
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.0021 0.005
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0042 0.0268 0.1787
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0423 0.0695
Schistosoma mansoni hypothetical protein 0.0698 0.609 1
Trypanosoma cruzi hypothetical protein, conserved 0.0178 0.148 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0474 0.3183
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0245 0.0579
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.0021 0.005
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0423 0.0695
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0086 0.058
Trichomonas vaginalis penicillin-binding protein, putative 0.0178 0.148 0.3506
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0711 0.1167
Onchocerca volvulus 0.0011 0 0.0001
Onchocerca volvulus Cathepsin L homolog 0.0017 0.005 0.0118
Entamoeba histolytica hypothetical protein 0.0456 0.3946 1
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0711 0.1167
Brugia malayi Calcitonin receptor-like protein seb-1 0.0399 0.3442 0.8074
Loa Loa (eye worm) Smad1 0.0016 0.0042 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Brugia malayi Phospholipase A2 family protein 0.0492 0.4263 1
Mycobacterium tuberculosis Probable lipase LipE 0.0178 0.148 0.1476
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0274 0.233 0.2327
Schistosoma mansoni transcription factor LCR-F1 0.0456 0.3946 0.6479
Leishmania major cathepsin L-like protease 0.0065 0.0474 0.3183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Brugia malayi beta-lactamase 0.0178 0.148 0.3472
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0005 0.0011
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0711 0.4785
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.005 0.0118
Brugia malayi CCR4 0.0012 0.0007 0.0016
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0005 0.0011
Brugia malayi SET domain containing protein 0.0014 0.002 0.0047
Schistosoma mansoni ran 0.0021 0.0086 0.0141
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0444 0.0729
Loa Loa (eye worm) latrophilin receptor protein 2 0.0126 0.102 0.2393
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0178 0.148 0.3472
Mycobacterium tuberculosis Conserved protein 0.0178 0.148 0.1476
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0285 0.0468
Brugia malayi MH2 domain containing protein 0.0236 0.1995 0.4679
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0029 0.0047
Giardia lamblia NADH oxidase lateral transfer candidate 0.0042 0.0268 0.3735
Schistosoma mansoni chromobox protein 0.0069 0.0515 0.0846
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0105 0.0678
Echinococcus multilocularis cysteine protease 0.0017 0.005 0.0082
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0711 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Brugia malayi RNA, U transporter 1 0.0081 0.0621 0.1456
Schistosoma mansoni hypothetical protein 0.0698 0.609 1
Echinococcus multilocularis cysteine protease 0.0017 0.005 0.0082
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0244 0.1623
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0086 0.0201
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0178 0.148 0.3472
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0423 0.0991
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0423 0.0694
Mycobacterium ulcerans beta-lactamase 0.0178 0.148 1
Trichomonas vaginalis esterase, putative 0.0178 0.148 0.3506
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.017 0.04
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0444 0.2999
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2325 0.5509
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0274 0.233 0.7581
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0285 0.0669
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0285 0.1901
Schistosoma mansoni smad1 5 8 and 0.0016 0.0042 0.0069
Plasmodium vivax vivapain-2 0.0017 0.005 0.0339
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0268 0.1787
Onchocerca volvulus 0.0487 0.4221 0.9901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0229 0.0542
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0021 0.0035
Trichomonas vaginalis penicillin-binding protein, putative 0.0178 0.148 0.3506
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0244 0.0401
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0711 0.1684
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0711 0.1684
Leishmania major trypanothione reductase 0.012 0.0965 0.6508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Echinococcus granulosus chromobox protein 1 0.0069 0.0515 0.0846
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0042 0.0268 0.1787
Brugia malayi glutathione reductase 0.012 0.0965 0.2263
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.0178 0.148 0.1476
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0244 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.015 0.0355
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.0021 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0186 0.0441
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0017 0.005 0.0118
Schistosoma mansoni ap endonuclease 0.0059 0.0423 0.0694
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Entamoeba histolytica cysteine protease, putative 0.0017 0.005 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.005 0.0119
Loa Loa (eye worm) hypothetical protein 0.0273 0.2321 0.5445
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Echinococcus multilocularis smad 0.0016 0.0042 0.0069
Brugia malayi Cathepsin L-like precursor 0.0017 0.005 0.0118
Echinococcus granulosus importin subunit beta 1 0.0029 0.0153 0.0251
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.0021 0.005
Plasmodium vivax SET domain protein, putative 0.0061 0.0444 0.2999
Schistosoma mansoni hypothetical protein 0.0273 0.2321 0.3811
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0086 0.0141
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0457 0.1071
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.005 0.0082
Plasmodium vivax glutathione reductase, putative 0.012 0.0965 0.6519
Echinococcus multilocularis Chromobox protein 3 0.0011 0.000000022815 0.000000037461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0021 0.005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0042 0.0268 0.0264
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0423 0.2831
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0423 0.0419
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0042 0.0098
Loa Loa (eye worm) hypothetical protein 0.0399 0.3442 0.8074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0128 0.0302
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0244 0.1623
Brugia malayi RNA binding protein 0.0063 0.0457 0.1071
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0244 0.0619
Giardia lamblia GTOR 0.0044 0.0285 0.3972
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0711 0.1667
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0423 0.1001
Echinococcus multilocularis GPCR, family 2 0.0126 0.102 0.1675
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0456 0.3946 0.6479
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0005 0.0033
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0021 0.005
Plasmodium falciparum glutathione reductase 0.0042 0.0268 0.2782
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0005 0.0008
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.005 0.052
Leishmania major cathepsin L-like protease 0.0017 0.005 0.0307
Leishmania major hypothetical protein, conserved 0.0178 0.148 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0042 0.0268 0.1814
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.0021 0.005
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0005 0.0008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0305 0.2602 0.2598
Leishmania major cathepsin L-like protease 0.0017 0.005 0.0307
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0244 0.1623
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0005 0.0011
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0423 0.0418
Loa Loa (eye worm) hypothetical protein 0.0178 0.148 0.3472
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0011
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0271 0.0635
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0268 0.1787
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0244 0.0401
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0011
Brugia malayi G-protein alpha subunit 0.0014 0.0021 0.005
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0268 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0144 0.034
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0423 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0186 0.0441
Loa Loa (eye worm) fibroinase 0.0017 0.005 0.0118
Schistosoma mansoni hypothetical protein 0.0126 0.102 0.1675
Echinococcus multilocularis thioredoxin glutathione reductase 0.0121 0.0974 0.1599
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0005 0.0008
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0021 0.0035
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0021 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0268 0.1787
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0005 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0711 0.1684
Onchocerca volvulus 0.0014 0.0021 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0285 0.0676
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0086 0.0141
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0178 0.148 0.1476
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0423 0.2838
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2325 0.5509
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0005 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0423 0.2831
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0126 0.102 0.1675
Mycobacterium tuberculosis Conserved protein 0.0178 0.148 0.1476
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0021 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0186 0.0441
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.005 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.274 0.4499
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0474 0.3183
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0186 0.1259
Brugia malayi Cathepsin L-like precursor 0.0011 0 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0274 0.233 0.2327
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0021 0.005
Brugia malayi hypothetical protein 0.0014 0.0021 0.005
Brugia malayi TAR-binding protein 0.0063 0.0457 0.1071
Trypanosoma brucei trypanothione reductase 0.012 0.0965 0.6508
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Giardia lamblia Kinase, PLK 0.0091 0.0711 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0285 0.0676
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0244 0.0401
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0005 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.032 0.274 0.6426
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0021 0.0035
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0042 0.0268 0.2782
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0444 0.0729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0108 0.0255
Echinococcus granulosus synaptojanin 1 0.0012 0.0005 0.0008
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0474 0.3183
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2325 0.5509
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0711 0.4785
Loa Loa (eye worm) hypothetical protein 0.0492 0.4263 1
Echinococcus multilocularis Smad4 0.0016 0.0042 0.0069
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0014 0.0021 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0126 0.102 0.1675
Brugia malayi latrophilin 2 splice variant baaae 0.0273 0.2321 0.5445
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0285 0.0669
Onchocerca volvulus 0.0014 0.0021 0.005
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0285 0.1901
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0021 0.005
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0285 0.1901
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0012
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0021 0.005
Entamoeba histolytica G protein alpha subunit, putative 0.0014 0.0021 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0 0.0001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0268 0.1787
Echinococcus multilocularis synaptojanin 1 0.0012 0.0005 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0186 0.0441
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0274 0.233 0.2327
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0042 0.0069
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0005 0.0012
Echinococcus multilocularis geminin 0.0698 0.609 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0153 0.1033
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0161
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0005 0.0008
Trichomonas vaginalis mercuric reductase, putative 0.0042 0.0268 0.0636
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2325 0.5509
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Onchocerca volvulus Cathepsin F homolog 0.0017 0.005 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.274 0.4499
Entamoeba histolytica hypothetical protein 0.0023 0.0105 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0005 0.0033
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0005 0.0012
Plasmodium vivax thioredoxin reductase, putative 0.012 0.0965 0.6519
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0042 0.0069
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0007 0.0016
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0515 0.1209
Loa Loa (eye worm) hypothetical protein 0.009 0.0694 0.1627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Leishmania major cathepsin L-like protease 0.0017 0.005 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0003 0.0006
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0711 0.1801
Plasmodium vivax vivapain-2 0.0017 0.005 0.0339
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0005 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0128 0.0302
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0423 0.1279
Echinococcus granulosus snurportin 1 0.0305 0.2608 0.4282
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0305 0.2602 0.2598
Plasmodium falciparum thioredoxin reductase 0.012 0.0965 1
Toxoplasma gondii exonuclease III APE 0.0059 0.0423 0.2855
Loa Loa (eye worm) hypothetical protein 0.0029 0.0153 0.0359
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0423 0.2855
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.005 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.006 0.0371
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0042 0.0069
Mycobacterium ulcerans hypothetical protein 0.0178 0.148 1
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0005 0.0011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0244 0.1623
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.005 0.0127
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0399 0.3442 0.8074
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0021 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0108 0.0255
Schistosoma mansoni smad1 5 8 and 0.0016 0.0042 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.005 0.0119
Mycobacterium tuberculosis Probable dehydrogenase 0.0274 0.233 0.2327
Brugia malayi Cathepsin L-like precursor 0.0017 0.005 0.0118
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.0021 0.005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0244 0.0579
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0005 0.0011
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0515 0.1221
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0012
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0005 0.0011
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0005 0.0011
Brugia malayi Thioredoxin reductase 0.012 0.0965 0.2263
Schistosoma mansoni ap endonuclease 0.0059 0.0423 0.0694
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0153 0.1004
Echinococcus granulosus smad 0.0016 0.0042 0.0069
Onchocerca volvulus 0.0014 0.0021 0.005
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0021 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0711 0.1684
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0105 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0489
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0285 0.0468
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0007 0.0017
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0711 0.4785
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0029 0.0067
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0161
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.0021 0.005
Brugia malayi chromobox protein homolog 3 0.0039 0.0245 0.0574
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0274 0.233 0.2327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0186 0.0441
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0021 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0086 0.0549
Leishmania major cysteine peptidase A (CPA) 0.0017 0.005 0.0307
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0423 0.5917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0487 0.4221 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1995 0.4679
Leishmania major cathepsin L-like protease 0.0017 0.005 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.005 0.0119
Echinococcus multilocularis chromobox protein 1 0.0069 0.0515 0.0846
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0042 0.0268 0.1814
Echinococcus granulosus Smad4 0.0016 0.0042 0.0069
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.005 0.052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0268 0.1787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0068
Onchocerca volvulus Phospholipase A2 homolog 0.009 0.0694 0.1627
Loa Loa (eye worm) ctsf protein 0.0017 0.005 0.0118
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0423 0.2861
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1577 0.3735
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0268 0.1787
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0033
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0029 0.0047
Brugia malayi MH2 domain containing protein 0.0016 0.0042 0.0098
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0086 0.0549
Echinococcus granulosus cathepsin l1 0.0017 0.005 0.0082
Leishmania major importin beta-1 subunit, putative 0.0023 0.0105 0.0678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0021 0.005
Brugia malayi Pre-SET motif family protein 0.0428 0.3697 0.8671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0005 0.0011
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0005 0.0008
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.005 0.0082
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.0021 0.0035
Schistosoma mansoni hypothetical protein 0.0126 0.102 0.1675
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0021 0.005
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0271 0.0641
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0457 0.1071
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.005 0.0082
Brugia malayi Cathepsin L-like precursor 0.0017 0.005 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.0178 0.148 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Brugia malayi Latrophilin receptor protein 2 0.0126 0.102 0.2393
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.3697 0.8671
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0005 0.005
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.0021 0.005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0423 0.2831
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0153 0.1004
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0474 0.3183
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0005 0.005
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0021 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.274 0.4499
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.005 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0444 0.0729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0107 0.0254
Trypanosoma cruzi trypanothione reductase, putative 0.012 0.0965 0.6508
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0444 0.0729
Leishmania major cathepsin L-like protease 0.0065 0.0474 0.3183
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0042 0.0268 0.1814
Toxoplasma gondii NADPH-glutathione reductase 0.0042 0.0268 0.1814
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0105 0.0248
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0005 0.005
Onchocerca volvulus 0.0017 0.005 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.005 0.0119
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0042 0.0268 0.5
Brugia malayi beta-lactamase family protein 0.0178 0.148 0.3472
Mycobacterium tuberculosis Probable lipase LipD 0.0178 0.148 0.1476
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0574
Schistosoma mansoni kinase 0.0046 0.0312 0.0512
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.012 0.0965 0.0961
Trichomonas vaginalis D-aminoacylase, putative 0.0178 0.148 0.3506
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0244 0.0579
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0207 0.1367
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0285 0.0468
Loa Loa (eye worm) hypothetical protein 0.0126 0.102 0.2393
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.032 0.274 0.6426
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0305 0.2602 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0423 0.0695
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0178 0.148 0.243
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0268 0.1787
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.274 0.4499
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0245 0.0574
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0005 0.0033
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0021 0.0035
Brugia malayi hypothetical protein 0.0157 0.1294 0.3034
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0126 0.102 0.1675
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0285 0.0723
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0711 0.1667
Schistosoma mansoni chromobox protein 0.0069 0.0515 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0474 0.3183
Brugia malayi Importin beta-1 subunit 0.0029 0.0153 0.0359
Brugia malayi Heterochromatin protein 1 0.0069 0.0515 0.1209
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.1491 0.3497
Echinococcus granulosus GPCR family 2 0.0126 0.102 0.1675
Brugia malayi cathepsin L-like precursor 0.0011 0 0.0001
Loa Loa (eye worm) cysteine protease 0.0017 0.005 0.0118
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.005 0.0082

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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