Detailed information for compound 550231

Basic information

Technical information
  • TDR Targets ID: 550231
  • Name: N-(2-methylbut-2-enylideneamino)-5-nitro-pyri din-2-amine
  • MW: 220.228 | Formula: C10H12N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C(/C=NNc1ccc(cn1)[N+](=O)[O-])\C
  • InChi: 1S/C10H12N4O2/c1-3-8(2)6-12-13-10-5-4-9(7-11-10)14(15)16/h3-7H,1-2H3,(H,11,13)
  • InChiKey: XGZWMLBCQAUOQB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-methylbut-2-enylideneamino)-5-nitro-2-pyridinamine
  • (2-methylbut-2-enylideneamino)-(5-nitro-2-pyridyl)amine
  • N-(2-methylbut-2-enylideneamino)-5-nitropyridin-2-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Curated by TDR Targets References
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 165 aa 143 aa 34.3 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 159 aa 140 aa 37.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.016 0.1362
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0012 0.023
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0147 0.016 0.1362
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0017 0.0295
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.011 0.0107 0.0103
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0041 0.1741
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0041 0.1741
Loa Loa (eye worm) hypothetical protein 0.0244 0.0298 0.327
Loa Loa (eye worm) twinkle helicase 0.023 0.0278 0.3054
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0017 0.019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0024 0.0047
Brugia malayi MH2 domain containing protein 0.0134 0.0141 0.2605
Loa Loa (eye worm) hypothetical protein 0.0147 0.016 0.1756
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0043 0.0012 0.023
Loa Loa (eye worm) hypothetical protein 0.011 0.0107 0.1177
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0037 0.0227
Loa Loa (eye worm) oxidoreductase 0.0043 0.0012 0.0137
Entamoeba histolytica Ran family GTPase 0.0047 0.0017 0.0328
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0017 0.0295
Plasmodium vivax importin-beta 2, putative 0.0063 0.0041 0.1741
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0141 0.1547
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0043 0.0012 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0024 1
Plasmodium falciparum importin beta, putative 0.0063 0.0041 0.1741
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0017 0.001
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0159 0.0177 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0806 0.1097 1
Trypanosoma cruzi DNA repair protein, putative 0.0069 0.005 0.2259
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0415 0.0541 0.4878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0024 0.0047
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0012 0.0009
Trichomonas vaginalis ran, putative 0.0047 0.0017 0.4184
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0159 0.0177 1
Echinococcus granulosus microtubule associated protein 2 0.3591 0.5058 1
Chlamydia trachomatis replicative DNA helicase 0.0806 0.1097 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.0099 0.0095
Schistosoma mansoni importin beta-1 0.0063 0.0041 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.016 0.1362
Mycobacterium ulcerans recombinase A 0.0225 0.0271 0.2384
Loa Loa (eye worm) hypothetical protein 0.011 0.0107 0.1177
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0141 0.1547
Brugia malayi Importin beta-1 subunit 0.0063 0.0041 0.0758
Brugia malayi RNA, U transporter 1 0.018 0.0207 0.3823
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0147 0.016 0.1362
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0806 0.1097 0.3269
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.016 0.8985
Onchocerca volvulus 0.0147 0.016 0.5169
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.0285 0.3128
Brugia malayi AMP-binding enzyme family protein 0.0147 0.016 0.2957
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0022 0.0043
Echinococcus granulosus snurportin 1 0.0676 0.0912 0.1782
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0012 0.0009
Plasmodium falciparum acyl-CoA synthetase 0.011 0.0107 0.577
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0024 0.0262
Brugia malayi dihydrofolate reductase family protein 0.0415 0.0541 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0037 0.1499
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0024 0.0023
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0159 0.0177 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.016 0.8985
Leishmania major GTP-binding protein, putative 0.0047 0.0017 0.0295
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0415 0.0541 0.0538
Schistosoma mansoni dihydrofolate reductase 0.0415 0.0541 0.107
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0012 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.0099 0.0095
Mycobacterium ulcerans fatty-acid-CoA ligase 0.011 0.0107 0.0874
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0012 0.023
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.0608 0.1181
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0041 0.1741
Schistosoma mansoni hypothetical protein 0.0676 0.0912 0.1802
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0023 0.0248
Loa Loa (eye worm) hypothetical protein 0.0147 0.016 0.1756
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0017 0.5
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0159 0.0177 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0017 0.001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0017 0.0295
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0159 0.0177 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.0099 0.0095
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0012 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0147 0.016 0.0156
Schistosoma mansoni microtubule-associated protein tau 0.3591 0.5058 1
Treponema pallidum replicative DNA helicase (dnaB) 0.0806 0.1097 1
Echinococcus granulosus dihydrofolate reductase 0.0415 0.0541 0.1048
Mycobacterium ulcerans hypothetical protein 0.0147 0.016 0.1362
Echinococcus granulosus neuropeptide s receptor 0.0462 0.0608 0.1181
Brugia malayi hypothetical protein 0.0244 0.0298 0.5507
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0024 0.0023
Entamoeba histolytica hypothetical protein 0.0051 0.0024 0.0785
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.6486 0.9174 0.9174
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0017 0.0295
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0037 0.1499
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0037 0.0227
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0159 0.0177 1
Onchocerca volvulus 0.0051 0.0024 0.04
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0023 0.0418
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.0608 0.1181
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0037 0.0073
Leishmania major importin beta-1 subunit, putative 0.0051 0.0024 0.0705
Brugia malayi follicle stimulating hormone receptor 0.0235 0.0285 0.5267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0023 0.0418
Echinococcus granulosus tumor protein p63 0.0339 0.0434 0.0835
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0043 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0147 0.016 0.1756
Entamoeba histolytica acyl-CoA synthetase, putative 0.0147 0.016 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.016 0.8985
Onchocerca volvulus 0.005 0.0022 0.0324
Loa Loa (eye worm) hypothetical protein 0.005 0.0022 0.0238
Loa Loa (eye worm) hypothetical protein 0.005 0.0023 0.0248
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0017 0.0295
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0043 0.0012 0.0009
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0024 0.0705
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0037 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0012 0.0009
Onchocerca volvulus Huntingtin homolog 0.0244 0.0298 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0037 0.0049
Echinococcus granulosus importin subunit beta 1 0.0063 0.0041 0.0057
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0415 0.0541 0.1595
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.0099 0.0095
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0147 0.016 0.1362
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0012 0.023
Schistosoma mansoni acetyl-CoA synthetase 0.0043 0.0012 0.0025
Entamoeba histolytica acyl-coA synthetase, putative 0.0147 0.016 1
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0012 0.023
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0043 0.0012 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.3591 0.5058 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0024 0.0047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0147 0.016 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.016 0.1362
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0069 0.005 0.2259
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0137
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0137
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0676 0.0912 1
Chlamydia trachomatis recombinase RecA 0.0225 0.0271 0.1655
Echinococcus multilocularis dihydrofolate reductase 0.0415 0.0541 0.1048
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0024 0.0023
Schistosoma mansoni ran 0.0047 0.0017 0.0034
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0024 1
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0024 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0147 0.016 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.011 0.0107 0.1177
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.016 0.0445
Plasmodium vivax acyl-CoA synthetase, putative 0.011 0.0107 0.577
Loa Loa (eye worm) hypothetical protein 0.011 0.0107 0.1177
Schistosoma mansoni Replicative DNA helicase 0.0806 0.1097 0.2169
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0225 0.0271 0.078
Loa Loa (eye worm) hypothetical protein 0.0244 0.0298 0.327
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0024 0.0441
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0012 0.0009
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.0608 0.1181
Mycobacterium leprae Conserved hypothetical protein 0.2376 0.3329 1
Onchocerca volvulus Huntingtin homolog 0.0244 0.0298 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0037 0.0227
Echinococcus multilocularis tumor protein p63 0.0339 0.0434 0.0835
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0043 0.0012 0.0009
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0017 0.032
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0012 0.023
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0037 0.0033
Trypanosoma cruzi DNA repair protein, putative 0.0069 0.005 0.2259
Loa Loa (eye worm) hypothetical protein 0.0063 0.0041 0.045
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0017 0.0295
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.178 0.2482 0.4894
Brugia malayi AMP-binding enzyme family protein 0.0147 0.016 0.2957
Loa Loa (eye worm) hypothetical protein 0.011 0.0107 0.1177
Brugia malayi AMP-binding enzyme family protein 0.0147 0.016 0.2957
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.016 0.0445
Schistosoma mansoni ran 0.0047 0.0017 0.0034
Echinococcus multilocularis snurportin 1 0.0676 0.0912 0.1782
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0147 0.016 0.1362
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0043 0.0012 0.0009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0037 0.0049
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0806 0.1097 1
Chlamydia trachomatis dihydrofolate reductase 0.0415 0.0541 0.4387
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0043 0.0012 0.0009
Loa Loa (eye worm) dihydrofolate reductase 0.0415 0.0541 0.5939
Brugia malayi Dihydrofolate reductase 0.0415 0.0541 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 256134  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10579848 10991861 11754594 12467708 12699390 12832132 14998335 15026078 15115391 15214795 15974594 17010625 9554874
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium avium 256134  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10052907 10991861 14998335 7486934 8913480 9835537
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 256134  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10052907 11597474 12384337
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium avium 5868  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10052907 10991861 14998335 7486934 8913480 9835537
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 5868  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10579848 10991861 11754594 12467708 12699390 12832132 14998335 15026078 15115391 15214795 15974594 17010625 9554874
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 5868  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10052907 11597474 12384337

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

19 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.