Detailed information for compound 550359

Basic information

Technical information
  • TDR Targets ID: 550359
  • Name: [(2R,3S)-3-hydroxy-5-(5-iodo-2,4-dioxo-pyrimi din-1-yl)tetrahydrofuran-2-yl]methyl dihydrog en phosphate
  • MW: 434.078 | Formula: C9H12IN2O8P
  • H donors: 4 H acceptors: 6 LogP: -2.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CC(O[C@@H]1COP(=O)(O)O)n1cc(I)c(=O)[nH]c1=O
  • InChi: 1S/C9H12IN2O8P/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18)/t5-,6+,7?/m0/s1
  • InChiKey: WXFYBFRZROJDLL-GFCOJPQKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(2R,3S)-3-hydroxy-5-(5-iodo-2,4-dioxo-1-pyrimidinyl)-2-tetrahydrofuranyl]methyl dihydrogen phosphate
  • [(2R,3S)-3-hydroxy-5-(5-iodo-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
  • [(2R,3S)-3-hydroxy-5-(5-iodo-2,4-diketo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate
  • [(2R,3S)-3-hydroxy-5-(5-iodo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
  • iododeoxyuridylate
  • 1763-02-6
  • 5'-Uridylic acid, 2'-deoxy-5-iodo-
  • 5-Iodo-2'-deoxyuridine 5'-monophosphate
  • 5-Iodo-dump
  • IdUMP

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0078 0.0388
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0211 0.1065
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0096 0.0242 0.073
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0078 0.0388
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0015 0.0003 0.0009
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0681 0.1966 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Echinococcus granulosus muscleblind protein 0.0147 0.0393 0.0545
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0155 0.0214
Trypanosoma cruzi trypanothione reductase, putative 0.0157 0.0421 0.3799
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0077 0.0672
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0054 0.0119 0.1065
Echinococcus granulosus GPCR family 2 0.0049 0.0105 0.0144
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0188 0.0949
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0015 0.0003 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0063 0.0086
Mycobacterium ulcerans thymidylate synthase 0.0389 0.1106 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0003 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0681 0.1966 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0211 0.0638
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0067 0.0155 0.047
Brugia malayi Carboxylesterase family protein 0.0192 0.0524 0.1586
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0054 0.0119 0.0164
Echinococcus multilocularis peregrin 0.0031 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.013
Schistosoma mansoni hypothetical protein 0.0366 0.1037 0.3137
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.0155 0.0154
Brugia malayi beta-lactamase family protein 0.004 0.0077 0.0234
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0039 0.0337
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0087 0.0119
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.005 0.044
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0077 0.0076
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0054 0.0119 0.1065
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.0155 0.0214
Schistosoma mansoni hypothetical protein 0.0053 0.0114 0.0342
Echinococcus granulosus sex peptide receptor 0.0067 0.0155 0.0214
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0077 0.0234
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0155 0.0466
Schistosoma mansoni hypothetical protein 0.0366 0.1037 0.3137
Mycobacterium ulcerans aldehyde dehydrogenase 0.0015 0.0003 0.0014
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0051 0.0155
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.004 0.0077 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0139 0.0417
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0021
Schistosoma mansoni BC026374 protein (S09 family) 0.0192 0.0524 0.1583
Loa Loa (eye worm) acetylcholinesterase 1 0.1135 0.3303 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0077 0.0386
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.042 0.1271
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0389 0.1106 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0211 0.1853
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0124 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.0155 0.0154
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0114 0.0346
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0015 0.0003 0.0008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0188 0.0949
Brugia malayi Carboxylesterase family protein 0.0192 0.0524 0.1586
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) hypothetical protein 0.0192 0.0524 0.1586
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0078 0.0696
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0015 0.0003 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0003 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0077 0.0687
Onchocerca volvulus 0.0067 0.0155 0.1392
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0026 0.0073
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0067 0.0155 0.047
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0155 0.0214
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0067 0.0202
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0015 0.0003 0.0014
Onchocerca volvulus 0.0067 0.0155 0.1392
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0003 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0015 0.0003 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0155 0.0154
Brugia malayi Carboxylesterase family protein 0.0192 0.0524 0.1586
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0015 0.0003 0.0014
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0067 0.0155 0.0214
Echinococcus multilocularis serotonin receptor 0.0067 0.0155 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.005 0.0147
Brugia malayi beta-lactamase 0.004 0.0077 0.0234
Onchocerca volvulus 0.0192 0.0524 0.4731
Trypanosoma brucei unspecified product 0.0016 0.0005 0.0032
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0164 0.1439
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0015 0.0003 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0026 0.0024
Loa Loa (eye worm) thymidylate synthase 0.0389 0.1106 0.3348
Schistosoma mansoni cpg binding protein 0.007 0.0164 0.0491
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0078 0.0235
Schistosoma mansoni amine GPCR 0.0067 0.0155 0.0466
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0192 0.0524 0.1583
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.0155 0.0214
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0054 0.0119 0.1065
Onchocerca volvulus 0.0067 0.0155 0.1392
Loa Loa (eye worm) hypothetical protein 0.004 0.0077 0.0234
Echinococcus multilocularis thioredoxin glutathione reductase 0.0157 0.0421 0.042
Plasmodium falciparum phd finger protein, putative 0.0031 0.0051 0.0451
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.005 0.0049
Onchocerca volvulus 0.0029 0.0043 0.0376
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0077 0.0687
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0078 0.3644
Echinococcus granulosus dna polymerase kappa 0.0023 0.0026 0.0034
Schistosoma mansoni opsin-like receptor 0.0067 0.0155 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Echinococcus multilocularis dro:myosuppressin receptor 0.0067 0.0155 0.0154
Loa Loa (eye worm) programmed cell death 8 0.0014 0.0001 0.0005
Schistosoma mansoni neuropeptide f receptor 76f 0.0067 0.0155 0.0466
Onchocerca volvulus 0.0053 0.0114 0.1021
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0051 0.0445
Echinococcus granulosus L aminoadipate semialdehyde 0.0096 0.0242 0.0336
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0148 0.0449
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0211 0.0292
Brugia malayi hypothetical protein 0.0185 0.0505 0.1528
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0014 0.0001 0.0007
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0015 0.0003 0.0014
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0005 0.0031
Echinococcus granulosus geminin 0.0366 0.1037 0.1444
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0188 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0081 0.0245
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0031
Brugia malayi putative neuropeptide receptor NPR1 0.0067 0.0155 0.047
Loa Loa (eye worm) melatonin receptor type 1A 0.0067 0.0155 0.047
Brugia malayi glutamate synthase 0.0014 0.0001 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0063 0.0188
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0398 0.1131 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.0155 0.0466
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0067 0.059
Onchocerca volvulus 0.0067 0.0155 0.1392
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Toxoplasma gondii ABC1 family protein 0.004 0.0077 0.0687
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0039 0.019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0155 0.0154
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.0155 0.0154
Schistosoma mansoni hypothetical protein 0.0049 0.0105 0.0313
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0077 0.0106
Echinococcus multilocularis para nitrobenzyl esterase 0.0192 0.0524 0.0523
Loa Loa (eye worm) hypothetical protein 0.1135 0.3303 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0192 0.0524 0.4628
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0067 0.0155 0.047
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0067 0.059
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0155 0.0214
Trypanosoma brucei trypanothione reductase 0.0157 0.0421 0.3799
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.0155 0.0214
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.0155 0.0154
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0188 0.1688
Schistosoma mansoni DNA polymerase eta 0.0023 0.0026 0.0073
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0015 0.0003 0.0014
Onchocerca volvulus 0.0067 0.0155 0.1392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0155 0.0154
Echinococcus granulosus neuropeptide receptor 0.0067 0.0155 0.0214
Treponema pallidum fructose-bisphosphate aldolase 0.0681 0.1966 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0139 0.0422
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0259 0.0359
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0067 0.0155 0.0154
Schistosoma mansoni hypothetical protein 0.0067 0.0155 0.0466
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0026 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0026 0.0078
Mycobacterium tuberculosis Hypothetical protein 0.0185 0.0505 0.4456
Onchocerca volvulus 0.004 0.0077 0.0687
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.053 0.16
Echinococcus multilocularis carboxylesterase 5A 0.1135 0.3303 0.3302
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0054 0.0119 0.1065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Plasmodium falciparum thioredoxin reductase 0.0157 0.0421 0.3803
Leishmania major trypanothione reductase 0.0157 0.0421 0.3799
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0067 0.0155 0.0154
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0054 0.0119 0.0585
Leishmania major DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0067 0.0155 0.1392
Schistosoma mansoni neuropeptide receptor 0.0067 0.0155 0.0466
Echinococcus granulosus orexin receptor type 2 0.0067 0.0155 0.0214
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.0155 0.0214
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0015 0.0003 0.0014
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0067 0.0065
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0014 0.0001 0.0005
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0389 0.1106 0.9782
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.053 0.0736
Schistosoma mansoni aldehyde dehydrogenase 0.0272 0.076 0.2296
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0031
Schistosoma mansoni inositol monophosphatase 0.0078 0.0188 0.0565
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0389 0.1106 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0015 0.0003 0.0075
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.0155 0.0214
Schistosoma mansoni cpg binding protein 0.007 0.0164 0.0491
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0003 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0119 0.1065
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0005 0.0031
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0054 0.0119 0.1071
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0067 0.0155 0.0466
Echinococcus multilocularis geminin 0.0366 0.1037 0.1036
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0067 0.0155 0.047
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0015 0.0003 0.0002
Brugia malayi G-protein coupled receptor 0.0067 0.0155 0.047
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0015 0.0003 0.0014
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0015 0.0003 0.0014
Brugia malayi hypothetical protein 0.0035 0.0063 0.0192
Echinococcus granulosus peptide allatostatin:somatostatin 0.0067 0.0155 0.0214
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0015 0.0003 0.0014
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0015 0.0003 0.0014
Mycobacterium leprae conserved hypothetical protein 0.004 0.0077 0.0672
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0105 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0067 0.0155 0.047
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0078 0.069
Schistosoma mansoni acetylcholinesterase 0.0192 0.0524 0.1583
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.001 0.0012
Onchocerca volvulus 0.0067 0.0155 0.1392
Onchocerca volvulus 0.0192 0.0524 0.4731
Loa Loa (eye worm) glutathione reductase 0.0157 0.0421 0.1275
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0155 0.0214
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0039 0.0343
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0015 0.0003 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0003 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.053 0.1603
Loa Loa (eye worm) hypothetical protein 0.0192 0.0524 0.1586
Leishmania major DNA polymerase eta, putative 0.0023 0.0026 0.0219
Onchocerca volvulus 0.0067 0.0155 0.1392
Brugia malayi Dopamine receptor protein 2 0.0067 0.0155 0.047
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0015 0.0003 0.0002
Loa Loa (eye worm) beta-lactamase 0.004 0.0077 0.0234
Brugia malayi G protein-coupled receptor 0.0067 0.0155 0.047
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0067 0.0155 0.0154
Onchocerca volvulus 0.0067 0.0155 0.1392
Leishmania major hypothetical protein, conserved 0.004 0.0077 0.0687
Onchocerca volvulus 0.0067 0.0155 0.1392
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0015 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) inositol-1 0.0078 0.0188 0.0569
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0005 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0505 0.2561
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0039 0.0337
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0211 0.1895
Echinococcus multilocularis cpg binding protein 0.007 0.0164 0.0162
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0015 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0005
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.0155 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Echinococcus multilocularis lamin 0.0029 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0211 0.19
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0681 0.1966 1
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0077 0.0672
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0077 0.0672
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0015 0.0003 0.0009
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Plasmodium vivax SET domain protein, putative 0.0031 0.005 0.0447
Schistosoma mansoni amine GPCR 0.0067 0.0155 0.0466
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0306 0.0925
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0333 0.0939 0.8308
Echinococcus multilocularis musashi 0.0029 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Onchocerca volvulus 0.0192 0.0524 0.4731
Echinococcus multilocularis L aminoadipate semialdehyde 0.0096 0.0242 0.0241
Brugia malayi Aldehyde dehydrogenase protein 4 0.0015 0.0003 0.0009
Brugia malayi Muscleblind-like protein 0.0147 0.0393 0.1189
Brugia malayi MH2 domain containing protein 0.0118 0.0306 0.0925
Echinococcus granulosus 7tm_1 domain containing protein 0.0067 0.0155 0.0214
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0067 0.0155 0.0154
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0015 0.0003 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0681 0.1966 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0192 0.0524 0.0523
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0192 0.0524 0.1583
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0081 0.0241
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0067 0.0197
Echinococcus multilocularis dnaJ subfamily B 0.048 0.1373 0.1372
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0681 0.1966 1
Echinococcus multilocularis neuroligin 0.0192 0.0524 0.0523
Echinococcus granulosus BC026374 protein S09 family 0.0192 0.0524 0.0728
Schistosoma mansoni amine GPCR 0.0067 0.0155 0.0466
Echinococcus multilocularis neuropeptide receptor 0.0067 0.0155 0.0154
Schistosoma mansoni aldehyde dehydrogenase 0.0272 0.076 0.2296
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0155 0.0214
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0015 0.0003 0.0014
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0124 0.0171
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.005 0.0049
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0054 0.0119 0.1065
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0155 0.0154
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0358 0.1013 0.8958
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0026 0.0219
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0315
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0043 0.0057
Schistosoma mansoni opsin-like receptor 0.0067 0.0155 0.0466
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0005 0.003
Echinococcus granulosus neuropeptide FF receptor 2 0.0067 0.0155 0.0214
Brugia malayi GnHR receptor homolog 0.0067 0.0155 0.047
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0026 0.0219
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.0329 0.2967
Plasmodium falciparum glutathione reductase 0.0054 0.0119 0.1071
Echinococcus multilocularis somatostatin receptor 0.0067 0.0155 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0155 0.0154
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0139 0.0422
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0014 0.0001 0.0005
Brugia malayi neuropeptide F receptor 0.0067 0.0155 0.047
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0259 0.0258
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0105 0.0103
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0026 0.0123
Echinococcus granulosus g-protein coupled receptor 0.0067 0.0155 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0051 0.0049
Schistosoma mansoni microtubule-associated protein tau 0.0736 0.2129 0.6443
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0077 0.0386
Loa Loa (eye worm) hypothetical protein 0.0192 0.0524 0.1586
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0192 0.0524 0.4628
Brugia malayi Tachykinin-like peptides receptor 99D 0.0067 0.0155 0.047
Leishmania major aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Onchocerca volvulus 0.0066 0.0153 0.1369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0003 0.0007
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0046 0.0392
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0188 0.1688
Echinococcus multilocularis G protein coupled receptor 139 0.0067 0.0155 0.0154
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0078
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0054 0.0119 0.1065
Echinococcus multilocularis lamin dm0 0.0029 0.0043 0.0042
Loa Loa (eye worm) RNA binding protein 0.0061 0.0139 0.0422
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.005 0.0147
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0105 0.0317
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0192 0.0524 0.266
Brugia malayi Serotonin receptor 0.0067 0.0155 0.047
Brugia malayi beta-lactamase family protein 0.004 0.0077 0.0234
Schistosoma mansoni alpha-1 adrenergic receptor 0.0067 0.0155 0.0466
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0067 0.0155 0.0466
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0067 0.0332
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0078 0.069
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0211 0.104
Echinococcus granulosus microtubule associated protein 2 0.0736 0.2129 0.2965
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0087 0.0085
Brugia malayi aldehyde dehydrogenase 0.0015 0.0003 0.0009
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0015 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) hypothetical protein 0.0147 0.0393 0.1189
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0054 0.0119 0.1065
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0054 0.0119 0.1071
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0015 0.0003 0.0014
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0015 0.0003 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0157 0.0421 0.0585
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0005 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0155 0.0214
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.0155 0.047
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0039 0.0185
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.0107 0.0274 0.083
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0315
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0067 0.0065
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.001 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0077 0.0386
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0003 0.0005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0067 0.0155 0.0154
Schistosoma mansoni cpg binding protein 0.0066 0.0153 0.0458
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0389 0.1106 1
Schistosoma mansoni hypothetical protein 0.0049 0.0105 0.0313
Schistosoma mansoni amine GPCR 0.0067 0.0155 0.0466
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0124 0.1085
Chlamydia trachomatis UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 0.0697 0.2012 1
Schistosoma mansoni biogenic amine receptor 0.0067 0.0155 0.0466
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0015 0.0003 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0119 0.1065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Mycobacterium tuberculosis Probable dehydrogenase 0.0358 0.1013 0.8958
Brugia malayi G-protein coupled receptor 0.0067 0.0155 0.047
Giardia lamblia PHD finger protein 15 0.0031 0.0051 0.025
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Echinococcus granulosus acetylcholinesterase 0.1135 0.3303 0.4602
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0051 0.0069
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0039 0.0337
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0155 0.0214
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0067 0.0155 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0139 0.0417
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0389 0.1106 0.9782
Loa Loa (eye worm) hypothetical protein 0.004 0.0077 0.0234
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0046 0.0407
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.004 0.0077 0.0232
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0015 0.0003 0.0014
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0015 0.0003 0.0014
Schistosoma mansoni hypothetical protein 0.0031 0.0051 0.0149
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0054 0.0119 0.1065
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0054 0.0119 0.5621
Echinococcus multilocularis muscleblind protein 0.0147 0.0393 0.0391
Schistosoma mansoni hypothetical protein 0.0067 0.0155 0.0466
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0315
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0014 0.0001 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0067 0.0332
Schistosoma mansoni ap endonuclease 0.004 0.0078 0.0231
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0015 0.0003 0.0014
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0054 0.0119 0.1042
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0039 0.033
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.0155 0.047
Giardia lamblia Fructose-bisphosphate aldolase 0.0681 0.1966 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0155 0.0154
Echinococcus granulosus lamin 0.0029 0.0043 0.0058
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0067 0.0155 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.005 0.0147
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.0012
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0389 0.1106 0.3345
Mycobacterium tuberculosis Conserved protein 0.004 0.0077 0.0672
Echinococcus granulosus peregrin 0.0031 0.0051 0.0069
Echinococcus multilocularis neuropeptide receptor A26 0.245 0.7176 0.7176
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0119 0.1065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0054 0.0119 0.1065
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0078 0.069
Treponema pallidum gamma-glutamyl phosphate reductase 0.0015 0.0003 0.0008
Schistosoma mansoni myosin xvIII 0.0067 0.0155 0.0466
Echinococcus multilocularis orexin receptor type 2 0.0067 0.0155 0.0154
Mycobacterium ulcerans carboxylesterase, LipT 0.0192 0.0524 0.4731
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0139 0.0417
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0067 0.0332
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0067 0.0155 0.0466
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0015 0.0003 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Echinococcus granulosus somatostatin receptor 0.0067 0.0155 0.0214
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0153 0.0462
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0398 0.1131 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0185 0.0505 0.4556
Schistosoma mansoni histamine h1 receptor 0.0067 0.0155 0.0466
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Echinococcus granulosus dnaJ subfamily B 0.048 0.1373 0.1912
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0202
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0067 0.059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0155 0.0154
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0393 0.0391
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0155 0.0466
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0031
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.0155 0.0214
Schistosoma mansoni lamin 0.0029 0.0043 0.0126
Brugia malayi larval opioid receptor 0.0067 0.0155 0.047
Schistosoma mansoni opsin-like receptor 0.0067 0.0155 0.0466
Brugia malayi hypothetical protein 0.0121 0.0315 0.0953
Loa Loa (eye worm) hypothetical protein 0.0121 0.0315 0.0953
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0157 0.0421 0.3716
Echinococcus granulosus tar DNA binding protein 0.0061 0.0139 0.0192
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0015 0.0003 0.0014
Schistosoma mansoni lamin 0.0029 0.0043 0.0126
Mycobacterium tuberculosis Conserved protein 0.004 0.0077 0.0672
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0054 0.0119 0.0118
Echinococcus granulosus neuropeptide receptor 0.0067 0.0155 0.0214
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0051 0.0153
Echinococcus granulosus hypothetical protein 0.0067 0.0155 0.0214
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0015 0.0003 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0105 0.0144
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Brugia malayi Pre-SET motif family protein 0.0031 0.005 0.0152
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0126
Echinococcus multilocularis neuropeptide receptor 0.0067 0.0155 0.0154
Entamoeba histolytica hypothetical protein 0.0027 0.0039 0.019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0067 0.0155 0.0214
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.0715 0.6322
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0078 0.0388
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0015 0.0003 0.0014
Mycobacterium ulcerans lipase LipD 0.004 0.0077 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Echinococcus granulosus fmrfamide receptor 0.0067 0.0155 0.0214
Onchocerca volvulus 0.0067 0.0155 0.1392
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0005 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0063 0.0062
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0124 0.1085
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0005 0.0032
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0192 0.0524 0.1586
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0015 0.0003 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0077 0.0386
Schistosoma mansoni biogenic amine receptor 0.0067 0.0155 0.0466
Plasmodium falciparum glutathione reductase 0.0157 0.0421 0.3803
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0003 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0077 0.023
Echinococcus granulosus tachykinin peptides receptor 99D 0.0067 0.0155 0.0214
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0015 0.0003 0.0008
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0333 0.0939 0.8308
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0015 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0049 0.0105 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0389 0.1106 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0078 0.069
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0014 0.0001 0.0005
Echinococcus granulosus acetylcholinesterase 0.1135 0.3303 0.4602
Echinococcus granulosus lamin dm0 0.0029 0.0043 0.0058
Loa Loa (eye worm) hypothetical protein 0.0147 0.0393 0.1189
Loa Loa (eye worm) aldehyde dehydrogenase 0.0015 0.0003 0.0009
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0043 0.013
Brugia malayi Dopamine receptor protein 1 0.0067 0.0155 0.047
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0077 0.0687
Brugia malayi glutathione reductase 0.0157 0.0421 0.1275
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0054 0.0119 0.1065
Echinococcus multilocularis microtubule associated protein 2 0.0736 0.2129 0.2127
Brugia malayi Carboxylesterase family protein 0.1135 0.3303 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0211 0.0209
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0015 0.0003 0.0008
Brugia malayi Melatonin receptor type 1A 0.0067 0.0155 0.047
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Echinococcus granulosus 7TM GPCR rhodopsin 0.0067 0.0155 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0015 0.0003 0.0014
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0188 0.1688
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0081 0.0241
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0015 0.0003 0.0014
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0067 0.0091
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0054 0.0119 0.1065
Mycobacterium tuberculosis Probable reductase 0.0358 0.1013 0.8958
Plasmodium vivax ferrodoxin reductase, putative 0.0014 0.0001 0.0007
Trichomonas vaginalis mercuric reductase, putative 0.0054 0.0119 0.0599
Brugia malayi Probable ClpP-like protease 0.0085 0.0211 0.0638
Mycobacterium tuberculosis Carboxylesterase LipT 0.0192 0.0524 0.4628
Brugia malayi Thioredoxin reductase 0.0157 0.0421 0.1275
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0039 0.0343
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.0155 0.0154
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0067 0.0155 0.047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0051 0.0451
Leishmania major aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Onchocerca volvulus 0.0067 0.0155 0.1392
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0294 0.0825 0.2497
Plasmodium falciparum thioredoxin reductase 0.0054 0.0119 0.1071
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0653 0.3315
Trichomonas vaginalis glutathione reductase, putative 0.0054 0.0119 0.0599
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0155 0.0154
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0067 0.0155 0.047
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Brugia malayi TAR-binding protein 0.0061 0.0139 0.0422
Mycobacterium tuberculosis Probable oxidoreductase 0.0398 0.1131 1
Brugia malayi PHD-finger family protein 0.0031 0.0051 0.0153
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0105 0.0317
Echinococcus multilocularis BC026374 protein (S09 family) 0.0192 0.0524 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0155 0.0154
Echinococcus multilocularis dna polymerase eta 0.0023 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0026 0.0219
Onchocerca volvulus 0.0067 0.0155 0.1392
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0139 0.0417
Schistosoma mansoni adenoreceptor 0.0067 0.0155 0.0466
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0078 0.0696
Echinococcus granulosus dna polymerase eta 0.0023 0.0026 0.0034
Echinococcus granulosus cpg binding protein 0.007 0.0164 0.0226
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0015 0.0003 0.0014
Toxoplasma gondii exonuclease III APE 0.004 0.0078 0.069
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0015 0.0003 0.0014
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0398 0.1131 1
Schistosoma mansoni hypothetical protein 0.0107 0.0274 0.0826
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0014 0.0001 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Echinococcus multilocularis acetylcholinesterase 0.1135 0.3303 0.3302
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Mycobacterium tuberculosis Conserved protein 0.004 0.0077 0.0672
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0272 0.076 0.6865
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0389 0.1106 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0358 0.1013 0.8958
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0005 0.0032
Brugia malayi jmjC domain containing protein 0.0041 0.0081 0.0245
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.007 0.0068
Echinococcus granulosus neuropeptide s receptor 0.245 0.7176 1
Brugia malayi Pre-SET motif family protein 0.0207 0.0569 0.1723
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0211 0.1895
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0015 0.0003 0.0002
Schistosoma mansoni neuropeptide receptor 0.0067 0.0155 0.0466
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0155 0.0466
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0054 0.0119 0.1065
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0054 0.0119 0.5621
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) hypothetical protein 0.004 0.0077 0.0234
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.0155 0.0466
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0046 0.0407
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Brugia malayi follicle stimulating hormone receptor 0.0294 0.0825 0.2497
Echinococcus multilocularis fmrfamide receptor 0.0067 0.0155 0.0154
Schistosoma mansoni hypothetical protein 0.0067 0.0155 0.0466
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0188
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0681 0.1966 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.005 0.0068
Loa Loa (eye worm) carboxylesterase 0.0192 0.0524 0.1586
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0119 0.1065
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0026 0.0123
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0211 0.0634
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.001 0.0009
Brugia malayi putative neuropeptide receptor 0.0067 0.0155 0.047
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0026 0.0123
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0164 0.1439
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0054 0.0119 0.1065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0153
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0067 0.0155 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0067 0.0332
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0078 0.069
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.0155 0.0154
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0005 0.001
Trypanosoma brucei unspecified product 0.0016 0.0005 0.0032
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0026 0.0219
Schistosoma mansoni survival motor neuron protein 0.0053 0.0114 0.0342
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0015 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Schistosoma mansoni hypothetical protein 0.0049 0.0105 0.0313
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0039 0.1779
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0003 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0054 0.0119 0.1065
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0067 0.059
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0046 0.0225
Brugia malayi Serotonin receptor 0.0067 0.0155 0.047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0155 0.0154
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0015 0.0003 0.0014
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0015 0.0003 0.0014
Echinococcus granulosus intermediate filament protein 0.0029 0.0043 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0155 0.0154
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0096 0.0242 0.0734
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0077 0.0672
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0211 1
Schistosoma mansoni neuropeptide receptor 0.0067 0.0155 0.0466
Brugia malayi RE15519p 0.0067 0.0155 0.047
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0026 0.0219
Loa Loa (eye worm) carboxylesterase 0.1135 0.3303 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0054 0.0119 0.0599
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0105 0.0144
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0003
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0333 0.0939 0.8493
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.0155 0.047
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0015 0.0003 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0026 0.0215
Echinococcus multilocularis allatostatin A receptor 0.0067 0.0155 0.0154
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0026 0.0078
Schistosoma mansoni ap endonuclease 0.004 0.0078 0.0231
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0389 0.1106 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0315 0.0953
Loa Loa (eye worm) hypothetical protein 0.0192 0.0524 0.1586
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0054 0.0119 0.1071
Toxoplasma gondii NADPH-glutathione reductase 0.0054 0.0119 0.1065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0272 0.076 0.6865
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0067 0.0155 0.0154
Schistosoma mansoni growth hormone secretagogue receptor 0.0067 0.0155 0.0466
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0026 0.0078
Onchocerca volvulus Alhambra homolog 0.0031 0.0051 0.0445
Onchocerca volvulus 0.0192 0.0524 0.4731
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0015 0.0003 0.0014
Echinococcus granulosus alpha 1A adrenergic receptor 0.0067 0.0155 0.0214
Schistosoma mansoni biogenic amine receptor 0.0067 0.0155 0.0466
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0315
Onchocerca volvulus 0.0235 0.0653 0.5897
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.004 0.0117
Loa Loa (eye worm) hypothetical protein 0.0192 0.0524 0.1586
Plasmodium vivax hypothetical protein, conserved 0.004 0.0077 0.0693
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.0188 0.8911
Schistosoma mansoni hypothetical protein 0.0049 0.0105 0.0313
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0192 0.0524 0.0728
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0078 0.0388
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0015 0.0003 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0003 0.0005
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0188 0.1688
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0067 0.0155 0.0466
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.042 0.1271
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0077 0.0672
Onchocerca volvulus 0.0029 0.0043 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.053 0.0528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0026 0.0219
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0078 0.0675
Leishmania major aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Brugia malayi sulfakinin receptor protein 0.0067 0.0155 0.047
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0051 0.0149
Schistosoma mansoni intermediate filament proteins 0.0029 0.0043 0.0126
Echinococcus multilocularis acetylcholinesterase 0.1135 0.3303 0.3302
Onchocerca volvulus 0.0096 0.0242 0.2182
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0272 0.076 0.6715
Brugia malayi Carboxylesterase family protein 0.1135 0.3303 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0026 0.0034
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0211 0.104
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0026 0.0219
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0026 0.0073
Onchocerca volvulus 0.0389 0.1106 1
Plasmodium vivax glutathione reductase, putative 0.0157 0.0421 0.3803
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0681 0.1966 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0139 0.0417
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0067 0.0155 0.0466
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.042 0.1271
Brugia malayi intermediate filament protein 0.0029 0.0043 0.013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0272 0.076 0.1057
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0005 0.0003
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.001 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Echinococcus granulosus carboxylesterase 5A 0.1135 0.3303 0.4602
Brugia malayi Bromodomain containing protein 0.0031 0.0051 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0003 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0078 0.0106
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.053 0.16
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0067 0.0155 0.0466
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0026 0.0215
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0373 0.1126
Brugia malayi CXXC zinc finger family protein 0.0066 0.0153 0.0462
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0067 0.0155 0.0154
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0139 0.0422
Onchocerca volvulus Huntingtin homolog 0.0121 0.0315 0.2837
Echinococcus multilocularis neuropeptide s receptor 0.245 0.7176 0.7176
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0014 0.0001 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0306 0.0925
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0155 0.0154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0119 0.1065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0015 0.0003 0.0002
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0015 0.0003 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.005 0.0147
Schistosoma mansoni gliotactin 0.0192 0.0524 0.1583
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0358 0.1013 0.8958
Toxoplasma gondii aldehyde dehydrogenase 0.0272 0.076 0.6865
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0155 0.0214
Brugia malayi hypothetical protein 0.0258 0.072 0.218
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0004 0.0012
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0005 0.0037
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0015 0.0003 0.0014
Treponema pallidum NADH oxidase 0.0054 0.0119 0.0599
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0188 0.0949
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0067 0.0155 0.047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0003 0.0007
Mycobacterium leprae Probable lipase LipE 0.004 0.0077 0.0672
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0067 0.0091
Brugia malayi Carboxylesterase family protein 0.0192 0.0524 0.1586
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.0155 0.047
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0272 0.076 0.6865
Echinococcus granulosus para nitrobenzyl esterase 0.0192 0.0524 0.0728
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0077 0.023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0067 0.0197
Onchocerca volvulus 0.0192 0.0524 0.4731
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0054 0.0119 0.0361
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0039 0.033
Schistosoma mansoni hypothetical protein 0.0067 0.0155 0.0466
Schistosoma mansoni hypothetical protein 0.048 0.1373 0.4155
Onchocerca volvulus Huntingtin homolog 0.0121 0.0315 0.2837
Schistosoma mansoni inositol monophosphatase 0.0078 0.0188 0.0565
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0015 0.0003 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.0155 0.0214
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0274 0.083
Schistosoma mansoni neuropeptide receptor 0.0067 0.0155 0.0466
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.0155 0.0466
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0681 0.1966 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0067 0.0155 0.0214
Echinococcus granulosus serotonin receptor 0.0067 0.0155 0.0214
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0352
Echinococcus multilocularis sex peptide receptor 0.0067 0.0155 0.0154
Loa Loa (eye worm) carboxylesterase 0.0192 0.0524 0.1586
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0211 0.19
Echinococcus granulosus neuropeptide receptor A26 0.245 0.7176 1
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0078 0.0235
Onchocerca volvulus 0.0067 0.0155 0.1392
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0026 0.0219
Echinococcus granulosus g protein coupled receptor 0.0067 0.0155 0.0214
Onchocerca volvulus 0.0067 0.0155 0.1392
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0039 0.0337
Loa Loa (eye worm) hypothetical protein 0.0096 0.0242 0.0734
Toxoplasma gondii hypothetical protein 0.0029 0.0046 0.04
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0155 0.0154
Echinococcus granulosus neuroligin 0.0192 0.0524 0.0728
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0067 0.0155 0.0154
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0155 0.0214
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0043 0.013
Brugia malayi isocitrate dehydrogenase 0.0016 0.0005 0.0015
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0077 0.0687
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0014 0.0001 0.0007
Echinococcus granulosus g protein coupled receptor 0.0067 0.0155 0.0214
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0015 0.0003 0.0002
Trichomonas vaginalis helicase, putative 0.0015 0.0003 0.0007
Onchocerca volvulus Neuropeptide F receptor homolog 0.0067 0.0155 0.1392
Trichomonas vaginalis spcc417.12 protein, putative 0.0192 0.0524 0.266
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0192 0.0524 0.1583
Onchocerca volvulus 0.004 0.0077 0.0687
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0681 0.1966 1
Brugia malayi AKH receptor 0.0067 0.0155 0.047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.0155 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0005 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0155 0.0154
Trichomonas vaginalis esterase, putative 0.004 0.0077 0.0386
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0003 0.0005
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0188 0.1688
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0015 0.0003 0.0014
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.053 0.0736
Echinococcus granulosus allatostatin A receptor 0.0067 0.0155 0.0214
Brugia malayi Dopamine receptor 0.0067 0.0155 0.047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) hypothetical protein 0.1135 0.3303 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.053 0.16
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.0155 0.0466
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0077 0.0672
Onchocerca volvulus 0.004 0.0077 0.0687
Loa Loa (eye worm) hypothetical protein 0.0192 0.0524 0.1586
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0211 0.1895
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0077 0.0234
Echinococcus granulosus thymidylate synthase 0.0389 0.1106 0.1539
Loa Loa (eye worm) thioredoxin reductase 0.0157 0.0421 0.1275
Loa Loa (eye worm) hypothetical protein 0.0156 0.042 0.1271
Echinococcus multilocularis G-protein coupled receptor, putative 0.0067 0.0155 0.0154
Echinococcus granulosus dro:myosuppressin receptor 0.0067 0.0155 0.0214
Trypanosoma brucei unspecified product 0.0023 0.0026 0.0219
Mycobacterium ulcerans hypothetical protein 0.004 0.0077 0.0687
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0078 0.0388
Brugia malayi hypothetical protein 0.0067 0.0155 0.047
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1135 0.3303 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0077 0.0234
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0188 0.1688
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0054 0.0119 0.0356
Brugia malayi jmjC domain containing protein 0.0102 0.0259 0.0785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0119 0.1065
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0272 0.076 0.0758
Giardia lamblia Alcohol dehydrogenase 0.0015 0.0003 0.0008
Mycobacterium ulcerans beta-lactamase 0.004 0.0077 0.0687
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.072 0.1002
Loa Loa (eye worm) TYRA-2 protein 0.0067 0.0155 0.047
Echinococcus multilocularis GPCR, family 2 0.0049 0.0105 0.0103
Plasmodium vivax thioredoxin reductase, putative 0.0157 0.0421 0.3803
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0009
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0081 0.0111
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0188 0.0949
Plasmodium falciparum ferrodoxin reductase-like protein 0.0014 0.0001 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0155 0.0214
Giardia lamblia DINP protein human, muc B family 0.0023 0.0026 0.0123
Brugia malayi hypothetical protein 0.0192 0.0524 0.1586
Brugia malayi thymidylate synthase 0.0389 0.1106 0.3348
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0198 0.0594
Schistosoma mansoni amine GPCR 0.0067 0.0155 0.0466
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0051 0.0445
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0681 0.1966 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0005 0.0015
Onchocerca volvulus 0.0031 0.005 0.044
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0015 0.0003 0.0014
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0067 0.0065
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0054 0.0119 0.1071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0155 0.0466
Echinococcus granulosus g protein coupled receptor 0.0067 0.0155 0.0214
Loa Loa (eye worm) hypothetical protein 0.004 0.0077 0.0234
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0029
Onchocerca volvulus 0.0067 0.0155 0.1392
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Schistosoma mansoni neuroligin 3 (S09 family) 0.0192 0.0524 0.1583
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0077 0.0687
Loa Loa (eye worm) hypothetical protein 0.004 0.0077 0.0234
Brugia malayi neuropeptide F receptor 0.0067 0.0155 0.047
Onchocerca volvulus 0.0067 0.0155 0.1392
Brugia malayi ORL1-like opioid receptor 0.0067 0.0155 0.047
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0067 0.0155 0.047
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0015 0.0003 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0026 0.0219
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0188 0.0186
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0077 0.0672
Echinococcus granulosus G protein coupled receptor 139 0.0067 0.0155 0.0214
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0569 0.1723
Echinococcus multilocularis g-protein coupled receptor 0.0067 0.0155 0.0154
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0015 0.0003 0.0014
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.0155 0.0214
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0039 0.0337
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.072 0.0719
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0152
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0015 0.0003 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.053 0.0528
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0067 0.0155 0.0214
Echinococcus multilocularis thymidylate synthase 0.0389 0.1106 0.1105
Loa Loa (eye worm) hypothetical protein 0.0067 0.0155 0.047
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0022 0.0067
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0358 0.1013 0.8958
Toxoplasma gondii thioredoxin reductase 0.0157 0.0421 0.3799
Loa Loa (eye worm) hypothetical protein 0.0258 0.072 0.218
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0211 0.1895
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0015 0.0003 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0077 0.0386
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.053 0.1603
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0067 0.0155 0.0154
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0139 0.0138
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0124 0.1085
Brugia malayi Inositol-1 0.0078 0.0188 0.0569
Brugia malayi G protein-coupled receptor F59B2.13 0.0067 0.0155 0.047
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0039 0.0337
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0005
Echinococcus multilocularis serotonin receptor 0.0067 0.0155 0.0154
Onchocerca volvulus 0.0067 0.0155 0.1392
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0358 0.1013 0.8958
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0015 0.0003 0.0014
Brugia malayi RNA binding protein 0.0061 0.0139 0.0422
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0119 0.1065
Echinococcus multilocularis fmrfamide receptor 0.0067 0.0155 0.0154
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0067 0.0332
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0272 0.076 0.6865
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0015 0.0003 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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