Detailed information for compound 550758

Basic information

Technical information
  • TDR Targets ID: 550758
  • Name: D 22888
  • MW: 300.356 | Formula: C16H20N4O2
  • H donors: 0 H acceptors: 3 LogP: 2.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c2ccc(nc2n2c(c1=O)c(C)nc2CC)OC
  • InChi: 1S/C16H20N4O2/c1-5-9-19-11-7-8-13(22-4)18-15(11)20-12(6-2)17-10(3)14(20)16(19)21/h7-8H,5-6,9H2,1-4H3
  • InChiKey: PJRYVTGCPZXGEY-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 182282-60-6
  • Imidazo(1,5-a)pyrido(3,2-e)pyrazinone, 1-ethyl-8-methoxy-3-methyl-5-propyl-
  • 1-ethyl-8-methoxy-3-methyl-5-propylimidazo(1,5-a)pyrido(3,2-e)pyrazinone
  • D-22888

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.6873 0.5
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.2771 0.2771
Loa Loa (eye worm) hypothetical protein 0.001 0.056 0.056
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.056 0.056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.8669 0.8669
Loa Loa (eye worm) RecQ helicase 0.0019 0.2771 0.2771
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.6873 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.056 0.0815
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.2771 0.2771
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0472 0.0687
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.8669 0.8669
Echinococcus granulosus bloom syndrome protein 0.0019 0.2771 0.2771
Entamoeba histolytica recQ family DNA helicase 0.001 0.056 0.0815
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.6873 0.6873
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.2771 0.2771
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.6873 0.6873
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.2771 0.2771
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 1 1
Onchocerca volvulus 0.0008 0 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0472 0.0472
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.056 0.056
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.2771 0.2771
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.6873 0.6873
Schistosoma mansoni serine/threonine protein kinase 0.0051 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 1 1
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.2771 0.2771
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.8669 0.8669
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.8669 0.8669
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.6873 0.6873
Schistosoma mansoni DNA helicase recq5 0.0019 0.2771 0.2771
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.6873 0.6873
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.2771 0.2771
Echinococcus multilocularis mitogen activated protein kinase 0.0051 1 1
Schistosoma mansoni ap endonuclease 0.0037 0.6873 0.6873
Toxoplasma gondii exonuclease III APE 0.0037 0.6873 0.6873
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.2771 0.2771
Echinococcus granulosus mitogen activated protein kinase 0.0051 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0051 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.6873 0.6873
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.6873 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.2771 0.2771
Onchocerca volvulus 0.0008 0 0.5
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.2771 0.2771
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.6873 0.6873
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.2771 0.2771
Trichomonas vaginalis CMGC family protein kinase 0.0051 1 1
Schistosoma mansoni ap endonuclease 0.0037 0.6873 0.6873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.8669 0.8669
Entamoeba histolytica recQ family helicase, putative 0.001 0.0472 0.0687
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.2771 0.2771
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.2771 0.2771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.8669 0.8669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.8669 0.8669
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.6873 0.6873
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.2771 0.2771
Trypanosoma brucei protein kinase, putative 0.0051 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.2771 0.4031
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.056 0.056
Entamoeba histolytica recQ family helicase, putative 0.0019 0.2771 0.4031
Schistosoma mansoni DNA helicase recq1 0.0019 0.2771 0.2771
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.6873 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.056 0.056
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.6873 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.6873 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0051 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.056 0.056
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 1 1
Onchocerca volvulus Putative neutral sphingomyelinase 0.0008 0 0.5
Echinococcus multilocularis bloom syndrome protein 0.0019 0.2771 0.2771
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.2771 0.2771
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.6873 0.6873
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.6873 0.6873
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.2771 0.4031
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.2771 0.2771
Treponema pallidum ATP-dependent DNA helicase 0.001 0.056 0.0815
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.6873 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.8669 0.8669
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.2771 0.2771
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.6873 0.6873
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 1 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.2771 0.2771
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.8669 0.8669
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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