TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 337.387 | Formula: C21H20FNO2
H donors: 1 H acceptors: 3 LogP: 5.33 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)c(C(=O)O)c(c(n2)CCCCc1ccccc1)C
InChi: 1S/C21H20FNO2/c1-14-18(10-6-5-9-15-7-3-2-4-8-15)23-19-12-11-16(22)13-17(19)20(14)21(24)25/h2-4,7-8,11-13H,5-6,9-10H2,1H3,(H,24,25)
InChiKey: SXTJZCJVYYJADE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dihydroorotate dehydrogenase (quinone)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530	Get druggable targets OG5_127289	All targets in OG5_127289
Theileria parva	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium berghei	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium falciparum	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Babesia bovis	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium knowlesi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium yoelii	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania major	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Candida albicans	likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin	Get druggable targets OG5_127289	All targets in OG5_127289
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma brucei gambiense	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania donovani	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Schistosoma mansoni	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma congolense	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	Get druggable targets OG5_127289	All targets in OG5_127289
Schistosoma japonicum	ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Neospora caninum	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Candida albicans	likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania braziliensis	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania mexicana	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	dihydroorotate dehydrogenase (quinone)	395 aa	361 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0636	0.0636
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0636	0.1131
Onchocerca volvulus		0.008	0.088	0.3158
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0263	0.3564	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0078	0.0857	0.0857
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0043	0.0342	0.096
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0043	0.0342	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Echinococcus granulosus	neurogenic locus notch protein	0.0025	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.008	0.088	0.088
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.008	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Onchocerca volvulus		0.008	0.088	0.3158
Trichomonas vaginalis	glucosylceramidase, putative	0.0263	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Onchocerca volvulus		0.008	0.088	0.3158
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.008	0.088	0.2469
Echinococcus granulosus	glycine receptor subunit alpha 1	0.008	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0342	0.0609
Echinococcus granulosus	glycine receptor subunit alpha 1	0.008	0.088	0.088
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.008	0.088	0.2469
Schistosoma mansoni	nAChR subunit	0.0037	0.0252	0.0252
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.0857	0.2405
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0037	0.0252	0.0448
Schistosoma mansoni	nAChR subunit	0.008	0.088	0.088
Brugia malayi	Cation transporter family protein	0.008	0.088	0.2469
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Schistosoma mansoni	laminin gamma-3 chain	0.0025	0.0073	0.0073
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.008	0.088	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0342	0.0609
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0037	0.0252	0.0707
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0078	0.0857	0.0857
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.008	0.088	0.1565
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.008	0.088	0.088
Onchocerca volvulus		0.008	0.088	0.3158
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.2641	0.7411
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Echinococcus granulosus	glycine receptor subunit beta	0.008	0.088	0.088
Brugia malayi	hypothetical protein	0.0037	0.0252	0.0707
Schistosoma mansoni	microtubule-associated protein tau	0.0703	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0263	0.3564	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0037	0.0252	0.0252
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.0857	0.2405
Schistosoma mansoni	nAChR subunit	0.008	0.088	0.088
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.2641	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.008	0.088	0.088
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.008	0.088	0.088
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.224	0.6286
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.02	0.2641	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0037	0.0252	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0129
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0636	0.1131
Brugia malayi	hypothetical protein	0.0037	0.0252	0.0707
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.008	0.088	0.2469
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0636	0.1131
Schistosoma mansoni	hypothetical protein	0.0039	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Echinococcus granulosus	glycine receptor subunit beta	0.008	0.088	0.088
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0037	0.0252	0.0252
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.0857	0.2405
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.008	0.088	0.2469
Schistosoma mansoni	cell polarity protein	0.0025	0.0073	0.0073
Onchocerca volvulus		0.008	0.088	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Echinococcus multilocularis	glycine receptor subunit beta	0.008	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.008	0.088	0.2469
Brugia malayi	Cation transporter family protein	0.008	0.088	0.2469
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.008	0.088	0.088
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0037	0.0252	0.0448
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.224	0.6286
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.008	0.088	0.088
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0636	0.0636
Onchocerca volvulus	Glucosylceramidase homolog	0.0173	0.224	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0043	0.0342	0.0342
Brugia malayi	hypothetical protein	0.0037	0.0252	0.0707
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.038	0.038
Brugia malayi	EGF-like domain containing protein	0.0025	0.0073	0.0204
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2376	0.6667
Brugia malayi	hypothetical protein	0.0039	0.0292	0.082
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.008	0.088	0.088
Entamoeba histolytica	hypothetical protein	0.0039	0.0292	0.3407
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.02	0.2641	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0252	0.0707
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.008	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Loa Loa (eye worm)	abnormal epIthelia family member	0.0025	0.0073	0.0129
Brugia malayi	TAR-binding protein	0.0063	0.0636	0.1784
Loa Loa (eye worm)	hypothetical protein	0.0214	0.2852	0.5074
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.038	0.038
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.224	0.6286
Onchocerca volvulus	Putative nachr subunit	0.008	0.088	0.3158
Brugia malayi	RNA binding protein	0.0063	0.0636	0.1784
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0129
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.008	0.088	0.2469
Echinococcus granulosus	nAChR subunit	0.008	0.088	0.088
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0037	0.0252	0.0252
Schistosoma mansoni	neurotransmitter gated ion channel	0.0037	0.0252	0.0252
Echinococcus multilocularis	expressed protein	0.038	0.5278	0.5278
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.02	0.2641	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0292	0.3407
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0263	0.3564	0.634
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.008	0.088	0.088
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0636	0.1784
Schistosoma mansoni	nAChR subunit	0.008	0.088	0.088
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0078	0.0857	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.008	0.088	0.088
Loa Loa (eye worm)	ACC-1 protein	0.008	0.088	0.1565
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.008	0.088	0.088
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.02	0.2641	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0025	0.0073	0.0073
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.008	0.088	0.088
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.008	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0025	0.0073	0.0204
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.008	0.088	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Schistosoma mansoni	nAChR subunit	0.0037	0.0252	0.0252
Echinococcus granulosus	expressed protein	0.038	0.5278	0.5278
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.224	0.6286
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0252	0.0707
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.224	0.6286
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0078	0.0857	0.0857
Echinococcus multilocularis	pikachurin	0.0025	0.0073	0.0073
Entamoeba histolytica	hypothetical protein	0.0039	0.0292	0.3407
Schistosoma mansoni	slit	0.0025	0.0073	0.0073
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.008	0.088	0.2469
Loa Loa (eye worm)	ACC-1 protein	0.008	0.088	0.1565
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0636	0.0636
Onchocerca volvulus		0.008	0.088	0.3158
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0078	0.0857	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0342	0.0609
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0043	0.0342	0.096
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.008	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0129
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.038	0.038
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.0857	0.2405
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0251	0.339	0.6031
Entamoeba histolytica	hypothetical protein	0.0043	0.0342	0.3992
Brugia malayi	laminin alpha chain	0.0025	0.0073	0.0204
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.0857	0.2405
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.038	0.1066
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0037	0.0252	0.0707
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.02	0.2641	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0263	0.3564	1
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.008	0.088	0.088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.038	0.038
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.008	0.088	0.088
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0636	0.0636
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0037	0.0252	0.0252
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0636	0.0636
Echinococcus multilocularis	slit 2 protein	0.0025	0.0073	0.0073
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.008	0.088	0.1565
Echinococcus multilocularis	glycine receptor subunit beta	0.008	0.088	0.088
Trichomonas vaginalis	glucosylceramidase, putative	0.0263	0.3564	1
Echinococcus multilocularis	nAChR subunit	0.0043	0.0342	0.0342
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0037	0.0252	0.0707
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.02	0.2641	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.008	0.088	0.2469
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Loa Loa (eye worm)	LGC-31 protein	0.008	0.088	0.1565
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0037	0.0252	0.0252
Loa Loa (eye worm)	GABA receptor subunit	0.0043	0.0342	0.0609
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0025	0.0073	0.0073
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.008	0.088	0.2469
Echinococcus multilocularis	nAChR subunit	0.008	0.088	0.088
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.008	0.088	0.088
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0078	0.0857	0.0857
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.02	0.2641	1
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0025	0.0073	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0342	0.0609
Echinococcus granulosus	nAChR subunit	0.0043	0.0342	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.224	0.6286
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0043	0.0342	0.096
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.008	0.088	0.088
Brugia malayi	hypothetical protein	0.0025	0.0081	0.0227
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0078	0.0857	0.3032
Brugia malayi	Cation transporter family protein	0.008	0.088	0.2469
Schistosoma mansoni	nAChR subunit	0.008	0.088	0.088
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0043	0.0342	0.096
Echinococcus granulosus	pikachurin	0.0025	0.0073	0.0073
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.02	0.2641	0.5
Echinococcus granulosus	slit 2 protein	0.0025	0.0073	0.0073
Echinococcus multilocularis	microtubule associated protein 2	0.0703	1	1
Schistosoma mansoni	acetylcholine receptor-related	0.0037	0.0252	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0081	0.0144
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.008	0.088	0.2469
Schistosoma mansoni	dihydroorotate dehydrogenase	0.02	0.2641	0.2641
Entamoeba histolytica	hypothetical protein	0.0039	0.0292	0.3407
Schistosoma mansoni	nAChR subunit	0.008	0.088	0.088
Plasmodium falciparum	dihydroorotate dehydrogenase	0.02	0.2641	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.008	0.088	0.2469
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.008	0.088	0.088
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0252	0.0707
Brugia malayi	hypothetical protein	0.0037	0.0252	0.0707
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.008	0.088	0.1565
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.008	0.088	0.088
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0636	0.0636
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.038	0.038
Leishmania major	dihydroorotate dehydrogenase	0.02	0.2641	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0263	0.3564	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.038	0.0676
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.008	0.088	0.088
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0292	0.0292
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.2641	0.7411
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0636	0.0636
Brugia malayi	hypothetical protein	0.0037	0.0252	0.0707
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Schistosoma mansoni	neurotransmitter gated ion channel	0.0037	0.0252	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0263	0.3564	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.008	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0292	0.0292
Brugia malayi	Zinc finger, C2H2 type family protein	0.0078	0.0857	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0342	0.0609
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0251	0.339	0.9512
Onchocerca volvulus		0.0043	0.0342	0.0454
Schistosoma mansoni	neurotransmitter gated ion channel	0.0043	0.0342	0.0342
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0342	0.0609
Schistosoma mansoni	nAChR subunit	0.008	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0342	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0404	0.5621	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.008	0.088	0.088
Onchocerca volvulus		0.0043	0.0342	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0342	0.0609
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.008	0.088	0.1565
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.008	0.088	0.088
Loa Loa (eye worm)	acetylcholine receptor protein	0.0037	0.0252	0.0448
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.008	0.088	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0448
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.224	0.6286
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.008	0.088	0.2469
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2376	0.6667
Schistosoma mansoni	nAChR subunit	0.008	0.088	0.088
Brugia malayi	excitatory GABA receptor EXP-1A	0.008	0.088	0.2469
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.02	0.2641	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.008	0.088	0.1565
Loa Loa (eye worm)	hypothetical protein	0.008	0.088	0.1565
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.008	0.088	0.2469

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 500 nM	Ability to inhibit proliferation in human lymphocytes by mixed lymphocyte reaction (MLR)	ChEMBL.	No reference
Ki (binding)	> 500 nM	Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.	ChEMBL.	No reference
Ki (binding)	> 500 nM	Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL39167

Bibliographic References

No literature references available for this target.

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Detailed information for compound 55118