Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.5019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1293 | 0.1231 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0948 | 0.1889 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0071 | 0.0142 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.1293 | 0.2577 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1768 | 0.1708 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0082 | 0.3035 | 1 |
Onchocerca volvulus | 0.0039 | 0.1293 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1293 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1654 | 0.3296 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1293 | 0.5 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0053 | 0.1889 | 0.3763 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.019 | 0.0378 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1654 | 0.3296 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.1293 | 0.2275 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.1293 | 0.1235 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0028 | 0.0855 | 0.0328 |
Onchocerca volvulus | 0.0039 | 0.1293 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1654 | 0.3296 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 0.6046 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.1293 | 0.1235 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1654 | 0.1598 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0881 | 0.0816 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1768 | 0.1712 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0082 | 0.3035 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.5019 | 0.4983 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0053 | 0.1889 | 0.0697 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0053 | 0.1889 | 0.0697 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1293 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0248 | 0.9834 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0028 | 0.0855 | 0.0328 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.036 | 0.0295 |
Onchocerca volvulus | 0.0039 | 0.1293 | 1 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.1293 | 0.1231 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1654 | 0.1594 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.1293 | 0.2577 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.5019 | 0.4983 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.1293 | 0.1231 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.1293 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0071 | 0.0142 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1768 | 0.1712 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.036 | 0.0718 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0401 | 0.0336 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5019 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 0.6046 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1116 | 0.2224 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.5019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1116 | 0.1052 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1654 | 0.3296 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1654 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1293 | 0.1231 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.036 | 0.0718 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.193 | 0.51 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1293 | 0.1231 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1293 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0082 | 0.3035 | 0.6046 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5019 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.1293 | 0.1235 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.019 | 0.0378 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.5019 | 0.4983 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.1293 | 0.2013 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.1293 | 0.2577 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0252 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1654 | 0.3296 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1768 | 0.1708 |
Brugia malayi | Probable ClpP-like protease | 0.0082 | 0.3035 | 0.2988 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0053 | 0.1889 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1293 | 0.1231 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0082 | 0.3035 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.1293 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.036 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3035 | 0.2984 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1293 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0781 | 0.0714 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.1293 | 0.2577 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.036 | 0.0295 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.036 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.036 | 0.0291 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0881 | 0.1756 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.036 | 0.0291 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0948 | 0.1889 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0.0855 | 0.0328 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.036 | 0.0718 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.1293 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0082 | 0.3035 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 0.5 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.019 | 0.0378 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5019 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5019 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.5019 | 0.4986 |
Brugia malayi | RNA binding protein | 0.013 | 0.5019 | 0.4986 |
Brugia malayi | TAR-binding protein | 0.013 | 0.5019 | 0.4986 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.1293 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0881 | 0.082 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.1293 | 0.2013 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.036 | 0.0718 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.3035 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.036 | 0.0718 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0053 | 0.1889 | 0.3763 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.036 | 0.0718 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.1293 | 0.2275 |
Brugia malayi | beta-lactamase | 0.0039 | 0.1293 | 0.1235 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0781 | 0.0719 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1116 | 0.1056 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1654 | 0.3296 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5019 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1293 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1293 | 0.1231 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.036 | 0.0718 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.036 | 0.0718 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0948 | 0.1889 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0948 | 0.1889 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.2196 | 0.4375 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.1293 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.