Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.4151 | 0.4151 |
Echinococcus granulosus | lamin | 0.0027 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.4151 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1026 | 0.1026 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.4151 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.4151 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.4151 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.4151 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.9646 | 0.9646 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.4151 | 0.4151 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.4151 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.4151 | 0.3482 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.4151 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.4151 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.4151 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.4151 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.4151 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.4151 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.4151 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.4151 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.4151 | 0.5 |
Echinococcus multilocularis | lamin | 0.0027 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.