Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0403 | 0.0403 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0403 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.1293 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0403 | 0.0224 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0403 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1293 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.8442 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0183 | 0.0183 |
Onchocerca volvulus | 0.0023 | 0.0403 | 0.0431 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.1293 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0403 | 0.0403 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0403 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3065 | 0.349 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0163 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.1293 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3065 | 0.349 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1293 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3065 | 0.3065 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0183 | 0.0183 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0183 | 0.0183 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3065 | 0.2936 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.1293 | 0.5 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.1293 | 0.1131 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0403 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0183 | 0.0183 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3065 | 0.2936 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0183 | 0.0183 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0403 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1293 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0183 | 0.0183 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0403 | 0.0224 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1293 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1293 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0403 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3065 | 0.3065 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0403 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.1293 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0403 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.1293 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.1293 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3065 | 0.3065 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0403 | 0.0403 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0403 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0403 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 1 | 1 |
Onchocerca volvulus | 0.0094 | 0.5282 | 1 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3065 | 0.2936 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.8442 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3065 | 0.349 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.1293 | 0.1131 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3065 | 0.349 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0183 | 0.0183 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0403 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3065 | 0.349 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0403 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0183 | 0.0183 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.1293 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.1293 | 0.1344 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1293 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0403 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1293 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0183 | 0.0183 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0183 | 0.0183 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3065 | 0.2936 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0183 | 0.0183 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3065 | 0.2936 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.1293 | 0.1293 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.1293 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.1293 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0183 | 0.0183 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.