Detailed information for compound 552710

Basic information

Technical information
  • TDR Targets ID: 552710
  • Name: 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymeth yl)tetrahydrofuran-2-yl]-3,7-dihydropurine-2, 6,8-trione
  • MW: 300.225 | Formula: C10H12N4O7
  • H donors: 6 H acceptors: 6 LogP: -3.24 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1c(=O)[nH]c2c1[nH]c(=O)[nH]c2=O
  • InChi: 1S/C10H12N4O7/c15-1-2-4(16)5(17)8(21-2)14-6-3(11-10(14)20)7(18)13-9(19)12-6/h2,4-5,8,15-17H,1H2,(H,11,20)(H2,12,13,18,19)/t2-,4-,5-,8-/m1/s1
  • InChiKey: XRFDFDQNRIGZOW-UMMCILCDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3,7-dihydropurine-2,6,8-trione
  • 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-2,6,8-trione
  • 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]uric acid
  • 9-N-ribofuranosyluric acid
  • 21082-30-4
  • 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-9-beta-D-ribofuranosyl-
  • 9-Ribosyluric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0062 0.3088 0.438
Brugia malayi Cytochrome P450 family protein 0.0011 0.0017 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0749 0.5
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0581 0.0824
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0581 0.0581
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0581 0.0824
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0581 0.0581
Brugia malayi steroid hormone receptor 0.002 0.0581 0.0824
Loa Loa (eye worm) hypothetical protein 0.002 0.0581 0.0824
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.1505 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0581 0.0824
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0749 0.1062
Loa Loa (eye worm) hypothetical protein 0.002 0.0581 0.0824
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0749 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0749 0.4917
Brugia malayi cytochrome P450 0.0011 0.0017 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0581 0.0581
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3088 0.3088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0749 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3088 0.438
Brugia malayi hypothetical protein 0.0128 0.705 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0581 0.0824
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0749 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0581 0.0581
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3088 0.438
Schistosoma mansoni nuclear hormone receptor 0.002 0.0581 0.0581
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0749 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0581 0.0824
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0017 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0749 1
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.1505 0.2136
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0581 0.0824
Loa Loa (eye worm) hypothetical protein 0.002 0.0581 0.0824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0581 0.0824
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2224 0.2224
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0581 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0581 0.0824
Schistosoma mansoni hypothetical protein 0.0177 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0581 0.0824
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0581 0.0581
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0581 0.0581
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0749 0.4917
Echinococcus multilocularis geminin 0.0177 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0581 0.0581
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3088 0.3088
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3088 0.3088
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.1505 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0581 0.0824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0581 0.0581
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0749 1
Echinococcus multilocularis 0.0011 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0581 0.0824
Loa Loa (eye worm) hypothetical protein 0.0017 0.0395 0.056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0749 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0581 0.0824
Echinococcus granulosus tar DNA binding protein 0.0062 0.3088 0.3088
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0023 0.0749 0.1062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0338 0.4387
Brugia malayi TAR-binding protein 0.0062 0.3088 0.438
Schistosoma mansoni coup transcription factor 0.002 0.0581 0.0581
Brugia malayi Cytochrome P450 family protein 0.0011 0.0017 0.0024
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.1505 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2224 0.2224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2224 0.2224
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0581 0.0581
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0581 0.0581
Schistosoma mansoni hypothetical protein 0.0177 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0749 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.2415 0.3426
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0395 0.5168
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0017 0.0395 0.056
Schistosoma mansoni thyroid hormone receptor 0.002 0.0581 0.0581
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3088 0.438
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0581 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0581 0.0824
Loa Loa (eye worm) hypothetical protein 0.0128 0.705 1
Loa Loa (eye worm) cytochrome P450 0.0011 0.0017 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0581 0.0581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0581 0.0824
Onchocerca volvulus Huntingtin homolog 0.0128 0.705 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0017 0.0024
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0017 0.0017
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.1505 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0581 0.0824
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.2224 0.3155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0581 0.0824
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0581 0.0581
Brugia malayi Cytochrome P450 family protein 0.0051 0.2415 0.3426
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0581 0.0581
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0581 0.0824
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0338 0.4387
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3088 0.3088
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.1505 0.1505
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0338 0.4387
Loa Loa (eye worm) hypothetical protein 0.0023 0.0749 0.1062
Onchocerca volvulus 0.0023 0.0749 0.0259
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0749 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0749 0.1062
Leishmania major hypothetical protein, conserved 0.0036 0.1505 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0581 0.0824
Mycobacterium ulcerans hypothetical protein 0.0023 0.0749 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.1505 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0581 0.0824
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.002 0.0581 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0581 0.0824
Schistosoma mansoni cytochrome P450 0.0011 0.0017 0.0017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0581 0.0824
Schistosoma mansoni thyroid hormone receptor 0.002 0.0581 0.0581
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.2224 0.3155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0581 0.0824
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2224 0.2224
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0581 0.0581
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0749 0.4917
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0749 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0749 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0581 0.0824
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0338 0.4387
Loa Loa (eye worm) hypothetical protein 0.0017 0.0395 0.056
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3088 0.3088
Loa Loa (eye worm) hypothetical protein 0.0128 0.705 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0395 0.5168
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0017 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0581 0.0581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0581 0.0824
Loa Loa (eye worm) hypothetical protein 0.0017 0.0395 0.056
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.1505 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0581 0.0824
Brugia malayi nuclear hormone receptor 0.002 0.0581 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0581 0.0824
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.1505 1
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.1505 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0581 0.0824
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0581 0.0581
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0581 0.0581
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3088 0.3088
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0395 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0581 0.0824
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0023 0.0749 0.1062
Brugia malayi RNA binding protein 0.0062 0.3088 0.438
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0017 0.0395 0.056
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.1505 0.1505
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2224 0.2224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2224 0.2224
Brugia malayi ecdysteroid receptor 0.002 0.0581 0.0824
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0581 0.0581
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0581 0.0581
Brugia malayi Augmenter of liver regeneration 0.0036 0.1505 0.2136
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0581 0.0581
Onchocerca volvulus Huntingtin homolog 0.0128 0.705 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0749 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2224 0.2224
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0581 0.0824
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0749 0.1062

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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