Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0261 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0987 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1137 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0528 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0083 | 0.2965 | 0.4544 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0345 | 0.0379 |
Loa Loa (eye worm) | mucolipin 1 | 0.0064 | 0.2223 | 0.2167 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.6339 | 0.9713 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.1137 | 0.1742 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.6339 | 0.9713 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.1137 | 0.1742 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0524 | 0.0777 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0666 | 0.1021 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0828 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0828 | 0.2881 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0408 | 0.0339 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0828 | 0.0695 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0383 | 0.0568 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0549 | 0.0842 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0275 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0383 | 0.0587 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0179 | 0.6744 | 0.6697 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1319 | 0.1256 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0083 | 0.2965 | 0.2864 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.088 | 0.0815 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.076 | 0.0627 |
Schistosoma mansoni | mucolipin | 0.0058 | 0.2013 | 0.2985 |
Echinococcus multilocularis | mucolipin 3 | 0.0064 | 0.2223 | 0.3407 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.2965 | 0.4397 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0828 | 0.0762 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0071 | 0.0109 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0407 | 0.0338 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0071 | 0.0109 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0018 | 0.0408 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.6339 | 0.6312 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.1137 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0013 | 0.0211 | 0.0323 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0345 | 0.0528 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0013 | 0.0211 | 0.0323 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0528 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0828 | 0.6245 |
Echinococcus granulosus | GPCR family 2 | 0.0083 | 0.2965 | 0.4544 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2135 | 0.3271 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1222 | 0.1096 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.015 | 0.5606 | 0.5575 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0828 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0528 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0205 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.015 | 0.5606 | 0.859 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.2193 | 0.3252 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.2965 | 0.4397 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0083 | 0.2965 | 0.4544 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.1137 | 0.5 |
Brugia malayi | Coelomocyte uptake defective protein 5 | 0.0064 | 0.2223 | 0.2111 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0345 | 0.0379 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0549 | 0.0842 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0828 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0987 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.1137 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0549 | 0.0814 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0666 | 0.0988 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0524 | 0.0456 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.2276 | 0.3375 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2503 | 0.2449 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.1023 | 0.1516 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.015 | 0.5606 | 0.859 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0313 | 0.0465 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1137 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0205 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.015 | 0.5606 | 0.8313 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0083 | 0.2965 | 0.2915 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0345 | 0.0379 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.015 | 0.5606 | 0.5543 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1129 | 0.1729 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0431 | 0.0293 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.1023 | 0.1567 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0018 | 0.0408 | 0.0626 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.1137 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0211 | 0.0313 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.015 | 0.5606 | 0.859 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.2965 | 0.4397 |
Echinococcus multilocularis | geminin | 0.0173 | 0.6526 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0227 | 0.8663 | 0.8653 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.6744 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.6744 | 0.672 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0408 | 0.0606 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1137 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0828 | 0.6245 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0528 |
Schistosoma mansoni | zinc finger protein | 0.0015 | 0.0313 | 0.0465 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0408 | 0.0606 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.015 | 0.5606 | 0.8313 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.1137 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.1137 | 0.1686 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0666 | 0.1021 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1129 | 0.1729 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.6526 | 0.9677 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0828 | 0.6245 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.1023 | 0.1567 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.1137 | 0.1073 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.015 | 0.5606 | 0.859 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0083 | 0.2965 | 0.4544 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0383 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1225 | 0.1162 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.015 | 0.5606 | 0.8313 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.1023 | 0.1516 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.2965 | 0.2915 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.088 | 0.0749 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.1137 | 0.1686 |
Brugia malayi | Inositol-1 | 0.0036 | 0.1137 | 0.1009 |
Schistosoma mansoni | mucolipin | 0.0064 | 0.2223 | 0.3297 |
Echinococcus granulosus | mucolipin 3 | 0.0064 | 0.2223 | 0.3407 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.2739 | 0.2634 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0828 | 0.6245 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1137 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0345 | 0.0379 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.6339 | 0.9713 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1461 | 0.1399 |
Echinococcus multilocularis | GPCR, family 2 | 0.0083 | 0.2965 | 0.4544 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.2022 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0227 | 0.8663 | 0.8644 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0083 | 0.2965 | 0.2864 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0511 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2135 | 0.3271 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0261 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.2965 | 0.4397 |
Onchocerca volvulus | 0.003 | 0.088 | 0.5 | |
Echinococcus granulosus | geminin | 0.0173 | 0.6526 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0083 | 0.2965 | 0.4544 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.1137 | 0.4725 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.088 | 0.1305 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.6339 | 0.6286 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0345 | 0.0528 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.1137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.6339 | 0.6312 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0383 | 0.0587 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0345 | 0.0379 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.6526 | 0.9677 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.