Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.2338 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.2338 | 0.5518 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4238 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.2338 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4238 | 1 |
Onchocerca volvulus | 0.0033 | 0.4238 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.405 | 0.9354 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4238 | 0.248 |
Schistosoma mansoni | lamin | 0.0033 | 0.4238 | 0.248 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.2338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.099 | 0.2336 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4123 | 0.9729 |
Onchocerca volvulus | 0.0033 | 0.4238 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.1648 | 0.3888 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1323 | 0.3123 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0875 | 0.2065 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4238 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.2338 | 0.3482 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4238 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2338 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.2338 | 0.4151 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4238 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.1648 | 0.1112 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4238 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0875 | 0.2065 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.2338 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2338 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2338 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4238 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2338 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4238 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.1648 | 0.1112 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.2338 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.405 | 0.9555 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.1648 | 0.3888 |
Schistosoma mansoni | lamin | 0.0033 | 0.4238 | 0.248 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2338 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.2338 | 0.5 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4238 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.2338 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.2338 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.2338 | 0.4151 |
Echinococcus granulosus | lamin | 0.0033 | 0.4238 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.1648 | 0.3888 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.2338 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4238 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2338 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.