Detailed information for compound 553588

Basic information

Technical information
  • TDR Targets ID: 553588
  • Name: [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3- yl] 2-(p-tolyl)acetate hydrochloride
  • MW: 309.831 | Formula: C17H24ClNO2
  • H donors: 0 H acceptors: 1 LogP: 4.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccc(cc1)C)OC1C[C@@H]2CC[C@H](C1)N2C.Cl
  • InChi: 1S/C17H23NO2.ClH/c1-12-3-5-13(6-4-12)9-17(19)20-16-10-14-7-8-15(11-16)18(14)2;/h3-6,14-16H,7-11H2,1-2H3;1H/t14-,15+,16?;
  • InChiKey: XCFIZMVCZBZSST-JXMYBXCISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(p-tolyl)acetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester hydrochloride
  • [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-(4-methylphenyl)ethanoate hydrochloride
  • [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-(4-methylphenyl)acetate hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0257 0.0624
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0048 0.0117
Trichomonas vaginalis histone deacetylase, putative 0.0793 0.4121 1
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0175 0.0425
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0048 0.0037
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.006 0.0257 0.1458
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0126 0.0305
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0253 0.0614
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0048 0.0118
Brugia malayi Ets-domain containing protein 0.007 0.0313 0.0759
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0028 0.0089 1
Schistosoma mansoni RAR-like nuclear receptor 0.006 0.0257 0.0624
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0041 0.01
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.006 0.0257 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.006 0.0257 0.0624
Loa Loa (eye worm) hypothetical protein 0.0145 0.0707 0.1716
Schistosoma mansoni nuclear hormone receptor 0.006 0.0257 0.0624
Brugia malayi hypothetical protein 0.0032 0.0108 0.0263
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0011 0.0027
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0073 0.0176
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0062 0.0123
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0129 0.062 0.1505
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0028 0.0089 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0126 0.0305
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0253 0.0614
Brugia malayi tailless protein 0.0028 0.0091 0.022
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0073 0.0176
Loa Loa (eye worm) hypothetical protein 0.0035 0.0126 0.0305
Schistosoma mansoni coup transcription factor 0.006 0.0257 0.0624
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.006 0.0257 0.0624
Entamoeba histolytica histone deacetylase, putative 0.0793 0.4121 1
Plasmodium falciparum cysteine--tRNA ligase 0.0028 0.0089 0.0215
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0343
Echinococcus multilocularis transcription factor btf3 0.0024 0.0071 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Echinococcus granulosus histone deacetylase 6 0.0331 0.1685 0.409
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.0011 0.0027
Echinococcus multilocularis dna polymerase kappa 0.002 0.0048 0.0118
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0624
Brugia malayi RNA binding protein 0.0044 0.0175 0.0425
Brugia malayi histone deacetylase 3 (HD3) 0.0793 0.4121 1
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0091 0.022
Brugia malayi TAR-binding protein 0.0044 0.0175 0.0425
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0013 0.0011 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.009 0.0217
Brugia malayi Cytochrome P450 family protein 0.0025 0.0073 0.0176
Trypanosoma cruzi histone deacetylase 1, putative 0.0793 0.4121 1
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0091 0.022
Echinococcus granulosus intermediate filament protein 0.0019 0.0041 0.01
Schistosoma mansoni retinoic acid receptor RXR 0.0129 0.062 0.1505
Toxoplasma gondii histone deacetylase HDAC5 0.03 0.1522 0.3693
Schistosoma mansoni lamin 0.0019 0.0041 0.01
Toxoplasma gondii histone deacetylase HDAC2 0.0793 0.4121 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-3 0.006 0.0257 0.0624
Schistosoma mansoni hypothetical protein 0.0024 0.0067 0.0164
Brugia malayi histone deacetylase 11 0.03 0.1522 0.3693
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0062 0.0149
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0108 0.0263
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0091 0.022
Brugia malayi nuclear hormone receptor 0.006 0.0257 0.0624
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0253 0.0242
Plasmodium falciparum histone deacetylase, putative 0.0331 0.1685 0.409
Echinococcus multilocularis dna polymerase eta 0.0047 0.0189 0.0459
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0257 0.0624
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0073 0.0176
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0263
Echinococcus granulosus histone deacetylase 6 0.0338 0.1721 0.4177
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0108 0.0263
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0263
Onchocerca volvulus 0.0028 0.0091 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Schistosoma mansoni importin beta-1 0.0028 0.009 0.0217
Echinococcus multilocularis lamin dm0 0.0019 0.0041 0.01
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0062 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0175 0.0425
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0091 0.022
Toxoplasma gondii histone deacetylase HDAC3 0.0793 0.4121 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1518 0.3685
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0091 0.022
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0793 0.4121 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.006 0.0257 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-41 0.006 0.0257 0.0624
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Trypanosoma cruzi histone deacetylase, putative 0.03 0.1522 0.3693
Schistosoma mansoni histone deacetylase 4 5 0.0331 0.1685 0.409
Echinococcus granulosus FTZ F1 alpha 0.006 0.0257 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.006 0.0257 0.0624
Leishmania major basic transcription factor 3a, putative 0.0024 0.0071 0.0171
Giardia lamblia DINP protein human, muc B family 0.002 0.0048 0.0091
Schistosoma mansoni zinc finger protein 0.0028 0.0091 0.022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0108 0.0263
Trichomonas vaginalis histone deacetylase, putative 0.0793 0.4121 1
Echinococcus granulosus histone deacetylase 1 0.0793 0.4121 1
Echinococcus multilocularis histone deacetylase 6 0.0331 0.1685 0.409
Loa Loa (eye worm) hypothetical protein 0.03 0.1522 0.3693
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0028 0.0089 0.0215
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0707 0.1716
Schistosoma mansoni thyroid hormone receptor 0.006 0.0257 0.0624
Trichomonas vaginalis histone deacetylase, putative 0.0793 0.4121 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0215
Loa Loa (eye worm) histone deacetylase 0.0331 0.1685 0.409
Trypanosoma cruzi transcription factor btf3, putative 0.0024 0.0071 0.0171
Leishmania major histone deacetylase, putative 0.0331 0.1685 0.409
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0048 0.0117
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0048 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0145
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0253 0.0253
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0108 0.0263
Echinococcus granulosus snurportin 1 0.0299 0.1518 0.3685
Brugia malayi hypothetical protein 0.0028 0.0091 0.022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.006 0.0257 0.0624
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0028 0.0089 0.0215
Echinococcus multilocularis geminin 0.0118 0.0566 0.1374
Echinococcus multilocularis histone deacetylase 1 0.0793 0.4121 1
Loa Loa (eye worm) histone deacetylase 1 0.0793 0.4121 1
Trichomonas vaginalis histone deacetylase, putative 0.0793 0.4121 1
Brugia malayi nuclear receptor NHR-88 0.0028 0.0091 0.022
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0091 0.022
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0048 0.0091
Giardia lamblia Histone deacetylase 0.0793 0.4121 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0257 0.0624
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0175 0.0425
Brugia malayi Ets-domain containing protein 0.007 0.0313 0.0759
Schistosoma mansoni histone deacetylase hda2 0.03 0.1522 0.3693
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.006 0.0257 0.0624
Plasmodium falciparum histone deacetylase 2 0.0331 0.1685 0.409
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0175 0.0425
Echinococcus granulosus histone deacetylase 6 0.0331 0.1685 0.409
Plasmodium vivax histone deacetylase, putative 0.0331 0.1685 0.409
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0073 0.0061
Loa Loa (eye worm) RNA binding protein 0.0044 0.0175 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-40 0.006 0.0257 0.0624
Trichomonas vaginalis histone deacetylase, putative 0.0793 0.4121 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.006 0.0257 0.0624
Loa Loa (eye worm) hypothetical protein 0.0047 0.0189 0.0459
Brugia malayi nuclear receptor RXR 0.0032 0.0108 0.0263
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0028 0.0089 0.0215
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0044 0.0175 0.0425
Schistosoma mansoni DNA polymerase eta 0.0047 0.0189 0.0459
Echinococcus granulosus importin subunit beta 1 0.0028 0.009 0.0217
Loa Loa (eye worm) hypothetical protein 0.0793 0.4121 1
Trypanosoma brucei histone deacetylase 3 0.0331 0.1685 0.409
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.009 0.0217
Echinococcus granulosus dna polymerase kappa 0.002 0.0048 0.0118
Brugia malayi follicle stimulating hormone receptor 0.0162 0.0795 0.193
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0048 0.0118
Echinococcus multilocularis histone deacetylase 3 0.0793 0.4121 1
Loa Loa (eye worm) ICD-1 protein 0.0024 0.0071 0.0172
Plasmodium falciparum cysteine--tRNA ligase 0.0028 0.0089 0.0215
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Plasmodium falciparum basic transcription factor 3b, putative 0.0024 0.0071 0.0171
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.006 0.0257 0.0624
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.0011 0.0027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0162 0.0795 0.193
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0048 0.0091
Plasmodium vivax basic transcription factor 3b, putative 0.0024 0.0071 0.0171
Brugia malayi Muscleblind-like protein 0.0145 0.0707 0.1716
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.1908 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0013 0.0011 0.0027
Trypanosoma brucei transcription factor BTF3, putative 0.0024 0.0071 0.0171
Plasmodium vivax histone deacetylase, putative 0.03 0.1522 0.3693
Toxoplasma gondii histone deacetylase HDAC4 0.03 0.1522 0.3693
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0091 0.0333
Brugia malayi nuclear receptor RXR 0.0028 0.0091 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0091 0.022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.006 0.0257 0.0624
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.006 0.0257 0.0624
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.006 0.0257 0.0624
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0624
Schistosoma mansoni lamin 0.0019 0.0041 0.01
Brugia malayi nuclear hormone receptor 0.0028 0.0091 0.022
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0624
Schistosoma mansoni histone deacetylase 0.0793 0.4121 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0189 0.0459
Echinococcus granulosus muscleblind protein 0.0145 0.0707 0.1716
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0313 0.0759
Brugia malayi photoreceptor-specific nuclear receptor 0.006 0.0257 0.0624
Onchocerca volvulus Histone deacetylase 10 homolog 0.03 0.1522 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0037
Trichomonas vaginalis histone deacetylase, putative 0.0793 0.4121 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0091 0.0333
Toxoplasma gondii exonuclease III APE 0.0013 0.0011 0.0027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.006 0.0257 0.0624
Plasmodium falciparum importin beta, putative 0.0028 0.009 0.0217
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0048 0.0118
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0028 0.0089 0.0215
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0091 0.022
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0073 0.0176
Entamoeba histolytica hypothetical protein 0.0024 0.0071 0.0145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0096
Trypanosoma cruzi transcription factor btf3, putative 0.0024 0.0071 0.0171
Brugia malayi Cytochrome P450 family protein 0.0025 0.0073 0.0176
Brugia malayi hypothetical protein 0.0028 0.0091 0.022
Brugia malayi Histone deacetylase family protein 0.0331 0.1685 0.409
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0067 0.0164
Leishmania major DNA polymerase eta, putative 0.0033 0.0116 0.028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0091 0.022
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0048 0.0118
Giardia lamblia Cysteinyl-tRNA synthetase 0.0028 0.0089 0.0188
Loa Loa (eye worm) histone deacetylase 3 0.0793 0.4121 1
Toxoplasma gondii NAC domain-containing protein 0.0024 0.0071 0.0171
Echinococcus multilocularis FTZ F1 alpha 0.006 0.0257 0.0624
Echinococcus multilocularis tar DNA binding protein 0.0044 0.0175 0.0425
Trypanosoma brucei histone deacetylase 1 0.0793 0.4121 1
Loa Loa (eye worm) fli-1 protein 0.0214 0.1068 0.2592
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0013 0.0011 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0257 0.0624
Schistosoma mansoni histone deacetylase 0.0793 0.4121 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0793 0.4121 1
Echinococcus multilocularis histone deacetylase 7 0.0331 0.1685 0.409
Trypanosoma cruzi histone deacetylase, putative 0.03 0.1522 0.3693
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0091 0.022
Brugia malayi histone deacetylase 1 (HD1) 0.0793 0.4121 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Schistosoma mansoni hypothetical protein 0.0118 0.0566 0.1374
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Schistosoma mansoni nuclear receptor 0.0028 0.0091 0.022
Onchocerca volvulus 0.0028 0.0091 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.006 0.0257 0.0624
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.006 0.0257 0.0624
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0013 0.0011 0.0027
Echinococcus granulosus leucyl tRNA synthetase 0.0028 0.0089 0.0215
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0091 0.022
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0091 0.022
Trypanosoma brucei histone deacetylase, putative 0.0331 0.1685 0.409
Brugia malayi RNA recognition motif domain containing protein 0.0044 0.0175 0.0425
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0189 0.0459
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.006 0.0257 0.0624
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0097 0.0454 0.1101
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0624
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0041 0.01
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0073 0.0176
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0257 0.0624
Schistosoma mansoni ets-related 0.0214 0.1068 0.2592
Brugia malayi Histone deacetylase 1 0.0793 0.4121 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0091 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0256
Trypanosoma brucei histone deacetylase 4 0.0331 0.1685 0.409
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0091 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.006 0.0257 0.0624
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0091 0.022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0091 0.022
Echinococcus multilocularis histone deacetylase 6 0.0331 0.1685 0.409
Echinococcus granulosus lamin 0.0019 0.0041 0.01
Trypanosoma cruzi histone deacetylase, putative 0.0331 0.1685 0.409
Entamoeba histolytica transcription factor BTF3, putative 0.0024 0.0071 0.0145
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0091 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0037
Trypanosoma brucei histone deacetylase 2 0.03 0.1522 0.3693
Schistosoma mansoni histone deacetylase 4 5 0.0331 0.1685 0.409
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0108 0.0263
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0073 0.0176
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0091 0.022
Echinococcus granulosus histone deacetylase 3 0.0793 0.4121 1
Plasmodium vivax histone deacetylase 1, putative 0.0793 0.4121 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Echinococcus multilocularis importin subunit beta 1 0.0028 0.009 0.0217
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0028 0.0089 0.0215
Brugia malayi Fli-1 protein 0.0214 0.1068 0.2592
Echinococcus granulosus tar DNA binding protein 0.0044 0.0175 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-14 0.006 0.0257 0.0624
Loa Loa (eye worm) hypothetical protein 0.0145 0.0707 0.1716
Echinococcus multilocularis musashi 0.0019 0.0041 0.01
Loa Loa (eye worm) steroid hormone receptor 0.006 0.0257 0.0624
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0257 0.0624
Echinococcus granulosus geminin 0.0118 0.0566 0.1374
Echinococcus multilocularis muscleblind protein 0.0145 0.0707 0.1716
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.0011 0.0027
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0091 0.022
Schistosoma mansoni thyroid hormone receptor 0.006 0.0257 0.0624
Echinococcus multilocularis histone deacetylase 0.0331 0.1685 0.409
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0048 0.0117
Echinococcus granulosus histone deacetylase 7 0.0331 0.1685 0.409
Brugia malayi hypothetical protein 0.0032 0.0108 0.0263
Trypanosoma brucei unspecified product 0.0014 0.0015 0.0037
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0048 0.0118
Echinococcus multilocularis thyroid hormone receptor alpha 0.006 0.0257 0.0624
Echinococcus granulosus lamin dm0 0.0019 0.0041 0.01
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0028 0.0089 0.0215
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0028 0.0089 0.0215
Plasmodium falciparum histone deacetylase 1 0.0793 0.4121 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0048 0.0091
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0624
Leishmania major histone deacetylase, putative 0.0793 0.4121 1
Leishmania major histone deacetylase, putative 0.0331 0.1685 0.409
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0624
Echinococcus granulosus transcription factor btf3 0.0024 0.0071 0.0172
Echinococcus granulosus dna polymerase eta 0.0047 0.0189 0.0459
Trypanosoma brucei unspecified product 0.0014 0.0015 0.0037
Schistosoma mansoni intermediate filament proteins 0.0019 0.0041 0.01
Brugia malayi Steroid receptor seven-up type 2 0.006 0.0257 0.0624
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0257 0.0624
Brugia malayi conserved hypotetical protein 0.0028 0.0091 0.022
Plasmodium vivax histone deacetylase 2, putative 0.0331 0.1685 0.409
Onchocerca volvulus 0.006 0.0257 0.1458
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0624
Brugia malayi beta-NAC-like protein 0.0024 0.0071 0.0172
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0048 0.0118
Echinococcus granulosus cysteinyl tRNA synthetase 0.0028 0.0089 0.0215
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0048 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0037
Loa Loa (eye worm) TAR-binding protein 0.0044 0.0175 0.0425
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0048 0.0037
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0028 0.0089 0.0215
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0189 0.0459
Trypanosoma cruzi histone deacetylase, putative 0.0331 0.1685 0.409
Loa Loa (eye worm) histone deacetylase 11 0.03 0.1522 0.3693
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0257 0.0624
Brugia malayi steroid hormone receptor 0.006 0.0257 0.0624
Echinococcus multilocularis lamin 0.0019 0.0041 0.01
Treponema pallidum cysteinyl-tRNA synthetase 0.0028 0.0089 1
Schistosoma mansoni nuclear receptor 0.0028 0.0091 0.022
Leishmania major DNA polymerase kappa, putative 0.002 0.0048 0.0117
Echinococcus granulosus ecdysone induced protein 78C 0.006 0.0257 0.0624
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0091 0.022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Echinococcus multilocularis ecdysone induced protein 78C 0.006 0.0257 0.0624
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0116 0.028
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0253 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0253 0.0613
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0313 0.0759
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0253 0.0614
Schistosoma mansoni steroid hormone receptor ad4bp 0.006 0.0257 0.0624
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0793 0.4121 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0028 0.0089 0.0188
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.006 0.0257 0.0624
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0164
Loa Loa (eye worm) hypothetical protein 0.006 0.0257 0.0624
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0091 0.022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.006 0.0257 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-1 0.006 0.0257 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.006 0.0257 0.0624
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0257 0.0624
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0091 0.022
Chlamydia trachomatis cysteine--tRNA ligase 0.0028 0.0089 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Brugia malayi Importin beta-1 subunit 0.0028 0.009 0.0217
Schistosoma mansoni ap endonuclease 0.0013 0.0011 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0048 0.0117
Plasmodium vivax importin-beta 2, putative 0.0028 0.009 0.0217
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.1908 1 1
Echinococcus granulosus histone deacetylase 8 0.03 0.1522 0.3693
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0085
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.009 0.0217
Echinococcus multilocularis snurportin 1 0.0299 0.1518 0.3685
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0028 0.0089 0.0215
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0253 0.0242
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0011 0.0027
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0091 0.022
Echinococcus multilocularis histone deacetylase 6 0.0338 0.1721 0.4177
Trypanosoma cruzi histone deacetylase, putative 0.0331 0.1685 0.409
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0116 0.028
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0091 0.022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0041 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0257 0.0624
Schistosoma mansoni hypothetical protein 0.0118 0.0566 0.1374
Leishmania major cytochrome p450-like protein 0.0025 0.0073 0.0176
Onchocerca volvulus 0.0028 0.0089 0.032
Schistosoma mansoni hypothetical protein 0.0299 0.1518 0.3685
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.01
Trypanosoma brucei unspecified product 0.002 0.0048 0.0117
Plasmodium vivax cysteine--tRNA ligase, putative 0.0028 0.0089 0.0215
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0091 0.022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0048 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0117
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0263
Schistosoma mansoni histone deacetylase 1 2 3 0.03 0.1522 0.3693
Loa Loa (eye worm) hypothetical protein 0.006 0.0259 0.0628
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0253 0.0242
Echinococcus granulosus histone deacetylase 0.0331 0.1685 0.409
Toxoplasma gondii histone deacetylase HDAC1 0.0331 0.1685 0.409
Schistosoma mansoni ap endonuclease 0.0013 0.0011 0.0027
Brugia malayi intermediate filament protein 0.0019 0.0041 0.01
Leishmania major DNA polymerase eta, putative 0.0047 0.0189 0.0459
Brugia malayi nuclear receptor NHR-88 0.006 0.0257 0.0624
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.006 0.0257 0.0624
Brugia malayi ecdysone receptor 0.0028 0.0091 0.022
Schistosoma mansoni gabp alpha 0.007 0.0313 0.0759
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0048 0.0117
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0253 0.0614
Entamoeba histolytica hypothetical protein 0.0023 0.0062 0.0123
Onchocerca volvulus Bile acid receptor homolog 0.006 0.0257 0.1458
Echinococcus multilocularis histone deacetylase 8 0.03 0.1522 0.3693
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0011 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0108 0.0263
Leishmania major importin beta-1 subunit, putative 0.0023 0.0062 0.0149
Leishmania major histone deacetylase, putative 0.0793 0.4121 1
Schistosoma mansoni transcription factor btf3 0.0024 0.0071 0.0172
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.009 0.0217
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0108 0.0263
Loa Loa (eye worm) histone deacetylase 7A 0.0331 0.1685 0.409
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0313 0.0759
Trypanosoma cruzi histone deacetylase 1, putative 0.0793 0.4121 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0257 0.0624
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0048 0.0117
Onchocerca volvulus Protein ultraspiracle homolog 0.006 0.0257 0.1458
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0071 0.0145
Brugia malayi RNA, U transporter 1 0.008 0.0362 0.0878
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.022
Brugia malayi Histone deacetylase family protein 0.0331 0.1685 0.409
Schistosoma mansoni histone deacetylase hda2 0.0338 0.1721 0.4177
Loa Loa (eye worm) DR-78 0.0028 0.0091 0.022
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0028 0.0089 0.0077
Brugia malayi nuclear receptor NHR-67 0.0028 0.0091 0.022
Leishmania major cysteinyl-tRNA synthetase, putative 0.0028 0.0089 0.0215
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.006 0.0257 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0257 0.0624
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0126 0.0305
Brugia malayi ecdysteroid receptor 0.006 0.0257 0.0624
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0175 0.0425
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0062 0.0123

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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