Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2503 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0164 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.6315 | 0.8342 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.1116 | 0.5 |
Leishmania major | trypanothione reductase | 0.0047 | 0.1116 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2503 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2503 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.6315 | 0.8342 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.1116 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1362 | 0.5442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2503 | 0.2503 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2503 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1362 | 0.5442 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0164 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.6315 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.6315 | 0.8342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0119 | 0.7348 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0164 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.1116 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2503 | 0.2503 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0119 | 0.7348 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2503 | 0.2503 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.1116 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2503 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0164 | 0.5 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2503 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.1116 | 0.4459 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.1116 | 0.4071 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2503 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.1116 | 0.4459 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.6315 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0119 | 0.7348 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.1116 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0119 | 0.7348 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1362 | 0.5442 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1362 | 0.5442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2503 | 0.2503 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2503 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.6315 | 0.8342 |
Brugia malayi | glutathione reductase | 0.0047 | 0.1116 | 0.4459 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0164 | 0.0164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2503 | 0.2503 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.1116 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.1116 | 0.4071 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.1116 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.1116 | 0.4459 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0164 | 0.0655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.