Detailed information for compound 553632

Basic information

Technical information
  • TDR Targets ID: 553632
  • Name: isopropylhydrazine sulfate
  • MW: 170.187 | Formula: C3H10N2O4S--
  • H donors: 2 H acceptors: 4 LogP: -1.69 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]S(=O)(=O)[O-].NNC(C)C
  • InChi: 1S/C3H10N2.H2O4S/c1-3(2)5-4;1-5(2,3)4/h3,5H,4H2,1-2H3;(H2,1,2,3,4)/p-2
  • InChiKey: PECRFPZAFZIMEN-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • propan-2-ylhydrazine sulfate
  • 68143-29-3
  • EINECS 268-852-8
  • Isopropylhydrazine sulphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Schistosoma mansoni nuclear receptor 0.0037 0.0043 0.0098
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Schistosoma mansoni hypothetical protein 0.0528 0.1573 0.3538
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0043 0.0098
Schistosoma mansoni zinc finger protein 0.0037 0.0043 0.0098
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0047 0.0075 0.0169
Brugia malayi hypothetical protein 0.0037 0.0043 0.0195
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0036 0.0081
Plasmodium vivax histone deacetylase, putative 0.0274 0.078 0.3452
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 0.0172 0.0774
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.008 0.0179
Toxoplasma gondii histone deacetylase HDAC3 0.0739 0.2228 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0739 0.2228 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0739 0.2228 1
Echinococcus granulosus histone deacetylase 0.0298 0.0856 0.1925
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0043 0.0098
Brugia malayi histone deacetylase 11 0.0274 0.078 0.3503
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0028 0.0124
Loa Loa (eye worm) hypothetical protein 0.0066 0.0135 0.0604
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0047 0.0075 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0057 0.0129
Echinococcus multilocularis tar DNA binding protein 0.0075 0.0162 0.0364
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.017 0.0382
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Trypanosoma cruzi histone deacetylase 1, putative 0.0739 0.2228 1
Echinococcus multilocularis microtubule associated protein 2 0.1451 0.4445 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0257
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0028 0.0124
Onchocerca volvulus 0.0037 0.0043 0.0343
Brugia malayi nuclear receptor NHR-88 0.0078 0.0172 0.0774
Loa Loa (eye worm) steroid hormone receptor 0.0078 0.0172 0.0774
Schistosoma mansoni transcription factor btf3 0.0041 0.0057 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0219 0.0494
Loa Loa (eye worm) hypothetical protein 0.0253 0.0717 0.3218
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0043 0.0098
Schistosoma mansoni histone deacetylase hda2 0.0274 0.078 0.1756
Brugia malayi jmjC domain containing protein 0.0035 0.0036 0.0161
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.3235 1 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0274 0.078 0.1756
Toxoplasma gondii histone deacetylase HDAC5 0.0274 0.078 0.3503
Trypanosoma brucei histone deacetylase 3 0.0298 0.0856 0.384
Schistosoma mansoni histone deacetylase 0.0739 0.2228 0.5012
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0047 0.0075 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0043 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 0.0172 0.0388
Echinococcus granulosus lamin dm0 0.0032 0.0028 0.0062
Brugia malayi histone deacetylase 1 (HD1) 0.0739 0.2228 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0043 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 0.0172 0.0774
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0172 0.0774
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0219 0.0985
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.0717 0.1613
Leishmania major cysteinyl-tRNA synthetase, putative 0.0047 0.0075 0.0337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 0.0172 0.0774
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0219 0.0494
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0739 0.2228 1
Onchocerca volvulus Bile acid receptor homolog 0.0078 0.0172 0.2035
Echinococcus granulosus FTZ F1 alpha 0.0078 0.0172 0.0388
Loa Loa (eye worm) hypothetical protein 0.0078 0.0172 0.0774
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0047 0.0075 0.0337
Schistosoma mansoni hypothetical protein 0.0049 0.008 0.0179
Echinococcus granulosus histone deacetylase 8 0.0274 0.078 0.1756
Echinococcus granulosus lamin 0.0032 0.0028 0.0062
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 0.0172 0.2035
Toxoplasma gondii histone deacetylase HDAC1 0.0298 0.0856 0.384
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.008 0.0178 0.0178
Brugia malayi hypothetical protein 0.0037 0.0043 0.0195
Plasmodium vivax histone deacetylase, putative 0.0298 0.0856 0.3793
Loa Loa (eye worm) TAR-binding protein 0.0075 0.0162 0.0726
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0172 0.0388
Echinococcus multilocularis histone deacetylase 7 0.0298 0.0856 0.1925
Plasmodium falciparum histone deacetylase 1 0.0739 0.2228 1
Giardia lamblia Cysteinyl-tRNA synthetase 0.0047 0.0075 0.0262
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0057 0.0129
Brugia malayi nuclear receptor NHR-88 0.0037 0.0043 0.0195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0219 0.0494
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0043 0.0195
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0057 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 0.0172 0.0774
Trypanosoma brucei histone deacetylase 1 0.0739 0.2228 1
Leishmania major histone deacetylase, putative 0.0298 0.0856 0.384
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0047 0.0075 0.0337
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0017 0.0039
Trypanosoma cruzi histone deacetylase, putative 0.0274 0.078 0.3503
Brugia malayi Bromodomain containing protein 0.0029 0.0017 0.0077
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0257
Toxoplasma gondii histone deacetylase HDAC4 0.0274 0.078 0.3503
Echinococcus multilocularis thyroid hormone receptor alpha 0.0078 0.0172 0.0388
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.008 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 0.0172 0.0774
Echinococcus multilocularis transcription factor btf3 0.0041 0.0057 0.0128
Loa Loa (eye worm) histone deacetylase 3 0.0739 0.2228 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0407 0.1826
Brugia malayi Histone deacetylase family protein 0.0298 0.0856 0.384
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0043 0.0098
Trypanosoma brucei histone deacetylase 4 0.0298 0.0856 0.384
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0124
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0043 0.0195
Echinococcus multilocularis histone deacetylase 1 0.0739 0.2228 0.5012
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.017 0.0382
Loa Loa (eye worm) hypothetical protein 0.0105 0.0255 0.1146
Brugia malayi RNA recognition motif domain containing protein 0.0075 0.0162 0.0726
Plasmodium vivax histone deacetylase 1, putative 0.0739 0.2228 1
Trichomonas vaginalis histone deacetylase, putative 0.0739 0.2228 1
Brugia malayi nuclear receptor RXR 0.0037 0.0043 0.0195
Echinococcus granulosus GPCR family 2 0.0049 0.008 0.0179
Loa Loa (eye worm) CYP4Cod1 0.008 0.0178 0.0799
Trypanosoma brucei cytochrome P450, putative 0.008 0.0178 0.0799
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0057 0.0256
Trichomonas vaginalis histone deacetylase, putative 0.0739 0.2228 1
Leishmania major cytochrome p450-like protein 0.008 0.0178 0.0799
Schistosoma mansoni thyroid hormone receptor 0.0078 0.0172 0.0388
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0015
Echinococcus granulosus geminin 0.0528 0.1573 0.3538
Trypanosoma cruzi histone deacetylase, putative 0.0298 0.0856 0.384
Brugia malayi nuclear receptor RXR 0.0041 0.0057 0.0257
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 0.0172 0.0388
Brugia malayi hypothetical protein 0.0253 0.0717 0.3218
Loa Loa (eye worm) hypothetical protein 0.0274 0.078 0.3503
Schistosoma mansoni histone deacetylase 0.0739 0.2228 0.5012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.008 0.0179
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0017 0.0039
Brugia malayi hypothetical protein 0.0041 0.0057 0.0257
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0112 0.0503
Trichomonas vaginalis histone deacetylase, putative 0.0739 0.2228 1
Plasmodium falciparum histone deacetylase, putative 0.0298 0.0856 0.3793
Echinococcus granulosus histone deacetylase 1 0.0739 0.2228 0.5012
Loa Loa (eye worm) histone deacetylase 7A 0.0298 0.0856 0.384
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0172 0.0774
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 0.0172 0.0388
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 0.0172 0.0388
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.008 0.0357
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Leishmania major histone deacetylase, putative 0.0739 0.2228 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0036 0.0081
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 0.0172 0.0388
Loa Loa (eye worm) hypothetical protein 0.0049 0.008 0.0357
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0043 0.0098
Plasmodium falciparum histone deacetylase 2 0.0298 0.0856 0.3793
Onchocerca volvulus 0.0032 0.0028 0.0137
Echinococcus multilocularis GPCR, family 2 0.0049 0.008 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0078 0.0172 0.0774
Echinococcus multilocularis lamin 0.0032 0.0028 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0162 0.0364
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0057 0.0257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.0783 0.3513
Leishmania major histone deacetylase, putative 0.0739 0.2228 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.008 0.0179
Schistosoma mansoni hypothetical protein 0.0049 0.008 0.0179
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0036 0.0161
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.008 0.0357
Echinococcus multilocularis peregrin 0.0029 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0162 0.0364
Brugia malayi Histone deacetylase family protein 0.0298 0.0856 0.384
Schistosoma mansoni lamin 0.0032 0.0028 0.0062
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0075 0.0162 0.0726
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0043 0.0098
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0047 0.0075 0.0075
Schistosoma mansoni thyroid hormone receptor 0.0078 0.0172 0.0388
Brugia malayi steroid hormone receptor 0.0078 0.0172 0.0774
Treponema pallidum cysteinyl-tRNA synthetase 0.0047 0.0075 0.5
Entamoeba histolytica histone deacetylase, putative 0.0739 0.2228 1
Brugia malayi ecdysone receptor 0.0037 0.0043 0.0195
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0057 0.0181
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Trichomonas vaginalis histone deacetylase, putative 0.0739 0.2228 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Trypanosoma cruzi histone deacetylase, putative 0.0298 0.0856 0.384
Schistosoma mansoni retinoic acid receptor RXR 0.0195 0.0536 0.1206
Trichomonas vaginalis histone deacetylase, putative 0.0739 0.2228 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0219 0.0494
Brugia malayi Histone deacetylase 1 0.0739 0.2228 1
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0162 0.0364
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0162 0.0364
Onchocerca volvulus 0.0037 0.0043 0.0343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0219 0.0494
Brugia malayi beta-NAC-like protein 0.0041 0.0057 0.0256
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 0.0172 0.0388
Brugia malayi jmjC domain containing protein 0.0094 0.022 0.0987
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0178 0.0799
Loa Loa (eye worm) fli-1 protein 0.0236 0.0661 0.2969
Giardia lamblia Histone deacetylase 0.0739 0.2228 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0219 0.0494
Brugia malayi Steroid receptor seven-up type 2 0.0078 0.0172 0.0774
Brugia malayi RNA binding protein 0.0075 0.0162 0.0726
Echinococcus multilocularis lamin dm0 0.0032 0.0028 0.0062
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 0.0172 0.0388
Schistosoma mansoni gabp alpha 0.0078 0.017 0.0382
Brugia malayi PHD-finger family protein 0.0029 0.0017 0.0077
Brugia malayi tailless protein 0.0037 0.0043 0.0195
Echinococcus multilocularis musashi 0.0032 0.0028 0.0062
Schistosoma mansoni ets-related 0.0236 0.0661 0.1488
Schistosoma mansoni nuclear receptor 0.0037 0.0043 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0172 0.0388
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0052 0.0117
Echinococcus granulosus tar DNA binding protein 0.0075 0.0162 0.0364
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0219 0.0985
Schistosoma mansoni hypothetical protein 0.0052 0.0089 0.02
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0407 0.1826
Schistosoma mansoni histone deacetylase hda2 0.0303 0.0872 0.1962
Echinococcus granulosus leucyl tRNA synthetase 0.0047 0.0075 0.0169
Chlamydia trachomatis cysteine--tRNA ligase 0.0047 0.0075 0.5
Toxoplasma gondii histone deacetylase HDAC2 0.0739 0.2228 1
Plasmodium falciparum cysteine--tRNA ligase 0.0047 0.0075 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0172 0.0774
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0043 0.0195
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0078 0.0172 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0162 0.0364
Schistosoma mansoni lamin 0.0032 0.0028 0.0062
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 0.0172 0.2035
Brugia malayi nuclear hormone receptor 0.0037 0.0043 0.0195
Brugia malayi hypothetical protein 0.0041 0.0057 0.0257
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0172 0.0774
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0078 0.0172 0.0774
Loa Loa (eye worm) hypothetical protein 0.0078 0.0172 0.0774
Loa Loa (eye worm) hypothetical protein 0.0078 0.0172 0.0774
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0043 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 0.0172 0.0774
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0255 0.1146
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0017 0.0039
Schistosoma mansoni RAR-like nuclear receptor 0.0078 0.0172 0.0388
Onchocerca volvulus 0.0032 0.0028 0.0137
Schistosoma mansoni survival motor neuron protein 0.0052 0.0089 0.02
Leishmania major histone deacetylase, putative 0.0298 0.0856 0.384
Echinococcus granulosus histone deacetylase 6 0.0303 0.0872 0.1962
Schistosoma mansoni hypothetical protein 0.0528 0.1573 0.3538
Echinococcus granulosus ecdysone induced protein 78C 0.0078 0.0172 0.0388
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 0.0172 0.0388
Echinococcus granulosus microtubule associated protein 2 0.1451 0.4445 1
Brugia malayi intermediate filament protein 0.0032 0.0028 0.0124
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0047 0.0075 0.0337
Loa Loa (eye worm) hypothetical protein 0.0031 0.0026 0.0116
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.022 0.0495
Brugia malayi Latrophilin receptor protein 2 0.0049 0.008 0.0357
Echinococcus granulosus histone deacetylase 6 0.0298 0.0856 0.1925
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0077
Brugia malayi Ets-domain containing protein 0.0078 0.017 0.0762
Schistosoma mansoni microtubule-associated protein tau 0.1451 0.4445 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 0.0172 0.0774
Echinococcus multilocularis histone deacetylase 0.0298 0.0856 0.1925
Loa Loa (eye worm) hypothetical protein 0.0049 0.0081 0.0363
Loa Loa (eye worm) RNA binding protein 0.0075 0.0162 0.0726
Schistosoma mansoni histone deacetylase 4 5 0.0298 0.0856 0.1925
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0257
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0043 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0172 0.0774
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0154 0.0407 0.0916
Plasmodium vivax cysteine--tRNA ligase, putative 0.0047 0.0075 0.0262
Loa Loa (eye worm) histone deacetylase 0.0298 0.0856 0.384
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0043 0.0195
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.3235 1 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0274 0.078 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0057 0.0129
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0043 0.0098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0172 0.0388
Loa Loa (eye worm) hypothetical protein 0.0739 0.2228 1
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0047 0.0075 0.0337
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0043 0.0098
Echinococcus granulosus transcription factor btf3 0.0041 0.0057 0.0128
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0017 0.0077
Brugia malayi follicle stimulating hormone receptor 0.0274 0.0783 0.3513
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0017 0.0077
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0178 0.0799
Loa Loa (eye worm) hypothetical protein 0.0078 0.0172 0.0774
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0043 0.0195
Brugia malayi conserved hypotetical protein 0.0037 0.0043 0.0195
Trypanosoma cruzi cytochrome P450, putative 0.008 0.0178 0.0799
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 0.0172 0.0774
Loa Loa (eye worm) hypothetical protein 0.0078 0.0172 0.0774
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 0.0172 0.0388
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.022 0.0495
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0057 0.0256
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0257
Brugia malayi histone deacetylase 3 (HD3) 0.0739 0.2228 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0075 0.0337
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0043 0.0195
Onchocerca volvulus 0.0052 0.0089 0.0941
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 0.0172 0.0774
Onchocerca volvulus 0.0047 0.0075 0.0757
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0043 0.0098
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 0.0172 0.0388
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 0.0172 0.0774
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0057 0.0256
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 0.0172 0.0388
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0047 0.0075 0.0169
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0057 0.0257
Echinococcus multilocularis geminin 0.0528 0.1573 0.3538
Loa Loa (eye worm) histone deacetylase 11 0.0274 0.078 0.3503
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0172 0.0388
Schistosoma mansoni jumonji domain containing protein 0.0074 0.016 0.036
Schistosoma mansoni hypothetical protein 0.0029 0.0017 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.0172 0.0388
Schistosoma mansoni hypothetical protein 0.0105 0.0255 0.0574
Brugia malayi nuclear hormone receptor 0.0078 0.0172 0.0774
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0089
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0043 0.0195
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0047 0.0075 0.0082
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0057 0.0129
Brugia malayi Ets-domain containing protein 0.0078 0.017 0.0762
Echinococcus multilocularis histone deacetylase 3 0.0739 0.2228 0.5012
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0057 0.0256
Echinococcus multilocularis histone deacetylase 6 0.0298 0.0856 0.1925
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.0172 0.0774
Loa Loa (eye worm) histone deacetylase 1 0.0739 0.2228 1
Trypanosoma cruzi cytochrome P450, putative 0.008 0.0178 0.0799
Schistosoma mansoni intermediate filament proteins 0.0032 0.0028 0.0062
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0036 0.0081
Schistosoma mansoni nuclear hormone receptor 0.0078 0.0172 0.0388
Trypanosoma brucei histone deacetylase, putative 0.0298 0.0856 0.384
Echinococcus granulosus peregrin 0.0029 0.0017 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0219 0.0494
Trypanosoma cruzi histone deacetylase, putative 0.0298 0.0856 0.384
Loa Loa (eye worm) hypothetical protein 0.0057 0.0106 0.0476
Echinococcus granulosus cysteinyl tRNA synthetase 0.0047 0.0075 0.0169
Loa Loa (eye worm) hypothetical protein 0.0078 0.0172 0.0774
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0017 0.0077
Brugia malayi TAR-binding protein 0.0075 0.0162 0.0726
Echinococcus granulosus intermediate filament protein 0.0032 0.0028 0.0062
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0028 0.0124
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 0.0172 0.0388
Loa Loa (eye worm) hypothetical protein 0.0078 0.0172 0.0774
Echinococcus granulosus histone deacetylase 6 0.0298 0.0856 0.1925
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0043 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 0.0172 0.0774
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0043 0.0343
Loa Loa (eye worm) hypothetical protein 0.0078 0.0172 0.0774
Echinococcus granulosus jumonji domain containing protein 0.004 0.0052 0.0117
Echinococcus multilocularis histone deacetylase 8 0.0274 0.078 0.1756
Echinococcus multilocularis histone deacetylase 6 0.0303 0.0872 0.1962
Schistosoma mansoni hypothetical protein 0.0049 0.008 0.0179
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0089 0.0399
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0043 0.0098
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0047 0.0075 0.0337
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0739 0.2228 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0257
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0043 0.0098
Echinococcus granulosus histone deacetylase 3 0.0739 0.2228 0.5012
Leishmania major basic transcription factor 3a, putative 0.0041 0.0057 0.0256
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0057 0.0257
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 0.0172 0.0774
Schistosoma mansoni histone deacetylase 4 5 0.0298 0.0856 0.1925
Echinococcus granulosus histone deacetylase 7 0.0298 0.0856 0.1925
Brugia malayi nuclear receptor NHR-67 0.0037 0.0043 0.0195
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0036 0.0081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Brugia malayi Cytochrome P450 family protein 0.008 0.0178 0.0799
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.0717 0.1613
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0407 0.1826
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0078 0.0172 0.0388
Brugia malayi Fli-1 protein 0.0236 0.0661 0.2969
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0043 0.0195
Trypanosoma brucei histone deacetylase 2 0.0274 0.078 0.3503
Loa Loa (eye worm) DR-78 0.0037 0.0043 0.0195
Brugia malayi ecdysteroid receptor 0.0078 0.0172 0.0774
Echinococcus multilocularis FTZ F1 alpha 0.0078 0.0172 0.0388
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0057 0.0256
Plasmodium falciparum cysteine--tRNA ligase 0.0047 0.0075 0.0262
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0195 0.0536 0.1206
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0047 0.0075 0.0337
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0195
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0047 0.0075 0.0169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0172 0.0774
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 0.0172 0.0774
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.017 0.0762
Trypanosoma cruzi histone deacetylase, putative 0.0274 0.078 0.3503
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0043 0.0343
Trichomonas vaginalis histone deacetylase, putative 0.0739 0.2228 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0043 0.0098
Echinococcus multilocularis histone deacetylase 6 0.0298 0.0856 0.1925
Schistosoma mansoni hypothetical protein 0.0049 0.008 0.0179
Plasmodium vivax histone deacetylase 2, putative 0.0298 0.0856 0.3793
Schistosoma mansoni coup transcription factor 0.0078 0.0172 0.0388
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0407 0.1826
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 0.0172 0.0388
Onchocerca volvulus 0.0078 0.0172 0.2035
Brugia malayi Cytochrome P450 family protein 0.008 0.0178 0.0799

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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