Detailed information for compound 553724

Basic information

Technical information
  • TDR Targets ID: 553724
  • Name: 7-chloro-3-hydroxy-5-phenyl-1-(2,2,2-trifluor oethyl)-3H-1,4-benzodiazepin-2-one
  • MW: 368.738 | Formula: C17H12ClF3N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.78 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C(=NC(C(=O)N2CC(F)(F)F)O)c1ccccc1
  • InChi: 1S/C17H12ClF3N2O2/c18-11-6-7-13-12(8-11)14(10-4-2-1-3-5-10)22-15(24)16(25)23(13)9-17(19,20)21/h1-8,15,24H,9H2
  • InChiKey: XQJAPOSYQSPTBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-hydroxyhalazepam
  • 22753-75-9
  • 3-OH-HZ
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-1-(2,2,2-trifluoroethyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0053 0.0277
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0117 0.0517
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0307 0.3822 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0018 0.0033
Schistosoma mansoni hypothetical protein 0.0166 0.2012 0.3983
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0744 0.442
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.1293 0.3289
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0053 0.0277
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0361 0.035
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0018 0.000005236
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.1293 0.1292
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0117 0.0116
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0053 0.0277
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0544 0.1302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0655 0.1272
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0161 0.0318
Brugia malayi Nuclear hormone receptor E75 0.001 0.0018 0.0107
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0018 0.0098
Brugia malayi Thioredoxin reductase 0.0037 0.0361 0.2147
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0744 0.4416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0161 0.0951
Echinococcus granulosus dnaJ subfamily B 0.0402 0.5025 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.0361 0.261
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.019
Loa Loa (eye worm) RNA binding protein 0.0067 0.0744 0.4416
Loa Loa (eye worm) hypothetical protein 0.0051 0.0544 0.3225
Schistosoma mansoni hypothetical protein 0.0402 0.5025 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0161 0.0318
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1684 0.3349
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0117 0.078
Onchocerca volvulus 0.0028 0.025 0.1824
Onchocerca volvulus 0.0021 0.0161 0.1125
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0161 0.0959
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0346 0.2058
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0161 0.016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0573 0.4288
Brugia malayi tailless protein 0.001 0.0018 0.0107
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0202 0.1342
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0161 0.0959
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0161 0.016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0161 0.016
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0307 0.3822 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0161 0.0959
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.019
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.001 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1684 0.3327
Brugia malayi hypothetical protein 0.0051 0.0544 0.3231
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0161 0.1125
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0951
Plasmodium falciparum thioredoxin reductase 0.0037 0.0361 0.0818
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0018 0.0107
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0307 0.3822 0.4283
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0101 0.0593
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0161 0.0287
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0161 0.0287
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0117 0.0669
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Loa Loa (eye worm) hypothetical protein 0.011 0.1293 0.7676
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0161 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0951
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1684 0.1683
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0053 0.0277
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0951
Trypanosoma brucei hypothetical protein, conserved 0.011 0.1293 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0202 0.1198
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0053 0.0071
Brugia malayi nuclear hormone receptor 0.001 0.0018 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0018 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0544 0.4127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.019
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0018 0.0033
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0401 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0183 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0161 0.0318
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0126 0.0848
Loa Loa (eye worm) DR-78 0.001 0.0018 0.0098
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0033 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0017
Schistosoma mansoni zinc finger protein 0.001 0.0018 0.000005236
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0744 0.4416
Schistosoma mansoni hypothetical protein 0.0023 0.0183 0.033
Loa Loa (eye worm) hypothetical protein 0.011 0.1293 0.7676
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0018 0.0033
Giardia lamblia GTOR 0.0018 0.0117 0.8753
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0161 0.016
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.001 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0161 0.0318
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0307 0.3822 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0161 0.0951
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0401 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0161 0.0287
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0053 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0744 0.1451
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0126 0.2824
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1293 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0126 0.0083
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0544 0.4059
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0361 0.2695
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0544 0.1302
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0018 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0053 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0161 0.0959
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0018 0.000005236
Brugia malayi beta-lactamase 0.011 0.1293 0.7678
Brugia malayi nuclear receptor NHR-88 0.0021 0.0161 0.0959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Brugia malayi RNA binding protein 0.0067 0.0744 0.442
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0161 0.016
Brugia malayi steroid hormone receptor 0.0021 0.0161 0.0959
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0161 0.0287
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0053 0.0165
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0018 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0161 0.0959
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0744 0.1451
Mycobacterium ulcerans hypothetical protein 0.011 0.1293 0.3289
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.1293 0.1409
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0361 0.214
Schistosoma mansoni coup transcription factor 0.0021 0.0161 0.0287
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.1293 0.2571
Leishmania major trypanothione reductase 0.0037 0.0361 0.2486
Loa Loa (eye worm) hypothetical protein 0.011 0.1293 0.7676
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0117 0.0513
Onchocerca volvulus 0.011 0.1293 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0117 0.0116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0558 0.3307
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1684 1
Schistosoma mansoni cpg binding protein 0.003 0.0271 0.0505
Mycobacterium tuberculosis Probable reductase 0.0084 0.0966 0.1037
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0161 0.1125
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0401 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0033 0.0063
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0202 0.1442
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0117 0.0669
Brugia malayi nuclear hormone receptor 0.0021 0.0161 0.0959
Trypanosoma brucei trypanothione reductase 0.0037 0.0361 0.261
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0951
Entamoeba histolytica hypothetical protein 0.0024 0.0202 0.4804
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0307 0.3822 1
Brugia malayi beta-lactamase family protein 0.011 0.1293 0.7678
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0018 0.0033
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0202 0.0399
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0053 0.0317
Onchocerca volvulus 0.011 0.1293 1
Brugia malayi hypothetical protein 0.0011 0.0033 0.0198
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0101 0.0199
Brugia malayi beta-lactamase family protein 0.011 0.1293 0.7678
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0018 0.0107
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.1293 0.1409
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0126 0.0193
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0161 0.0959
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0931
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0018 0.0017
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.5025 0.5025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0161 0.0951
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1086 0.1173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0161 0.0951
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0183 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0161 0.0959
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0161 0.016
Mycobacterium leprae conserved hypothetical protein 0.011 0.1293 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Plasmodium vivax glutathione reductase, putative 0.0037 0.0361 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Brugia malayi hypothetical protein 0.001 0.0018 0.0107
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0117 0.023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0126 0.0248
Echinococcus granulosus cpg binding protein 0.003 0.0271 0.0537
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0161 0.0959
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0033 0.0198
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0018 0.0098
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0117 0.0513
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Brugia malayi hypothetical protein 0.001 0.0018 0.0107
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0053 0.0165
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0117 0.0777
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0117 0.0694
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1293 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0966 0.1037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1293 0.2546
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0361 0.0818
Echinococcus multilocularis GPCR, family 2 0.0017 0.0101 0.01
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0018 0.0107
Leishmania major hypothetical protein, conserved 0.0051 0.0544 0.3959
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0368 0.0729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1684 0.3327
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.1293 0.1409
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0101 0.01
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0117 0.0198
Schistosoma mansoni ap endonuclease 0.0018 0.0126 0.0216
Toxoplasma gondii ABC1 family protein 0.011 0.1293 1
Echinococcus granulosus tar DNA binding protein 0.0067 0.0744 0.1479
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0161 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0161 0.0959
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0951
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0126 0.0848
Schistosoma mansoni cpg binding protein 0.0028 0.025 0.0464
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0161 0.016
Brugia malayi glutathione reductase 0.0037 0.0361 0.2147
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0161 0.0318
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0101 0.0199
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0053 0.0103
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1684 0.3327
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0053 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0368 0.0366
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0126 0.0741
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0126 0.0848
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0701 0.8854 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0117 0.0777
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0126 0.0748
Schistosoma mansoni cpg binding protein 0.003 0.0271 0.0505
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0053 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0161 0.0959
Toxoplasma gondii exonuclease III APE 0.0018 0.0126 0.0741
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0053 0.0277
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.1293 0.1409
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0126 0.0848
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0158 0.1099
Mycobacterium tuberculosis Probable hydrolase 0.011 0.1293 0.1409
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0117 0.0513
Brugia malayi CXXC zinc finger family protein 0.0028 0.025 0.1487
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0744 0.0743
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0544 0.1302
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1684 0.3349
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0126 0.0193
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0161 0.0959
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0161 0.0318
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0161 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1293 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0951
Brugia malayi nuclear receptor RXR 0.0011 0.0033 0.0198
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0161 0.0287
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0593
Brugia malayi nuclear receptor NHR-67 0.001 0.0018 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0544 0.4059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0161 0.0959
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0161 0.0951
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1293 0.2546
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0202 0.0367
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0117 0.2587
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Loa Loa (eye worm) hypothetical protein 0.011 0.1293 0.7676
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0053 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0115
Loa Loa (eye worm) hypothetical protein 0.011 0.1293 0.7676
Loa Loa (eye worm) hypothetical protein 0.011 0.1293 0.7676
Brugia malayi TAR-binding protein 0.0067 0.0744 0.442
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0033 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1293 1
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.1293 0.1409
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0117 0.0513
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0117 0.0687
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0166
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0117 0.0694
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0161 0.0959
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1684 0.1683
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1086 0.3669
Loa Loa (eye worm) hypothetical protein 0.0036 0.0346 0.2051
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0053 0.0277
Schistosoma mansoni nuclear hormone receptor 0.001 0.0018 0.000005236
Schistosoma mansoni ap endonuclease 0.0018 0.0126 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0161 0.0959
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0117 0.0777
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1086 0.1173
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0033 0.0032
Schistosoma mansoni nuclear receptor 0.001 0.0018 0.000005236
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0966 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Mycobacterium tuberculosis Conserved protein 0.011 0.1293 0.1409
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1293 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0117 0.023
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0966 0.1037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0161 0.0287
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0018 0.0017
Brugia malayi hypothetical protein 0.0033 0.0312 0.1854
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.019
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0126 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Brugia malayi ecdysteroid receptor 0.0021 0.0161 0.0959
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0101 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Brugia malayi Nuclear hormone receptor E75 0.001 0.0018 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0053 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0117 0.0669
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0053 0.0052
Leishmania major hypothetical protein, conserved 0.011 0.1293 1
Echinococcus granulosus geminin 0.0166 0.2012 0.4003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0018 0.0106
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0401 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0161 0.0287
Plasmodium falciparum glutathione reductase 0.0037 0.0361 0.0818
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.019
Echinococcus multilocularis cpg binding protein 0.003 0.0271 0.027
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0744 0.1451
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0117 0.0198
Mycobacterium leprae Probable lipase LipE 0.011 0.1293 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Plasmodium vivax hypothetical protein, conserved 0.011 0.1293 0.3289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Loa Loa (eye worm) glutathione reductase 0.0037 0.0361 0.214
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0161 0.0287
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0307 0.3822 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0117 0.0669
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0161 0.0287
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0053 0.0165
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.025 0.148
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0126 0.0125
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0117 0.2587
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0117 0.0777
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0117 0.0513
Schistosoma mansoni nuclear hormone receptor 0.001 0.0018 0.000005236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0053 0.0165
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0161 0.0318
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0101 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1293 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0018 0.0107
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0161 0.0287
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0307 0.3822 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0744 0.1451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0544 0.4127
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.1293 0.1409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0951
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0966 0.1037
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0166
Brugia malayi conserved hypotetical protein 0.001 0.0018 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0117 0.0687
Mycobacterium ulcerans beta-lactamase 0.011 0.1293 0.3289
Brugia malayi hypothetical protein 0.0011 0.0033 0.0198
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0161 0.1125
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0126 0.0193
Echinococcus multilocularis geminin 0.0166 0.2012 0.2011
Loa Loa (eye worm) beta-lactamase 0.011 0.1293 0.7676
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0018 0.0098
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0161 0.0318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0558 0.3313
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0126 1
Mycobacterium tuberculosis Conserved protein 0.011 0.1293 0.1409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0951
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0018 0.0017
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0117 0.0669
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0018 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0098
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0126 0.0193
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1293 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1086 0.1173
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0307 0.3822 1
Echinococcus granulosus GPCR family 2 0.0017 0.0101 0.0199
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0018 0.000005236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0161 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0202 0.1442
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0101 0.0601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0161 0.0951
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0185
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.1293 0.3289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0161 0.0951
Mycobacterium tuberculosis Conserved protein 0.011 0.1293 0.1409
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.1293 0.7676
Brugia malayi ecdysone receptor 0.001 0.0018 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1684 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0053 0.0165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.1293 0.7678
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0401 1
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0018 0.0107
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0126 0.0586
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0202 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0161 0.0287
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0117 0.0777
Schistosoma mansoni hypothetical protein 0.0166 0.2012 0.3983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0033 0.0115
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0033 0.0198
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0033 0.0031
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0161 0.0287
Schistosoma mansoni hypothetical protein 0.0036 0.0346 0.0656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0744 0.1451
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0126 0.074
Onchocerca volvulus 0.011 0.1293 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0966 0.1037
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0202 0.1342
Trichomonas vaginalis esterase, putative 0.011 0.1293 1
Schistosoma mansoni nuclear receptor 0.001 0.0018 0.000005236
Loa Loa (eye worm) hypothetical protein 0.0052 0.0558 0.3307
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0117 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0117 0.0777
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0161 0.0959
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0558 0.3313
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0161 0.0959
Brugia malayi nuclear receptor RXR 0.001 0.0018 0.0107
Mycobacterium ulcerans lipase LipD 0.011 0.1293 0.3289

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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