Detailed information for compound 553827

Basic information

Technical information
  • TDR Targets ID: 553827
  • Name: azidocodeine
  • MW: 327.401 | Formula: C18H23N4O2
  • H donors: 0 H acceptors: 0 LogP: 3.72 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [NH-]=[N+]=N[C@@H]1CC[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1OC
  • InChi: 1S/C18H22N4O2/c1-22-8-7-18-11-4-5-12(20-21-19)17(18)24-16-14(23-2)6-3-10(15(16)18)9-13(11)22/h3,6,11-13,17H,4-5,7-9H2,1-2H3/t11-,12+,13+,17-,18-/m0/s1
  • InChiKey: HHODTHJTFYCYHK-KEMUOJQUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 22958-08-3
  • 6-Deoxy-6-azidodihydroisocodeine
  • Morphinan, 6-azido-4,5-epoxy-3-methoxy-17-methyl-, (5-alpha,6-beta)-
  • Morphinan, 6-beta-azido-4,5-alpha-epoxy-3-methoxy-17-methyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0197 0.139
Loa Loa (eye worm) hypothetical protein 0.0064 0.0181 0.0458
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0676 0.0676
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0131 0.0526 0.3778
Entamoeba histolytica rodhanase-like domain containing protein 0.011 0.042 0.2984
Entamoeba histolytica recQ family helicase, putative 0.0131 0.0526 0.3793
Trypanosoma cruzi DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Echinococcus granulosus bloom syndrome protein 0.0228 0.1029 0.1029
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0127 0.0883
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0354 0.0354
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0657 0.8324
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0197 0.139
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0326 0.0326
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0574 0.798
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.3356 0.3356
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.011 0.042 0.2984
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0168 0.0718 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0111 0.0424 0.4119
Onchocerca volvulus 0.011 0.042 0.3996
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0037 0.0037
Brugia malayi mbt repeat family protein 0.0098 0.0354 0.3439
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.1334 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0168 0.0718 0.5172
Echinococcus granulosus SAM and MBT domain containing protein 0.0098 0.0354 0.0354
Echinococcus granulosus histone acetyltransferase MYST2 0.0111 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.011 0.042 0.1067
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1052 0.7837
Schistosoma mansoni DNA polymerase eta 0.0226 0.102 0.102
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.1383 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0064 0.0429
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0064 0.0429
Echinococcus granulosus alkaline phosphatase 0.1959 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0105 0.0395 0.4366
Leishmania major phosphoglycerate kinase B, cytosolic 0.0168 0.0718 0.5172
Echinococcus multilocularis dna polymerase kappa 0.0097 0.0353 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Schistosoma mansoni DNA helicase recq5 0.0105 0.0395 0.0395
Brugia malayi Phosphoglycerate kinase 0.0062 0.0168 0.1629
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1334 1
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.011 0.042 0.042
Entamoeba histolytica rodhanase-like domain containing protein 0.011 0.042 0.2984
Schistosoma mansoni hypothetical protein 0.1015 0.5108 0.5108
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0105 0.0395 0.5497
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.0353 0.2527
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1334 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0105 0.0395 0.0395
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0168 0.0718 1
Echinococcus granulosus dna polymerase eta 0.0226 0.102 0.102
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0168 0.0718 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0032 0.0196
Loa Loa (eye worm) hypothetical protein 0.0098 0.0354 0.0898
Mycobacterium ulcerans DNA polymerase IV 0.0097 0.0353 0.4885
Loa Loa (eye worm) MBCTL1 0.0111 0.0424 0.1076
Leishmania major DNA polymerase eta, putative 0.0226 0.102 0.7363
Loa Loa (eye worm) RecQ helicase 0.0228 0.1029 0.2612
Plasmodium falciparum phosphoglycerate kinase 0.0168 0.0718 0.7989
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.011 0.042 0.2984
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0575 0.4134
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.1383 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.102 0.2589
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0005 0.007
Trichomonas vaginalis cdc25b, putative 0.011 0.042 0.2984
Mycobacterium ulcerans DNA polymerase IV 0.0097 0.0353 0.4885
Entamoeba histolytica hypothetical protein 0.0036 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.0322
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0032 0.0081
Brugia malayi jmjC domain containing protein 0.0151 0.063 0.6123
Echinococcus multilocularis SAM and MBT domain containing protein 0.0098 0.0354 0.0354
Onchocerca volvulus 0.011 0.042 0.3996
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Mycobacterium ulcerans hypothetical protein 0.0156 0.0657 0.9143
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0111 0.0424 0.0424
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.1959 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0037 0.0037
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0858 0.4298 0.4298
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.1959 1 1
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0676 0.0676
Leishmania major phosphoglycerate kinase C, glycosomal 0.0168 0.0718 0.5172
Loa Loa (eye worm) hypothetical protein 0.011 0.042 0.1067
Schistosoma mansoni blooms syndrome DNA helicase 0.0174 0.075 0.075
Trichomonas vaginalis DNA helicase recq, putative 0.0131 0.0526 0.3793
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0105 0.0395 0.0395
Giardia lamblia DINP protein human, muc B family 0.0097 0.0353 0.2621
Trypanosoma brucei unspecified product 0.0097 0.0353 0.2527
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0326 0.0326
Echinococcus granulosus geminin 0.1015 0.5108 0.5108
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0097 0.0353 0.0353
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.1383 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.0561 0.0561
Trypanosoma cruzi DNA polymerase eta, putative 0.0159 0.0672 0.4836
Echinococcus multilocularis alkaline phosphatase 0.1959 1 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0098 0.0354 0.0354
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0032 0.0032
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0384 0.184 0.184
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0168 0.1179
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.0326 0.0326
Brugia malayi Rhodanese-like domain containing protein 0.011 0.042 0.4088
Brugia malayi jmjC domain containing protein 0.0092 0.0326 0.3165
Entamoeba histolytica rodhanase-like domain containing protein 0.011 0.042 0.2984
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0151 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0102 0.0376 0.0954
Schistosoma mansoni phosphoglycerate kinase 0.0168 0.0718 0.0718
Brugia malayi polk-prov protein 0.003 0.0005 0.0049
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0105 0.0395 0.1002
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0152 0.0387
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0131 0.0526 0.3778
Brugia malayi MH2 domain containing protein 0.0116 0.0452 0.4391
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0131 0.0526 0.3778
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0105 0.0395 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Onchocerca volvulus 0.011 0.042 0.3996
Schistosoma mansoni hypothetical protein 0.1018 0.5123 0.5123
Trypanosoma brucei unspecified product 0.0067 0.0197 0.139
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0064 0.0429
Onchocerca volvulus 0.0092 0.0327 0.311
Trichomonas vaginalis DNA polymerase eta, putative 0.0097 0.0353 0.2468
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Entamoeba histolytica phosphoglycerate kinase, putative 0.0168 0.0718 0.5269
Echinococcus granulosus microtubule associated protein 2 0.0677 0.3356 0.3356
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.1959 1 1
Echinococcus multilocularis polycomb protein SCMH1 0.0098 0.0354 0.0354
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0452 0.1147
Schistosoma mansoni terminal deoxycytidyl transferase 0.0097 0.0353 0.0353
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0168 0.1179
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0168 0.0718 0.5172
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.016 0.016
Trichomonas vaginalis DNA helicase recq1, putative 0.0228 0.1029 0.7655
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0105 0.0395 0.1002
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.0353 0.2527
Brugia malayi hypothetical protein 0.0036 0.0037 0.0359
Entamoeba histolytica recQ family DNA helicase 0.0054 0.0127 0.0728
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0151 0.063 0.8769
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0105 0.0395 0.0395
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.1334 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0097 0.0353 0.2468
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0052 0.0116 0.1618
Echinococcus multilocularis intestinal type alkaline phosphatase 0.1959 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0037 0.0037
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0064 0.0429
Loa Loa (eye worm) jmjC domain-containing protein 0.0092 0.0326 0.0827
Echinococcus granulosus m phase inducer phosphatasecdc25 0.011 0.042 0.042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0037 0.0037
Toxoplasma gondii hypothetical protein 0.0048 0.0096 0.1335
Schistosoma mansoni lipoxygenase 0.0054 0.0129 0.0129
Schistosoma mansoni DNA helicase recq1 0.0105 0.0395 0.0395
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0159 0.0672 0.9354
Trichomonas vaginalis cdc25b, putative 0.011 0.042 0.2984
Trichomonas vaginalis DNA helicase recq, putative 0.0228 0.1029 0.7655
Onchocerca volvulus 0.0232 0.1052 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0424 0.1076
Echinococcus granulosus dna polymerase kappa 0.0097 0.0353 0.0353
Brugia malayi DnaJ domain containing protein 0.006 0.016 0.1552
Echinococcus granulosus polycomb protein SCMH1 0.0098 0.0354 0.0354
Brugia malayi Phosphoglycerate kinase 0.0168 0.0718 0.698
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0013
Entamoeba histolytica recQ family helicase, putative 0.0052 0.0116 0.0646
Echinococcus multilocularis dna polymerase eta 0.0226 0.102 0.102
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0032 0.0196
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0097 0.0353 0.0897
Loa Loa (eye worm) hypothetical protein 0.0789 0.3939 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1334 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1334 1
Echinococcus granulosus lysine specific demethylase 5A 0.0092 0.0326 0.0326
Schistosoma mansoni alkaline phosphatase 0.1959 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0676 0.6576
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0129 0.0129
Schistosoma mansoni alpha-glucosidase 0.0138 0.0561 0.0561
Echinococcus granulosus phosphoglycerate kinase 1 0.0168 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.0168 0.0718 0.1823
Schistosoma mansoni alkaline phosphatase 0.1959 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0105 0.0395 0.5497
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Mycobacterium ulcerans phosphoglycerate kinase 0.0168 0.0718 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1334 1
Brugia malayi mbt repeat family protein 0.0098 0.0354 0.3439
Echinococcus multilocularis phosphoglycerate kinase 1 0.0168 0.0718 0.0718
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.1383 1
Onchocerca volvulus 0.0098 0.0354 0.3362
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0574 0.6052
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0202 0.0898 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0168 0.1179
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0129 0.0129
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0005 0.007
Echinococcus multilocularis bloom syndrome protein 0.0228 0.1029 0.1029
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0168 0.1179
Trichomonas vaginalis cdc25c, putative 0.011 0.042 0.2984
Leishmania major DNA polymerase eta, putative 0.0159 0.0672 0.4836
Treponema pallidum phosphoglycerate kinase 0.0168 0.0718 0.4898
Entamoeba histolytica hypothetical protein 0.0036 0.0037 0.0037
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0168 0.0718 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0105 0.0395 0.3837
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1334 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0575 0.4134
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0037 0.0037
Plasmodium vivax DNA repair protein REV1, putative 0.003 0.0005 0.007
Leishmania major DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0149 0.0619 0.8621
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.0353 0.2527
Schistosoma mansoni phosphoglycerate kinase 0.0168 0.0718 0.0718
Trypanosoma cruzi DNA polymerase eta, putative 0.0226 0.102 0.7363
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0452 0.1147
Schistosoma mansoni hypothetical protein 0.0036 0.0037 0.0037
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0105 0.0395 0.3837
Trypanosoma brucei unspecified product 0.0067 0.0197 0.139
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0032 0.0311
Schistosoma mansoni hypothetical protein 0.1015 0.5108 0.5108
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.016 0.016
Schistosoma mansoni myelin transcription factor 1 myt1 0.0111 0.0424 0.0424
Echinococcus granulosus jumonji domain containing protein 0.004 0.0053 0.0053
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.1959 1 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0032 0.0446
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.011 0.042 0.2984
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0168 0.1179
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0906 0.2301
Schistosoma mansoni DNA polymerase IV / kappa 0.003 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1334 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0676 0.0676
Loa Loa (eye worm) hypothetical protein 0.0102 0.0376 0.0954
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0168 0.1179
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0097 0.0353 0.2527
Brugia malayi Rhodanese-like domain containing protein 0.011 0.042 0.4088
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0127 0.0883
Entamoeba histolytica deoxycytidyl transferase, putative 0.0097 0.0353 0.2468
Trypanosoma cruzi DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Onchocerca volvulus 0.011 0.042 0.3996
Schistosoma mansoni hypothetical protein 0.0593 0.2921 0.2921
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0354 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0197 0.139
Brugia malayi Pre-SET motif family protein 0.0204 0.0906 0.881
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0168 0.1179
Schistosoma mansoni jumonji domain containing protein 0.0132 0.0531 0.0531
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0097 0.0353 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Brugia malayi Bloom's syndrome protein homolog 0.0228 0.1029 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0105 0.0395 0.2932
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1334 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0054 0.0127 0.0127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0168 0.0718 0.5269
Schistosoma mansoni alpha glucosidase 0.0035 0.0032 0.0032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0676 0.1717
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.011 0.042 0.042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0575 0.4134
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0384 0.184 0.184
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0098 0.0354 0.3362
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.016 0.0405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.3356 0.3356
Brugia malayi ImpB/MucB/SamB family protein 0.0097 0.0353 0.3435
Trypanosoma brucei phosphoglycerate kinase 0.0168 0.0718 0.5172
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.011 0.042 0.2984
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0097 0.0353 0.0353
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0032 0.0196
Trypanosoma brucei phosphoglycerate kinase 0.0168 0.0718 0.5172
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0168 0.0718 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1334 1
Giardia lamblia Phosphoglycerate kinase 0.0168 0.0718 0.5365
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0151 0.063 0.063
Brugia malayi ImpB/MucB/SamB family protein 0.0226 0.102 0.9915
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0168 0.0718 0.5269
Trypanosoma brucei glucosidase, putative 0.0035 0.0032 0.0196
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0111 0.0771
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0054 0.0127 0.1765
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.016 0.098
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0053 0.0053
Trypanosoma brucei DNA polymerase eta, putative 0.0226 0.102 0.7363
Echinococcus multilocularis geminin 0.1015 0.5108 0.5108
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0111 0.0424 0.0424
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0168 0.1179
Echinococcus multilocularis histone acetyltransferase MYST2 0.0111 0.0424 0.0424
Plasmodium vivax phosphoglycerate kinase, putative 0.0168 0.0718 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1334 1
Chlamydia trachomatis phosphoglycerate kinase 0.0168 0.0718 0.5
Loa Loa (eye worm) mbt repeat family protein 0.0098 0.0354 0.0898
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.011 0.042 0.2984
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0353 0.2527
Schistosoma mansoni hypothetical protein 0.006 0.016 0.016

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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