Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0178 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0178 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0178 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0178 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0178 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.5 | 0.5 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0178 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0178 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0178 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0178 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0178 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 100 uM | Cytotoxicity in uninfected CEM cells | ChEMBL. | 12672254 |
CC50 (functional) | > 100 uM | Cytotoxicity in uninfected CEM cells | ChEMBL. | 12672254 |
CC50 (functional) | > 175 uM | Cytotoxicity in uninfected Daudi cells | ChEMBL. | 12672254 |
CC50 (functional) | > 175 uM | Cytotoxicity in uninfected Daudi cells | ChEMBL. | 12672254 |
CC50 (functional) | = 279 uM | Cytotoxicity in uninfected MEF cells | ChEMBL. | 12672254 |
CC50 (functional) | = 279 uM | Cytotoxicity in uninfected MEF cells | ChEMBL. | 12672254 |
Cytotoxicity (functional) | = 3.8 | Visual cytotoxicity was scored on uninfected HFF cells not affected by virus in the HCMV (Towne strain) plaque reduction assay | ChEMBL. | 12672254 |
Cytotoxicity (functional) | = 52 | Cytotoxicity was scored on uninfected HFF cells not affected by virus in the HCMV (AD169 strain) by neutral red uptake | ChEMBL. | 12672254 |
Cytotoxicity (functional) | > 349 | Cytotoxicity was scored on uninfected HFF cells not affected by virus in the HCMV (AD169 strain) by neutral red uptake | ChEMBL. | 12672254 |
EC50 (functional) | = 0.56 uM | Concentration inhibiting the replication of EBV in Daudi cells | ChEMBL. | 12672254 |
EC50 (functional) | = 1.7 uM | Concentration inhibiting the replication of MCMV in MEF cells | ChEMBL. | 12672254 |
EC50 (functional) | = 2.5 uM | Concentration inhibiting the replication of HSV-1 in BSC-1 cells determined by ELISA assay | ChEMBL. | 12672254 |
EC50 (functional) | = 7 uM | Concentration of the compound inhibiting the replication of EBV in Daudi cells by DNA hybridization assay | ChEMBL. | 12672254 |
EC50 (functional) | = 7 uM | Concentration of the compound inhibiting the replication of EBV in Daudi cells by DNA hybridization assay | ChEMBL. | 12672254 |
EC50 (functional) | = 10.8 uM | Concentration inhibiting the replication of HBV in HFF cells by plaque reduction assay | ChEMBL. | 12672254 |
EC50 (functional) | > 20 uM | Concentration inhibiting the replication of EBV in H-1 cells by DNA hybridization assay | ChEMBL. | 12672254 |
EC50 (functional) | > 20 uM | Inhibition of the replication of HBV in 2.2.15 cells, by DNA hybridization assay | ChEMBL. | 12672254 |
EC50 (functional) | = 25 uM | Concentration inhibiting the replication of HSV-1 in Vero cells determined by plaque reduction assay | ChEMBL. | 12672254 |
EC50 (functional) | > 50 uM | Concentration inhibiting the replication of HSV-2 in Vero cells. | ChEMBL. | 12672254 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12672254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.