Detailed information for compound 554012

Basic information

Technical information
  • TDR Targets ID: 554012
  • Name: 3-benzhydrylidene-1-ethyl-pyrrolidine hydroch loride
  • MW: 299.838 | Formula: C19H22ClN
  • H donors: 0 H acceptors: 0 LogP: 5.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCC(=C(c2ccccc2)c2ccccc2)C1.Cl
  • InChi: 1S/C19H21N.ClH/c1-2-20-14-13-18(15-20)19(16-9-5-3-6-10-16)17-11-7-4-8-12-17;/h3-12H,2,13-15H2,1H3;1H
  • InChiKey: NXYDGUJRZMAZQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-benzhydrylidene-1-ethylpyrrolidine hydrochloride
  • pridefine
  • 23239-78-3
  • NSC300625
  • Pyrrolidine, 3-(diphenylmethylene)-1-ethyl-, hydrochloride
  • 1-Ethyl-3-diphenylmethylenepyrrolidine hydrochloride
  • 3-(Diphenylmethylene)-1-ethylpyrrolidine hydrochloride
  • AHR-1118
  • NSC 300625
  • D05608
  • Pridefine hydrochloride (USAN)
  • Pridefine hydrochloride [USAN]
  • PRIDEFINE HYDROCHLORIDE

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0549 0.0549
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0033 0.0033
Echinococcus granulosus microsomal glutathione S transferase 3 0.0114 0.2161 0.9216
Entamoeba histolytica hypothetical protein 0.0035 0.0549 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0033 0.0033
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0033 0.0139
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2215 1
Schistosoma mansoni thyroid hormone receptor 0.0132 0.2547 0.2547
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0549 0.2342
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0033 0.0128
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.2547 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0033 0.0033
Toxoplasma gondii MAPEG family protein 0.0114 0.2161 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0033 0.0128
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0033 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0549 0.2156
Echinococcus granulosus FTZ F1 alpha 0.001 0.0033 0.0139
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0 0.5
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0 0.5
Onchocerca volvulus 0.001 0.0033 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0033 0.0033
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0033 0.0139
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0114 0.2161 0.8486
Entamoeba histolytica hypothetical protein 0.0035 0.0549 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0033 0.0128
Brugia malayi hypothetical protein 0.0035 0.0549 0.2367
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0033 0.0128
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0033 0.0139
Entamoeba histolytica hypothetical protein 0.0035 0.0549 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.2345 0.9207
Schistosoma mansoni coup transcription factor 0.001 0.0033 0.0033
Brugia malayi MH2 domain containing protein 0.0116 0.2215 1
Schistosoma mansoni microsomal glutathione s-transferase 0.0114 0.2161 0.2161
Trypanosoma brucei RNA helicase, putative 0.0207 0.4082 0.5
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0 0.5
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.2345 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0033 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0033 0.0139
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0033 0.0139
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0033 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0033 0.0139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0033 0.0128
Schistosoma mansoni hypothetical protein 0.0207 0.4082 0.4082
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0033 0.0139
Entamoeba histolytica hypothetical protein 0.0035 0.0549 0.5
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0033 0.0128
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0033 0.0128
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0035 0.0549 0.0549
Trichomonas vaginalis ferritin, putative 0.0008 0 0.5
Schistosoma mansoni hypothetical protein 0.0122 0.2345 0.2345
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0033 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0033 0.0139
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0 0.5
Treponema pallidum bacterioferrin (TpF1) 0.0008 0 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0033 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0033 0.0033
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0033 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2215 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0033 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0132 0.2547 0.2547
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0033 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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