Detailed information for compound 554049

Basic information

Technical information
  • TDR Targets ID: 554049
  • Name: 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2 -ium
  • MW: 194.25 | Formula: C11H16NO2+
  • H donors: 1 H acceptors: 0 LogP: 1.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2C[NH2+]CCc2cc1OC
  • InChi: 1S/C11H15NO2/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2/h5-6,12H,3-4,7H2,1-2H3/p+1
  • InChiKey: CEIXWJHURKEBMQ-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • 6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ium
  • ZINC03881969

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0042 0.0042
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0042 0.0071
Brugia malayi ecdysteroid receptor 0.0011 0.0042 0.0234
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0042 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0042 0.0234
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0022 0.0123
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0022 0.0037
Treponema pallidum ribonuclease H (rnhA) 0.011 0.0798 0.3462
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0195 0.0368
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0025
Schistosoma mansoni lamin 0.0028 0.0176 0.0176
Brugia malayi MH2 domain containing protein 0.0116 0.0845 0.4663
Echinococcus multilocularis microtubule associated protein 2 0.0792 0.5986 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0223 0.32
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0337 0.0736
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0195 0.3254
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0042 0.0042
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0913 0.8665
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0818 0.7493
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0042 0.0234
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0013 0.0058 0.0097
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0825 0.1864
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Echinococcus granulosus geminin 0.0341 0.2551 0.4262
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0042 0.0234
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0111 0.0152
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0042 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0013 0.0058 0.0097
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0131 0.022
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0013 0.0058 0.0067
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0042 0.0071
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Onchocerca volvulus 0.0028 0.0176 0.0868
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0234
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0111 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0302 0.0504
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0096
Schistosoma mansoni coup transcription factor 0.0011 0.0042 0.0042
Echinococcus multilocularis musashi 0.0028 0.0176 0.0294
Brugia malayi hypothetical protein 0.0013 0.0058 0.032
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0195 0.0505
Leishmania major thymidine kinase, putative 0.0521 0.3923 1
Plasmodium vivax glutathione reductase, putative 0.0049 0.0337 0.5709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0042 0.0234
Trypanosoma cruzi ribonuclease H1, putative 0.011 0.0798 0.1927
Echinococcus granulosus smad 0.0008 0.0022 0.0037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0008
Leishmania major thymidylate kinase-like protein 0.0075 0.0533 0.1242
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0092 0.0354
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0013 0.0058 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0361
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0042 0.0042
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0825 0.455
Loa Loa (eye worm) hypothetical protein 0.0013 0.0062 0.0339
Brugia malayi Muscleblind-like protein 0.0146 0.1071 0.591
Brugia malayi MH2 domain containing protein 0.0008 0.0022 0.0123
Echinococcus granulosus bloom syndrome protein 0.0022 0.0131 0.022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0042 0.0234
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0111 0.0207
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1022 1
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0825 0.455
Loa Loa (eye worm) hypothetical protein 0.0028 0.0176 0.0972
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Schistosoma mansoni protein kinase 0.0013 0.0058 0.0058
Echinococcus granulosus ribonuclease H1 0.011 0.0798 0.1334
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0825 0.1995
Entamoeba histolytica thymidine kinase, putative 0.0521 0.3923 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1022 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0092 0.0096
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0042 0.0042
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0092 0.1199
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Schistosoma mansoni Smad4 0.0008 0.0022 0.0022
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0195 0.0368
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0302 0.0504
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0302 0.1665
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Onchocerca volvulus Ribonuclease H1 homolog 0.011 0.0798 0.3933
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0013 0.0058 0.0013
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3923 1
Trypanosoma brucei trypanothione reductase 0.0049 0.0337 0.0688
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0195 0.0368
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0092 0.0784
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0092 0.1199
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0223 0.2488
Loa Loa (eye worm) hypothetical protein 0.0013 0.0062 0.0339
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0032 0.00000000041529
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0234
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0172 0.095
Schistosoma mansoni phosphoglucomutase 0.011 0.0798 0.0798
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0337 0.0564
Echinococcus granulosus intermediate filament protein 0.0028 0.0176 0.0294
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0042 0.0209
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.011 0.0798 1
Schistosoma mansoni thymidylate kinase 0.0075 0.0533 0.0533
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0825 0.359
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0042 0.0042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0102
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0111 0.0615
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0042 0.0042
Schistosoma mansoni thymidylate kinase 0.0075 0.0533 0.0533
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0825 0.1995
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0102
Schistosoma mansoni DNA helicase recq1 0.0009 0.0032 0.0032
Toxoplasma gondii thymidylate kinase 0.0075 0.0533 0.654
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0042 0.0234
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0845 0.4663
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0042 0.0042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0236 0.0475
Trypanosoma brucei ingi protein (ORF1) 0.0123 0.0894 0.2033
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0005 0.0025
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Brugia malayi RNase H family protein 0.011 0.0798 0.4406
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0111 0.0554
Brugia malayi reverse transcriptase 0.0013 0.0058 0.032
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0195 0.0368
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0042 0.0234
Onchocerca volvulus 0.0028 0.0176 0.0868
Trypanosoma brucei ingi protein (ORF1) 0.0123 0.0894 0.2033
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0825 0.1995
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0013 0.0058 0.0058
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0111 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0234
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Onchocerca volvulus 0.0013 0.0058 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0302 0.0302
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0092 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0102
Loa Loa (eye worm) inositol-1 0.0036 0.0236 0.1304
Brugia malayi Smad1 0.0008 0.0022 0.0123
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0111 0.0272
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0058 0.0058
Onchocerca volvulus 0.0272 0.203 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0195 0.2335
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0195 0.2596
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0042 0.0071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0042 0.0071
Brugia malayi intermediate filament protein 0.0028 0.0176 0.0972
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Echinococcus granulosus RNA directed DNA polymerase 0.0013 0.0058 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0195 0.0368
Trypanosoma brucei RNA helicase, putative 0.0557 0.4193 1
Schistosoma mansoni hypothetical protein 0.0341 0.2551 0.2551
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0236 0.0475
Loa Loa (eye worm) hypothetical protein 0.0146 0.1071 0.591
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0195 0.2128
Trypanosoma brucei thymidine kinase 0.0521 0.3923 0.9346
Giardia lamblia CDC8 0.0075 0.0533 0.1288
Brugia malayi Thioredoxin reductase 0.0049 0.0337 0.1861
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0032 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0825 0.1995
Plasmodium falciparum thioredoxin reductase 0.0017 0.0092 0.1199
Echinococcus multilocularis geminin 0.0341 0.2551 0.4262
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0236 0.0444
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0102
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0092 0.0509
Loa Loa (eye worm) hypothetical protein 0.0146 0.1071 0.591
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0042 0.0071
Brugia malayi phosphofructokinase 0.0113 0.0825 0.455
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0302 0.1665
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0111 0.0152
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0065 0.0109
Echinococcus multilocularis ribonuclease H1 0.011 0.0798 0.1334
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0845 0.4663
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0042 0.0042
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0013 0.0058 0.0014
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0092 0.0784
Schistosoma mansoni phosphoglucomutase 0.011 0.0798 0.0798
Loa Loa (eye worm) RecQ helicase 0.0022 0.0131 0.0725
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0825 0.1995
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0818 0.7882
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0013 0.0058 0.0067
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0013 0.0058 0.0067
Echinococcus multilocularis smad 0.0008 0.0022 0.0037
Schistosoma mansoni hypothetical protein 0.0013 0.0058 0.0058
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Echinococcus multilocularis thymidylate kinase 0.0075 0.0533 0.0891
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0337 0.0564
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0195 0.0419
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Brugia malayi nuclear receptor NHR-88 0.0011 0.0042 0.0234
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0131 0.0204
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0013 0.0058 0.0286
Brugia malayi 6-phosphofructokinase 0.0113 0.0825 0.455
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0029 0.0186 0.0345
Loa Loa (eye worm) Smad1 0.0008 0.0022 0.0123
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0337 0.5709
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0042 0.0234
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0111 0.1583
Schistosoma mansoni hypothetical protein 0.0075 0.0533 0.0533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0042 0.0234
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0302 0.0504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0223 0.0223
Echinococcus multilocularis muscleblind protein 0.0146 0.1071 0.1789
Schistosoma mansoni lamin 0.0028 0.0176 0.0176
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0025
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0013 0.0058 0.0013
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0092
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0075 0.0533 0.4929
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0042 0.0071
Brugia malayi hypothetical protein 0.0013 0.0058 0.032
Brugia malayi steroid hormone receptor 0.0011 0.0042 0.0234
Treponema pallidum thymidylate kinase (tmk) 0.0075 0.0533 0.2162
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0913 0.8873
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0131 0.0725
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.1779 0.9816
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0131 0.0204
Echinococcus granulosus KRAB A domain containing protein 0.0013 0.0058 0.0097
Schistosoma mansoni hypothetical protein 0.0013 0.0058 0.0058
Brugia malayi Zinc knuckle family protein 0.0013 0.0058 0.032
Entamoeba histolytica Thymidylate kinase, putative 0.0075 0.0533 0.1242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0042 0.0234
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0025
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3923 1
Trypanosoma brucei hypothetical protein, conserved 0.0123 0.0894 0.2033
Brugia malayi nuclear receptor RXR 0.0006 0.0005 0.0025
Brugia malayi hypothetical protein 0.0006 0.0005 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0102
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0236 0.2042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0102
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0913 0.8873
Plasmodium falciparum thioredoxin reductase 0.0049 0.0337 0.6091
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0195 0.0368
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0337 0.2897
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0223 0.0223
Leishmania major ribonuclease H1, putative 0.011 0.0798 0.1927
Echinococcus multilocularis Smad4 0.0008 0.0022 0.0037
Schistosoma mansoni hypothetical protein 0.0341 0.2551 0.2551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0042 0.0234
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0111 0.0094
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0042 0.0234
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0008
Loa Loa (eye worm) glutathione reductase 0.0049 0.0337 0.1861
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0042 0.0234
Brugia malayi RNase H family protein 0.011 0.0798 0.4406
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0032 0.0054
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0092 0.0102
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0042 0.0234
Leishmania major hypothetical protein, conserved 0.0029 0.0186 0.0345
Schistosoma mansoni inositol monophosphatase 0.0036 0.0236 0.0236
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0096
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Giardia lamblia Reverse transcriptase/endonuclease 0.0013 0.0058 0.0067
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0236 0.2666
Brugia malayi hypothetical protein 0.0013 0.0058 0.032
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0195 0.2596
Brugia malayi MH1 domain containing protein 0.0008 0.0022 0.0123
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0154
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0013 0.0058 0.0097
Plasmodium falciparum thymidylate kinase 0.0075 0.0533 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1022 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0176 0.0972
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0123 0.0894 0.2033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0302 0.0504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0042 0.0234
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0013 0.0058 0.0097
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0111 0.0761
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0825 0.7951
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0818 0.7882
Giardia lamblia Thymidine kinase 0.0521 0.3923 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0223 0.0372
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0029 0.0186 0.0345
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0042 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0042 0.0234
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0825 0.1995
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0234
Echinococcus granulosus muscleblind protein 0.0146 0.1071 0.1789
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0825 0.455
Brugia malayi RNase H family protein 0.011 0.0798 0.4406
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0092 0.0155
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0092 0.0102
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0825 0.7574
Schistosoma mansoni ap endonuclease 0.002 0.0111 0.0111
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0818 0.7882
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0234
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Echinococcus granulosus lamin 0.0028 0.0176 0.0294
Schistosoma mansoni hypothetical protein 0.0557 0.4193 0.4193
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0042 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0042 0.0042
Brugia malayi MH2 domain containing protein 0.0008 0.0022 0.0123
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0058 0.0318
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0913 0.8873
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0042 0.0071
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0092 0.034
Mycobacterium ulcerans thymidylate kinase 0.0075 0.0533 0.4743
Onchocerca volvulus 0.0011 0.0042 0.0209
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.2132 1
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0058 0.0014
Trichomonas vaginalis reverse transcriptases, putative 0.0013 0.0058 0.0014
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0032 0.0054
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0096 0.0096
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0818 0.7882
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0042 0.0071
Plasmodium falciparum glutathione reductase 0.0049 0.0337 0.6091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0223 0.0223
Echinococcus granulosus Smad4 0.0008 0.0022 0.0037
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0022 0.0123
Brugia malayi Inositol-1 0.0036 0.0236 0.1304
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0825 0.7876
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0111 0.0152
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0092 0.0096
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0236 0.1551
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0042 0.0071
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.024 0.1787 0.1787
Echinococcus multilocularis lamin 0.0028 0.0176 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0042 0.0234
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0065 0.0109
Schistosoma mansoni phosphoglucomutase 0.011 0.0798 0.0798
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0042 0.0234
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0111 0.0204
Leishmania major trypanothione reductase 0.0049 0.0337 0.0736
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1071 0.1789
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0042 0.0234
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0195 0.2128
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0111 0.0152
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0825 0.1995
Trypanosoma cruzi ribonuclease H1, putative 0.011 0.0798 0.1927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0302 0.0302
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0042 0.0234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0022 0.0022
Trypanosoma cruzi thymidine kinase, putative 0.0521 0.3923 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0236 0.0395
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0195 0.0368
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0825 0.1378
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0025
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0042 0.0042
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0236 0.0395
Schistosoma mansoni intermediate filament proteins 0.0028 0.0176 0.0176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0042 0.0071
Trypanosoma brucei unspecified product 0.0123 0.0894 0.2033
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0195 0.2335
Mycobacterium tuberculosis Probable reductase 0.0113 0.0818 0.7882
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3923 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0176 0.0972
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0337 0.1861
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0195 0.0368
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0208 0.1552
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0234
Trichomonas vaginalis reverse transcriptases, putative 0.0013 0.0058 0.0014
Trypanosoma cruzi thymidine kinase, putative 0.0521 0.3923 1
Brugia malayi reverse transcriptase 0.0013 0.0058 0.032
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0042 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0102
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0022 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0042 0.0234
Brugia malayi hypothetical protein 0.0013 0.0058 0.032
Toxoplasma gondii ribonuclease HI protein 0.011 0.0798 1
Trichomonas vaginalis thymidylate kinase, putative 0.0075 0.0533 0.1242
Trypanosoma brucei ribonuclease H1 0.011 0.0798 0.1801
Schistosoma mansoni DNA helicase recq5 0.0009 0.0032 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0302 0.0302
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0236 0.0475
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0154
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0092 0.0102
Onchocerca volvulus 0.0013 0.0058 0.0286
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0013 0.0058 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0825 0.1995
Trypanosoma cruzi thymidylate kinase, putative 0.0075 0.0533 0.1242
Echinococcus granulosus lamin dm0 0.0028 0.0176 0.0294
Toxoplasma gondii exonuclease III APE 0.002 0.0111 0.1035
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0042 0.0234
Brugia malayi Pre-SET motif family protein 0.0239 0.1779 0.9816
Trypanosoma brucei thymidylate kinase, putative 0.0075 0.0533 0.1161
Brugia malayi follicle stimulating hormone receptor 0.0243 0.1812 1
Trypanosoma cruzi thymidylate kinase, putative 0.0075 0.0533 0.1242
Trichomonas vaginalis thymidylate kinase, putative 0.0075 0.0533 0.1242
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0013 0.0058 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0013 0.0058 0.0097
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0825 0.1378
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0092 0.0102
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0825 0.1995
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0818 0.7882
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0092 0.0102
Loa Loa (eye worm) thymidylate kinase 0.0075 0.0533 0.2942
Onchocerca volvulus 0.0034 0.0223 0.1097
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0042 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0223 0.0223
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0102
Schistosoma mansoni inositol monophosphatase 0.0036 0.0236 0.0236
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0213 0.0356
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Trypanosoma brucei thymidylate kinase, putative 0.0075 0.0533 0.1161
Schistosoma mansoni microtubule-associated protein tau 0.0792 0.5986 0.5986
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0236 0.0475
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0825 0.0825
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0223 0.0372
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0236 0.0475
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0042 0.0209
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0032 0.0054
Trichomonas vaginalis ribonuclease H1, putative 0.011 0.0798 0.1927
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0022 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0234
Brugia malayi hypothetical protein 0.0006 0.0005 0.0025
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0536
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0042 0.0071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0223 0.1229
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0022 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0223 0.0372
Echinococcus multilocularis lamin dm0 0.0028 0.0176 0.0294
Plasmodium falciparum glutathione reductase 0.0017 0.0092 0.1199
Brugia malayi Zinc knuckle family protein 0.0013 0.0058 0.032
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.1812 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0236 0.0475
Plasmodium vivax thymidylate kinase, putative 0.0075 0.0533 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0236 0.0475
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0058 0.0318
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0032 0.0177
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0177
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0111 0.0142
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0032 0.0177
Chlamydia trachomatis thymidylate kinase 0.0075 0.0533 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0042 0.0071
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0825 0.0825
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0075 0.0564
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0042 0.0209
Brugia malayi 6-phosphofructokinase 0.0113 0.0825 0.455
Toxoplasma gondii thioredoxin reductase 0.0049 0.0337 0.3983
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.2132 0.5373
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0195 0.2128
Brugia malayi nuclear hormone receptor 0.0011 0.0042 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0042 0.0234
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0022
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0032 0.0177
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0077 0.0424
Trichomonas vaginalis set domain proteins, putative 0.0272 0.203 0.5109
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0075 0.0533 0.3998
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0042 0.0071
Brugia malayi thymidylate kinase 0.0075 0.0533 0.2942
Onchocerca volvulus Putative thymidylate kinase 0.0075 0.0533 0.2627
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0092 0.034
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0013 0.0058 0.0067
Schistosoma mansoni ap endonuclease 0.002 0.0111 0.0111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0176 0.0972
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0077 0.0424
Schistosoma mansoni smad 0.0008 0.0022 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0111 0.0152
Brugia malayi glutathione reductase 0.0049 0.0337 0.1861
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0075 0.0533 0.6245
Brugia malayi MH1 domain containing protein 0.0008 0.0022 0.0123
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0092 0.0102
Giardia lamblia Ribonuclease H 0.011 0.0798 0.197
Brugia malayi Pao retrotransposon peptidase family protein 0.0013 0.0058 0.032
Brugia malayi Pre-SET motif family protein 0.0034 0.0223 0.1229
Brugia malayi reverse transcriptase 0.0013 0.0058 0.032
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0111 0.1573
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.2132 0.5398
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0234
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0042 0.0071
Echinococcus multilocularis RNA directed DNA polymerase 0.0013 0.0058 0.0097
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0111 0.0186
Echinococcus granulosus microtubule associated protein 2 0.0792 0.5986 1
Echinococcus granulosus thymidylate kinase 0.0075 0.0533 0.0891
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0195 0.3254
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0111 0.0615

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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