Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0153 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0153 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Disruption of mitochondria in insecticide-susceptible Drosophila melanogaster Hikone-R assessed as increase in cytochrome c release from mitochondria to cytosol at 1 mM by western blot analysis | ChEMBL. | 19278021 | |
Activity (functional) | Disruption of mitochondria in insecticide-susceptible Drosophila melanogaster Canton-S assessed as increase in cytochrome c release from mitochondria to cytosol at 1 mM by western blot analysis | ChEMBL. | 19278021 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.