Detailed information for compound 554311

Basic information

Technical information
  • TDR Targets ID: 554311
  • Name: 5-methoxy-1H-indol-6-ol
  • MW: 163.173 | Formula: C9H9NO2
  • H donors: 2 H acceptors: 1 LogP: 1.66 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2cc[nH]c2cc1O
  • InChi: 1S/C9H9NO2/c1-12-9-4-6-2-3-10-7(6)5-8(9)11/h2-5,10-11H,1H3
  • InChiKey: RWEBZZKCIMKUTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-hydroxy-5-methoxyindole
  • 2380-82-7
  • 6H5MI
  • 1H-Indol-6-ol, 5-methoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyruvate kinase 0.0026 0.3739 0.3618
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.6027 0.5708
Echinococcus granulosus pyruvate kinase 0.0034 0.6027 0.595
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.6027 0.5
Echinococcus multilocularis pyruvate kinase 0.0034 0.6027 0.595
Giardia lamblia Pyruvate kinase 0.0034 0.6027 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 1 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.6027 0.6027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.2741 0.2741
Loa Loa (eye worm) hypothetical protein 0.0032 0.5387 0.5387
Echinococcus granulosus intermediate filament protein 0.0032 0.5577 0.5492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 1 1
Schistosoma mansoni lamin 0.0032 0.5577 0.5224
Echinococcus granulosus lamin dm0 0.0032 0.5577 0.5492
Loa Loa (eye worm) hypothetical protein 0.0016 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0034 0.6027 0.6027
Loa Loa (eye worm) pyruvate kinase 0.0034 0.6027 0.6027
Plasmodium falciparum pyruvate kinase 0.0034 0.6027 1
Chlamydia trachomatis pyruvate kinase 0.0034 0.6027 0.5
Schistosoma mansoni pyruvate kinase 0.0034 0.6027 0.571
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 1 1
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.6027 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.6027 0.6027
Echinococcus multilocularis lamin 0.0032 0.5577 0.5492
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.6027 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.6027 0.5708
Echinococcus multilocularis pyruvate kinase 0.0017 0.0741 0.0561
Echinococcus multilocularis pyruvate kinase 0.0017 0.0741 0.0561
Schistosoma mansoni intermediate filament proteins 0.0032 0.5577 0.5224
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.6027 0.5
Brugia malayi intermediate filament protein 0.0032 0.5577 0.5222
Loa Loa (eye worm) hypothetical protein 0.0032 0.5577 0.5577
Schistosoma mansoni pyruvate kinase 0.0034 0.6027 0.571
Mycobacterium ulcerans pyruvate kinase 0.0034 0.6027 0.5
Echinococcus multilocularis pyruvate kinase 0.0034 0.6027 0.595
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.2741 0.2741
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.6027 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0743 0.0743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 1 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.6027 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.5577 0.5222
Echinococcus multilocularis musashi 0.0032 0.5577 0.5492
Plasmodium vivax pyruvate kinase, putative 0.0034 0.6027 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0741 0.0561
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.6027 0.5
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.6027 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 1 1
Echinococcus multilocularis lamin dm0 0.0032 0.5577 0.5492
Leishmania major pyruvate kinase 0.0034 0.6027 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 1 1
Schistosoma mansoni lamin 0.0032 0.5577 0.5224
Echinococcus granulosus pyruvate kinase 0.0017 0.0741 0.0561
Echinococcus granulosus pyruvate kinase 0.0017 0.0741 0.0561
Leishmania major pyruvate kinase 0.0034 0.6027 0.5
Trypanosoma brucei pyruvate kinase 1 0.0034 0.6027 0.5
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.6027 0.5
Echinococcus granulosus pyruvate kinase 0.0017 0.0741 0.0561
Loa Loa (eye worm) intermediate filament protein 0.0032 0.5577 0.5577
Echinococcus granulosus lamin 0.0032 0.5577 0.5492
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.6027 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 1 1
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.2741 0.5
Echinococcus granulosus pyruvate kinase 0.0034 0.6027 0.595
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.5577 0.5577
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.6027 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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