Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | loxhd1 | 0.0024 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Toxoplasma gondii | MAPEG family protein | 0.0135 | 0.528 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0241 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0241 | 1 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0024 | 0.0294 | 1 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.4919 | 0.4919 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.5607 | 0.5607 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0113 | 0.4309 | 0.4309 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0241 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0241 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.3687 | 0.3687 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0241 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0127 | 0.4919 | 0.4919 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0241 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0113 | 0.4309 | 0.4309 |
Echinococcus granulosus | RUN | 0.0024 | 0.0294 | 0.0294 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0127 | 0.4919 | 0.4919 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0241 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0241 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0241 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0294 | 0.0294 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0241 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | conserved hypotetical protein | 0.0113 | 0.4309 | 0.4309 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0241 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.4919 | 0.4919 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.4919 | 0.4919 |
Trypanosoma brucei | alpha tubulin | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | polycystin 1-related | 0.0024 | 0.0294 | 0.0294 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0241 | 1 | 1 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0017 | 0 | 0.5 |
Onchocerca volvulus | 0.0241 | 1 | 1 | |
Brugia malayi | Doublecortin family protein | 0.0024 | 0.0294 | 0.0294 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0294 | 0.0294 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0241 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Schistosoma mansoni | nuclear hormone receptor | 0.0241 | 1 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.5607 | 0.5607 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0127 | 0.4919 | 0.4919 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0241 | 1 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0017 | 0 | 0.5 |
Onchocerca volvulus | 0.0113 | 0.4309 | 0.4137 | |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0294 | 0.0294 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0241 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0241 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.5607 | 0.5607 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0113 | 0.4309 | 0.4309 |
Schistosoma mansoni | nuclear receptor | 0.0113 | 0.4309 | 0.4309 |
Schistosoma mansoni | nuclear receptor | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0241 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | tailless protein | 0.0113 | 0.4309 | 0.4309 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0294 | 0.0294 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0241 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0241 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | DR-78 | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0241 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0113 | 0.4309 | 0.4137 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0241 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0241 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0127 | 0.4919 | 0.4919 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0241 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0113 | 0.4309 | 0.4309 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0241 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0113 | 0.4309 | 0.4309 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0241 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0113 | 0.4309 | 0.4309 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0241 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.4919 | 0.4919 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0127 | 0.4919 | 0.4919 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0.0294 | 0.0294 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0241 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0241 | 1 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0024 | 0.0294 | 0.0294 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0241 | 1 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0024 | 0.0294 | 0.0294 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0241 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0241 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0294 | 0.0294 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0241 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0127 | 0.4919 | 0.4919 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0135 | 0.528 | 0.528 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0241 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0113 | 0.4309 | 0.4137 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0241 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | hypothetical protein | 0.0127 | 0.4919 | 0.4919 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0135 | 0.528 | 0.528 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0241 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0241 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0127 | 0.4919 | 0.4919 |
Brugia malayi | nuclear hormone receptor | 0.0241 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0127 | 0.4919 | 0.4919 |
Schistosoma mansoni | thyroid hormone receptor | 0.0241 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0294 | 0.0294 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0113 | 0.4309 | 0.4309 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0017 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | ecdysone receptor | 0.0113 | 0.4309 | 0.4309 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0135 | 0.528 | 0.528 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0113 | 0.4309 | 0.4309 |
Leishmania major | alpha tubulin | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0113 | 0.4309 | 0.4309 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0241 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0127 | 0.4919 | 0.4919 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0294 | 0.0294 |
Echinococcus multilocularis | RUN | 0.0024 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0113 | 0.4309 | 0.4309 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0241 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0241 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0113 | 0.4309 | 0.4309 |
Schistosoma mansoni | nuclear hormone receptor | 0.0113 | 0.4309 | 0.4309 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0135 | 0.528 | 0.528 |
Giardia lamblia | Alpha-tubulin | 0.0017 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0241 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0241 | 1 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0017 | 0 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0024 | 0.0294 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.4919 | 0.4919 |
Onchocerca volvulus | 0.0113 | 0.4309 | 0.4137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Compound was tested for inhibition of 5-lipoxygenase activity in a broken cell supernatant rat basophilic leukemia cells; No data | ChEMBL. | No reference |
IC50 (functional) | = 0.27 uM | Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils | ChEMBL. | No reference |
IC50 (functional) | = 2.2 uM | Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay | ChEMBL. | No reference |
Inhibition (functional) | = 46 % | Compound was tested in vivo against rat anaphylaxis in the peritoneal cavity at concentration of 100 micromol/kg | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.