Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosylhomocysteinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | adenosylhomocysteinase | Adenosylhomocysteinase | 432 aa | 427 aa | 51.1 % |
Drosophila melanogaster | CG9977 gene product from transcript CG9977-RA | Adenosylhomocysteinase | 432 aa | 428 aa | 51.4 % |
Schistosoma mansoni | adenosylhomocysteinase | Adenosylhomocysteinase | 432 aa | 385 aa | 50.9 % |
Onchocerca volvulus | N-acetyllactosamine synthase homolog | Adenosylhomocysteinase | 432 aa | 436 aa | 75.7 % |
Schistosoma mansoni | adenosylhomocysteinase | Adenosylhomocysteinase | 432 aa | 427 aa | 51.1 % |
Schistosoma japonicum | ko:K01251 adenosylhomocysteinase [EC3.3.1.1], putative | Adenosylhomocysteinase | 432 aa | 427 aa | 51.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | General substrate transporter | 0.0087 | 0.4176 | 0.2158 |
Echinococcus multilocularis | muscleblind protein | 0.0165 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0156 | 0.9326 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0165 | 1 | 1 |
Brugia malayi | Sugar transporter family protein | 0.0102 | 0.5245 | 0.3597 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0156 | 0.9326 | 0.9092 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0156 | 0.9326 | 0.9092 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.9326 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.4872 | 0.3405 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 0.5245 | 0.3597 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0156 | 0.9326 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 0.5245 | 0.3956 |
Echinococcus granulosus | General substrate transporter | 0.0087 | 0.4176 | 0.2158 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0156 | 0.9326 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.4872 | 0.3405 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 0.5245 | 0.3597 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0156 | 0.9326 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0102 | 0.5245 | 0.3597 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0156 | 0.9326 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0156 | 0.9326 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.9326 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 0.5245 | 0.3956 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.5245 | 0.3956 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0102 | 0.5245 | 0.3597 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.4872 | 0.3405 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0156 | 0.9326 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 0.5245 | 0.3597 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0049 | 0.131 | 0.1404 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0165 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.9326 | 1 |
Brugia malayi | Adenosylhomocysteinase | 0.0156 | 0.9326 | 0.9092 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 0.5245 | 0.3597 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0156 | 0.9326 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0156 | 0.9326 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.9326 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 0.5245 | 0.3597 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 0.5245 | 0.3597 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0156 | 0.9326 | 0.9092 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0156 | 0.9326 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 0.5245 | 0.3597 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.9326 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 0.5245 | 0.3956 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0102 | 0.5245 | 0.5624 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.4872 | 0.3405 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC20 (functional) | > 80 uM | Cytotoxicity data HepG2 CC20 (uM) | ChEMBL. | No reference |
IC50 (binding) | = 0.03 uM | Inhibition of S-adenosyl-L-homocysteine hydrolase in intact rat hepatocytes | ChEMBL. | 19692248 |
Inhibition (binding) | Compound was evaluated for the inhibition of human FECH at 10uM | MMV_PBOX. | No reference | |
Inhibition (functional) | = | AntiCryptosporidium parvum activity Compounds added 3h after t0, IC 50 (uM) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.