Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0113 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0113 | 0.1438 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.4353 | 0.596 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0594 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.1457 | 0.7695 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0373 | 0.7227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0594 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0113 | 0.0594 |
Onchocerca volvulus | 0.0037 | 0.0113 | 0.5 | |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0373 | 0.7227 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.1457 | 0.7695 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.0783 | 0.4133 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0373 | 0.7227 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.1457 | 0.7695 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0373 | 0.7227 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0504 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0373 | 0.7227 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0113 | 0.0113 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0373 | 0.7227 | 1 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0113 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0594 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0373 | 0.7227 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0113 | 0.0113 |
Onchocerca volvulus | 0.0037 | 0.0113 | 0.5 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0113 | 0.0594 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0113 | 0.1438 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0373 | 0.7227 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0113 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0783 | 0.4133 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0594 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0113 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.1893 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0373 | 0.7227 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0594 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0594 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.1893 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0113 | 0.0594 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.1893 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0113 | 0.0594 |
Onchocerca volvulus | 0.0037 | 0.0113 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1457 | 0.7695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.