Detailed information for compound 554583

Basic information

Technical information
  • TDR Targets ID: 554583
  • Name: disodium (3E)-3-[[2-methoxy-4-[3-methoxy-4-[( N'E)-N'-(1-oxo-4-sulfonato-2-naphthylidene)hy drazino]phenyl]phenyl]hydrazono]-4-oxo-naphth alene-1-sulfonate
  • MW: 760.701 | Formula: C34H26N4Na2O10S2
  • H donors: 2 H acceptors: 8 LogP: 3.7 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1N/N=C\1/C=C(c2c(C1=O)cccc2)S(=O)(=O)[O-])c1ccc(c(c1)OC)N/N=C\1/C=C(c2c(C1=O)cccc2)S(=O)(=O)[O-].[NaH+].[NaH+]
  • InChi: 1S/C34H26N4O10S2.2Na/c1-47-29-15-19(11-13-25(29)35-37-27-17-31(49(41,42)43)21-7-3-5-9-23(21)33(27)39)20-12-14-26(30(16-20)48-2)36-38-28-18-32(50(44,45)46)22-8-4-6-10-24(22)34(28)40;;/h3-18,35-36H,1-2H3,(H,41,42,43)(H,44,45,46);;/q;2*+1/p-2/b37-27+,38-28+;;
  • InChiKey: FJCLABNSNOPCBX-SNAZUYTISA-L  


Substructure search Similarity search

Network

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Synonyms

  • disodium (3E)-3-[[2-methoxy-4-[3-methoxy-4-[(N'E)-N'-(1-oxo-4-sulfonato-2-naphthylidene)hydrazino]phenyl]phenyl]hydrazono]-4-oxo-1-naphthalenesulfonate
  • disodium (3E)-3-[[2-methoxy-4-[3-methoxy-4-[(2E)-2-(1-oxo-4-sulfonato-naphthalen-2-ylidene)hydrazinyl]phenyl]phenyl]hydrazinylidene]-4-oxo-naphthalene-1-sulfonate
  • disodium (3E)-4-keto-3-[[4-[4-[(N'E)-N'-(1-keto-4-sulfonato-2-naphthylidene)hydrazino]-3-methoxy-phenyl]-2-methoxy-phenyl]hydrazono]naphthalene-1-sulfonate
  • disodium (3E)-3-[[2-methoxy-4-[3-methoxy-4-[(2E)-2-(1-oxo-4-sulfonatonaphthalen-2-ylidene)hydrazinyl]phenyl]phenyl]hydrazinylidene]-4-oxonaphthalene-1-sulfonate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 0.0145 0.2693 0.2644
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Onchocerca volvulus 0.0048 0.076 0.0918
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0371 0.0305
Trichomonas vaginalis heat shock protein, putative 0.0026 0.033 0.0605
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0392 0.1043
Schistosoma mansoni tar DNA-binding protein 0.019 0.3571 0.3527
Schistosoma mansoni heat shock protein 0.0045 0.0701 0.0638
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0701 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.0546 0.154
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.3846 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Leishmania major hypothetical protein, conserved 0.0035 0.0508 0.6942
Treponema pallidum heat shock protein 90 0.0042 0.0647 1
Onchocerca volvulus 0.0035 0.0508 0.0288
Echinococcus granulosus GPCR family 2 0.0033 0.0458 0.0394
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0508 0.7596
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0183 0.1819
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0183 0.1819
Loa Loa (eye worm) hypothetical protein 0.0035 0.0508 0.0886
Echinococcus multilocularis tar DNA binding protein 0.019 0.3571 0.3527
Mycobacterium tuberculosis Conserved protein 0.0035 0.0508 0.1053
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.3571 0.9248
Leishmania major DNA polymerase eta, putative 0.0019 0.0183 0.1819
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0739 0.2157
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0068 0.0011
Loa Loa (eye worm) hypothetical protein 0.0082 0.1429 0.3402
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1672 0.3839
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0701 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0546 0.0993
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0573 0.7976
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.1429 0.3715
Schistosoma mansoni hypothetical protein 0.0514 1 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0508 0.1415
Plasmodium vivax glutathione reductase, putative 0.0037 0.0546 0.154
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0733 0.1501
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1486 0.3392
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0573 0.1167
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.1429 0.1371
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Echinococcus granulosus expressed protein 0.0047 0.0739 0.0676
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0392 0.1043
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0701 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0508 0.1053
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0403 0.108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0733 0.067
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0508 0.0886
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Loa Loa (eye worm) endoplasmin 0.0045 0.0701 0.1415
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0508 0.1015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0183 0.1819
Echinococcus granulosus dna polymerase eta 0.0019 0.0183 0.0116
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0573 0.8731
Brugia malayi Pre-SET motif family protein 0.0029 0.0392 0.1019
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0573 0.7976
Brugia malayi Hsp90 protein 0.003 0.0403 0.1048
Plasmodium falciparum heat shock protein 90 0.0045 0.0701 0.2037
Echinococcus multilocularis tumor protein p63 0.0326 0.628 0.6255
Trypanosoma brucei unspecified product 0.0013 0.0068 0.0011
Echinococcus granulosus heat shock protein 90 0.0045 0.0701 0.0638
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0183 0.1819
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0647 0.914
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0647 0.1336
Brugia malayi Thioredoxin reductase 0.0037 0.0546 0.1421
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0183 0.1819
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0458 0.1192
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0458 0.0394
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1672 1
Trichomonas vaginalis set domain proteins, putative 0.0232 0.4404 1
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0739 0.2157
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0508 0.0886
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1672 0.3839
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1207 0.3137
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0508 0.0443
Mycobacterium ulcerans lipase LipD 0.0035 0.0508 0.7596
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.1429 0.1371
Trypanosoma brucei heat shock protein, putative 0.0045 0.0701 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0392 0.0327
Loa Loa (eye worm) hypothetical protein 0.0035 0.0508 0.0886
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0599 0.0535
Schistosoma mansoni hypothetical protein 0.007 0.1207 0.1147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1852 0.4555
Plasmodium vivax heat shock protein 90, putative 0.003 0.0403 0.108
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0573 0.1626
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0403 0.0028
Schistosoma mansoni tar DNA-binding protein 0.019 0.3571 0.3527
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0458 0.0394
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.1429 0.1371
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0647 0.1336
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.4248 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1852 0.4814
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0599 0.1708
Leishmania major trypanothione reductase 0.0037 0.0546 0.7557
Loa Loa (eye worm) RNA binding protein 0.019 0.3571 0.9248
Echinococcus granulosus neuropeptide s receptor 0.0508 0.9871 0.987
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0546 0.7557
Trypanosoma brucei unspecified product 0.0013 0.0068 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0183 0.0475
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0508 0.1015
Schistosoma mansoni ap endonuclease 0.0038 0.0573 0.0509
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0573 0.1626
Plasmodium vivax heat shock protein, putative 0.017 0.3179 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0508 0.6942
Echinococcus multilocularis dna polymerase eta 0.0019 0.0183 0.0116
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0573 0.121
Schistosoma mansoni hypothetical protein 0.0033 0.0458 0.0394
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0458 0.09
Echinococcus granulosus endoplasmin 0.0042 0.0647 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0068 0.0011
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0183 0.0276
Onchocerca volvulus 0.0035 0.0508 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0733 0.067
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.1486 0.8398
Mycobacterium ulcerans beta-lactamase 0.0035 0.0508 0.7596
Plasmodium falciparum thioredoxin reductase 0.0037 0.0546 0.154
Schistosoma mansoni tar DNA-binding protein 0.019 0.3571 0.3527
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0183 0.1991
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0508 0.1053
Schistosoma mansoni endoplasmin 0.0045 0.0701 0.0638
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0183 0.0116
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0067 0.0175
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0508 0.6942
Brugia malayi Muscleblind-like protein 0.0145 0.2693 0.7002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0508 0.0886
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1486 0.3392
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0701 0.2037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Trypanosoma brucei heat shock protein, putative 0.0045 0.0701 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Echinococcus multilocularis GPCR, family 2 0.0033 0.0458 0.0394
Echinococcus granulosus dna polymerase kappa 0.0019 0.0183 0.0116
Loa Loa (eye worm) beta-lactamase 0.0035 0.0508 0.0886
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0573 0.798
Loa Loa (eye worm) hypothetical protein 0.0145 0.2693 0.6852
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0599 0.1557
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Brugia malayi beta-lactamase family protein 0.0035 0.0508 0.1319
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Brugia malayi hypothetical protein 0.0036 0.0523 0.1359
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.1429 0.1371
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Mycobacterium tuberculosis Conserved protein 0.0035 0.0508 0.1053
Trypanosoma brucei trypanothione reductase 0.0037 0.0546 0.7557
Echinococcus multilocularis endoplasmin 0.0042 0.0647 0.0583
Trypanosoma brucei heat shock protein, putative 0.0045 0.0701 1
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.033 0.0843
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0183 0.1819
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0733 0.067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.076 0.0697
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0508 0.1053
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0701 0.1462
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0392 0.0327
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.1429 0.1371
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0508 0.1015
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0573 0.1166
Echinococcus granulosus tumor protein p63 0.0326 0.628 0.6255
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0739 0.2157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0733 0.067
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0508 0.6942
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Giardia lamblia Grp94/Hsp90 0.0042 0.0647 0.914
Mycobacterium tuberculosis Probable reductase 0.0084 0.1486 0.3392
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0508 0.0886
Trypanosoma brucei heat shock protein, putative 0.0045 0.0701 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1672 0.3839
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0067 0.5
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0458 0.09
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0546 0.0993
Trypanosoma brucei unspecified product 0.0019 0.0183 0.1819
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0573 0.0509
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0458 0.1192
Brugia malayi TAR-binding protein 0.019 0.3571 0.9284
Brugia malayi hypothetical protein 0.0036 0.0523 0.1359
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0573 0.0509
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0403 0.0338
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0701 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0647 0.1386
Brugia malayi beta-lactamase family protein 0.0035 0.0508 0.1319
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0701 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0573 0.798
Schistosoma mansoni tar DNA-binding protein 0.019 0.3571 0.3527
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Plasmodium falciparum glutathione reductase 0.0037 0.0546 0.154
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0647 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1486 0.3392
Loa Loa (eye worm) heat shock protein 75 0.003 0.0403 0.0602
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0599 0.1708
Plasmodium falciparum endoplasmin, putative 0.0033 0.0458 0.1255
Schistosoma mansoni apoptosis regulator bax 0.0082 0.1429 0.1371
Echinococcus granulosus neuropeptide receptor A26 0.0508 0.9871 0.987
Schistosoma mansoni tar DNA-binding protein 0.019 0.3571 0.3527
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0647 0.1196
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0701 0.1415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0733 0.067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0508 0.1319
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0556 0.0492
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1852 0.4814
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0701 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0508 0.1053
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0701 0.2037
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0392 0.0327
Mycobacterium tuberculosis Conserved protein 0.0035 0.0508 0.1053
Loa Loa (eye worm) hypothetical protein 0.0145 0.2693 0.6852
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0403 0.4253
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0599 0.1557
Onchocerca volvulus 0.0035 0.0508 0.0288
Schistosoma mansoni hypothetical protein 0.0082 0.1429 0.1371
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0573 0.798
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0573 0.7976
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0701 1
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0739 0.1517
Schistosoma mansoni hypothetical protein 0.0033 0.0458 0.0394
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0183 0.1991
Brugia malayi N-terminal motif family protein 0.0175 0.3288 0.8549
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Leishmania major heat shock protein, putative 0.003 0.0403 0.5298
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0183 0.0266
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1486 0.3392
Echinococcus multilocularis neuropeptide receptor A26 0.0508 0.9871 0.987
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0508 0.1415
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0183 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0733 0.067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0508 0.0886
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0733 0.1905
Loa Loa (eye worm) hypothetical protein 0.0033 0.0458 0.0752
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0458 0.0394
Echinococcus multilocularis heat shock protein 0.0045 0.0701 0.0638
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.1429 0.3402
Loa Loa (eye worm) hypothetical protein 0.0103 0.1852 0.4555
Plasmodium vivax endoplasmin, putative 0.0045 0.0701 0.2037
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0573 0.0509
Loa Loa (eye worm) hypothetical protein 0.007 0.1207 0.2795
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0573 0.1066
Brugia malayi Endoplasmin precursor 0.0045 0.0701 0.1823
Schistosoma mansoni hypothetical protein 0.0514 1 1
Echinococcus multilocularis heat shock protein 90 0.0038 0.0573 0.0509
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0183 0.0475
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0573 0.149
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0573 0.8731
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0392 0.0327
Loa Loa (eye worm) hypothetical protein 0.004 0.0599 0.1136
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0573 0.7531
Schistosoma mansoni heat shock protein 0.003 0.0403 0.0338
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0733 0.067
Schistosoma mansoni hypothetical protein 0.0082 0.1429 0.1371
Schistosoma mansoni hypothetical protein 0.0033 0.0458 0.0394
Echinococcus multilocularis expressed protein 0.0047 0.0739 0.0676
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.3288 0.722
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0183 0.0266
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0183 0.0116
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Brugia malayi heat shock protein 90 0.0045 0.0701 0.1823
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Plasmodium falciparum heat shock protein 90, putative 0.017 0.3179 1
Echinococcus multilocularis muscleblind protein 1 0.0145 0.2693 0.2644
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0508 0.0443
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0508 0.1015
Schistosoma mansoni heat shock protein 0.0045 0.0701 0.0638
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0739 0.0676
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0068 0.0011
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0403 0.5298
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0458 0.0752
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0599 0.1708
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0647 1
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0701 0.2037
Echinococcus multilocularis heat shock protein 90 0.0045 0.0701 0.0638
Echinococcus granulosus heat shock protein 0.0045 0.0701 0.0638
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0183 0.0276
Trypanosoma cruzi heat shock protein, putative 0.003 0.0403 0.5298
Leishmania major DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Brugia malayi Pre-SET motif family protein 0.0204 0.3846 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0573 0.8731
Toxoplasma gondii exonuclease III APE 0.0038 0.0573 0.1626
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Echinococcus multilocularis neuropeptide s receptor 0.0508 0.9871 0.987
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0508 0.7596
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0739 0.192
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0546 0.154
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1486 0.3392
Brugia malayi RNA binding protein 0.019 0.3571 0.9284
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0599 0.1557
Mycobacterium ulcerans hypothetical protein 0.0035 0.0508 0.7596
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0739 0.2157
Brugia malayi glutathione reductase 0.0037 0.0546 0.1421
Schistosoma mansoni hypothetical protein 0.004 0.0599 0.0535
Onchocerca volvulus 0.0232 0.4404 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.3288 0.8477
Trypanosoma brucei heat shock protein, putative 0.0045 0.0701 1
Echinococcus multilocularis geminin 0.0514 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0508 0.0443
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0556 0.0492
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0508 0.1053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0183 0.1819
Echinococcus granulosus tar DNA binding protein 0.019 0.3571 0.3527
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0183 0.0116
Brugia malayi beta-lactamase 0.0035 0.0508 0.1319
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0573 0.798
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0185 0.1857
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0392 0.0327
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0701 1
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0508 0.1053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0392 0.0327
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0508 0.1015
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0508 0.0443
Giardia lamblia DINP protein human, muc B family 0.0019 0.0183 0.1819
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0403 0.0338
Trypanosoma brucei heat shock protein, putative 0.0045 0.0701 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0701 1
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0701 1
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.3179 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0392 0.0327
Brugia malayi RNA recognition motif domain containing protein 0.019 0.3571 0.9284
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0546 0.1146
Leishmania major heat shock protein 83-1 0.0045 0.0701 1
Schistosoma mansoni hypothetical protein 0.0082 0.1429 0.1371
Loa Loa (eye worm) hypothetical protein 0.0029 0.0392 0.0571
Loa Loa (eye worm) hypothetical protein 0.0048 0.076 0.1575
Schistosoma mansoni endoplasmin 0.0045 0.0701 0.0638
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0508 0.1053
Schistosoma mansoni DNA polymerase eta 0.0019 0.0183 0.0116
Echinococcus granulosus heat shock protein 90 0.0038 0.0573 0.0509
Trypanosoma brucei heat shock protein, putative 0.0045 0.0701 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0573 0.1167
Echinococcus granulosus muscleblind protein 0.0145 0.2693 0.2644
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0183 0.0116
Schistosoma mansoni hypothetical protein 0.0033 0.0458 0.0394
Trichomonas vaginalis esterase, putative 0.0035 0.0508 0.1015
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0573 0.798
Schistosoma mansoni ap endonuclease 0.0038 0.0573 0.0509
Loa Loa (eye worm) TAR-binding protein 0.019 0.3571 0.9248
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0458 0.0394

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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